Effects of black cumin, fenugreek, and sesame seeds as a mixture on performance, intestinal morphology, and blood traits of broilers under chronic heat stress conditions

References

• Abd El-Hack ME, Abdelnour SA, Taha AE, Khafaga AF, Arif M, Ayasan T, Swelum AA, Abukhalil MH, Alkahtani S, Aleya L, et al. 2020. Herbs as thermoregulatory agents in poultry: an overview. Sci Total Environ. 703:134399. doi: 10.1016/j.scitotenv.2019.134399.
   PubMed Web of Science ®Google Scholar
• Abdel-Moneim A-ME, Shehata AM, Khidr RE, Paswan VK, Ibrahim NS, El-Ghoul AA, Aldhumri SA, Gabr SA, Mesalam NM, Elbaz AM, et al. 2021. Nutritional manipulation to combat heat stress in poultry – a comprehensive review. J Therm Biol. 98:102915. doi: 10.1016/j.jtherbio.2021.102915.
   PubMed Web of Science ®Google Scholar
• Abdollahi A, Karimi A, Sadeghi AA, Bedford MR, Ashengroph M. 2021. The effects of the fibre source and xylanase supplementation on production, egg quality, digestibility, and intestinal morphology in the aged laying hen. Poult Sci. 100(3):100936. doi: 10.1016/j.psj.2020.12.033.
   PubMed Web of Science ®Google Scholar
• Abo Ghanima MM, Bin-Jumah M, Abdel-Moneim AME, Khafaga AF, Abd El-Hack ME, Allam AA, El-Kasrawy NI. 2019. Impacts of strain variation on response to heat stress and boldo extract supplementation to broiler chickens. Animals (Basel). 10(1):24. doi: 10.3390/ani10010024.
   PubMedGoogle Scholar
• Abou-Gharbia HA, Shehata AAY, Shahidi F. 2000. Effect of processing on oxidative stability and lipid classes of sesame oil. Int Food Res J. 33(5):331–340. doi: 10.1016/S0963-9969(00)00052-1.
   Web of Science ®Google Scholar
• Abu-Dieyeh ZH, Abu-Darwish MS. 2008. Effect of feeding powdered black cumin seeds (Nigella sativa L.) on growth performance of 4-8 week-old broilers. J Anim Vet Adv. 3:286–290. https://medwelljournals.com/abstract/?doi=javaa.2008.286.290.
   Google Scholar
• Adil S, Qureshi S, Pattoo RA. 2015. A review on positive effects of fenugreek as feed additive in poultry production. Int J Poul Sci. 14(12):664–669. doi: 10.3923/ijps.2015.664.669.
   Google Scholar
• Ahmed SA, Ajiboye AT, Ibrahim YA, Olagunju AT, Salau S, Adetunji O. 2022. Anti-hyperglycemic and antioxidant potentials of some bioactive compounds identified from the methanolic kernel extract of anacadium ocidentale in vitro and in silico investigations. Nig J Chem Res. 27(1):061–082. doi: 10.4314/njcr.v27i1.7.
   Google Scholar
• Al-Azraqi AA. 2008. Pattern of leptin secretion and oxidative markers in heat-stressed pigeons. Int J Poul Sci. 7(12):1174–1176. doi: 10.3923/ijps.2008.1174.1176.
   Google Scholar
• Al-Beitawi NA, El-Ghousein SS, Nofal AH. 2009. Replacing bacitracin methylene disalicylate by crushed Nigella sativa seeds in broiler rations and its effects on growth, blood constituents and immunity. Livest Sci. 125(2-3):304–307. doi: 10.1016/j.livsci.2009.03.012.
   Web of Science ®Google Scholar
• Ali AH, Yeasmin T, Mohamed YA, Mohamud AI, Mishra P. 2021. Evaluation of dietary supplementation of fenugreek seed (Trigonella foenum-graecum L.) as a growth promoter in broiler diet and its impacts on growth performance, carcass quality and cost effectiveness. J İstanbul Vet Sci. 5(1):6–12. doi: 10.30704/http-www-jivs-net.815835.
   Google Scholar
• Alimohamadi K, Taherpour K, Ghasemi HA, Fatahnia F. 2014. Comparative effects of using black seed (Nigella sativa), cumin seed (C uminum cyminum), probiotic or prebiotic on growth performance, blood haematology and serum biochemistry of broiler chicks. J Anim Physiol Anim Nutr (Berl). 98(3):538–546. doi: 10.1111/jpn.12115.
   PubMed Web of Science ®Google Scholar
• Alloui N, Aksa S, Alloui MN, Ibrir F. 2011. Utilization of fenugreek (Trigonella foenum-graecum) as growth promoter for broiler chickens. Mortality. 68:0–94.
   Google Scholar
• Al-Mushhadani TM, Al-Hayali HL. 2020. Biochemical and physiological study of the effect of sesame seeds on quail males exposed to thermal stress. Indian J Public Health. 11(04):1077.
   Google Scholar
• Al-Rikaby AA, Al-Rikaby MA, Majeed SK, Al-Jaberi S. 2020. Influence of sesame oil on physiologic and histopathological changes in alloxnized male guinea pigs. IJFMT. 14(4):1523–1529. doi: 10.37506/ijfmt.v14i4.11759.
   Google Scholar
• Anandakumar P, Kamaraj S, Vanitha MK. 2021. D‐limonene: a multifunctional compound with potent therapeutic effects. J Food Biochem. 45(1):e13566. doi: 10.1111/jfbc.13566.
   PubMed Web of Science ®Google Scholar
• AOAC. 1995. Official methods of analysis 16th Ed. J. Assoc. Off. Anal. Chem. Washington DC: Science Education http://www.sciepub.com/reference/141205.
   Google Scholar
• Asad T, Mehmood S, Mahmud A, Basheer A, Saleem G, Jatoi AS, Hussain J, Husnain F, Younis M. 2019. Ameliorating effect of different anti-stressors on growth performance, and immunophysiological responses in heat stressed broilers chickens. PVJ. 39(02):285–288. doi: 10.29261/pakvetj/2018.066.
   Google Scholar
• Gilani AUH, Jabeen Q, Khan MAU 2004. A review of medicinal uses and pharmacological activities of Nigella sativa. Pakistan J Biol Sci. 7(4):441–451. doi: 10.3923/pjbs.2004.441.451.
   Google Scholar
• Azeem T, Zaib-Ur-Rehman US, Asif M, Arif M, Rahman A. 2014. Effect of Nigella sativa on poultry health and production: a review. Sci Lett. 2(2):76–82.
   Google Scholar
• Babayan VK, Koottungal D, Halaby GA. 1978. Proximate analysis, fatty acid and amino acid composition of Nigella sativa L. seeds. J Food Sci. 43(4):1314–1315. doi: 10.1111/j.1365-2621.1978.tb15297.x.
   Web of Science ®Google Scholar
• Badary OA, Abdel-Naim AB, Abdel-Wahab MH, Hamada FM. 2000. The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats. Toxicology. 143(3):219–226. doi: 10.1016/S0300-483X(99)00179-1.
   PubMed Web of Science ®Google Scholar
• Banan A, Fitzpatrick L, Zhang Y, Keshavarzian A. 2001. OPC-compounds prevent oxidant-induced carbonylation and depolymerization of the F-actin cytoskeleton and intestinal barrier hyperpermeability. Free Radic Biol Med. 30(3):287–298. doi: 10.1016/S0891-5849(00)00471-8.
   PubMed Web of Science ®Google Scholar
• Bancroft JD, Gamble M. 2008. Theory and practice of histological techniques. Elsevier Health Sci. 6:135–160.
   Google Scholar
• Bartlett JR, Smith MO. 2003. Effects of different levels of zinc on the performance and immunocompetence of broilers under heat stress. Poult Sci. 82(10):1580–1588. doi: 10.1093/ps/82.10.1580.
   PubMed Web of Science ®Google Scholar
• Basha SA, El-Gawad A, Eman A, A Abbass A. 2018. Dietary effect of fenugreek (Trigonella foenum graecum) and liquorice (Glycyrrhiza glabra) on growth performance, antioxidant activities and stress resistance in Oreochromis niloticus. BVMJ. 34(3):355–370. doi: 10.21608/bvmj.2018.47876.
   Google Scholar
• Beeharry N, Lowe JE, Hernandez AR, Chambers JA, Fucassi F, Cragg PJ, Green MH, Green IC. 2003. Linoleic acid and antioxidants protect against DNA damage and apoptosis induced by palmitic acid. Mutat Res. 530(1-2):27–33. doi: 10.1016/s0027-5107(03)00134-9.
   PubMed Web of Science ®Google Scholar
• Belay T, Bartels KE, Wiernusz CJ, Teeter RG. 1993. A detailed colostomy procedure and its application to quantify water and nitrogen balance and urine contribution to thermobalance in broilers exposed to thermoneutral and heat-distressed environments. Poult Sci. 72(1):106–115. doi: 10.3382/ps.0720106.
   PubMed Web of Science ®Google Scholar
• Borges SA, Da Silva AF, Maiorka A. 2007. Acid-base balance in broilers. Worlds Poult Sci J. 63(1):73–81. doi: 10.1017/S0043933907001286.
   Web of Science ®Google Scholar
• Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. 1999. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol. 94(9):2467–2474. doi: 10.1016/S0002-9270(99)00433-5.
   PubMed Web of Science ®Google Scholar
• Caulfield MP, Cambridge H, Foster SF, McGreevy PD. 2014. Heat stress: a major contributor to poor animal welfare associated with long-haul live export voyages. Vet J. 199(2):223–228. doi: 10.1016/j.tvjl.2013.09.018.
   PubMed Web of Science ®Google Scholar
• Chen IC, Hill JK, Ohlemüller R, Roy DB, Thomas CD. 2011. Rapid range shifts of species associated with high levels of climate warming. Science. 333(6045):1024–1026. doi: 10.1126/science.1206432.
   PubMed Web of Science ®Google Scholar
• Chevassus H, Molinier N, Costa F, Galtier F, Renard E, Petit P. 2009. A fenugreek seed extract selectively reduces spontaneous fat consumption in healthy volunteers. Eur J Clin Pharmacol. 65(12):1175–1178. doi: 10.1007/s00228-009-0733-5.
   PubMed Web of Science ®Google Scholar
• Cho KH, Hong JH, Lee KT. 2010. Monoacylglycerol (MAG)-oleic acid has stronger antioxidant, anti-atherosclerotic, and protein glycation inhibitory activities than MAG-palmitic acid. J Med Food. 13(1):99–107. doi: 10.1089/jmf.2009.1024.
   PubMed Web of Science ®Google Scholar
• Contant C, Rouabhia M, Loubaki L, Chandad F, Semlali A. 2021. Anethole induces anti-oral cancer activity by triggering apoptosis, autophagy and oxidative stress and by modulation of multiple signaling pathways. Sci Rep. 11(1):13087. doi: 10.1038/s41598-021-92456-w.
   PubMed Web of Science ®Google Scholar
• Crowell PL. 1999. Prevention and therapy of cancer by dietary monoterpenes. J Nutr. 129(3):775S–778S. doi: 10.1093/jn/129.3.775S.
   PubMed Web of Science ®Google Scholar
• De Christo Scherer MM, Marques FM, Figueira MM, Peisino MCO, Schmitt EFP, Kondratyuk TP, Endringer DC, Scherer R, Fronza M. 2019. Wound healing activity of terpinolene and α-phellandrene by attenuating inflammation and oxidative stress in vitro. J Tissue Viability. 28(2):94–99. doi: 10.1016/j.jtv.2019.02.003.
   PubMed Web of Science ®Google Scholar
• Ebeid TA. 2009. Organic selenium enhances the antioxidative status and quality of cockerel semen under high ambient temperature. Br Poult Sci. 50(5):641–647. doi: 10.1080/00071660903303415.
   PubMed Web of Science ®Google Scholar
• EL-Shoukary RD, Darwish MH, Abdel-Rahman MA. 2014. Behavioral, performance, carcass traits and hormonal changes of heat stressed broilers feeding black and coriander seeds. J Adv Vet Res. 4(3):97–101.
   Google Scholar
• Erener G, Altop A, Ocak N, Aksoy HM, Cankaya S, Ozturk E. 2010. Influence of black cumin seed (Nigella sativa L.) and seed extract on broilers performance and total coliform bacteria count. Asian J Anim Vet Adv. 5(2):128–135. doi: 10.3923/ajava.2010.128.135.
   Google Scholar
• FASS. 1999. Guide for the care and use of agricultural animals in agricultural research and teaching. Federation of Animal Science Societies. https://www.asas.org/docs/default-source/default-document-library/agguide_4th.pdf?sfvrsn=56b44ed1_2.
   Google Scholar
• Flees J, Rajaei-Sharifabadi H, Greene E, Beer L, Hargis BM, Ellestad L, Porter T, Donoghue A, Bottje WG, Dridi S. 2017. Effect of Morinda citrifolia (noni)-enriched diet on hepatic heat shock protein and lipid metabolism-related genes in heat stressed broiler chickens. Front Physiol. 8:919. doi: 10.3389/fphys.2017.00919.
   PubMed Web of Science ®Google Scholar
• Furlan RL, Macari M, Malheiros EB, Secato ER, Guerreiro JR. 1998. Effect of indomethacin on hyperthermia induced by heat stress in broiler chickens. Int J Biometeorol. 42(2):73–76. doi: 10.1007/s004840050087.
   PubMed Web of Science ®Google Scholar
• Ghazi SH, Habibian M, Moeini MM, Abdolmohammadi AR. 2012. Effects of different levels of organic and inorganic chromium on growth performance and immunocompetence of broilers under heat stress. Biol Trace Elem Res. 146(3):309–317. doi: 10.1007/s12011-011-9260-1.
   PubMed Web of Science ®Google Scholar
• Greene ES, Maynard C, Owens CM, Meullenet JF, Dridi S. 2021. Effects of herbal adaptogen feed-additive on growth performance, carcass parameters, and muscle amino acid profile in heat-stressed modern broilers. Front Physiol. 12:784952. doi: 10.3389/fphys.2021.784952.
   PubMed Web of Science ®Google Scholar
• Habashy WS, Milfort MC, Fuller AL, Attia YA, Rekaya R, Aggrey SE. 2017. Effect of heat stress on protein utilization and nutrient transporters in meat-type chickens. Int J Biometeorol. 61(12):2111–2118. doi: 10.1007/s00484-017-1414-1.
   PubMed Web of Science ®Google Scholar
• Hemalatha S. 2004. Lignans and tocopherols in Indian sesame cultivars. JAOCS. 81(5):467. doi: 10.1007/s11746-004-0924-5.
   Web of Science ®Google Scholar
• Hirata F, Fujita K, Ishikura Y, Hosoda K, Ishikawa T, Nakamura H. 1996. Hypocholesterolemic effect of sesamin lignan in humans. Atherosclerosis. 122(1):135–136. doi: 10.1016/0021-9150(95)05769-2.
   PubMed Web of Science ®Google Scholar
• Hsu DZ, Su SB, Chien SP, Chiang PJ, Li YH, Lo YJ, Liu MY. 2005. Effect of sesame oil on oxidative-stress-associated renal injury in endotoxemic rats: involvement of nitric oxide and proinflammatory cytokines. Shock. 24(3):276–280. doi: 10.1097/01.shk.0000172366.73881.c7.
   PubMed Web of Science ®Google Scholar
• Islam MS, Tahjib-Ul-Arif M, Islam MA, Hossain MA, Siddiqui MN, Sayed MA. 2016. Dietary effects of buckwheat (Fagopyrum esculentum) and black cumin (Nigella sativa) seed on growth performance, serum lipid profile and intestinal microflora of broiler chicks. SA J an Sci. 46(1):103–111. doi: 10.4314/sajas.v46i1.13.
   Web of Science ®Google Scholar
• Kahyaoglu T, Kaya S. 2006. Modeling of moisture, color and texture changes in sesame seeds during the conventional roasting. J Food Eng. 75(2):167–177. doi: 10.1016/j.jfoodeng.2005.04.011.
   Web of Science ®Google Scholar
• Kanu PJ, Bahsoon JZ, Kanu JB, Kandeh JBA. 2010. Nutraceutical importance of sesame seed and oil: a review of the contribution of their lignans. Sierra Leone J Biomed Res. 2(1):4–16. doi: 10.4314/sljbr.v2i1.56583.
   Google Scholar
• Katsuzaki H, Kawakishi S, Osawa T. 1994. Sesaminol glucosides in sesame seeds. Phytochemistry. 35(3):773–776. doi: 10.1016/S0031-9422(00)90603-4.
   PubMed Web of Science ®Google Scholar
• Khalaji S, Zaghari M, Hatami KH, Hedari-Dastjerdi S, Lotfi L, Nazarian H. 2011. Black cumin seeds, Artemisia leaves (Artemisia sieberi), and Camellia L. plant extract as phytogenic products in broiler diets and their effects on performance, blood constituents, immunity, and cecal microbial population. Poult Sci. 90(11):2500–2510. doi: 10.1016/S0031-9422(00)90603-4.
   PubMed Web of Science ®Google Scholar
• Khan SH, Ansari J, Haq AU, Abbas G. 2012. Black cumin seeds as phytogenic product in broiler diets and its effects on performance, blood constituents, immunity and caecal microbial population. Ital J Anim Sci. 11(4):e77. doi: 10.4081/ijas.2012.e77.
   Web of Science ®Google Scholar
• Koeduka T, Baiga TJ, Noel JP, Pichersky E. 2009. Biosynthesis of t-anethole in anise: characterization of t-anol/isoeugenol synthase and an O-methyltransferase specific for a C7-C8 propenyl side chain. Plant Physiol. 149(1):384–394. doi: 10.1104/pp.108.128066.
   PubMed Web of Science ®Google Scholar
• Kumar P, Patra AK. 2017. Beneficial uses of black cumin (Nigella sativa L.) seeds as a feed additive in poultry nutrition. Worlds Poult Sci J. 73(4):872–885. doi: 10.1017/S0043933917000848.
   Web of Science ®Google Scholar
• Kumar P, Patra AK, Mandal GP, Samanta I, Pradhan S. 2017. Effect of black cumin seeds on growth performance, nutrient utilization, immunity, gut health and nitrogen excretion in broiler chickens. J Sci Food Agric. 97(11):3742–3751. doi: 10.1002/jsfa.8237.
   PubMed Web of Science ®Google Scholar
• Kusnadi E, Rahim F. 2009. Performa dan kandungan hormon triiodotironin plasma ayam broiler akibat pengaruh cekaman panas di daerah tropis. Media Peternakan. 32(3):155–162.
   Google Scholar
• Kutlu HR, Forbes JM. 1993. Changes in growth and blood parameters in heat-stressed broiler chicks in response to dietary ascorbic acid. Livest Prod Sci. 36(4):335–350. doi: 10.1016/0301-6226(93)90050-R.
   Google Scholar
• Lara LJ, Rostagno MH. 2013. Impact of heat stress on poultry production. Animals (Basel). 3(2):356–369. doi: 10.3390/ani3020356.
   PubMedGoogle Scholar
• Lentfer TL, Pendl H, Gebhardt-Henrich SG, Fröhlich EKF, Von Borell E. 2015. H/L ratio as a measurement of stress in laying hens – methodology and reliability. Br Poult Sci. 56(2):157–163. doi: 10.1080/00071668.2015.1008993.
   PubMed Web of Science ®Google Scholar
• Lin JJ, Lu KW, Ma YS, Tang NY, Wu PP, Wu CC, Lu HF, Lin JG, Chung JG. 2014. Alpha-phellandrene, a natural active monoterpene, influences a murine WEHI-3 leukemia model in vivo by enhancing macrophague phagocytosis and natural killer cell activity. In Vivo. 28(4):583–588.
   PubMed Web of Science ®Google Scholar
• Mahmoud HED, Ijiri D, Ebeid TA, Ohtsuka A. 2016. Effects of dietary nano-selenium supplementation on growth performance, antioxidative status, and immunity in broiler chickens under thermoneutral and high ambient temperature conditions. J Poult Sci. 53(4):274–283. doi: 10.2141/jpsa.0150133.
   PubMed Web of Science ®Google Scholar
• Mamoun T, Mukhtar MA, Tabidi MH. 2014. Effect of fenugreek seed powder on the performance, carcass characteristics and some blood serum attributes. Adv Res Agri Vet Sci. 1(1):6–11.
   Google Scholar
• Meral I, Donmez N, Baydas B, Belge F, Kanter M. 2004. Effect of Nigella sativa L. on heart rate and some haematological values of alloxan-induced diabetic rabbits. Scand J Lab Anim Sci. 31(1):49–53. 10.23675/sjlas.v31i1.59.
   Web of Science ®Google Scholar
• Michael D, Kumawat D. 2003. Legend and archeology of fenugreek, constitutions and modern applications of fenugreek seeds. Int Symp USA. 41:42.
   Google Scholar
• Monson MS, Van Goor AG, Ashwell CM, Persia ME, Rothschild MF, Schmidt CJ, Lamont SJ. 2018. Immunomodulatory effects of heat stress and lipopolysaccharide on the bursal transcriptome in two distinct chicken lines. BMC Genomics. 19(1):643. doi: 10.1186/s12864-018-5033-y.
   PubMed Web of Science ®Google Scholar
• Mujahid A, Akiba Y, Toyomizu M. 2009. Olive oil-supplemented diet alleviates acute heat stress-induced mitochondrial ROS production in chicken skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 297(3):R690–R698. doi: 10.1152/ajpregu.90974.2008.
   PubMed Web of Science ®Google Scholar
• Mundim AV, da Silva Martins JM, Marchini CFP, Guimarães EC, Gotardo LRM, Rinaldi FP, Bueno JPR, de Mattos Nascimento MRB, de Sousa GMR. 2017. Effect of age and cyclical heat stress on the serum biochemical profile of broiler chickens. SCA. 38(3):1383–1392. doi: 10.5433/1679-0359.2017v38n3p1383.
   Google Scholar
• Murali R, Karthikeyan A, Saravanan R. 2013. Protective effects of D‐limonene on lipid peroxidation and antioxidant enzymes in streptozotocin‐induced diabetic rats. Basic Clin Pharmacol Toxicol. 112(3):175–181. doi: 10.1111/bcpt.12010.
   PubMed Web of Science ®Google Scholar
• Nassiri‐Asl M, Hosseinzadeh H. 2016. Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds. Phytother Res. 30(9):1392–1403. doi: 10.1002/ptr.5644.
   PubMed Web of Science ®Google Scholar
• Nawab A, Ibtisham F, Li G, Kieser B, Wu J, Liu W, Zhao Y, Nawab Y, Li K, Xiao M, et al. 2018. Heat stress in poultry production: mitigation strategies to overcome the future challenges facing the global poultry industry. J Therm Biol. 78:131–139. doi: 10.1016/j.jtherbio.2018.08.010.
   PubMed Web of Science ®Google Scholar
• Nickavar B, Mojab F, Javidnia K, Amoli MAR. 2003. Chemical composition of the fixed and volatile oils of Nigella sativa L. from Iran. Z Naturforsch/J Biosci. 58(9-10):629–631. doi: 10.1515/znc-2003-9-1004.
   PubMed Web of Science ®Google Scholar
• Oganija KY, Apata DF. 2022. Haematological parameters, lipid and hormonal profile of heat stressed broilers fed beniseed (sesamum indicum) oil. Niger J Animal Sci. 24(2):175–181.
   Google Scholar
• Quinteiro-Filho WM, Ribeiro A, Ferraz-de-Paula V, Pinheiro ML, Sakai M, Sá LRMD, Ferreira AJP, Palermo-Neto J. 2010. Heat stress impairs performance parameters, induces intestinal injury, and decreases macrophage activity in broiler chickens. Poult Sci. 89(9):1905–1914. doi: 10.3382/ps.2010-00812.
   PubMed Web of Science ®Google Scholar
• Qureshi S, Banday MT, Adil S, Shakeel I, Munshi ZH. 2015. Effect of dandelion leaves and fenugreek seeds with or without enzyme addition on performance and blood biochemistry of broiler chicken and evaluation of their in vitro antibacterial activity. Indian J Anim Sci. 85(11):1248–1254.
   Web of Science ®Google Scholar
• Rajaei-Sharifabadi H, Ellestad L, Porter T, Donoghue A, Bottje WG, Dridi S. 2017. Noni (Morinda citrifolia) modulates the hypothalamic expression of stress-and metabolic-related genes in broilers exposed to acute heat stress. Front Genet. 8:192. doi: 10.3389/fgene.2017.00192.
   PubMed Web of Science ®Google Scholar
• Rama Rao SV, Raju MVLN, Panda AK, Poonam NS, Sunder GS, Sharma RP. 2008. Utilisation of sesame (Sesamum indicum) seed meal in broiler chicken diets. Br Poult Sci. 49(1):81–85. doi: 10.1080/00071660701827888.
   PubMed Web of Science ®Google Scholar
• Rashidi AA, Gofrani Iv Y, Khatibjoo A, Vakili R. 2010. Effects of dietary fat, vitamin E and zinc on immune response and blood parameters of broiler reared under heat stress. Res J Poult Sci. 3(2):32–38. doi: https://doi.org/10.3923/rjpscience.2010.32.38.
   Google Scholar
• Rastad A, Sadeghi AA, Chamani M, Shawrang P. 2016. Effects of thymoquinone on cortisol level, blood antioxidant parameters and capacity in broiler chickens under oxidative stress. Kafkas Univ Vet Fak Derg. 22(6):903–908. doi: https://doi.org/10.9775/kvfd.2016.15618.
   Web of Science ®Google Scholar
• Roberts KT. 2011. The potential of fenugreek (Trigonella foenum-graecum) as a functional food and nutraceutical and its effects on glycemia and lipidemia. J Med Food. 14(12):1485–1489. doi: 10.1089/jmf.2011.0002.
   PubMed Web of Science ®Google Scholar
• Sahoo N, Mishra SK, Swain RK, Acharya AP, Pattnaik S, Sethy K, Sahoo L. 2019. Effect of turmeric and ginger supplementation on immunity, antioxidant, liver enzyme activity, gut bacterial load and histopathology of broilers. Indian J Anim Sci. 89(7):774–779. doi: 10.56093/ijans.v89i7.92046.
   Web of Science ®Google Scholar
• Salam S, Sunarti D, Isroli I. 2013. Physiological responses of blood and immune organs of broiler chicken fed dietary black cumin powder (Nigella sativa) during dry seasons. J Indonesian Trop Anim Agric. 38(3):185–191. doi: 10.14710/jitaa.38.3.185-191.
   Google Scholar
• Salehi B, Upadhyay S, Erdogan Orhan I, Kumar Jugran A, L D Jayaweera S, A Dias D, Sharopov F, Taheri Y, Martins N, Baghalpour N, et al. 2019. Therapeutic potential of α-and β-pinene: a miracle gift of nature. Biomolecules. 9(11):738. doi: 10.3390/biom9110738.
   PubMed Web of Science ®Google Scholar
• SAS Institute. 2001. SAS/STAT User, Guide. Release Version 9.1. Cary, NC: SAS Institute. https://support.sas.com/documentation/onlinedoc/91pdf/sasdoc_91/stat_ug_7313.pdf.
   Google Scholar
• Senatore F, Oliviero F, Scandolera E, Taglialatela-Scafati O, Roscigno G, Zaccardelli M, De Falco E. 2013. Chemical composition, antimicrobial and antioxidant activities of anethole-rich oil from leaves of selected varieties of fennel [Foeniculum vulgare Mill. ssp. vulgare var. azoricum (Mill.) Thell]. Fitoterapia. 90(surplus):214–219. doi: 10.1016/j.fitote.2013.07.021.
   PubMedGoogle Scholar
• Shabil M, Bushi G, Bodige PK, Maradi PS, Patra BP, Padhi BK, Khubchandani J. 2023. Effect of fenugreek on hyperglycemia: a systematic review and meta-analysis. Medicina (Kaunas). 59(2):248. doi: 10.3390/medicina59020248.
   PubMed Web of Science ®Google Scholar
• Shahriari M, Zibaee A, Sahebzadeh N, Shamakhi L. 2018. Effects of α-pinene, trans-anethole, and thymol as the essential oil constituents on antioxidant system and acetylcholine esterase of Ephestia kuehniella Zeller (Lepidoptera: pyralidae). Pestic Biochem Physiol. 150(surplus):40–47. doi: 10.1016/j.pestbp.2018.06.015.
   PubMedGoogle Scholar
• Shimizu S, Akimoto K, Shinmen Y, Kawashima H, Sugano M, Yamada H. 1991. Sesamin is a potent and specific inhibitor of Δ5 desaturase in polyunsaturated fatty acid biosynthesis. Lipids. 26(7):512–516. doi: 10.1007/BF02536595.
   PubMed Web of Science ®Google Scholar
• Short FJ, Gorton P, Wiseman J, Boorman KN. 1996. Determination of titanium dioxide added as an inert marker in chicken digestibility studies. Anim Feed Sci Technol. 59(4):215–221. doi: 10.1016/0377-8401(95)00916-7.
   Web of Science ®Google Scholar
• Shoukary RDE, Darwish MH, Abdel-Rahman MA. 2015. Differential leucocyte count and total colony count changes in heat stressed broiler. J Adv Vet Res. 5(1):21–28.
   Google Scholar
• Shyu YS, Hwang LS. 2002. Antioxidative activity of the crude extract of lignan glycosides from unroasted Burma black sesame meal. Food Res Int. 35(4):357–365. doi: 10.1016/S0963-9969(01)00130-2.
   Web of Science ®Google Scholar
• Singh G, Marimuthu P, de Heluani CS, Catalan C. 2005. Chemical constituents and antimicrobial and antioxidant potentials of essential oil and acetone extract of Nigella sativa seeds. J Sci Food Agric. 85(13):2297–2306. doi: 10.1002/jsfa.2255.
   Web of Science ®Google Scholar
• Sola-Ojo FE, Adeyemi KD, Alli OI, Ibiwoye DI, Taiwo O, Onyebuchi KU, Akilapa MA. 2019. Effects of acute heat stress on performance and blood parameters of four broiler chicken strains reared in north central Nigeria. J Agric Food Environ. 6:1–15.
   Google Scholar
• Soleimani AF, Kasim A, Alimon AR, Zulkifli I. 2008. Durability of induced heat tolerance by short-term heat challenge at broilers marketing age. Pakistan J Biol Sci. 11(17):2163–2166. doi: 10.3923/pjbs.2008.2163.2166.
   PubMedGoogle Scholar
• Star L, Decuypere E, Parmentier HK, Kemp B. 2008. Effect of single or combined climatic and hygienic stress in four layer lines: 2. Endocrine and oxidative stress responses. Poult Sci. 87(6):1031–1038. doi: 10.3382/ps.2007-00143. 18492989.
   PubMed Web of Science ®Google Scholar
• Sun X, Zhang H, Sheikhahmadi A, Wang Y, Jiao H, Lin H, Song Z. 2015. Effects of heat stress on the gene expression of nutrient transporters in the jejunum of broiler chickens (Gallus gallus domesticus). Int J Biometeorol. 59(2):127–135. doi: 10.1007/s00484-014-0829-1.
   PubMed Web of Science ®Google Scholar
• Tang LP, Liu YL, Zhang JX, Ding KN, Lu MH, He YM. 2022. Heat stress in broilers of liver injury effects of heat stress on oxidative stress and autophagy in liver of broilers. Poult Sci. 101(10):102085. doi: 10.1016/j.psj.2022.102085.
   PubMed Web of Science ®Google Scholar
• Tawfeek SS, Hassanin KMA, Youssef IMI. 2014. The effect of dietary supplementation of some antioxidants on performance, oxidative stress, and blood parameters in broilers under natural summer conditions. J World Poult Res. 4(1):10–19.
   Google Scholar
• Tewari D, Jóźwik A, Łysek-Gładysińska M, Grzybek W, Adamus-Białek W, Bicki J, Strzałkowska N, Kamińska A, Horbańczuk OK, Atanasov AG. 2020. Fenugreek (Trigonella foenum-graecum L.) seeds dietary supplementation regulates liver antioxidant defense systems in aging mice. Nutrients. 12(9):2552. doi: 10.3390/nu12092552.
   PubMed Web of Science ®Google Scholar
• Tumosienė I, Kantminienė K, Klevinskas A, Petrikaitė V, Jonuškienė I, Mickevičius V. 2020. Antioxidant and anticancer activity of novel derivatives of 3-[(4-methoxyphenyl) amino] propanehydrazide. Molecules. 25(13):2980. doi: 10.3390/molecules25132980.
   PubMed Web of Science ®Google Scholar
• Vahdatpour T, Nazer Adl K, Ebrahim Ne Y, Mahery Sis N, R. Riyazi S, Vahdatpour S. 2008. Effects of corticosterone intake as stress alternative hormone on broiler chickens: performance and blood parameters. Asian J Anim Vet Adv. 4(1):16–21. doi: 10.3923/ajava.2009.16.21.
   Google Scholar
• Vaz NP, De Oliveira DR, Abouelella GA, Khater HF. 2018. The black seed, Nigella sativa (Ranunculaceae), for prevention and treatment of hypertension. JN Govil Bhardwaj N. 48:221–244.
   Google Scholar
• Virden WS, Kidd MT. 2009. Physiological stress in broilers: ramifications on nutrient digestibility and responses. J Appl Poult Res. 18(2):338–347. doi: 10.3382/japr.2007-00093.
   Web of Science ®Google Scholar
• Wagner DD, Furrow RD, Bradley BD. 1983. Subchronic toxicity of monensin in broiler chickens. Vet Pathol. 20(3):353–359. doi: 10.1177/030098588302000311.
   PubMed Web of Science ®Google Scholar
• Waheed S, Hasnain A, Ahmad A, Tarar OM, Yaqeen Z, Ali TM. 2017. Effect of spices and sweet violet extracts to replace antibiotics and antioxidants in feed on broiler performance, hematology, lipid profile and immunity. J Anim Plant Sci. 27(3):714–724.
   Web of Science ®Google Scholar
• Weerasingha AS, Atapattu NSBM. 2013. Effects of fenugreek (Trigonella foenum-graecum L.) seed powder on growth performance, visceral organ weight, serum cholesterol levels and the nitrogen retention of broiler chicken. Trop Agric Res. 24(3):289–295. doi: 10.4038/tar.v24i3.8014.
   Google Scholar
• Wenk C. 2003. Herbs and botanicals as feed additives in monogastric animals. Asian Australas J Anim Sci. 16(2):282–289. doi: 10.5713/ajas.2003.282.
   Web of Science ®Google Scholar
• Whitehead CC, Keller T. 2003. An update on ascorbic acid in poultry. Worlds Poult Sci J. 59(2):161–184. doi: 10.1079/WPS20030010.
   Web of Science ®Google Scholar
• Xanthis V, Fitsiou E, Voulgaridou GP, Bogadakis A, Chlichlia K, Galanis A, Pappa A. 2021. Antioxidant and cytoprotective potential of the essential oil Pistacia lentiscus var. chia and its major components myrcene and α-pinene. Antioxidants. 10(1):127. doi: 10.3390/antiox10010127.
   Web of Science ®Google Scholar
• Xue WL, Li XS, Zhang J, Liu YH, Wang ZL, Zhang RJ. 2007. Effect of Trigonella foenum-graecum (fenugreek) extract on blood glucose, blood lipid and hemorheological properties in streptozotocin-induced diabetic rats. Asia Pac J Clin Nutr. 16(Suppl 1):422–426.
   PubMedGoogle Scholar
• Yang L, Chen L, Zheng K, Ma YJ, He RX, Arowolo MA, Zhou YJ, Xiao DF, He JH. 2022. Effects of fenugreek seed extracts on growth performance and intestinal health of broilers. Poult Sci. 101(7):101939. doi: 10.1016/j.psj.2022.101939.
   PubMedGoogle Scholar
• Yargholi A, Najafi MH, Zareian MA, Hawkins J, Shirbeigi L, Ayati MH. 2021. The effects of sesame consumption on glycemic control in adults: a systematic review and meta-analysis of randomized clinical trial. Evid Based Complem Altern Med. 2021:1–11. doi: 10.1155/2021/2873534.
   Google Scholar
• Yatoo MA, Sharma RK, Khan N, Rastogi A, Pathak AK. 2012. Effect of fenugreek and black cumin seeds as feed additives on blood biochemical profile and performance of broilers. IJAN. 29(2):174–178.
   Google Scholar
• Yoshida H, Shigezaki J, Takagi S, Kajimoto G. 1995. Variations in the composition of various acyl lipids, tocopherols & lignans in sesame seed oils roasted in a microwave oven. J Sci Food Agric. 68(4):407–415. doi: 10.1002/jsfa.2740680403.
   Web of Science ®Google Scholar
• Zitouni H, Fauconnier ML, Hssaini L, Ouaabou R, Viuda-Martos M, Hernández F, Ercisli S, Haddou LA, Messaoudi Z, Hanine H. 2022. Phenols, volatile compounds, organic acids and antioxidant activity of strawberry trvolatile compounds, organic acids and antioxidant activity of strawberry tree (Arbutus Unedo L.) fruits belonging to five genotypes growing in morocco. Int J Fruit Sci. 22(1):414–437. doi: 10.1080/15538362.2022.2037038
   Web of Science ®Google Scholar