Advanced search
Publication Cover
Clinical Toxicology Volume 60, 2022 - Issue 9
Submit an article Journal homepage
354
Views
1
CrossRef citations to date
0
Altmetric
Poison Centre Research

Single-substance trazodone exposures reported to US poison centers from 2000 to 2019

Nicholas Husaka Department of Pharmacy Practice and Science, Maryland Poison Center, University of Maryland School of Pharmacy, Baltimore, MD, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9833-760X
ORCID Icon,
James Brewer Leonarda Department of Pharmacy Practice and Science, Maryland Poison Center, University of Maryland School of Pharmacy, Baltimore, MD, USAORCID Iconhttps://orcid.org/0000-0002-6444-8950
ORCID Icon,
Hyunuk Seungb Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, MD, USA
&
Wendy Klein-Schwartza Department of Pharmacy Practice and Science, Maryland Poison Center, University of Maryland School of Pharmacy, Baltimore, MD, USA
Pages 1032-1038 | Received 24 Sep 2021, Accepted 17 Apr 2022, Published online: 27 Apr 2022

References

  • Haria M, Fitton A, McTavish D. Trazodone. A review of its pharmacology, therapeutic use in depression and therapeutic potential in other disorders. Drugs Aging. 1994;4(4):331–355.
  • Kane SP. Trazodone, ClinCalc DrugStats Database, Version 2021.10; [updated 2021 Sept 15; cited 2021 Dec 13]. Available from: https://clincalc.com/DrugStats/Drugs/Trazodone
  • Trazodone [package insert]. Locust Valley, NY: Pragma Pharmaceuticals, LLC; 2017.
  • Jaffer KY, Chang T, Vanle B, et al. Trazodone for insomnia: a systematic review. Innov Clin Neurosci. 2017;14(7-8):24–34.
  • Service JA, Waring WS. QT prolongation and delayed atrioventricular conduction caused by acute ingestion of trazodone. Clin Toxicol. 2008;46(1):71–73.
  • Camacho LD, Stearns J, Amini R. Management of trazodone overdose with severe hypotension. Case Rep Emerg Med. 2019;2019:2470592.
  • Soe KK, Lee MY. Arrhythmias in severe trazodone overdose. Am J Case Rep. 2019;20:1949–1955.
  • Winkler D, Ortner R, Pjrek E, et al. Trazodone-induced cardiac arrhythmias: a report of two cases. Hum Psychopharmacol. 2006;21(1):61–62.
  • de Meester A, Carbutti G, Gabriel L, et al. Fatal overdose with trazodone: case report and literature review. Acta Clin Belg. 2001;56(4):258–261.
  • White N, Litovitz T, Clancy C. Suicidal antidepressant overdoses: a comparative analysis by antidepressant type. J Med Toxicol. 2008;4(4):238–250.
  • El Zahran T, Morgan BW, Hon S, et al. Unintentional trazodone overdoses in children ≤6 years of age: data from poison center over a period of 16 years. Clin Toxicol. 2019;57(1):56–59.
  • Nelson JC, Spyker DA. Morbidity and mortality associated with medications used in the treatment of depression: an analysis of cases reported to U.S. Poison control centers, 2000-2014. Am J Psychiatry. 2017;174(5):438–450.
  • Gummin DD, Mowry JB, Beuhler MC, et al. 2019 Annual report of the american association of poison control centers’ national poison data system (NPDS): 37th annual report. Clin Toxicol. 2020;58(12):1360–1541.
  • Anderson BD, Seung H, Klein-Schwartz W. Trends in types of calls managed by U.S. poison centers 2000-2015. Clin Toxicol. 2018;56(7):640–645.
  • Bertisch SM, Herzig SJ, Winkelman JW, et al. National use of prescription medications for insomnia: NHANES 1999-2010. Sleep. 2014;37(2):343–349.
  • Wong J, Horwitz MM, Bertisch SM, et al. Trends in dispensing of zolpidem and Low-Dose trazodone among commercially insured adults in the United States, 2011-2018. JAMA. 2020;324(21):2211–2213.
  • Forrester MB. Immediate- and controlled-release zolpidem ingestions reported to Texas poison centers. Hum Exp Toxicol. 2009;28(8):505–509.
  • Lee S, Lee HA, Kim SJ, et al. Cellular mechanisms for trazodone-induced cardiotoxicity. Hum Exp Toxicol. 2016;35(5):501–510.
  • Campleman SL, Brent J, Pizon AF, et al. Toxicology investigators’ consortium (ToxIC). drug-specific risk of severe QT prolongation following acute drug overdose. Clin Toxicol. 2020;58(12):1326–1334.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.