Use of poxvirus display to select antibodies specific for complex membrane antigens

References

• Mullard A. FDA approves 100th monoclonal antibody product. Nat Rev Drug Discov. 2021;20(7):491–13. doi:10.1038/d41573-021-00079-7.
   PubMed Web of Science ®Google Scholar
• Hutchings CJ, Koglin M, Marshall FH. Therapeutic antibodies directed at G protein-coupled receptors. MAbs. 2010;2:594–606. doi:10.4161/mabs.2.6.13420.
   PubMed Web of Science ®Google Scholar
• Foord SM, Bonner TI, Neubig RR, Rosser EM, Pin JP, Davenport AP, Spedding M, Harmar AJ. International Union of Pharmacology. XLVI. G protein-coupled receptor list. Pharmacol Rev. 2005;57:279–88. doi:10.1124/pr.57.2.5. PMID: 15914470.
   PubMed Web of Science ®Google Scholar
• Hauser AS, Attwood MM, Rask-Andersen M, Schiöth HB, Gloriam DE. Trends in GPCR drug discovery: new agents, targets and indications. Nat Rev Drug Discov. 2017;16:829–42. doi:10.1038/nrd.2017.178.
   PubMed Web of Science ®Google Scholar
• Fredriksson R, Lagerström MC, Lundin LG, Schiöth HB. The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol. 2003;63:1256–72. doi:10.1124/mol.63.6.1256. PMID: 12761335.
   PubMed Web of Science ®Google Scholar
• Katritch V, Cherezov V, Stevens RC. Structure-function of the G protein–coupled receptor Superfamily. Annu Rev Pharmacol Toxicol. 2013;53(1):531–56. doi:10.1146/annurev-pharmtox-032112-135923. PMID: 23140243.
   PubMed Web of Science ®Google Scholar
• Lagerström MC, Schiöth HB. Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov. 2008;7:339–57. doi:10.1038/nrd2518. PMID: 18382464.
   PubMed Web of Science ®Google Scholar
• Congreve M, de Graaf C, Swain NA, Tate CG. Impact of GPCR Structures on Drug discovery. Cell. 2020;181:81–91. doi:10.1016/j.cell.2020.03.003. PMID: 32243800.
   PubMed Web of Science ®Google Scholar
• Carter PJ, Lazar GA. Next generation antibody drugs: pursuit of the ‘high-hanging fruit’. Nat Rev Drug Discov. 2018;17(3):197–223. doi:10.1038/nrd.2017.227. PMID: 29192287.
   PubMed Web of Science ®Google Scholar
• Lundstrom K, Wagner R, Reinhart C, Desmyter A, Cherouati N, Magnin T, Zeder-Lutz G, Courtot M, Prual C, André N, et al. Structural genomics on membrane proteins: comparison of more than 100 GPCRs in 3 expression systems. J Struct Funct Genomics. 2006;7(2):77–91. doi:10.1007/s10969-006-9011-2. PMID: 17120110.
   PubMedGoogle Scholar
• Jo M, Jung ST. Engineering therapeutic antibodies targeting G-protein–coupled receptors. Experimental & Molecular Medicine. 2016;48(2):e207. doi:10.1038/emm.2015.105. PMID: 26846450.
   PubMedGoogle Scholar
• Wiseman DN, Otchere A, Patel JH, Uddin R, Pollock NL, Routledge SJ, Rothnie AJ, Slack C, Poyner DR, Bill RM, et al. Expression and purification of recombinant G protein-coupled receptors: A review. Protein Expr Purif. 2020;167:105524. doi:10.1016/j.pep.2019.105524. PMID: 31678667.
   PubMed Web of Science ®Google Scholar
• Sarkar CA, Dodevski I, Kenig M, Dudli S, Mohr A, Hermans E, Plückthun A. Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity. Proc Natl Acad Sci U S A. 2008;105:14808–13. doi:10.1073/pnas.0803103105. PMID: 18812512.
   PubMed Web of Science ®Google Scholar
• Dunham JH, Hall RA. Enhancement of the surface expression of G protein-coupled receptors. Trends Biotechnol. 2009;27:541–45. doi:10.1016/j.tibtech.2009.06.005. PMID: 19679364.
   PubMed Web of Science ®Google Scholar
• Moss B. Membrane fusion during poxvirus entry. Semin Cell Dev Biol. 2016;60:89–96. doi:10.1016/j.semcdb.2016.07.015. PMID: 27423915.
   PubMed Web of Science ®Google Scholar
• Smith GL, Vanderplasschen A, Law M. The formation and function of extracellular enveloped vaccinia virus. J Gen Virol. 2002;83(12):2915–31. doi:10.1099/0022-1317-83-12-2915. PMID: 12466468.
   PubMedGoogle Scholar
• Moss B. Vaccinia virus: a tool for research and vaccine development. Sci. 1991;252(5013):1662–67. doi:10.1126/science.2047875. PMID: 2047875.
   PubMed Web of Science ®Google Scholar
• Smith ES, Zauderer M. Antibody library display on a mammalian virus vector: combining the advantages of both phage and yeast display into one technology. Curr Drug Discov Technol. 2014;11(1):48–55. doi:10.2174/157016381101140124163634. PMID: 24090134.
   PubMedGoogle Scholar
• Vaccinia Virus and Poxvirology. vaccinia virus and poxvirology. Vol. 890, 2nd ed. New Jersey: Humana Totowa; 2012.
   Google Scholar
• Carroll MW, Moss B. Host range and cytopathogenicity of the highly attenuated MVA strain of vaccinia virus: propagation and generation of recombinant viruses in a nonhuman mammalian cell line. Virology. 1997;238(2):198–211. doi:10.1006/viro.1997.8845. PMID: 9400593.
   PubMed Web of Science ®Google Scholar
• Antoine G, Scheiflinger F, Dorner F, Falkner FG. The complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxviruses. Virology. 1998;244(2):365–96. doi:10.1006/viro.1998.9123. PMID: 9601507.
   PubMed Web of Science ®Google Scholar
• Verheust CGM, Pauwels K, Breyer D. Biosafety aspects of modified vaccinia virus Ankara (MVA)-based vectors used for gene therapy or vaccination. Vaccine. 2012;30(16):2623–32. doi:10.1016/j.vaccine.2012.02.016.
   PubMed Web of Science ®Google Scholar
• DeHaven BC, Gupta K, Isaacs SN. The vaccinia virus A56 protein: a multifunctional transmembrane glycoprotein that anchors two secreted viral proteins. J Gen Virol. 2011;92:1971–80. doi:10.1099/vir.0.030460-0. PMID: 21715594.
   PubMed Web of Science ®Google Scholar
• Okines AF, Cunningham D. Trastuzumab: a novel standard option for patients with HER-2-positive advanced gastric or gastro-oesophageal junction cancer. Therap Adv Gastroenterol. 2012;5(5):301–18. doi:10.1177/1756283x12450246. PMID: 22973416.
   PubMed Web of Science ®Google Scholar
• Fisher TL, Reilly CA, Winter LA, Pandina T, Jonason A, Scrivens M, Balch L, Bussler H, Torno S, Seils J, et al. Generation and preclinical characterization of an antibody specific for SEMA4D. MAbs. 2016;8(1):150–62. doi:10.1080/19420862.2015.1102813. PMID: 26431358.
   PubMed Web of Science ®Google Scholar
• Spehner D, Drillien R, Proamer F, Houssais-Pêcheur C, Zanta MA, Geist M, Dott K, Balloul JM. Enveloped virus is the major virus form produced during productive infection with the modified vaccinia virus Ankara strain. Virology. 2000;273:9–15. doi:10.1006/viro.2000.0411.
   PubMed Web of Science ®Google Scholar
• Drexler IHK, Wahren B, Erfle V, Sutter G. Highly attenuated modified vaccinia virus Ankara replicates in baby hamster kidney cells, a potential host for virus propagation, but not in various human transformed and primary cells. Journal of General Virology. 1998;79(2):347–52. doi:10.1099/0022-1317-79-2-347.
   PubMedGoogle Scholar
• Schmutz CWR. Release of extracellular particles by recombinant vaccinia virus over-expressing the major envelope protein p37K. Gen Virol. 1995;76(12):2963–68. doi:10.1099/0022-1317-76-12-2963.
   PubMedGoogle Scholar
• Honeychurch KMYG, Jordan R, Hruby DE. The vaccinia virus F13L YPPL motif is required for efficient release of extracellular enveloped virus. J Virol. 2007;81(13):7310–15. doi:10.1128/JVI.00034-07.
   PubMed Web of Science ®Google Scholar
• Reff ME, Carner K, Chambers KS, Chinn PC, Leonard JE, Raab R, Newman RA, Hanna N, Anderson DR. Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20. Blood. 1994;83(2):435–45. doi:10.1182/blood.V83.2.435.435.
   PubMed Web of Science ®Google Scholar
• Klein C, Lammens A, Schäfer W, Georges G, Schwaiger M, Mössner E, Hopfner KP, Umaña P, Niederfellner G. Epitope interactions of monoclonal antibodies targeting CD20 and their relationship to functional properties. MAbs. 2013;5(1):22–33. doi:10.4161/mabs.22771. PMID: 23211638.
   PubMed Web of Science ®Google Scholar
• Ray-Saha S, Huber T, Sakmar TP. Antibody epitopes on G protein-coupled receptors mapped with genetically encoded photoactivatable cross-linkers. Biochemistry. 2014;53(8):1302–10. doi:10.1021/bi401289p.
   PubMed Web of Science ®Google Scholar
• Spatola BN, Lerner AG, Wong C, Dela Cruz T, Welch M, Fung W, Kovalenko M, Losenkova K, Yegutkin GG, Beers C, et al. Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism. MAbs. 2020;12(1):1838036. doi:10.1080/19420862.2020.1838036. PMID: 33146056.
   PubMed Web of Science ®Google Scholar
• Duquenne C, Psomas C, Gimenez S, Guigues A, Carles M-J, Barbuat C, Lavigne J-P, Sotto A, Reynes J, Guglielmi P, et al. The two human CXCR4 isoforms display different HIV receptor activities: Consequences for the emergence of X4 strains. J Immunol. 2014;193:4188–94. doi:10.4049/jimmunol.1303298.
   PubMed Web of Science ®Google Scholar
• Roland J, Murphy BJ, Ahr B, Robert-Hebmann V, Delauzun V, Nye KE, Devaux C, Biard-Piechaczyk M. Role of the intracellular domains of CXCR4 in SDF-1–mediated signaling. Blood. 2003;101:399–406. doi:10.1182/blood-2002-03-0978.
   PubMed Web of Science ®Google Scholar
• Zeng CM, Chen Z, Fu L. Frizzled receptors as potential therapeutic targets in human cancers. Int J Mol Sci. 2018;19(5):1543. doi:10.3390/ijms19051543. PMID: 29789460.
   PubMed Web of Science ®Google Scholar
• Marks JD, Hoogenboom HR, Bonnert HR, McCafferty TP, Griffiths J, Winter AD, By-Passing Immunization G. Human antibodies from V-gene libraries displayed on phage. J Mol Bio. 1991; Dec 5;222(3):581–97. doi:10.1016/0022-2836(91)90498-U.
   PubMed Web of Science ®Google Scholar
• Lee CM, Iorno N, Sierro F, Christ D. Selection of human antibody fragments by phage display. Nat Protoc. 2007;2:3001–08. doi:10.1038/nprot.2007.448. PMID: 18007636.
   PubMed Web of Science ®Google Scholar