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Letters to the Editor: Original Scientific Contributions

Hemodialysis enhances elimination of ethosuximide in massive overdose

ORCID Icon, , , &
Pages 1078-1079 | Received 05 Jun 2022, Accepted 13 Jul 2022, Published online: 27 Jul 2022

References

  • Hugenard J. Block of T-type Ca + 2 channels is an important action of succinimide antiabsence drugs. Epilepsy Curr. 2002;2(2):49–52.
  • Kim P, Westover R, Shulman J. Case report: ethosuximide overdose. Clin Toxicol. 2020;58(11):1158. [abstract]
  • Ethosuximide [package insert]. New York (NY): Pfizer, Inc.; 2010.
  • Battino D, Estienne M, Avanzini G. Clinical pharmacokinetics of antiepileptic drugs in pediatric patients. Part I: phenobarbital, primidone, valproic acid, ethosuximide and mesuximide. Clin Pharmacokinet. 1995;29(4):257–286.
  • Patsalos PN, Zugman M, Lake C, et al. Serum protein binding of 25 antiepileptic drugs in a routine clinical setting: a comparison of free non-protein-bound concentrations. Epilepsia. 2017;58(7):1234–1243.
  • Marbury T, Lee C, Perchalski R, et al. Hemodialysis clearance of ethosuximide in patients with chronic renal disease. Am J Hosp Pharm. 1981;38(11):1757–1760.

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