References
- Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. DOI:10.3322/caac.21660
- Herbst RS, Morgensztern D, Boshoff C. The biology and management of non-small cell lung cancer. Nature. 2018;553(7689):446–454. DOI:10.1038/nature25183
- Duma N, Santana-Davila R, Molina JR. Non-small cell lung cancer: epidemiology, screening, diagnosis, and treatment. Mayo Clin Proc. 2019;94(8):1623–1640. DOI:10.1016/j.mayocp.2019.01.013
- Gazdar AF, Minna JD. Molecular techniques for early detection of lung cancer and for studying preneoplasia. In: Pass HI, Carbone DP, Johnson DH, Minna JD, Turrisi AT, editor. Lung cancer principles and practice. 3rd ed. New York: Lippincott, Williams & Wilkins; 2004. p. 201.
- Bhattacharjee A, Richards WG, Staunton J, et al. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci USA. 2001;98(24):13790–5. DOI:10.1073/pnas.191502998
- Braiteh F, Kurzrock R. Uncommon tumors and exceptional therapies: paradox or paradigm? Mol Cancer Ther. 2007;6(4):1175–1179. DOI:10.1158/1535-7163.MCT-06-0674
- Westcott PM, Halliwill KD, To MD, et al. The mutational landscapes of genetic and chemical models of Kras-driven lung cancer. Nature. 2015;517(7535):489–492. DOI:10.1038/nature13898
- Malkinson AM. Primary lung tumors in mice as an aid for understanding, preventing, and treating human adenocarcinoma of the lung. Lung Cancer. 2001;32(3):265–279. DOI:10.1016/s0169-5002(00)00232-4
- Regala RP, Justilien V, Walsh MP, et al. Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation. PLoS One. 2011;6(10):e26439. DOI:10.1371/journal.pone.0026439
- Hamzawy MA, Abo-youssef AM, Salem HF, et al. An additional risk of lung cancer from recurrent exposure to ethyl carbamate EC in BALB/C mice. J Cancer Sci Ther. 2015;7:359–362. DOI:10.4172/1948-5956.1000375
- Zappa C, Mousa SA. Non-small cell lung cancer: current treatment and future advances. Transl Lung Cancer Res. 2016;5(3):288–300. DOI:10.21037/tlcr.2016.06.07
- Rosenberg B, VanCamp L, Trosko JE, et al. Platinum compounds: a new class of potent antitumour agents. Nature. 1969;222(5191):385–386. DOI:10.1038/222385a0
- Kostova I. Platinum complexes as anticancer agents. Recent Pat Anti-Cancer Drug Discov. 2006;1:1–22. DOI:10.2174/157489206775246458
- Aldossary SA. Review on pharmacology of cisplatin: clinical use, toxicity and mechanism of resistance of cisplatin. Biomed Pharmacol J. 2019;12:7–15. DOI:10.13005/bpj/1608
- Kelland LR. New platinum antitumor complexes. Crit Rev Oncol Hematol. 1993;15(3):191–219. DOI:10.1016/1040-8428(93)90042-3
- Lai PK, Roy J. Antimicrobial and chemopreventive properties of herbs and spices. Curr Med Chem. 2004;11(11):1451–1460. DOI:10.2174/0929867043365107
- Mohamed OT, Nariman MM, Amany AM, et al. Synergistic anti-tumour effect of propolis against Ehrlich carcinoma. Am J Sci. 2012;8(1):102–109.
- Campos JF, Santos UP, Rocha PD, et al. Antimicrobial, antioxidant, anti-inflammatory, and cytotoxic activities of propolis from the stingless bee evid-based complement. Altern Med. 2015: 1–11. DOI:10.1155/2015/296186
- Pimenta HC, Violante IM, Musis CR, et al. In vitro effectiveness of Brazilian brown propolis against enterococcus faecalis. Braz Oral Res. 2015;29:S1806–83242015000100255. DOI:10.1590/1807-3107BOR-2015.vol29.0058
- Kedzia B, Holderna-Kedzia E. Pinocembryna–flawonoidowy składnik krajowego propolisu odziałaniu opózniaj ˛acym rozwój choroby Alzheimera. Pinocembrin–flavonoid component of domestic propolis with delaying effect of the development of Alzheimer’s disease. Post Fitoter. 2017;18:223–228.
- Sforcin JM. Biological properties and therapeutic applications of propolis. Phytother Res. 2016;30(6):894–905. DOI:10.1002/ptr.5605
- Pakkirisamy M, Kalakandan SK, Ravichandran K. Phytochemical screening, GC-MS, FT-IR analysis of methanolic extract of curcuma caesia Roxb (Black turmeric). Pharmacog J. 2017;9(6):952–956. DOI:10.5530/pj.2017.6.149
- Janker F, Weder W, Jang JH, et al. Preclinical, non-genetic models of lung adenocarcinoma: a comparative survey. Oncotarget. 2018;9(55):30527–30538. DOI:10.18632/oncotarget.25668
- Ramadan A, Soliman G, Mahmoud SS, et al. Evaluation of the safety and antioxidant activities of crocus sativus and propolis ethanolic extracts. J Saudi Chem Soc. 2012;16(1):13–21. DOI:10.1016/j.jscs.2010.10.012
- Jafri SH, Glass J, Shi R, et al. Thymoquinone and cisplatin as a therapeutic combination in lung cancer: in vitro and in vivo. J Exp Clin Cancer Res. 2010;29(1):87. DOI:10.1186/1756-9966-29-87
- Rhodes A. Fixation of tissues. In: Suvarna SK, Layton C, Bancroft JD, editor. Bancroft’s theory and practice of histological techniques. 7th ed. Churchill Livingstone: ExpertConsultcom; 2013. p. 69–93.
- Spencer LT, Bancroft JD. Tissue processing. In: Suvarna SK, Layton C, Bancroft JD, editor. Bancroft’s theory and practice of histological techniques 7th ed. Churchill Livingstone: ExpertConsultcom; 2013. p. 105–123.
- Suvarna SK, Layton C, Bancroft JD, editors. Bancroft’s theory and practice of histological techniques Eighth edition ed. Amsterdam: Elsevier; 2018.
- Dong C, Wang G, Li B, et al. Anti-asthmatic agents alleviate pulmonary edema by upregulating AQP1 and AQP5 expression in the lungs of mice with OVA-induced asthma. Respir Physiol Neurobiol. 2012;181(1):21–28. DOI:10.1016/j.resp.2011.12.008
- Bancroft JD, Layton C. The hematoxylin, eosin. In: Suvarna SK, Layton C, Bancroft JD, editor. Theory practice of histological tech niques 7th edition Chapter 10, 11. Philadelphia, PA: Churchill Livingstone of El Sevier; 2013. p. 179–220.
- da Silva Brum I, Frigo L, Lana Devita R, et al. Histomorphometric, immunohistochemical, ultrastructural characterization of a nano-hydroxyapatite/beta-tricalcium phosphate composite and a bone xenograft in sub-critical size bone defect in rat calvaria. Materials (Basel). 2020;13(20):4598. DOI:10.3390/ma13204598
- Zhou X, Moore BB. Lung section staining and microscopy. Bio Protoc. 2017;7(10):e2286. DOI:10.21769/BioProtoc.2286
- Hernández-Morera P, Castaño-González I, TraviesoGonzález CM, et al. Quantification, statistical analysis methods for vessel wall components from stained images with Masson’s Trichrome. PLoS One. 2016;11:e0146954.
- Meyerholz DK, Beck AP, Goeken JA, et al. Glycogen depletion can increase the specificity of mucin detection in airway tissues. BMC Res Notes. 2018;11(1):763. DOI:10.1186/s13104-018-3855-y
- Soyab T. Special stains used in histopathological techniques. A brief view Indian. J Forensic Med Toxicol. 2020;14:4.
- Bancroft JD, Gamble M. Theory, practice of histological techniques. 6th ed. London: Churchill Livingstone; 2013; 125–158.
- Naryzhny SN. Proliferating cell nuclear antigen: a proteomics view. Cell Mol Life Sci. 2008;65(23):3789–3808. DOI:10.1007/s00018-008-8305-x
- Ahmed RF, Moussa RA, Eldemerdash RS, et al. Ameliorative effects of silymarin on HCl-induced acute lung injury in rats; role of the Nrf-2/HO-1 pathway. Iran J Basic Med Sci. 2019;22(12):1483–1492. DOI:10.22038/IJBMS.2019.14069
- Graham L, Orenstein JM. Processing tissue and cells for transmission electron microscopy in diagnostic pathology and research. Nat Protoc. 2007;2(10):2439–2450. DOI:10.1038/nprot.2007.304
- Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med. 1963;61:882–888. PMID: 13967893.
- Nishikimi M, Rao NA, Yogi K. Colorimetric determination of super oxide dismutase. Biochem Bioph Common. 1972;46:849–854.
- Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95(2):351–358. DOI:10.1016/0003-2697(79)90738-3
- Shahin NN, Abdelkader NF, Safar MM. A novel role of irbesartan in gastroprotection against indomethacin-induced gastric injury in rats: targeting DDAH/ADMA and EGFR/ERK signaling. Sci Rep. 2018;8(1):4280. DOI:10.1038/s41598-018-22727-6
- Hussein SA, El-Senosi YA, Esmael TEA, et al. Thymoquinone suppressed cyclosporine A-induced nephrotoxicity in rats via antioxidant activation, inhibition of inflammatory, apoptotic signaling pathway. BVMJ. 2020;39(1):40–46.
- Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C (T)) method. Methods. 2001;25(4):402–408. DOI:10.1006/meth.2001.1262
- Magesh V, Singh JP, Selvendiran K, et al. Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies. Mol Cell Biochem. 2006;287(1-2):127–135. DOI:10.1007/s11010-005-9088-0
- Siegel R, Ward E, Brawley O, et al. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 2011;61(4):212–236. DOI:10.3322/caac.20121
- Sakano K, Oikawa S, Hiraku Y, et al. Metabolism of carcinogenic urethane to nitric oxide is involved in oxidative DNA damage. Free Radic Biol Med. 2002;33(5):703–714. DOI:10.1016/s0891-5849(02)00969-3
- da Cunha MJ, da Cunha AA, Ferreira GK, et al. The effect of exercise on the oxidative stress induced by experimental lung injury. Life Sci. 2013;92(3):218–227. DOI:10.1016/j.lfs.2012.12.005
- Kawanishi S, Hiraku Y, Oikawa S. Mechanism of guanine-specific DNA damage by oxidative stress, its role in carcinogenesis and aging. Mutat Res. 2001;488:65–76.
- Kowaltowski AJ, de Souza-Pinto NC, Castilho RF, et al. Mitochondria and reactive oxygen species. Free Radic Biol Med. 2009;47(4):333–343. DOI:10.1016/j.freeradbiomed.2009.05.004
- Brihoum H, Maiza M, Sahali H, et al. Dual effect of Algerian propolis on lung cancer: antitumor and chemopreventive effects involving antioxidant activity. Braz J Pharm Sci. 2018;54. DOI:10.1590/s2175-97902018000117396
- Hemieda FAE, El-Kholy WM, El-Habibi EM, et al. Influence of propolis on oxidative stress, inflammation and apoptosis in streptozotocin-induced diabetic rats Int. J Adv Res. 2015;3:831–845. (ISSN: 2320-5407).
- Sobral F, Sampaio A, Falcão S, et al. Chemical characterization, antioxidant, anti-inflammatory and cytotoxic properties of bee venom collected in Northeast Portugal. Food Chem Toxicol. 2016;94:172–177. DOI:10.1016/j.fct.2016.06.008
- Meseure D, Vacher S, Drak Alsibai K, et al. Profiling of EGFR mRNA and protein expression in 471 breast cancers compared with 10 normal tissues: a candidate biomarker to predict EGFR inhibitor effectiveness. Int J Cancer. 2012;131(4):1009–1010. DOI:10.1002/ijc.26434
- Janku F, Garrido-Laguna I, Petruzelka LB, et al. Novel therapeutic targets in non-small cell lung cancer. J Thorac Oncol. 2011;6(9):1601–1612. DOI:10.1097/JTO.0b013e31822944b3
- Yarden Y, Pines G. The ERBB network: at last, cancer therapy meets systems biology. Nat Rev Cancer. 2012;12(8):553–563. DOI:10.1038/nrc3309
- Mellman I, Yarden Y. Endocytosis and cancer. Cold Spring Harb Perspect Biol. 2013;5(12):a016949. DOI:10.1101/cshperspect.a016949
- National Toxicology Program. Urethane CAS No 51-79-6. Natl Toxicol Program Tech Rep on Carcinogens Fourteenth Edition. https.//ntpniehsnihgov/ntp/roc/content/profiles/urethane.pdf 2021 [accessed 3 March 2021].
- Stakisaitis D, Uleckiene S, Didziapetriene J, et al. Sodium valproate enhances urethane tumorigenicity in lungs of male but not female mice. EXCLI J. 2014;13:667–687.
- Ding Y, Xuan W, Chen C, et al. Differences in carcinoembryonic antigen levels between colon and rectal cancer. Mol Clin Oncol. 2014;2(4):618–622. DOI:10.3892/mco.2014.286
- Stakisaitis D, Mozuraite R, Juodziukyniene N, et al. Sodium valproate enhances the urethane-induced lung adenomas and suppresses malignization of adenomas in ovariectomized female mice. Int J Endocrinol. 2015: 218–219. DOI:10.1155/2015/218219
- Frión-Herrera Y, Díaz-García A, Ruiz-Fuentes J, et al. Brazilian green propolis induced apoptosis in human lung cancer A549 cells through mitochondrial-mediated pathway. J Pharm Pharmacol. 2015;67(10):1448–1456. DOI:10.1111/jphp.12449
- Turan I, Demir S, Misir S, et al. Cytotoxic effect of Turkish propolis on liver, colon, breast, cervix and prostate cancer cell lines. Trop J Pharm Res. 2015;14(5):777–782. DOI:10.4314/tjpr.v14i5.5
- Sak K. Chemotherapy and dietary phytochemical agents. Chemother Res Pract. 2012: 282570. DOI:10.1155/2012/282570
- Anandakumar P, Kamaraj S, Jagan S, et al. The anticancer role of capsaicin in experimentally induced lung carcinogenesis. J Pharmacopuncture. 2015;18(2):19–25. DOI:10.3831/KPI.2015.18.011
- Zidan RA. Effect of long-term administration of amiodarone on rat lung and the possible protective role of vitamin E. a histological and immunohistochemical study. Egypt J Histol. 2011;34:117–128.
- Machado B, Pulcino TN, Silva AL, et al. Propolis as an alternative in prevention and control of dental cavity. Immunity. 2017;19:24. DOI:10.5455/ja.20160726115117
- Kaira K, Okumura T, Nakagawa K, et al. MUC1 expression in pulmonary metastatic tumors. A comparison of primary lung cancer. Pathol Oncol Res. 2012;18:439–447.
- Kwon KY, Ro JY, Singhal N, et al. MUC4 expression in non-small cell lung carcinomas: relationship to tumor histology and patient survival. Arch Pathol Lab Med. 2007;131(4):593–598. DOI:10.5858/2007-131-593-MEINCL
- Lange P, Nyboe J, Appleyard M, et al. Ventilatory function and chronic mucus hypersecretion as predictors of death from lung cancer. Am Rev Respir Dis. 1990;141(3):613–617. DOI:10.1164/ajrccm/141.3.613
- Nanji AA, Tahan SR. Association between endothelial cell proliferation and pathologic changes in experimental alcoholic liver disease. Toxicol Appl Pharmacol. 1996;140(1):101–107. DOI:10.1006/taap.1996.0202
- Wang L, Kong W, Liu B, et al. Proliferating cell nuclear antigen promotes cell proliferation and tumorigenesis by up-regulating STAT3 in non-small cell lung cancer. Biomed Pharmacother. 2018;104:595–602. DOI:10.1016/j.biopha.2018.05.071
- Singh G, Katyal SL. Clara cell proteins. Ann NY Acad Sci. 2000;923:43–58. DOI:10.1111/j.1749-6632.2000.tb05518.x
- Reznik-Schüller H. Ultrastructural alterations of nonciliated cells after nitrosamine treatment and their significance for pulmonary carcinogenesis. Am J Pathol. 1976;85(3):549–554.
- Phimister AJ, Williams KJ, Van Winkle LS, et al. Consequences of abrupt glutathione depletion in murine Clara cells: ultrastructural and biochemical investigations into the role of glutathione loss in naphthalene cytotoxicity. J Pharmacol Exp Ther. 2005;314(2):506–513. DOI:10.1124/jpet.105.084533
- Manygoats KR, Yazzie M, Stearns DM. Ultrastructural damage in chromium picolinate-treated cells: a TEM study. Transmission electron microscopy. J Biol Inorg Chem. 2002;7(7-8):791–798. DOI:10.1007/s00775-002-0357-z
- Blundell P. The biology of Clara cells – review paper. Int J Molec Med Adv Sci. 2006;2:307–311.
- Reynolds SD, Malkinson AM. Clara cell: progenitor for the bronchiolar epithelium. Int J Biochem Cell Biol. 2010;42(1):1–4. DOI:10.1016/j.biocel.2009.09.002