Staphylococcus pseudintermedius induces pyroptosis of canine corneal epithelial cells by activating the ROS–NLRP3 signalling pathway

References

• Wang Z, Guo L, Li J, et al. Antibiotic resistance, biofilm formation, and virulence factors of isolates of staphylococcus pseudintermedius from healthy dogs and dogs with keratitis frontiers in veterinary science. Front Vet Sci. 2022;9. doi: 10.3389/fvets.2022.903633
   Web of Science ®Google Scholar
• Joksimovic M, Ford BA, Lazic T, et al. Antibiotic recommendations for treatment of canine. Stromal Corneal Ulcers Vet Sci. 2023;10(2):66. ARTN 6610.3390/vetsci10020066
   Google Scholar
• Hewitt JS, Allbaugh RA, Kenne DE, et al. Prevalence and antibiotic susceptibility of bacterial isolates from dogs with ulcerative keratitis in Midwestern United States frontiers in veterinary science. 2020;7:ARTN 583965. doi: 10.3389/fvets.2020.583965
   Google Scholar
• Savini V, Kosecka M, Marrollo R, et al. CAMP test detected Staphylococcus delphini ATCC49172 β-haemolysin production. Pol J Microbiol. 2013;62(4):465–22. doi: 10.33073/pjm-2013-065
   PubMed Web of Science ®Google Scholar
• Tolar EL, Hendrix DV, Rohrbach BW, et al. Evaluation of clinical characteristics and bacterial isolates in dogs with bacterial keratitis: 97 cases (1993–2003). J Am Vet Med Assoc. 2006;228(1):80–85. doi: 10.2460/javma.228.1.80
   PubMed Web of Science ®Google Scholar
• Wang Y, Yang J, Logue CM, et al. Methicillin-resistant Staphylococcus pseudintermedius isolated from canine pyoderma in North China. J Appl Microbiol. 2012;112(4):623–630 doi: 10.1111/j.1365-2672.2012.05233.x
   PubMed Web of Science ®Google Scholar
• Meroni G, Soares Filipe JF, Drago L, et al. Investigation on antibiotic-resistance, biofilm formation and virulence factors in multi drug resistant and non multi drug resistant Staphylococcus pseudintermedius. Microorganisms. 2019;7(12):702. doi: 10.3390/microorganisms7120702
   PubMed Web of Science ®Google Scholar
• Kmieciak W, andSzewczyk EM. Are zoonotic Staphylococcus pseudintermedius strains a growing threat for humans? Folia Microbiol (Praha). 2018;63(6):743–747. doi: 10.1007/s12223-018-0615-2
   PubMed Web of Science ®Google Scholar
• Pickering AC, Vitry P, Prystopiuk V, et al. Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion. PLoS Pathogens. 2019;15(6):e1007816. doi: 10.1371/journal.ppat.1007816
   PubMed Web of Science ®Google Scholar
• Kang MH, Chae MJ, Yoon JW, et al. Resistance to fluoroquinolones and methicillin in ophthalmic isolates of staphylococcus pseudintermedius from companion animals. Can Vet J. 2014;55(7):678–682.
   PubMed Web of Science ®Google Scholar
• Kovacs SB, andMiao EA. Gasdermins: effectors of pyroptosis. Trends Cell Biol. 2017;27(9):673–684. doi: 10.1016/j.tcb.2017.05.005
   PubMed Web of Science ®Google Scholar
• Pietrocola G, Gianotti V, Richards A, et al. Fibronectin binding proteins SpsD and SpsL both support invasion of canine epithelial cells by staphylococcus pseudintermedius. Infect Immun. 2015;83(10):4093–4102. doi: 10.1128/IAI.00542-15
   PubMed Web of Science ®Google Scholar
• Guo L, Wang Z, Li J, et al. MCC950 attenuates inflammation-mediated damage in canines with Staphylococcus pseudintermedius keratitis by inhibiting the NLRP3 inflammasome. Int Immunopharmacol. 2022;108:108857. doi: 10.1016/j.intimp.2022.108857
   PubMed Web of Science ®Google Scholar
• Broz P, Pelegrin P, andShao F. The gasdermins, a protein family executing cell death and inflammation. Nat Rev Immunol. 2020;20(3):143–157. doi: 10.1038/s41577-019-0228-2
   PubMed Web of Science ®Google Scholar
• Shi JJ, Gao WQ, andShao F. Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci. 2017;42(4):245–254. doi: 10.1016/j.tibs.2016.10.004
   PubMed Web of Science ®Google Scholar
• Wang X, Liu M, Geng N, et al. Staphylococcus aureus mediates pyroptosis in bovine mammary epithelial cell via activation of NLRP3 inflammasome. Vet Res. 2022;53(1):10 doi: 10.1186/s13567-022-01027-y
   Web of Science ®Google Scholar
• Mancuso M, Bonanni E, LoGerfo A, et al. Oxidative stress biomarkers in patients with untreated obstructive sleep apnea syndrome sleep med. Sleep Med. 2012;13(6):632–636. doi: 10.1016/j.sleep.2011.10.030
   PubMed Web of Science ®Google Scholar
• Mishra A, Behura A, Kumar A, et al. Soybean lectin induces autophagy through P2RX7 dependent activation of NF-κB-ROS pathway to kill intracellular mycobacteria. Biochim Biophys Acta Gen Subj. 2021;1865(2):129806. doi: 10.1016/j.bbagen.2020.129806
   PubMed Web of Science ®Google Scholar
• Zhou R, Yazdi AS, Menu P, et al. A role for mitochondria in NLRP3 inflammasome activation nature. Nature. 2011;469(7329):221–225. doi: 10.1038/nature09663
   PubMed Web of Science ®Google Scholar
• Ko J, Kang HJ, Kim DA, et al. Paricalcitol attenuates TGF-β1–induced phenotype transition of human peritoneal mesothelial cells (HPMCs) via modulation of oxidative stress and NLRP3 inflammasome. FASEB J. 2019;33(2):3035–3050. doi: 10.1096/fj.201800292RR
   PubMed Web of Science ®Google Scholar
• Council N. Guide for the care and use of laboratory animals: eighth edition. Publication 2010;327:963–965.
   Google Scholar
• Abaza A, Meacham N. American Veterinary Medical Association.
   Google Scholar
• Guo L, Wang ZH, Li J, et al. Immortalization effect of SV40T lentiviral vectors on canine corneal epithelial cells. BMC Vet Res 2022; 18(1). doi: 10.1186/s12917-022-03288-3
   Web of Science ®Google Scholar
• Gelatt, Kirk N. Veterinary ophthalmic surgery 191-236. 2011.
   Google Scholar
• Wang L, Pan QS, Zhang LB, et al. Investigation of bacterial microorganisms in the conjunctival sac of clinically normal dogs and dogs with ulcerative keratitis in Beijing China. VO. 2008;11(3):145–149. doi: 10.1111/j.1463-5224.2008.00579.x
   Google Scholar
• Krecny M, Tichy A, Rushton J, et al. A retrospective survey of ocular abnormalities in pugs: 130 cases. J Small Anim Pract. 2015;56(2):96–102. doi: 10.1111/jsap.12291
   PubMed Web of Science ®Google Scholar
• Liu KJ, Tao LY, Li JJ, et al. Characterization of staphylococcus aureus isolates from cases of clinical bovine mastitis on large-scale Chinese dairy farms frontiers in veterinary science. Front Vet Sci. 2020;7:ARTN 580129. doi: 10.3389/fvets.2020.580129
   Web of Science ®Google Scholar
• Swift T, Katsikogianni M, Hoskins R, et al. Highly-branched poly(N-isopropyl acrylamide) functionalised with pendant nile red and chain end vancomycin for the detection of Gram-positive bacteria. Acta Biomaterialia. 2019;87:197–206. doi: 10.1016/j.actbio.2019.01.066
   PubMed Web of Science ®Google Scholar
• Prochnicki T, andLatz E. Inflammasomes on the crossroads of innate immune recognition and metabolic control cell metab. Cell Metab. 2017;26(1):71–93. doi: 10.1016/j.cmet.2017.06.018
   PubMed Web of Science ®Google Scholar
• Haneklaus M, AndO’neill LAJ. NLRP3 at the interface of metabolism and inflammation Immunol Rev. Immunol Rev. 2015;265(1):53–62. doi: 10.1111/imr.12285
   PubMed Web of Science ®Google Scholar
• Li Z, Guo JL, andBi LQ. Role of the NLRP3 inflammasome in autoimmune diseases. Biomed Pharmacother. 2020;130:110542. doi: 10.1016/j.biopha.2020.110542. ARTN 110542.
   PubMed Web of Science ®Google Scholar
• Dowds TA, Masumoto J, Zhu L, et al. Cryopyrin-induced interleukin 1β secretion in monocytic cells. J Biol Chem. 2004;279(21):21924–21928. doi: 10.1074/jbc.M401178200
   PubMed Web of Science ®Google Scholar
• Sun L, Ma W, Gao W, et al. Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome. Cell Death Dis. 2019;10(8):542. doi: 10.1038/s41419-019-1761-4
   PubMedGoogle Scholar
• Ding JJ, Wang K, Liu W, et al. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature. 2016;540(7631):150–150. doi: 10.1038/nature20106
   PubMed Web of Science ®Google Scholar
• Liu X, Zhang Z, Ruan J, et al. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores nature. Nature. 2016;535(7610):153–158. doi: 10.1038/nature18629
   PubMed Web of Science ®Google Scholar
• Aglietti RA, Estevez A, Gupta A, et al. GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes. Proc Nat Acad Sci USA. 2016;113(28):7858–7863. doi: 10.1073/pnas.1607769113
   PubMed Web of Science ®Google Scholar
• Hachim MY, Khalil BA, Elemam NM, et al. Pyroptosis: the missing puzzle among innate and adaptive immunity crosstalk. J Leukoc Biol. 2020;108(1):323–338 10.1002/Jlb.3mir0120–625r. doi: 10.1002/JLB.3MIR0120-625R
   PubMed Web of Science ®Google Scholar
• Russo HM, Rathkey J, Boyd-Tressler A, et al. Active caspase-1 induces plasma membrane pores that precede pyroptotic lysis and are blocked by. Lanthanides J Immunol. 2016;197(4):1353–1367. doi: 10.4049/jimmunol.1600699
   PubMed Web of Science ®Google Scholar
• Chen X, He WT, Hu LC, et al. Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis. Cell Res. 2016;26(9):1007–1020. doi: 10.1038/cr.2016.100
   PubMed Web of Science ®Google Scholar
• Dhital S, Deo P, Stuart I, et al. Bacterial outer membrane vesicles and host cell death signaling. Trends Microbiol. 2021;29(12):1106–1116. doi: 10.1016/j.tim.2021.04.003
   PubMed Web of Science ®Google Scholar
• Panicker N, Kam TI, Wang H, et al. Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease. Neuron. 2022;110(15):2422–2437 e2429. doi: 10.1016/j.neuron.2022.05.009
   PubMed Web of Science ®Google Scholar
• Cao H, Liang JY, Liu J, et al. Novel effects of combination therapy through inhibition of caspase-1/Gasdermin D induced-pyroptosis in lupus nephritis. Front Immunol. 2021;12. 10.3389/fimmu.2021.720877
   Web of Science ®Google Scholar
• Zhang J, Dai YQ, Yang YJ, et al. Calcitriol alleviates hyperosmotic stress-induced corneal epithelial cell damage via inhibiting the NLRP3-ASC-Caspase-1-GSDMD Pyroptosis Pathway in dry eye disease. J Inflamm Res. 2021;14:2955–2962. doi: 10.2147/Jir.S310116
   PubMed Web of Science ®Google Scholar
• Pedre B, Barayeu U, Ezerina D, et al. The mechanism of action of N-acetylcysteine (NAC): the emerging role of H(2)S and sulfane sulfur species. Pharmacol Ther. 2021;228:107916. doi: 10.1016/j.pharmthera.2021.107916
   PubMed Web of Science ®Google Scholar
• Coll RC, Robertson AA, Chae JJ, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015;21(3):248–255. doi: 10.1038/nm.3806
   PubMed Web of Science ®Google Scholar
• Primiano MJ, Lefker BA, Bowman MR, et al. Efficacy and pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in murine models of dermal and pulmonary inflammation. J Immunol. 2016;197(6):2421–2433. doi: 10.4049/jimmunol.1600035
   PubMed Web of Science ®Google Scholar
• Scaturro P, andPichlmair A. Oxeiptosis: a discreet way to respond to radicals. Curr Opin Immunol. 2019;56:37–43. doi: 10.1016/j.coi.2018.10.006
   PubMed Web of Science ®Google Scholar
• Saha S, Buttari B, Panieri E, et al. An overview of Nrf2 signaling pathway and its role in inflammation. Molecules. 2020;25(22):5474. doi: 10.3390/molecules25225474
   PubMed Web of Science ®Google Scholar
• Ma X, Xu S, Li J, et al. Selenomethionine protected BMECs from inflammatory injury and oxidative damage induced by Klebsiella pneumoniae by inhibiting the NF-κB and activating the Nrf2 signaling pathway. Int Immunopharmacol. 2022;110:109027. doi: 10.1016/j.intimp.2022.109027
   PubMed Web of Science ®Google Scholar
• Cui L, Guo J, Wang Z, et al. Meloxicam inhibited oxidative stress and inflammatory response of LPS-stimulated bovine endometrial epithelial cells through Nrf2 and NF-κB pathways. Int Immunopharmacol. 2023;116:109822. doi: 10.1016/j.intimp.2023.109822
   PubMed Web of Science ®Google Scholar
• Bellezza I, Giambanco I, Minelli A, et al. Nrf2-Keap1 signaling in oxidative and reductive stress. Biochim Biophys Acta Mol Cell Res. 2018;1865(5):721–733. doi: 10.1016/j.bbamcr.2018.02.010
   PubMed Web of Science ®Google Scholar
• Teng JF, Mei QB, Zhou XG, et al. Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer. Cancers (Basel). 2020;12(1):193. doi: 10.3390/cancers12010193
   PubMed Web of Science ®Google Scholar
• Ni B, Pei W, Qu Y, et al. MCC950, the NLRP3 Inhibitor, protects against cartilage degradation in a mouse Model of osteoarthritis. Oxid Med Cell Longevity. 2021;2021:1–14. doi: 10.1155/2021/4139048
   Web of Science ®Google Scholar