596
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Dentatin triggers ROS-mediated apoptosis, G0/G1 cell cycle arrest and release of Th1-related cytokines in colorectal carcinoma cells

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Article: 2194231 | Received 16 Nov 2022, Accepted 19 Mar 2023, Published online: 03 Apr 2023

References

  • Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. DOI:10.3322/caac.21660
  • Hassan MR A, Ismail I, Mohd Suan MA, et al. Incidence and mortality rates of colorectal cancer in Malaysia. Epidemiol Health. 2016;38:e2016007. DOI:10.4178/epih.e2016007
  • Wong SW, Ling DY, Yeow RQ, et al. Clinicopathological patterns and survival outcomes of colorectal cancer among young adults in Malaysia: An institutional cohort study. Singapore Med J. 2021;62(12):636–641. DOI:10.11622/smedj.2021051
  • Hofseth LJ, Hebert JR, Chanda A, et al. Early-onset colorectal cancer: initial clues and current views. Nat Rev Gastroenterol Hepatol. 2020;17(6):352–364. DOI:10.1038/s41575-019-0253-4
  • Latchman J, Guastella A, Tofthagen C. 5-Fluorouracil toxicity and dihydropyrimidine dehydrogenase enzyme: implications for practice. Clin J Oncol Nurs. 2014;18(5):581–585. DOI:10.1188/14.CJON.581-585
  • Sara JD, Kaur J, Khodadadi R, et al. 5-fluorouracil and cardiotoxicity: a review. Ther Adv Med Oncol. 2018. DOI:10.1177/1758835918780140
  • Huang M, Lu JJ, Ding J. Natural products in cancer therapy: past, present and future. Nat Prod Bioprospect. 2021;11(1):5–13. DOI:10.1007/s13659-020-00293-7
  • Diederich M. Natural compound inducers of immunogenic cell death. Arch Pharmacal Res. 2019;42(7):629–645. DOI:10.1007/s12272-019-01150-z
  • Greten FR, Grivennikov SI. Inflammation and cancer: triggers, mechanisms, and consequences. Immunity. 2019;51(1):27–41. DOI:10.1016/j.immuni.2019.06.025
  • Arbab IA, Abdul AB, Hassan BA, et al. Dentatin induces apoptosis in PC3 and LNCaP prostate cancer cells via Bcl- 2, bcl-xl, survivin downregulation, caspase-9, -3/7 activation, and NF-κB inhibition. Asian Pac J Trop Dis. 2014;4(3):230. DOI:10.1016/S2222-1808(14)60525-9
  • Xiong W, Dong J, Kong S. Dentatin exerts anticancer effects on human colon cancer cell lines via cell cycle arrest, autophagy, inhibition of cell migration and JAK/STAT signalling pathway. J BUON. 2019;24(4):1488–1493.
  • Andas ARJ, Abdul AB, Rahman HS, et al. Dentatin from clausena excavata induces apoptosis in HepG2 cells via mitochondrial mediated signaling. Asian Pac J Cancer Prev. 2015;16(10):4311–4316. DOI:10.7314/APJCP.2015.16.10.4311
  • Arbab IA, Abdul AB, Sukari MA, et al. Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cells through the intrinsic pathway with involvement of NF-κB signalling and G0/G1 cell cycle arrest: a bioassay-guided approach. J Ethnopharmacol. 2013;145(1):343–354. DOI:10.1016/j.jep.2012.11.020
  • AL-Abboodi A, Rasedee A, Abdul AB, et al. Anticancer effect of dentatin and dentatin-hydroxypropyl-β-cyclodextrin complex on human colon cancer (HT-29) cell line. Drug Des Devel Ther. 2017;11:3309–3319. DOI:10.2147/DDDT.S147626
  • Sethy C, Kundu CN. 5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: implication of DNA repair inhibition. Biomed Pharmacother. 2021;137:111285. DOI:10.1016/j.biopha.2021.111285
  • Barathan M, Zulpa AK, Mee Hoong S, et al. Synergistic effect of hyperforin and paclitaxel on growth inhibition, apoptotic mediator activation in MCF-7 human breast cancer cells. J Taibah Univ Sci. 2021;15(1):918–927. DOI:10.1080/16583655.2021.2010910
  • Zulpa AK, Barathan M, Iyadorai T, et al. Release of pro-inflammatory cytokines TNF-α, IFN-γ and IL-6 by Burkholderia pseudomallei-stimulated peripheral blood mononucleocytes of acute myeloid leukemia patients. Trop Biomed. 2021;38(2):180–185. DOI:10.47665/tb.38.2.055
  • Bishehsari F. Epidemiological transition of colorectal cancer in developing countries: environmental factors, molecular pathways, and opportunities for prevention. World J Gastroenterol. 2014;20(20):6055. DOI:10.3748/wjg.v20.i20.6055
  • Amaral RG, dos Santos SA, Andrade LN, et al. Natural products as treatment against cancer: a historical and current vision. Clin Oncol. 2019;4(1562):1–5.
  • Arbab IA, Looi CY, Abdul AB, et al. Dentatin induces apoptosis in prostate cancer cells via Bcl-2, Bcl-xL, survivin downregulation, caspase-9, -3/7 activation, and NF-κB inhibition. Evidence-Based Complementary Altern Med. 2012. DOI:10.1155/2012/856029
  • Zhao H. Extrinsic and intrinsic apoptosis signal pathway review. Sch Environ Sci. 2012;1:1–29.
  • Mhaidat NM, Bouklihacene M, Thorne RF. 5-Fluorouracil-induced apoptosis in colorectal cancer cells is caspase-9-dependent and mediated by activation of protein kinase C-δ. Oncol Lett. 2014;8(2):699–704. DOI:10.3892/ol.2014.2211
  • Martin-Cordero C, Jose Leon-Gonzalez A, Manuel Calderon-Montano J, et al. Pro-oxidant natural products as anticancer agents. Curr Drug Targets. 2012;13(8):1006–1028. DOI:10.2174/138945012802009044
  • Ashwaq A-A, Al-Qubaisi M, Rasedee A, et al. Inducing G2/M cell cycle arrest and apoptosis through generation reactive oxygen species (ROS)-mediated mitochondria pathway in HT-29 cells by dentatin (DEN) and dentatin incorporated in hydroxypropyl-β-cyclodextrin (DEN-HPβCD). Int J Mol Sci. 2016;17(10):1653. DOI:10.3390/ijms17101653
  • Ayob AZ, Ramasamy TS. Cancer stem cells as key drivers of tumour progression. J Biomed Sci. 2018;25(1):20. DOI:10.1186/s12929-018-0426-4
  • Yao W, Qiu H-M, Cheong K-L, et al. Advances in anti-cancer effects and underlying mechanisms of marine algae polysaccharides. Int J Biol Macromol. 2022;221:472–485. DOI:10.1016/j.ijbiomac.2022.09.055
  • Linke SP, Clarkin KC, Di Leonardo A, et al. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev. 1996;10(8):934–947. DOI:10.1101/gad.10.8.934
  • Deveci HA, Nazıroğlu M, Nur G. 5-Fluorouracil-induced mitochondrial oxidative cytotoxicity and apoptosis are increased in MCF-7 human breast cancer cells by TRPV1 channel activation but not Hypericum perforatum treatment. Mol Cell Biochem. 2018;439(1–2):189–198. DOI:10.1007/s11010-017-3147-1
  • Showalter A, Limaye A, Oyer JL, et al. Cytokines in immunogenic cell death: applications for cancer immunotherapy. Cytokine. 2017;97(May):123–132. DOI:10.1016/j.cyto.2017.05.024
  • Castro F, Cardoso AP, Gonçalves RM, et al. Interferon-Gamma at the crossroads of tumor immune surveillance or evasion. Front Immunol. 2018;9(MAY):1–19. DOI:10.3389/fimmu.2018.00847
  • Sun Q, Shang Y, Sun F, et al. Interleukin-6 promotes epithelial-mesenchymal transition and cell invasion through integrin β 6 upregulation in colorectal cancer. Oxid Med Cell Longevity. 2020;2020:1–13. DOI:10.1155/2020/8032187
  • Li S, Tian J, Zhang H, et al. Down-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancer. Apoptosis. 2018;23(5–6):356–374. DOI:10.1007/s10495-018-1460-0
  • Wu D, Wu P, Huang Q, et al. Interleukin-17: a promoter in colorectal cancer progression. Clin Dev Immunol. 2013;2013:1–7. DOI:10.1155/2013/436307