Transgene and islet cell delivery systems using nano-sized carriers for the treatment of diabetes mellitus

References

• Collaboration NCDRF. Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet. 2016 Apr 9;387(10027):1–11. PubMed PMID: 27061677.
   Web of Science ®Google Scholar
• Group AC, Patel A, MacMahon S, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008 Jun 12;358(24):2560–2572. PubMed PMID: 18539916.
   PubMed Web of Science ®Google Scholar
• Ohkubo Y, Kishikawa H, Araki E, et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract. 1995 May;28(2):103–117. PubMed PMID: 7587918.
   PubMed Web of Science ®Google Scholar
• Wong JK, Mohseni R, Hamidieh AA, et al. Will nanotechnology bring new hope for gene delivery? Trends Biotechnol. 2017 Jan 17;35:434–451. PubMed PMID: 28108036.; eng.
   PubMed Web of Science ®Google Scholar
• Tang Y, Zeng Z, He X, et al. SiRNA crosslinked nanoparticles for the treatment of inflammation-induced liver injury. Adv Sci (Weinh). 2017 Feb;4(2):1600228. PubMed PMID: 28251047; PubMed Central PMCID: PMC5323819. eng.
   Google Scholar
• Chahal H, Chowdhury TA. Gliptins: a new class of oral hypoglycaemic agent. Qjm. 2007 Nov;100(11):671–677. PubMed PMID: 17881415.
   Web of Science ®Google Scholar
• Ahren B. DPP-4 inhibitors. Best Pract Res Clin Endocrinol Metab. 2007 Dec;21(4):517–533. PubMed PMID: 18054733.
   PubMed Web of Science ®Google Scholar
• Damdindorj B, Dezaki K, Kurashina T, et al. Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet beta-cells. FEBS Lett. 2012 Jul 30;586(16):2555–2562. PubMed PMID: 22750144.
   PubMed Web of Science ®Google Scholar
• Yosida M, Dezaki K, Uchida K, et al. Involvement of cAMP/EPAC/TRPM2 activation in glucose- and incretin-induced insulin secretion. Diabetes. 2014 Oct;63(10):3394–3403. PubMed PMID: 24824430.
   Web of Science ®Google Scholar
• Taniguchi H, Yamato E, Tashiro F, et al. beta-cell neogenesis induced by adenovirus-mediated gene delivery of transcription factor pdx-1 into mouse pancreas. Gene Ther. 2003 Jan;10(1):15–23. PubMed PMID: 12525833.
   Web of Science ®Google Scholar
• Miyazaki S, Tashiro F, Fujikura J, et al. Acinar-to-ductal metaplasia induced by adenovirus-mediated pancreatic expression of Isl1. PLoS One. 2012;7(10):e47536. PubMed PMID: 23077629; PubMed Central PMCID: PMC3471997.
   Web of Science ®Google Scholar
• Phillips N, Kay MA. Characterization of vector-based delivery of neurogenin-3 in murine diabetes. Hum Gene Ther. 2014 Jul;25(7):651–661. PubMed PMID: 24635696; PubMed Central PMCID: PMCPMC4098120.
   Web of Science ®Google Scholar
• Lee Y, Kwon MK, Kang ES, et al. Adenoviral vector-mediated glucagon-like peptide 1 gene therapy improves glucose homeostasis in Zucker diabetic fatty rats. J Gene Med. 2008 Mar;10(3):260–268. PubMed PMID: 18085721.
   Web of Science ®Google Scholar
• Parsons GB, Souza DW, Wu H, et al. Ectopic expression of glucagon-like peptide 1 for gene therapy of type II diabetes. Gene Ther. 2007 Jan;14(1):38–48. PubMed PMID: 16929351.
   Web of Science ®Google Scholar
• Lee YS, Shin S, Shigihara T, et al. Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis. Diabetes. 2007 Jun;56(6):1671–1679. PubMed PMID: 17369525.
   Web of Science ®Google Scholar
• Choi SH, Lee HC. Long-term, antidiabetogenic effects of GLP-1 gene therapy using a double-stranded, adeno-associated viral vector. Gene Ther. 2011 Feb;18(2):155–163. PubMed PMID: 20720576.
   Web of Science ®Google Scholar
• Liu MJ, Shin S, Li N, et al. Prolonged remission of diabetes by regeneration of beta cells in diabetic mice treated with recombinant adenoviral vector expressing glucagon-like peptide-1. Mol Ther. 2007 Jan;15(1):86–93. PubMed PMID: 17164779.
   Web of Science ®Google Scholar
• Gaddy DF, Riedel MJ, Pejawar-Gaddy S, et al. In vivo expression of HGF/NK1 and GLP-1 From dsAAV vectors enhances pancreatic ss-cell proliferation and improves pathology in the db/db mouse model of diabetes. Diabetes. 2010 Dec;59(12):3108–3116. PubMed PMID: 20841608; PubMed Central PMCID: PMCPMC2992772.
   Web of Science ®Google Scholar
• Riedel MJ, Gaddy DF, Asadi A, et al. DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes. Gene Ther. 2010 Feb;17(2):171–180. PubMed PMID: 19865180.
   Web of Science ®Google Scholar
• Gaddy DF, Riedel MJ, Bertera S, et al. dsAAV8-mediated gene transfer and beta-cell expression of IL-4 and beta-cell growth factors are capable of reversing early-onset diabetes in NOD mice. Gene Ther. 2012 Aug;19(8):791–799. PubMed PMID: 22089495.
   Web of Science ®Google Scholar
• Tonne JM, Sakuma T, Deeds MC, et al. Global gene expression profiling of pancreatic islets in mice during streptozotocin-induced beta-cell damage and pancreatic Glp-1 gene therapy. Dis Model Mech. 2013 Sep;6(5):1236–1245. PubMed PMID: 23828045; PubMed Central PMCID: PMCPMC3759343.
   Web of Science ®Google Scholar
• Flores RR, Zhou L, Robbins PD. Expression of IL-2 in beta cells by AAV8 gene transfer in pre-diabetic NOD mice prevents diabetes through activation of FoxP3-positive regulatory T cells. Gene Ther. 2014 Aug;21(8):715–722. PubMed PMID: 24849041.
   Web of Science ®Google Scholar
• Lin Y, Sun Z. Antiaging gene klotho attenuates pancreatic beta-cell apoptosis in type 1 diabetes. Diabetes. 2015 Dec;64(12):4298–4311. PubMed PMID: 26340932; PubMed Central PMCID: PMCPMC4657580.
   PubMed Web of Science ®Google Scholar
• Kim JY, Park KJ, Kim GH, et al. In vivo activating transcription factor 3 silencing ameliorates the AMPK compensatory effects for ER stress-mediated beta-cell dysfunction during the progression of type-2 diabetes. Cell Signal. 2013 Dec;25(12):2348–2361. PubMed PMID: 23916985.
   Web of Science ®Google Scholar
• Jeong JH, Kim SH, Lee M, et al. Non-viral systemic delivery of Fas siRNA suppresses cyclophosphamide-induced diabetes in NOD mice. J Control Release. 2010 Apr 2;143(1):88–94. PubMed PMID: 20004692; PubMed Central PMCID: PMCPMC2840072.
   Web of Science ®Google Scholar
• Choi S, Oh S, Lee M, et al. Glucagon-like peptide-1 plasmid construction and delivery for the treatment of type 2 diabetes. Mol Ther. 2005 Nov;12(5):885–891. PubMed PMID: 16039908.
   Web of Science ®Google Scholar
• Mandke R, Singh J. Cationic nanomicelles for delivery of plasmids encoding interleukin-4 and interleukin-10 for prevention of autoimmune diabetes in mice. Pharm Res. 2012 Mar;29(3):883–897. PubMed PMID: 22076555.
   PubMed Web of Science ®Google Scholar
• Jean M, Alameh M, Buschmann MD, et al. Effective and safe gene-based delivery of GLP-1 using chitosan/plasmid-DNA therapeutic nanocomplexes in an animal model of type 2 diabetes. Gene Ther. 2011 Aug;18(8):807–816. PubMed PMID: 21412280.
   PubMed Web of Science ®Google Scholar
• Kim PH, Lee M, Kim SW. Delivery of two-step transcription amplification exendin-4 plasmid system with arginine-grafted bioreducible polymer in type 2 diabetes animal model. J Control Release. 2012 Aug 20;162(1):9–18. PubMed PMID: 22705459; PubMed Central PMCID: PMCPMC3426869.
   Web of Science ®Google Scholar
• Chen S, Jh D, Bekeredjian R, et al. Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology. Proc Natl Acad Sci USA. 2006 May 30;103(22):8469–8474. PubMed PMID: 16709667; PubMed Central PMCID: PMCPMC1482516.
   PubMed Web of Science ®Google Scholar
• Ayuso E, Chillon M, Agudo J, et al. In vivo gene transfer to pancreatic beta cells by systemic delivery of adenoviral vectors. Hum Gene Ther. 2004 Aug;15(8):805–812. PubMed PMID: 15319037.
   Web of Science ®Google Scholar
• Ayuso E, Chillon M, Garcia F, et al. In vivo gene transfer to healthy and diabetic canine pancreas. Mol Ther. 2006 Apr;13(4):747–755. PubMed PMID: 16330257.
   Web of Science ®Google Scholar
• McClane SJ, Hamilton TE, DeMatteo RP, et al. Effect of adenoviral early genes and the host immune system on in vivo pancreatic gene transfer in the mouse. Pancreas. 1997 Oct;15(3):236–245. PubMed PMID: 9336786.
   Web of Science ®Google Scholar
• Wang AY, Peng PD, Ehrhardt A, et al. Comparison of adenoviral and adeno-associated viral vectors for pancreatic gene delivery in vivo. Hum Gene Ther. 2004 Apr;15(4):405–413. PubMed PMID: 15053865.
   PubMed Web of Science ®Google Scholar
• Summerford C, Samulski RJ. Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. J Virol. 1998 Feb;72(2):1438–1445. PubMed PMID: 9445046; PubMed Central PMCID: PMCPMC124624.
   PubMed Web of Science ®Google Scholar
• Qing K, Mah C, Hansen J, et al. Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2. Nat Med. 1999 Jan;5(1):71–77. PubMed PMID: 9883842.
   PubMed Web of Science ®Google Scholar
• Summerford C, Bartlett JS, Samulski RJ. AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection. Nat Med. 1999 Jan;5(1):78–82. PubMed PMID: 9883843.
   PubMed Web of Science ®Google Scholar
• Kashiwakura Y, Tamayose K, Iwabuchi K, et al. Hepatocyte growth factor receptor is a coreceptor for adeno-associated virus type 2 infection. J Virol. 2005 Jan;79(1):609–614. PubMed PMID: 15596854; PubMed Central PMCID: PMCPMC538679.
   PubMed Web of Science ®Google Scholar
• Cheng H, Wolfe SH, Valencia V, et al. Efficient and persistent transduction of exocrine and endocrine pancreas by adeno-associated virus type 8. J Biomed Sci. 2007 Sep;14(5):585–594. PubMed PMID: 17387636.
   Web of Science ®Google Scholar
• Inagaki K, Fuess S, Storm TA, et al. Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8. Mol Ther. 2006 Jul;14(1):45–53. PubMed PMID: 16713360; PubMed Central PMCID: PMC1564441.
   PubMed Web of Science ®Google Scholar
• Jimenez V, Ayuso E, Mallol C, et al. In vivo genetic engineering of murine pancreatic beta cells mediated by single-stranded adeno-associated viral vectors of serotypes 6, 8 and 9. Diabetologia. 2011 May;54(5):1075–1086. PubMed PMID: 21311856.
   PubMed Web of Science ®Google Scholar
• Loiler SA, Tang Q, Clarke T, et al. Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts. Mol Ther. 2005 Sep;12(3):519–527. PubMed PMID: 15979413.
   Web of Science ®Google Scholar
• Chae HY, Lee BW, Oh SH, et al. Effective glycemic control achieved by transplanting non-viral cationic liposome-mediated VEGF-transfected islets in streptozotocin-induced diabetic mice. Exp Mol Med. 2005 Dec 31;37(6):513–523. PubMed PMID: 16391512.
   Web of Science ®Google Scholar
• Wang Z, Zhu T, Rehman KK, et al. Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes. Diabetes. 2006 Apr;55(4):875–884. PubMed PMID: 16567506.
   PubMed Web of Science ®Google Scholar
• Vetrini F, Ng P. Gene therapy with helper-dependent adenoviral vectors: current advances and future perspectives. Viruses. 2010 Sep;2(9):1886–1917. PubMed PMID: 21994713; PubMed Central PMCID: PMCPMC3186006.
   PubMed Web of Science ®Google Scholar
• Morro M, Teichenne J, Jimenez V, et al. Pancreatic transduction by helper-dependent adenoviral vectors via intraductal delivery. Hum Gene Ther. 2014 Sep;25(9):824–836. PubMed PMID: 25046147; PubMed Central PMCID: PMC4175029.
   Web of Science ®Google Scholar
• Lu Y, McNearney TA, Lin W, et al. Treatment of inflamed pancreas with enkephalin encoding HSV-1 recombinant vector reduces inflammatory damage and behavioral sequelae. Mol Ther. 2007 Oct;15(10):1812–1819. PubMed PMID: 17565349; PubMed Central PMCID: PMCPMC2592562.
   Web of Science ®Google Scholar
• Shaw KL, Pais E, Ge S, et al. Lentiviral vectors with amplified beta cell-specific gene expression. Gene Ther. 2009 Aug;16(8):998–1008. PubMed PMID: 19440227; PubMed Central PMCID: PMC2726899.
   Web of Science ®Google Scholar
• Xu X, D’Hoker J, Stange G, et al. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell. 2008 Jan 25;132(2):197–207. PubMed PMID: 18243096.
   PubMed Web of Science ®Google Scholar
• Yang H, McNearney TA, Chu R, et al. Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model. Mol Pain. 2008;4:8. PubMed PMID: 18307791; PubMed Central PMCID: PMCPMC2292157.
   Web of Science ®Google Scholar
• Alemany R, Suzuki K, Curiel DT. Blood clearance rates of adenovirus type 5 in mice. J Gen Virol. 2000 Nov;81(Pt 11):2605–2609. PubMed PMID: 11038370.
   PubMed Web of Science ®Google Scholar
• Ye X, Jerebtsova M, Ray PE. Liver bypass significantly increases the transduction efficiency of recombinant adenoviral vectors in the lung, intestine, and kidney. Hum Gene Ther. 2000 Mar 1;11(4):621–627. PubMed PMID: 10724040.
   PubMed Web of Science ®Google Scholar
• Nakai H, Fuess S, Storm TA, et al. Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice. J Virol. 2005 Jan;79(1):214–224. PubMed PMID: 15596817; PubMed Central PMCID: PMC538708.
   PubMed Web of Science ®Google Scholar
• Chae HY, Kang JG, Kim CS, et al. Effect of glucagon-like peptide-1 gene expression on graft function in mouse islet transplantation. Transpl Int. 2012 Feb;25(2):242–249. PubMed PMID: 22171669.
   Web of Science ®Google Scholar
• Harush-Frenkel O, Rozentur E, Benita S, et al. Surface charge of nanoparticles determines their endocytic and transcytotic pathway in polarized MDCK cells. Biomacromolecules. 2008 Feb;9(2):435–443. PubMed PMID: 18189360.
   PubMed Web of Science ®Google Scholar
• Chung YI, Kim JC, Kim YH, et al. The effect of surface functionalization of PLGA nanoparticles by heparin- or chitosan-conjugated Pluronic on tumor targeting. J Control Release. 2010 May 10;143(3):374–382. PubMed PMID: 20109508.
   PubMed Web of Science ®Google Scholar
• Tung CH, Weissleder R. Arginine containing peptides as delivery vectors. Adv Drug Deliv Rev. 2003 Feb 10;55(2):281–294. PubMed PMID: 12564981.
   PubMed Web of Science ®Google Scholar
• Chai R, Chen S, Ding J, et al. Efficient, glucose responsive and islet-specific transgene expression by a modified rat insulin promoter. Gene Ther. 2009 Oct;16(10):1202–1209. PubMed PMID: 19727136; PubMed Central PMCID: PMCPMC2762485.
   Web of Science ®Google Scholar
• Medarova Z, Kumar M, Ng SW, et al. Multifunctional magnetic nanocarriers for image-tagged SiRNA delivery to intact pancreatic islets. Transplantation. 2008 Nov 15;86(9):1170–1177. PubMed PMID: 19005396; PubMed Central PMCID: PMCPMC2678246.
   Web of Science ®Google Scholar
• Ge Y, Zhang Y, Xia J, et al. Effect of surface charge and agglomerate degree of magnetic iron oxide nanoparticles on KB cellular uptake in vitro. Colloids Surf B Biointerfaces. 2009 Oct 15;73(2):294–301. PubMed PMID: 19564099.
   PubMed Web of Science ®Google Scholar
• Calero M, Chiappi M, Lazaro-Carrillo A, et al. Characterization of interaction of magnetic nanoparticles with breast cancer cells. J Nanobiotechnology. 2015 Feb 26;13:16. PubMed PMID: 25880445; PubMed Central PMCID: PMCPMC4403785.
   PubMed Web of Science ®Google Scholar
• Habener JF, Kemp DM, Thomas MK. Minireview: transcriptional regulation in pancreatic development. Endocrinology. 2005 Mar;146(3):1025–1034. PubMed PMID: 15604203.
   PubMed Web of Science ®Google Scholar
• Watada H, Kajimoto Y, Miyagawa J, et al. PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin. Diabetes. 1996 Dec;45(12):1826–1831. PubMed PMID: 8922372.
   Web of Science ®Google Scholar
• Wang S, Jensen JN, Seymour PA, et al. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci USA. 2009 Jun 16;106(24):9715–9720. PubMed PMID: 19487660; PubMed Central PMCID: PMCPMC2701002.
   Web of Science ®Google Scholar
• Wang S, Yan J, Anderson DA, et al. Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas. Dev Biol. 2010 Mar 1;339(1):26–37. PubMed PMID: 20025861; PubMed Central PMCID: PMCPMC2824035.
   Web of Science ®Google Scholar
• Cim A, Sawyer GJ, Zhang X, et al. In vivo studies on non-viral transdifferentiation of liver cells towards pancreatic beta cells. J Endocrinol. 2012 Sep;214(3):277–288. PubMed PMID: 22685335.
   Web of Science ®Google Scholar
• Liu MJ, Han J, Lee YS, et al. Amelioration of hyperglycemia by intestinal overexpression of glucagon-like peptide-1 in mice. J Mol Med (Berl). 2010 Apr;88(4):351–358. PubMed PMID: 20016875.
   Web of Science ®Google Scholar
• Poy MN, Eliasson L, Krutzfeldt J, et al. A pancreatic islet-specific microRNA regulates insulin secretion. Nature. 2004 Nov 11;432(7014):226–230. PubMed PMID: 15538371.
   PubMed Web of Science ®Google Scholar
• Xia HQ, Pan Y, Peng J, et al. Over-expression of miR375 reduces glucose-induced insulin secretion in Nit-1 cells. Mol Biol Rep. 2011 Jun;38(5):3061–3065. PubMed PMID: 20221699.
   PubMed Web of Science ®Google Scholar
• El Ouaamari A, Baroukh N, Martens GA, et al. miR-375 targets 3ʹ-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells. Diabetes. 2008 Oct;57(10):2708–2717. PubMed PMID: 18591395; PubMed Central PMCID: PMCPMC2551681.
   PubMed Web of Science ®Google Scholar
• Nathan G, Kredo-Russo S, Geiger T, et al. MiR-375 promotes redifferentiation of adult human beta cells expanded in vitro. PLoS One. 2015;10(4):e0122108. PubMed PMID: 25875172; PubMed Central PMCID: PMC4395232.
   Web of Science ®Google Scholar
• Poy MN, Hausser J, Trajkovski M, et al. miR-375 maintains normal pancreatic alpha- and beta-cell mass. Proc Natl Acad Sci USA. 2009 Apr 7;106(14):5813–5818. PubMed PMID: 19289822; PubMed Central PMCID: PMC2656556.
   PubMed Web of Science ®Google Scholar
• Backe MB, Novotny GW, Christensen DP, et al. Altering beta-cell number through stable alteration of miR-21 and miR-34a expression. Islets. 2014;6(1):e27754. PubMed PMID: 25483877; PubMed Central PMCID: PMC4281945.
   PubMed Web of Science ®Google Scholar
• Ramachandran D, Roy U, Garg S, et al. Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic beta-islets. The FEBS Journal. 2011 Apr;278(7):1167–1174. PubMed PMID: 21288303.
   Web of Science ®Google Scholar
• Ruan Q, Wang T, Kameswaran V, et al. The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death. Proc Natl Acad Sci USA. 2011 Jul 19;108(29):12030–12035. PubMed PMID: 21730150; PubMed Central PMCID: PMC3141944.
   PubMed Web of Science ®Google Scholar
• Sebastiani G, Po A, Miele E, et al. MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion. Acta Diabetologica. 2015 Jun;52(3):523–530. PubMed PMID: 25408296.
   PubMed Web of Science ®Google Scholar
• Lu H, Hao L, Li S, et al. Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway. Diabetologia. 2016 Jun;59(6):1247–1257. PubMed PMID: 26969487.
   PubMed Web of Science ®Google Scholar
• Benhamou PY, Milliat-Guittard L, Wojtusciszyn A, et al. Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials. Diabet Med. 2009 Jun;26(6):617–621. PubMed PMID: 19538237.
   Web of Science ®Google Scholar
• Saito T, Gotoh M, Satomi S, et al. Islet transplantation using donors after cardiac death: report of the Japan Islet transplantation registry. Transplantation. 2010 Oct 15;90(7):740–747. PubMed PMID: 20811319.
   PubMed Web of Science ®Google Scholar
• Teramura Y, Iwata H. Improvement of graft survival by surface modification with poly(ethylene glycol)-lipid and urokinase in intraportal islet transplantation. Transplantation. 2011 Feb 15;91(3):271–278. PubMed PMID: 21344734.
   PubMed Web of Science ®Google Scholar
• Teramura Y, Oommen OP, Olerud J, et al. Microencapsulation of cells, including islets, within stable ultra-thin membranes of maleimide-conjugated PEG-lipid with multifunctional crosslinkers. Biomaterials. 2013 Apr;34(11):2683–2693. PubMed PMID: 23347835.
   PubMed Web of Science ®Google Scholar
• Juang JH, Bonner-Weir S, Ogawa Y, et al. Outcome of subcutaneous islet transplantation improved by polymer device. Transplantation. 1996 Jun 15;61(11):1557–1561. PubMed PMID: 8669096.
   Web of Science ®Google Scholar
• Balamurugan AN, Gu Y, Tabata Y, et al. Bioartificial pancreas transplantation at prevascularized intermuscular space: effect of angiogenesis induction on islet survival. Pancreas. 2003 Apr;26(3):279–285. PubMed PMID: 12657955.
   PubMed Web of Science ®Google Scholar
• Gu YJ, Cui WX, Miyamoto M, et al. Development of a new bioartificial pancreas possessing angiogenesis-inducing function. Transplant Proc. 2000 Nov;32(7):2475. PubMed PMID: 11120252.
   Web of Science ®Google Scholar
• Gu YJ, Miyamoto M, Cui WX, et al. Effect of neovascularization-inducing bioartificial pancreas on survival of syngeneic islet grafts. Transplant Proc. 2000 Nov;32(7):2494–2495. PubMed PMID: 11120263.
   Web of Science ®Google Scholar
• Kawakami Y, Iwata H, Gu YJ, et al. Successful subcutaneous pancreatic islet transplantation using an angiogenic growth factor-releasing device. Pancreas. 2001 Nov;23(4):375–381. PubMed PMID: 11668206.
   Web of Science ®Google Scholar
• Hwang HJ, Lee M, Park JH, et al. Improved islet transplantation outcome by the co-delivery of siRNAs for iNOS and 17beta-estradiol using an R3V6 peptide carrier. Biomaterials. 2015 Jan;38:36–42. PubMed PMID: 25457981.
   Web of Science ®Google Scholar
• Wang P, Yigit MV, Medarova Z, et al. Combined small interfering RNA therapy and in vivo magnetic resonance imaging in islet transplantation. Diabetes. 2011 Feb;60(2):565–571. PubMed PMID: 21270267; PubMed Central PMCID: PMCPMC3028356.
   Web of Science ®Google Scholar
• Wang P, Yigit MV, Ran C, et al. A theranostic small interfering RNA nanoprobe protects pancreatic islet grafts from adoptively transferred immune rejection. Diabetes. 2012 Dec;61(12):3247–3254. PubMed PMID: 22923469; PubMed Central PMCID: PMCPMC3501867.
   Web of Science ®Google Scholar
• Kemp CB, Knight MJ, Scharp DW, et al. Effect of transplantation site on the results of pancreatic islet isografts in diabetic rats. Diabetologia. 1973 Dec;9(6):486–491. PubMed PMID: 4204180.
   PubMed Web of Science ®Google Scholar
• Veriter S, Gianello P, Dufrane D. Bioengineered sites for islet cell transplantation. Curr Diab Rep. 2013 Oct;13(5):745–755. PubMed PMID: 23959794.
   Web of Science ®Google Scholar
• Bennet W, Groth CG, Larsson R, et al. Isolated human islets trigger an instant blood mediated inflammatory reaction: implications for intraportal islet transplantation as a treatment for patients with type 1 diabetes. Ups J Med Sci. 2000;105(2):125–133. PubMed PMID: 11095109.
   PubMed Web of Science ®Google Scholar
• Pepper AR, Gala-Lopez B, Ziff O, et al. Revascularization of transplanted pancreatic islets and role of the transplantation site. Clin Dev Immunol. 2013;2013:352315. PubMed PMID: 24106517; PubMed Central PMCID: PMCPMC3782812.
   Google Scholar
• Sakata N, Aoki T, Yoshimatsu G, et al. Strategy for clinical setting in intramuscular and subcutaneous islet transplantation. Diabetes Metab Res Rev. 2014 Jan;30(1):1–10. PubMed PMID: 24000195.
   Web of Science ®Google Scholar
• Teramura Y, Iwata H. Bioartificial pancreas microencapsulation and conformal coating of islet of Langerhans. Adv Drug Deliv Rev. 2010 Jun 15;62(7–8):827–840. PubMed PMID: 20138097.
   PubMed Web of Science ®Google Scholar
• Veiseh O, Tang BC, Whitehead KA, et al. Managing diabetes with nanomedicine: challenges and opportunities. Nat Rev Drug Discov. 2015 Jan;14(1):45–57. PubMed PMID: 25430866; PubMed Central PMCID: PMCPMC4751590.
   PubMed Web of Science ®Google Scholar