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Editor’s Corner

The legacy of János Kovács: a lifelong devotion to advancing autophagy research

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Pages 2017-2019 | Received 10 Jun 2022, Accepted 14 Jun 2022, Published online: 23 Jun 2022

References

  • Kovács J. Forty-five years of research and teaching. Acta Biol Hung. 2001;52(4):377–382.
  • Molnár I, Migh E, Szikora S, et al. DAAM is required for thin filament formation and sarcomerogenesis during muscle development in Drosophila. PLoS Genet. 2014 Feb;10(2):e1004166.
  • Kardos J, Kiss B, Micsonai A, et al. Phosphorylation as conformational switch from the native to amyloid state: Trp-cage as a protein aggregation model. J Phys Chem B. 2015 Feb 19 119(7):2946–2955.
  • Kovacs J, Hafiek B. Effect of neutral red on mouse liver cells. Acta Biol Acad Sci Hung. 1964;15:191–201.
  • Kovács J, Péczely P. Electron microscopic examination of the effect of neutral red on the epithelial cells of the seminal vesicle of the mouse. Acta Biol Acad Sci Hung. 1966;16(3):275–283.
  • Réz G, Kovács J. Prevention by cycloheximide of neutral red-induced formation of autophagic vacuoles and krinom granules in mouse pancreatic acinar cells. Virchows Arch B Cell Pathol. 1973 Jan 31;12(2):123–132.
  • Kovács J, Réz G, Kiss A. Vinblastine induced autophagocytosis and its prevention by calcoheximide and ementine in mouse pancreatic cells in vivo. Cytobiologie. 1975;11:309–313.
  • Kovács J, László L, Kovács AL. Regression of autophagic vacuoles in pancreatic acinar, seminal vesicle epithelial, and liver parenchymal cells: a comparative morphometric study of the effect of vinblastine and leupeptin followed by cycloheximide treatment. Exp Cell Res. 1988 Jan;174(1):244–251.
  • Kovacs J, Karpati AP. Regression of autophagic vacuoles in mouse pancreatic cells: a morphometric study of the effect of methylamine and chloroquine followed by cycloheximide treatment. Cell Biol Int Rep. 1989 Sep;13(9):805–811.
  • Kovács AL, László L, Fellinger E, et al. Combined effects of fasting and vinblastine treatment on serum insulin level, the size of autophagic-lysosomal compartment, protein content and lysosomal enzyme activities of liver and exocrine pancreatic cells of the mouse. Comp Biochem Physiol B. 1989;94(3):505–510.
  • Kovács AL, László L, Kovács J. Effect of amino acids and cycloheximide on changes caused by vinblastine, leupeptin and methylamine in the autophagic/lysosomal system of mouse hepatocytes in vivo. Exp Cell Res. 1985 Mar;157(1):83–94.
  • Sass M, Kovacs J. Ultrastructural changes in the fat body cells of Mamestra brassicae (Noctuidae, Lepidoptera) during metamorphosis. Ann Univ Sci Budap Rolando Eotvos Sect Biol. 1974;16:189–205.
  • Sass M, Kovacs J. Ecdysterone and an analogue of juvenile hormone on the autophagy in the cells of fat body of Mamestra brassicae. Acta Biol Acad Sci Hung. 1975;26(3–4):189–196.
  • Sass M, Kovacs J. The effect of ecdysone on the fat body cells of the penultimate larvae of Mamestra brassicae. Cell Tissue Res. 1977;180(3):403–409.
  • Sass M, Csikos G, Komuves L, et al. Cyclic AMP in the fat body of Mamestra brassicae during the last instar and its possible involvement in the cellular autophagocytosis induced by 20-hydroxyecdysone. Gen Comp Endocrinol. 1983 Apr;50(1):116–123.
  • Kovács A, Kovács J. Quantitative characterization of the autophagic process in mouse seminal vesicle cells in vitro. Acta Biol Acad Sci Hung. 1977;28(4):425–428.
  • Kovacs AL, Kovacs J. Autophagocytosis in mouse seminal vesicle cells in vitro. Temperature dependence and effects of vinblastine and inhibitors of protein synthesis. Virchows Arch B Cell Pathol Incl Mol Pathol. 1980;32(2):97–104.
  • Kovács J, Réz G. Quantitative aspects of cellular autophagocytosis. Morphometric and cell fractionation studies. Revis Biol Celular. 1989;20:63–78.
  • Fellinger E, Réz G. Isolation of pancreatic autophagic vacuoles induced by vinblastine or neutral red. Separation of autophagosomes and autolysosomes by Percoll density gradient centrifugation. Eur J Cell Biol. 1990 Apr;51(2):220–228.
  • Rez G, Meldolesi J. Freeze-fracture of drug-induced autophagocytosis in the mouse exocrine pancreas. Lab Invest. 1980 Sep;43(3):269–277.
  • Kovács AL, Grinde B, Seglen PO. Inhibition of autophagic vacuole formation and protein degradation by amino acids in isolated hepatocytes. Exp Cell Res. 1981 Jun;133(2):431–436.
  • Kovács AL, Seglen PO. Inhibition of hepatocytic protein degradation by methylaminopurines and inhibitors of protein synthesis. Biochim Biophys Acta. 1981 Aug 17;676(2):213–220.
  • Kovács AL, Molnár K, Seglen PO. Inhibition of autophagic sequestration and endogenous protein degradation in isolated rat hepatocytes by methylated adenosine derivatives. FEBS Lett. 1981 Nov 16;134(2):194–196.
  • Kovács AL, Reith A, Seglen PO. Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine. Exp Cell Res. 1982 Jan;137(1):191–201.
  • Réz G, Tóth S, Pálfia Z. Cellular autophagic capacity is highly increased in azaserine-induced premalignant atypical acinar nodule cells. Carcinogenesis. 1999 Oct;20(10):1893–1898.
  • Tóth S, Nagy K, Pálfia Z, et al. Cellular autophagic capacity changes during azaserine-induced tumour progression in the rat pancreas. Up-regulation in all premalignant stages and down-regulation with loss of cycloheximide sensitivity of segregation along with malignant transformation. Cell Tissue Res. 2002 Sep;309(3):409–416.
  • Telbisz A, Kovacs AL. Complete dissociation of rat pancreas into acini by a perfusion-incubation method: measurement of protein synthesis and the degradation of endogenous proteins. Pancreas. 1999 May;18(4):342–348.
  • Telbisz A, Kovacs AL. Intracellular protein degradation and autophagy in isolated pancreatic acini of the rat. Cell Biochem Funct. 2000 Mar;18(1):29–40.
  • Kovács AL, Réz G, Pálfia Z, et al. Autophagy in the epithelial cells of murine seminal vesicle in vitro. Formation of large sheets of nascent isolation membranes, sequestration of the nucleus and inhibition by wortmannin and 3-ethyladenine. Cell Tissue Res. 2000 Nov;302(2):253–261.
  • Juhasz G, Csikos G, Sinka R, et al. The Drosophila homolog of Aut1 is essential for autophagy and development. FEBS Lett. 2003 May 22;543(1–3):154–158.
  • Sigmond T, Fehér J, Baksa A, et al. Chapter twenty‐eight qualitative and quantitative characterization of autophagy in Caenorhabditis elegans by electron microscopy. Methods in Enzymology. 2008;451:467–491.
  • Toth ML, Simon P, Kovacs AL, et al. Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans [Research Support, Non-U.S. Gov’t]. J Cell Sci. 2007 Mar 15 120(Pt 6):1134–1141.
  • Aladzsity I, Toth ML, Sigmond T, et al. Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans [Research Support, Non-U.S. Gov’t]. Genetics. 2007 Sep;177(1):655–660.
  • Toth ML, Sigmond T, Borsos E, et al. Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans. Autophagy. 2008 Apr 1 4(3):330–338.
  • Tian Y, Li Z, Hu W, et al. C. elegans screen identifies autophagy genes specific to multicellular organisms. Cell. 2010 Jun 11 141(6):1042–1055.
  • Lu Q, Yang P, Huang X, et al. The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes [Research Support, Non-U.S. Gov’t]. Dev Cell. 2011 Aug 16 21(2):343–357.
  • Juhasz G, Erdi B, Sass M, et al. Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev. 2007 Dec 1 21(23):3061–3066.
  • Juhasz G, Hill JH, Yan Y, et al. The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol. 2008 May 19;181(4):655–666.
  • Juhasz G, Puskas LG, Komonyi O, et al. Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Cell Death Differ. 2007 Jun;14(6):1181–1190.
  • Takáts S, Nagy P, Varga Á, et al. Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila. J Cell Biol. 2013 May 13;201(4):531–539.
  • Takáts S, Pircs K, Nagy P, et al. Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila. Mol Biol Cell. 2014 Apr;25(8):1338–1354.
  • Hegedűs K, Takáts S, Boda A, et al. The Ccz1-Mon1-Rab7 module and Rab5 control distinct steps of autophagy. Mol Biol Cell. 2016 Oct 15;27(20):3132–3142.
  • Lőrincz P, Tóth S, Benkő P, et al. Rab2 promotes autophagic and endocytic lysosomal degradation. J Cell Biol. 2017 Jul 3;216(7):1937–1947.
  • Lőrincz P, Kenéz LA, Tóth S, et al. Vps8 overexpression inhibits HOPS-dependent trafficking routes by outcompeting Vps41/Lt. Elife. 2019;8:e45631 .
  • Csizmadia T, Lőrincz P, Hegedűs K, et al. Molecular mechanisms of developmentally programmed crinophagy in Drosophila. J Cell Biol. 2018 Jan 2;217(1):361–374.
  • Csizmadia T, Lőw P. The role of deubiquitinating enzymes in the various forms of autophagy. Int J Mol Sci. 2020 Jun 12;21(12):4196.
  • Brattås PL, Hersbach BA, Madsen S, et al. Impact of differential and time-dependent autophagy activation on therapeutic efficacy in a model of Huntington disease. Autophagy. 2021 June;17(6):1316–1329.
  • Lakatos Z, Benkő P, Juhász G, et al. Drosophila Rab39 attenuates lysosomal degradation. Int J Mol Sci. 2021 Sep 30 22(19):10635.
  • Takáts S, Lévay L, Boda A, et al. The Warburg micro syndrome-associated Rab3GAP-Rab18 module promotes autolysosome maturation through the Vps34 complex I. FEBS J. 2021 01; 288(1):190–211.
  • Dósa A, Csizmadia T. The role of K63-linked polyubiquitin in several types of autophagy. Biol Futura. 2022 May 2. DOI:10.1007/s42977-022-00117-4

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