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Case Report

BRAF V600E-mutant colorectal cancer with CNS metastases treated successfully with encorafenib, binimetinib and cetuximab

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Article: 2347824 | Received 02 Oct 2023, Accepted 23 Apr 2024, Published online: 22 May 2024

References

  • Christensen TD, Spindler KL, Palshof JA, Nielsen DL. Systematic review: brain metastases from colorectal cancer–Incidence and patient characteristics. BMC Cancer. 2016;16:260. doi:10.1186/s12885-016-2290-5
  • Yaeger R, Cowell E, Chou JF, et al. RAS mutations affect pattern of metastatic spread and increase propensity for brain metastasis in colorectal cancer. Cancer. 2015;121(8):1195–1203. doi:10.1002/cncr.29196
  • Tran B, Kopetz S, Tie J, et al. Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer. Cancer. 2011;117(20):4623–4632. doi:10.1002/cncr.26086
  • Dienstmann R, Salazar R, Tabernero J. Molecular subtypes and the evolution of treatment decisions in metastatic colorectal cancer. Am. Soc. Clin. Oncol. Educ. Book. 2018;38:231–238. doi:10.1200/EDBK_200929
  • Śmiech M, Leszczyński P, Kono H, Wardell C, Taniguchi H. Emerging BRAF mutations in cancer progression and their possible effects on transcriptional networks. Genes (Basel). 2020;11(11):1342. doi:10.3390/genes11111342
  • Modest DP, Ricard I, Heinemann V, et al. Outcome according to KRAS-, NRAS- and BRAF-mutation as well as KRAS mutation variants: pooled analysis of five randomized trials in metastatic colorectal cancer by the AIO colorectal cancer study group. Ann. Oncol. 2016;27(9):1746–1753. doi:10.1093/annonc/mdw261
  • Tabernero J, Ros J, Élez E. The evolving treatment landscape in BRAF V600E-mutated metastatic colorectal cancer. Am. Soc. Clin. Oncol. Educ. Book. 2022;42:1–10. doi:10.1200/EDBK_349561
  • Kopetz S, Grothey A, Yaeger R, et al. Encorafenib, binimetinib, and cetuximab in BRAF V600E-mutated colorectal cancer. N. Engl. J. Med. 2019;381(17):1632–1643. doi:10.1056/NEJMoa1908075
  • Mjahed RB, Astaras C, Roth A, Koessler T. Where are we now and where might we be headed in understanding and managing brain metastases in colorectal cancer patients? Curr. Treat. Options Oncol. 2022;23(7):980–1000. doi:10.1007/s11864-022-00982-0
  • Davies MA, Saiag P, Robert C, et al. Dabrafenib plus trametinib in patients with BRAF(V600)-mutant melanoma brain metastases (COMBI-MB): a multicentre, multicohort, open-label, Phase II trial. Lancet Oncol. 2017;18(7):863–873. doi:10.1016/S1470-2045(17)30429-1
  • Sakji-Dupré L, Le Rhun E, Templier C, Desmedt E, Blanchet B, Mortier L. Cerebrospinal fluid concentrations of vemurafenib in patients treated for brain metastatic BRAF-V600 mutated melanoma. Melanoma Res. 2015;25(4):302–305. doi:10.1097/CMR.0000000000000162
  • Wang J, Gan C, Sparidans RW, et al. P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) affect brain accumulation and intestinal disposition of encorafenib in mice. Pharmacol. Res. 2018;129:414–423. doi:10.1016/j.phrs.2017.11.006
  • Holbrook K, Lutzky J, Davies MA, et al. Intracranial antitumor activity with encorafenib plus binimetinib in patients with melanoma brain metastases: a case series. Cancer. 2020;126(3):523–530. doi:10.1002/cncr.32547
  • Saberian C, Sperduto P, Davies MA. Targeted therapy strategies for melanoma brain metastasis. Neurooncol. Adv. 2021;3(Suppl. 5):v75–v85. doi:10.1093/noajnl/vdab131
  • Wolchok JD, Chiarion-Sileni V, Gonzalez R, et al. Long-term outcomes with nivolumab plus ipilimumab or nivolumab alone versus ipilimumab in patients with advanced melanoma. J. Clin. Oncol. 2022;40(2):127–137. doi:10.1200/JCO.21.02229
  • Prasanna D, Elrafei T, Shum E, Strakhan M. More than a headache: a case of cetuximab-induced aseptic meningitis. BMJ Case Rep. 2015;2015:bcr2015209622. doi:10.1136/bcr-2015-209622
  • Rades D, Nadrowitz R, Buchmann I, et al. Radiolabeled cetuximab plus whole-brain irradiation (WBI) for the treatment of brain metastases from non-small-cell lung cancer (NSCLC). Strahlenther Onkol. 2010;186(8):458–462. doi:10.1007/s00066-010-2153-y
  • Kurihara H, Hamada A, Yoshida M, et al. (64)Cu-DOTA-trastuzumab PET imaging and HER2 specificity of brain metastases in HER2-positive breast cancer patients. EJNMMI Res. 2015;5:8. doi:10.1186/s13550-015-0082-6
  • Stemmler HJ, Schmitt M, Willems A, Bernhard H, Harbeck N, Heinemann V. Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier. Anticancer Drugs. 2007;18(1):23–28. doi:10.1097/01.cad.0000236313.50833.ee
  • HERCEPTIN for Intravenous Infusion, Pharmaceuticals and medical devices agency. https://www.pmda.go.jp/PmdaSearch/iyakuDetail/450045_4291406D5024_1_11#HDR_Warnings (28 Aug 2023).
  • ERBITUX Injection 100 mg, Pharmaceuticals and medical devices agency. https://www.pmda.go.jp/PmdaSearch/iyakuDetail/380079_4291415A1021_1_15#HDR_Warnings (28 Aug 2023).
  • Lampson LA. Monoclonal antibodies in neuro-oncology: getting past the blood-brain barrier. MAbs. 2011;3(2):153–160. doi:10.4161/mabs.3.2.14239
  • Van Cutsem E, Taieb J, Yaeger R, et al. ANCHOR CRC: Results from a single-arm, phase II study of encorafenib plus binimetinib and cetuximab in previously untreated braf(V600E)-mutant metastatic colorectal cancer. J. Clin. Oncol. 2023;41(14):2628–2637. doi:10.1200/JCO.22.01693
  • Xu T, Wang X, Wang Z, et al. Molecular mechanisms underlying the resistance of BRAF V600E-mutant metastatic colorectal cancer to EGFR/BRAF inhibitors. Ther. Adv. Med. Oncol. 2022;14:17588359221105022.
  • Loupakis F, Intini R, Cremolini C, et al. A validated prognostic classifier for (V600E)BRAF-mutated metastatic colorectal cancer: the ‘BRAF BeCool’ study. Eur. J. Cancer. 2019;118:121–130. doi:10.1016/j.ejca.2019.06.008
  • Elez E, Ros J, Fernández J, et al. RNF43 mutations predict response to anti-BRAF/EGFR combinatory therapies in BRAF(V600E) metastatic colorectal cancer. Nat. Med. 2022;28(10):2162–2170. doi:10.1038/s41591-022-01976-z
  • Kopetz S, Murphy DA, Pu J, et al. Molecular correlates of clinical benefit in previously treated patients (pts) with BRAF V600E-mutant metastatic colorectal cancer (mCRC) from the BEACON study. J. Clin. Oncol. 2021;39(Suppl. 15):3513–3513. doi:10.1200/JCO.2021.39.15_suppl.3513
  • Ros J, Matito J, Villacampa G, et al. Plasmatic BRAF-V600E allele fraction as a prognostic factor in metastatic colorectal cancer treated with BRAF combinatorial treatments. Ann. Oncol. 2023;34(6):543–552. doi:10.1016/j.annonc.2023.02.016