Boric acid is associated with the suppression of apoptosis and endoplasmic reticulum stress in rat model of paracetamol -induced hepatotoxicity

References

• Kartal NT. Investigation of the effects of agomelatine on acute kidney toxicity induced by paracetamol. MSc, Atatürk University Institute of Health Sciences; 2013.
   Google Scholar
• Doğan N. Protective effect of capparis ovata in acute liver toxicity due to paracetamol in rats [Medical specialty thesis]. Suleyman Demirel University Faculty of Medicine; 2014.
   Google Scholar
• Liu ZX, Han D, Gunawan B, et al. Neutrophil depletion protects against murine Acetaminophen hepatotoxicity. Hepatology. 2006;43:1220–1230. DOI:10.1002/hep.21175
   PubMed Web of Science ®Google Scholar
• Erfidan MA. Effects of pomegranate (Punica Granatum L.) on acute liver injury induced by paracetamol in mice. Afyonkarahisar: MSc, Afyon Kocatepe University Institute of Health Sciences; 2016.
   Google Scholar
• Çalışkan D. Protective effect of pomegranate juice in acute liver toxicity due to paracetamol in rats [Specialization thesis]. Suleyman Demirel University Faculty of Medicine; 2014.
   Google Scholar
• Özaltın S. Investigation of the effects of bosentan on paracetamol-induced acute kidney toxicity. Erzurum: MSc, Atatürk University Institute of Health Sciences; 2015.
   Google Scholar
• Yayla N. Investigation of the effects of Nigella sativa L. ethanol extract on acute liver toxicity induced by paracetamol in rats. Erzurum: MSc, Atatürk University Institute of Health Sciences; 2014.
   Google Scholar
• Çamaş M. Investigation of genotoxic effects of boron on Hordeum vulgare L., M.Sc., Gebze Institute of Technology. Institute of Engineering and Science. 2006:5–13.
   Google Scholar
• Yılmaz S. Investigation of the antioxidant activity of boric acid in cell culture. Ankara: M.Sc., Ankara University Institute of Health Sciences; 2014. p. 6–15.
   Google Scholar
• Karabağ Çoban F, İnce S, Küçükkurt İ, et al. Boron attenuates malathion-induced oxidative stress and acetylcholinesterase inhibition in rats. Drug Chem Toxicol. 2015;38(4):391–399. DOI:10.3109/01480545.2014.974109
   PubMed Web of Science ®Google Scholar
• Gezmen Karadağ M, Türközü D. The interaction of dietary boron intake with health: an updated view. Gumushane Univ J Health Sci. 2014;3(2):770–785.
   Google Scholar
• Küçükkurt İ, Akbel E, Karabağ Çoban F, et al. The effects of dietary boron compounds in supplemented diet on hormonal activity and some biochemical parameters in rats. J Toxicol Ind Health. 2013;31(3):255–260.
   Google Scholar
• Karcıoğlu S, Palabıyık S, Bayır Y. The role of RAAS inhibition by Aliskiren on paracetamol-induced hepatotoxicity model in rats. J Cell Biochem. 2015;117(3):638–646. DOI:10.1002/jcb.25313
   PubMed Web of Science ®Google Scholar
• Uzunkeser M, Karakuş E, Albayrak A, et al. Protective effect of Panax ginseng against N-acetyl-paminophenol-induced hepatotoxicity in rats. Afr J Pharm Pharmacol. 2012;6(36):2634–2642. DOI:10.5897/AJPP12.658
   Google Scholar
• Hany MA, Taha M, Raouf F, et al. Ameliorating effect of N-acetylcysteine on iron toxicity of the liver and pancreas in albino rats: histochemical and ultrastructural study. Eur J Anat. 2021;25(4):385–396.
   Web of Science ®Google Scholar
• İnce S, Kucukkurt İ, Cigerci İ, et al. The effects of dietary boric acid and borax supplementation on lipid peroxidation, antioxidant activity, and DNA damage in rats. J Trace Elem Med Biol. 2010:161–164.
   PubMed Web of Science ®Google Scholar
• Beutler E, Blume KG, Kaplan JC, et al. International committee for standardization in haematology: recommended methods for red-cell enzyme analysis. Br J Haematol. 2006;35:331–340. DOI:10.1111/j.1365-2141.1977.tb00589.x
   Google Scholar
• Luna LG. Manual of histologic staining methods of the armed forces institute of path-ology. New York: McGraw-Hill.
   Google Scholar
• McCormick WF, Coleman SA. A membrane filter technique for cytology ofspinal fluid. Am J Clin Pathol. 1968;38:180–191.
   Google Scholar
• Ajith TA, Aswathy MS, Hema U. Zingiber officinale Roscoe preventsacetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status. Food Chem Toxicol. 2007;45:2267–2272. DOI:10.1016/j.fct.2007.06.001
   PubMed Web of Science ®Google Scholar
• Rushworth GF, Megson L. Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits. Pharmacol Ther. 2013;141(2):150–159. DOI:10.1016/j.pharmthera.2013.09.006
   PubMed Web of Science ®Google Scholar
• Hinson JA, Reid AB, McCullough SS, et al. Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition. Drug Metab Rev. 2004;36:805–822. DOI:10.1081/DMR-200033494
   PubMed Web of Science ®Google Scholar
• Romero P, Obradovic Z, Kissinger CR, et al. Thousands of proteins likely to have long disordered regions. Pac Symp Biocomput. 1998;3:437–448.
   Google Scholar
• Halliwell B. Biochemistry of oxidative stress. Biochem Soc Trans. 2007;35(5):1147–1150. DOI:10.1042/BST0351147
   PubMed Web of Science ®Google Scholar
• Wildburger NC, Lin-Ye A, Baird MA, et al. Neuroprotective effects of blockers for T-type calcium channels. Mol Neurobiol. 2009;28(4):44.
   Google Scholar
• Freeman BA, Crappo JD. Free radicals and tissue injury. Lab Invest. 1982;47(5):412–426.
   PubMed Web of Science ®Google Scholar
• Halliwell B, Gutteridge JM. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J. 1984;219(1):1–14. DOI:10.1042/bj2190001
   PubMed Web of Science ®Google Scholar
• Gang L, Jun-Bao C, Chao W, et al. Curcumin protects against Acetaminophen-induced apoptosis in hepatic injury. World J Gastroenterol. 2013;19(42):7440–7446. DOI:10.3748/wjg.v19.i42.7440
   PubMed Web of Science ®Google Scholar
• Hoşbaş S, Hartevioğlu A, Pekcan M, et al. Assessment of hepatoprotective activity of Achillea biebersteinii ethanol extract on carbon tetrachlorideinduced liver damage in rats. FABAD J Pharm Sci. 2011;36:33–39.
   Google Scholar
• Jyoti P, Priyanka S, Preeti V, et al. Anti-tumor and anti-oxidative activity of rosmarinus officinalis in 7, 12 dimethyl benz(a) anthracene induced skin carcinogenesis in mice. Am J Biomed Sci. 2011;3(3):199–209.
   Google Scholar
• Olaleye M, Rocha BT. Acetaminophen-induced liver damage in mice: effects of some medicinal plants on the oxidative defense system. Exp Toxicol Pathol. 2008;59(5):319–327. DOI:10.1016/j.etp.2007.10.003
   PubMed Web of Science ®Google Scholar
• Hu C, Kitts DD. Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cells. Mol Cell Biochem. 2004;265:107–113. DOI:10.1023/B:MCBI.0000044364.73144.fe
   PubMed Web of Science ®Google Scholar
• Nielsen F. The emergence of boron as nutritionally ımportant throughout the life cycle. Nutrition. 2000;16:512–514. DOI:10.1016/S0899-9007(00)00324-5
   PubMed Web of Science ®Google Scholar
• Karakuş E, Halıcı Z, Albayrak A, et al. Agomelatine: an antidepressant with new potent hepatoprotective effects on paracetamol-induced liver damage in rats. Hum Exp Toxicol. 2013;32(8):67–98. DOI:10.1177/0960327112472994
   Web of Science ®Google Scholar
• Pizzorno L. Nothing boring about boron. Integr Med. 2015;14(4):35–48.
   Google Scholar
• Benderdour M, Belleville F, Buıvan T, et al. In vivo and in vitro effects of boron and boronated compounds. J Trace Elem Med Biol. 1998;12(1):2–7. DOI:10.1016/S0946-672X(98)80014-X
   PubMed Web of Science ®Google Scholar