Vegetative part of Nigella sativa L. potential antineoplastic sources against Hep2 and MCF7 human cancer cell lines

References

• Woo C, Hsu A, Kumar A, et al. Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: the role of p38 MAPK and ROS. Peer-rev Open Acces Sci J. 2013;8(10):1–14. doi:10.1371/journal.pone.0075356.
   Google Scholar
• Stewart BW, Wild CP. World Cancer Report. IARC Publications; 2014.
   Google Scholar
• McGrowder DA, Miller FG, Nwokocha CR, et al. Medicinal herbs used in traditional management of breast cancer: mechanisms of action. Medicines. 2020;7(8):47, doi:10.3390/medicines7080047.
   Google Scholar
• Kuruppu A, Paranagama P, Goonasekara C. Medicinal plants commonly used against cancer in traditional medicine formulae in Sri Lanka. Saudi Pharm J. 2019;27(4):565–573. doi:10.1016/j.jsps.2019.02.004.
   PubMed Web of Science ®Google Scholar
• Gordaliza M. Natural products as leads to anticancer drugs. Clin Transl Oncol. 2007;9(12):767–776. doi:10.1007/s12094-007-0138-9.
   PubMed Web of Science ®Google Scholar
• Krishnan V, Bupesh G, Manikandan E, et al. Green synthesis of silver nanoparticles using Piper nigrum concoction and its anticancer activity against MCF-7 and Hep-2 cell lines. J Antimicrob Chemother. 2016;2(3):2472–1212. DOI: 10.4172/2472-1212.1000123.
   Google Scholar
• Ahmad A, Husain A, Mujeeb M, et al. A review on therapeutic potential of Nigella sativa: a miracle herb. Asian Pac J Trop Biomed. 2013;3(5):337–352. doi:10.1016/s2221-1691(13)60075-1.
   PubMedGoogle Scholar
• Khan A, Chen HC, Tania M, et al. Anticancer activities of Nigella sativa (black cumin). Afr J Trad, Complement Altern Med. 2011;8(5S):671–678. doi:10.4314/ajtcam.v8i5SS.10.
   Google Scholar
• Randhawa MA, Alghamdi MS. Anticancer activity of Nigella sativa (black seed)—a review. Am J Chin Med. 2011;39(06):1075–1091. doi:10.1142/S0192415X1100941X.
   PubMedGoogle Scholar
• Venugopal K, Bupesh G, Manikandan E, et al. Green synthesis of silver nanoparticles using Piper nigrum concoction and its anticancer activity against MCF-7 and Hep-2 cell lines. J Antimicrob Chemother. 2016;2:3, doi:10.4172/2472-1212.1000123.
   Google Scholar
• Mirabelli P, Luigi C, Marco S. Cancer cell lines are useful model systems for medical research. Cancers (Basel). 2019;11(8):1098, doi:10.3390/cancers11081098.
   PubMed Web of Science ®Google Scholar
• Pang Y, Ahmed S, Xu Y, et al. Bound phenolic compounds and antioxidant properties of whole grain and bran of white, red and black rice. Food Chem. 2018;240:212–221. doi:10.1016/j.foodchem.2017.07.095.
   PubMed Web of Science ®Google Scholar
• Li A-N, Li S, Zhang Y-J, et al. Resources and biological activities of natural polyphenols. Nutrients. 2014;6:6020–6047. doi:10.3390/nu6126020.
   PubMed Web of Science ®Google Scholar
• Dewanto V, Wu X, Adom KK, et al. Thermal processing enhances the nutritional value of tomatoes by increasing total antioxidant activity. J Agric Food Chem. 2002;50(10):3010–3014. doi:10.1021/jf0115589.
   PubMed Web of Science ®Google Scholar
• Barkat M, Harshita  Pottoo F, Beg S, et al. Evidence-based review on clinical potential of thymoquinone in breast cancer. Nanomed Bioactiv. 2020;17(1):471–486. doi:10.1007/978-981-15-1664-1_19.
   Google Scholar
• Dai X, Cheng H, Bai Z, et al. Breast cancer cell line classification and its relevance with breast tumor subtyping. J Cancer. 2017;8(16):3131–3141. doi:10.7150/jca.18457.
   PubMed Web of Science ®Google Scholar
• Sweeney EE, Mcdaniel RE, Maximov PY, et al. Models and mechanisms of acquired antihormone resistance in breast cancer: significant clinical progress despite limitations. Horm Mol Biol Clin Investig. 2013;9:143–163. doi:10.1515/hmbci-2011-0004.
   Google Scholar
• Korch C, Capes-Davis A. The extensive and expensive impacts of HEp-2 [HeLa], intestine 407 [HeLa], and other false cell lines in journal publications. SLAS Discovery. 2021;26(10):1268–1279. doi:10.1177/24725552211051963.
   PubMed Web of Science ®Google Scholar
• Ralph PETER, Moore MA, Nilsson K. Lysozyme synthesis by established human and murine histiocytic lymphoma cell lines. J Exp Med. 1976;143(6):1528–1533. doi:10.1084/jem.143.6.1528.
   PubMed Web of Science ®Google Scholar
• Rubinstein LV, Shoemaker RH, Paull KD, et al. Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines. J Natl Cancer Inst. 1990;82(13):1113–1117. doi:10.1093/jnci/82.13.1113.
   PubMed Web of Science ®Google Scholar
• Shahraki S, Khajavirad A, Shafei MN, et al. Effect of total hydroalcholic extract of Nigella sativa and its n-hexane and ethyl acetate fractions on ACHN and GP-293 cell lines. J Tradit Complement Med. 2016;6:89–96. doi:10.1016/j.jtcme.2014.11.018.
   PubMedGoogle Scholar
• Soltanian S, Mohamadi N, Sheikhbahaei M. Cytotoxicity evaluation of methanol extracts of some medicinal plants on P19 embryonal carcinoma cells. J Appl Pharm Sci. 2017;21(12):1801–1818. doi:10.7324/japs.2017.70722.
   Google Scholar
• Derwich E, Benziane Z, Boukir A. GC/MS Analysis and Antibacterial Activity of the Essential Oil of Mentha pulegium Grown in Morocco. Res J. Agric Biol Sci. 2010;6:191–198.
   Google Scholar
• Grimes BA, Liapis AI. Modeling and analysis of the electrokinetic mass transport and adsorption mechanisms of a charged adsorbate in capillary electrochromatography systems employing charged nonporous adsorbent particles. J Colloid Interface Sci. 2001;234(1):223–243.
   PubMed Web of Science ®Google Scholar
• Aslany S, Tafvizi F, Naseh V. Characterization and evaluation of cytotoxic and apoptotic effects of green synthesis of silver nanoparticles using Artemisia Ciniformis on human gastric adenocarcinoma. Mater Today Commun. 2020;24:101011, doi:10.1016/j.mtcomm.2020.101011.
   Web of Science ®Google Scholar
• Thomas AB, Shetane TD, Singha RG, et al. Employing central composite design for evaluation of biomass production by Fusarium venenatum: in vivo antioxidant and antihyperlipidemic properties. Appl Biochem Biotechnol. 2017;183(1):91–109.
   PubMed Web of Science ®Google Scholar
• Ikeda A, Mori M, Kiguchi K, et al. Advantages and potential of lipid-membrane-incorporating fullerenes prepared by the fullerene-exchange method. Chem – Asian J. 2012;7(3):605–613.
   PubMed Web of Science ®Google Scholar
• Yaguchi T, Nagata T, Nishizaki T. 1, 2-Dilinoleoyl-sn-glycero-3-phosphoethanolamine ameliorates age-related spatial memory deterioration by preventing neuronal cell death. Behav Brain Funct. 2010;6(1):1–9.
   PubMedGoogle Scholar
• Cheong H, Lu C, Lindsten T, et al. Therapeutic targets in cancer cell metabolism and autophagy. Nat Biotechnol . 2012;30:671–678.
   PubMed Web of Science ®Google Scholar
• Ibrahim A, Musa B. Liquid Chromatography Mass Spectrometer (Lc/Ms) profile revealed flavonoids and terpenoids with antioxidant potential in aqueous fraction of Combretum micranthum leaf extract. Zanco J. Pure Appl Sci. 2021;7(4):236–247.
   Google Scholar
• Khan MA, Tania M, Zhang D-Z, et al. Antioxidant enzymes and cancer. Chin J Canc Res. 2011;22(2):87–92. doi:10.1016/j.biopha.2017.09.115.
   Web of Science ®Google Scholar
• Einbonda LS, Soffritti M, Esposti DD, et al. Actein activates stress and statin associated responses and is bioavailable in Sprague-Dawley rats. Fund Clin Pharmacol. 2009;23:311–321. doi:10.1111/j.1472-8206.2009.00673.x.
   PubMed Web of Science ®Google Scholar
• Haghighi T, Saharkhiz M. Phytotoxic potential of Vitex pseudo-negundo leaf and flower extracts and analysis of phenolic compounds. Biocatal Agr Biotechn. 2021;34:102018, doi:10.1016/j.bcab.2021.102018.
   Web of Science ®Google Scholar
• Swamy SM, Huat BT. Intracellular glutathione depletion and reactive oxygen species generation are important in alpha-hederin-induced apoptosis of P388 cells. Mol Cell Biochem. 2003;245:127–139. doi:10.1023/a:1022807207948.
   PubMed Web of Science ®Google Scholar
• Solowey E, Lichtenstein M, Sallon S, et al. Evaluating medicinal plants for anticancer activity. Sci World J. 2014;6:1–12. doi:10.1155/2014/721402.
   Google Scholar
• Cordier W, Steenkamp P, Steenkamp V. Extracts of Moringa oleifera lack cytotoxicity and attenuate oleic acid-induced steatosis in an in vitro HepG2 model. S Afr J Bot. 2020;129:123–133. doi:10.1016/j.sajb.2019.03.001.
   Web of Science ®Google Scholar
• Majdalawieh A, Fayyad M. Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive. J Ayurveda Integr Med. 2016;7(3):173–180. doi:10.1016/j.jaim.2016.07.004.
   PubMed Web of Science ®Google Scholar
• Van-Nguyen-Thien T, Huynh V, Vo L, et al. Two new compounds and α-glucosidase inhibitors from the leaves of Bidens pilosa L. Phytochem Lett. 2017;20:119–122. doi:10.1016/j.phytol.2017.04.015.
   Web of Science ®Google Scholar
• Seca AML, Pinto D. Plant secondary metabolites as anticancer agents: successes in clinical trials and therapeutic application. Int J Mol Sci. 2018;19(1):368–375. doi:10.3390/ijms19010263.
   PubMed Web of Science ®Google Scholar
• Greenwell M, Rahman PKSM. Medicinal plants: their use in anticancer treatment. Int J Pharm Sci Res. 2015;6(10):4103), doi:10.13040/IJPSR.0975-8232.6(10).4103-12.
   PubMed Web of Science ®Google Scholar
• Alenzi FQ, El-Bolkiny YS, Salem ML. Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anticancer drug cyclophosphamide. British J Biomed Sci. 2010;67(1):20–28. doi:10.1080/09674845.2010.11730285.
   PubMed Web of Science ®Google Scholar
• Khan MA, Chen HA, Mousumi T, et al. Anticancer activities of Nigella sativa (black cumin) African. J Trad Complem Alternat Med. 2011;8(5 Suppl):226–232. DOI: 10.4314/ajtcam.v8i5S.10
   PubMedGoogle Scholar
• Bajkin Branislav, Selakovic Srecko, Mirkovic Sinisa, etal. Comparison of efficacy of local hemostatic modalities in anticoagulated patients undergoing tooth extractions. Vojnosanitetski pregled. 2014;71(12):1097–1101. https://doi.org/10.2298/VSP1412097B.
   PubMed Web of Science ®Google Scholar
• Amin FM, Muneera W, Fayyad T. Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive. J Ayurveda Integr Med. 2016;7:173–180. doi:10.1016/j.jaim.2016.07.004.
   PubMedGoogle Scholar
• Salih HM, Aljabre O, Alakloby M. Dermatological effects of Nigella sativa. J Dermat Derm Surv. 2015;19(2):92–98. doi:10.1016/j.jdds.2015.04.002
   Google Scholar
• Huang M, Lu JJ, Huang MQ, et al. Terpenoids: natural products for cancer therapy. Expert Opin Invest Drugs. 2012;21(12):1801–1818. doi:10.1517/13543784.2012.727395.
   PubMed Web of Science ®Google Scholar
• Guesmi F, Prasad S, Tyagi AK, et al. Antinflammatory and anticancer effects of terpenes from oily fractions of Teucruimalopecurus, blocker of IκBα kinase, through downregulation of NF-κB activation, potentiation of apoptosis and suppression of NF-κB-regulated gene expression. Biomed Pharmaco. 2017;9(5):1876–1885. doi:10.1016/j.biopha.2017.09.115.
   Google Scholar
• Shams R, Ghafouri-Fard S. No association between expression of RAS Guanyl releasing protein 3 (RASGRP3) in breast cancer and clinicopathological data. Int J Cancer Manage. 2018;11(9) DOI: 10.5812/ijcm.69551,
   Web of Science ®Google Scholar
• Effenberger K, Breyer S, Schobert R. Terpene conjugates of the Nigella sativa seed-oil constituent thymoquinone with enhanced efficacy in cancer cells. Chemical Biodiversity. 2010;7:129–139.
   PubMed Web of Science ®Google Scholar
• Tesfaye T, Ravichadran YD. A review on anticancer activity of some plant-derived compounds and their mode of action. Nat Prod Chem Res. 2018;6(4):2–9.
   Google Scholar
• Shakya AK. Medicinal plants: future source of new drugs. Int J Herb Med. 2016;4:59–64. Potential of N. sativa. Ethnobotanical Review, 13: 946–955. DOI:10.13140/RG.2.1.1395.6085.
   Google Scholar
• Fabian CJ, Bruce FK, Stephen DH. Omega-3 fatty acids for breast cancer prevention and survivorship. Breast Cancer Res. 2015;17(1):62, 39(6):1075–1091. doi:10.1186/s13058-015-0571-6.
   PubMed Web of Science ®Google Scholar
• Djordjevic NM, Houdiere F, Fowler P. High temperature and temperature programming in capillary HPLC. Biomed Chromatogr. 2008;12(3):153–154.
   Google Scholar
• Ismail M, Al-Naqeep G, Chan KW. Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats. Free Radical Biology and Medicine. 2010;48(5):664–672.
   PubMed Web of Science ®Google Scholar