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Clinical Research

Duloxetine overdose causes sympathomimetic and serotonin toxicity without major complications

ORCID Icon, , , & ORCID Icon
Pages 1019-1023 | Received 06 Apr 2022, Accepted 24 May 2022, Published online: 06 Jun 2022

References

  • Bymaster FP, Dreshfield-Ahmad LJ, Threlkeld PG, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001;25(6):871–880.
  • Lunn MP, Hughes RA, Wiffen PJ. Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia. Cochrane Database Syst Rev. 2014;3(1):CD007115.
  • Derby MA, Zhang L, Chappell JC, et al. The effects of supratherapeutic doses of duloxetine on blood pressure and pulse rate. J Cardiovasc Pharmacol. 2007;49(6):384–393.
  • Brunton S, Wang F, Edwards SB, et al. Profile of adverse events with duloxetine treatment: a pooled analysis of placebo-controlled studies. Drug Saf. 2010;33(5):393–407.
  • Vuppalanchi R, Hayashi PH, Chalasani N, Drug-Induced Liver Injury Network (DILIN), et al. Duloxetine hepatotoxicity: a case-series from the drug-induced liver injury network. Aliment Pharmacol Ther. 2010;32(9):1174–1183.
  • Darracq MA, Clark A, Qian L, et al. A retrospective review of isolated duloxetine-exposure cases. Clin Toxicol (Phila). 2013;51(2):106–110.
  • Jacob J, Albert D, Heard K. Single-agent duloxetine ingestions. Hum Exp Toxicol. 2013;32(4):427–433.
  • Brown J, Gunja N. Toxicity profile of duloxetine: a poisons centre cohort study. [abstract. ]. Clinical Toxicology. 2011;49(3):1.
  • Just S, Gros S, Reichert C, et al. Duloxetine overdose: a case series. Clin Toxicol. 2015;53(4):1.
  • Dunkley EJ, Isbister GK, Sibbritt D, et al. The hunter serotonin toxicity criteria: simple and accurate diagnostic decision rules for serotonin toxicity. QJM. 2003;96(9):635–642.
  • Chan A, Isbister GK, Kirkpatrick CM, et al. Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. QJM. 2007;100(10):609–615.
  • Isbister GK, Bowe SJ, Dawson A, et al. Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose. J Toxicol Clin Toxicol. 2004;42(3):277–285.
  • Hoyt BT, Rasmussen R, Giffin S, et al. Poison center data accuracy: a comparison of rural hospital chart data with the TESS database. Toxic exposure surveillance system. Acad Emerg Med. 1999;6(8):851–855.
  • Mari F, Gualco B, Rensi R, et al. Acute massive pulmonary thromboembolism due to acute intoxication by duloxetine: a case report. Cardiovasc Toxicol. 2012;12(3):258–262.
  • Oliver WD, D'Angelo R, Gonzales J, et al. Acute severe hyponatremia induced by a duloxetine overdose in an elderly woman. Cureus. 2020;12(9):e10318.
  • Scanlon KA, Stoppacher R, Blum LM, et al. Comprehensive duloxetine analysis in a fatal overdose. J Anal Toxicol. 2016;40(2):167–170.
  • Adachi K, Beppu S, Nishiyama K, et al. Pharmacokinetics of duloxetine self-administered in overdose with quetiapine and other antipsychotic drugs in a Japanese patient admitted to hospital. J Pharm Health Care Sci. 2021;7(1):6.
  • Alibegovic A, Kariz S, Volavsek M. Fatal overdose with a combination of SNRIs venlafaxine and duloxetine. Forensic Sci Med Pathol. 2019;15(2):258–261.
  • Menchetti M, Gozzi BF, Saracino MA, et al. Non-fatal overdose of duloxetine in combination with other antidepressants and benzodiazepines. World J Biol Psychiatry. 2009;10(4 Pt 2):385–389.
  • Paulzen M, Hiemke C, Grunder G. Plasma levels and cerebrospinal fluid penetration by duloxetine in a patient with a non-fatal overdose during a suicide attempt. Int J Neuropsychopharmacol. 2009;12(10):1431–1432.
  • Zhang L, Chappell J, Gonzales CR, et al. QT effects of duloxetine at supratherapeutic doses: a placebo and positive controlled study. J Cardiovasc Pharmacol. 2007;49(3):146–153.
  • Gelener P, Gorgulu U, Kutlu G, et al. Serotonin syndrome due to duloxetine. Clin Neuropharmacol. 2011;34(3):127–128.
  • Whyte IM, Dawson AH, Buckley NA. Relative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants. QJM. 2003; 96(5):369–374.
  • Pellicciari A, Balzarro B, Scaramelli A, et al. Generalized tonic-clonic seizure secondary to duloxetine poisoning: a short report with favorable outcome. Neurotoxicology. 2012;33(2):189–190.
  • Kumar VV, Isbister GK, Duffull SB. The effect of decontamination procedures on the pharmacodynamics of venlafaxine in overdose. Br J Clin Pharmacol. 2011;72(1):125–132.
  • Knadler MP, Lobo E, Chappell J, et al. Duloxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2011;50(5):281–294.
  • Jasiak NM, Bostwick JR. Risk of QT/QTc prolongation among newer non-SSRI antidepressants. Ann Pharmacother. 2014;48(12):1620–1628.
  • Isbister GK, Friberg LE, Stokes B, et al. Activated charcoal decreases the risk of QT prolongation after citalopram overdose. Ann Emerg Med. 2007;50(5):593–600.
  • Friberg LE, Isbister GK, Hackett LP, et al. The population pharmacokinetics of citalopram after deliberate self-poisoning: a Bayesian approach. J Pharmacokinet Pharmacodyn. 2005;32(3-4):571–605.
  • Isbister GK, Friberg LE, Hackett LP, et al. Pharmacokinetics of quetiapine in overdose and the effect of activated charcoal. Clin Pharmacol Ther 2007;81(6):821–827.

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