Alpha1-antitrypsin impacts innate host–pathogen interactions with Candida albicans by stimulating fungal filamentation

References

• Wisplinghoff H, Ebbers J, Geurtz L, et al. Nosocomial bloodstream infections due to Candida spp. In the USA: species distribution, clinical features and antifungal susceptibilities. Int J Antimicrob Agents. 2014;43(1):78–19. doi: 10.1016/j.ijantimicag.2013.09.005. PubMed PMID: 24182454.
   PubMed Web of Science ®Google Scholar
• d’Enfert C, Kaune AK, Alaban LR, et al. The impact of the fungus-host-microbiota interplay upon Candida albicans infections: current knowledge and new perspectives. FEMS Microbiol Rev. 2021;45(3). doi: 10.1093/femsre/fuaa060 PubMed PMID: 33232448; PubMed Central PMCID: PMC8100220.
   PubMed Web of Science ®Google Scholar
• Brown GD, Denning DW, Gow NA, et al. Hidden killers: human fungal infections. Sci Transl Med. 2012;4(165):165rv13. doi: 10.1126/scitranslmed.3004404 PubMed PMID: 23253612.
   PubMed Web of Science ®Google Scholar
• König A, Müller R, Mogavero S, et al. Fungal factors involved in host immune evasion, modulation and exploitation during infection. Cell Microbiol. 2021;23(1):e13272. doi: 10.1111/cmi.13272
   PubMed Web of Science ®Google Scholar
• Erwig LP, Gow NA. Interactions of fungal pathogens with phagocytes. Nat Rev Microbiol. 2016;14(3):163–176. doi: 10.1038/nrmicro.2015.21 Epub 2016/02/09 PubMed PMID: 26853116.
   PubMed Web of Science ®Google Scholar
• Austermeier S, Kasper L, Westman J, et al. I want to break free - macrophage strategies to recognize and kill Candida albicans, and fungal counter-strategies to escape. Curr Opin Microbiol. 2020;58:15–23. doi: 10.1016/j.mib.2020.05.007. Epub 20200627 PubMed PMID: 32599492.
   PubMed Web of Science ®Google Scholar
• Brown AJP, Gow NAR, Warris A, et al. Memory in fungal pathogens promotes immune evasion, colonisation, and infection. Trends Microbiol. 2019;27(3):219–30. doi: 10.1016/j.tim.2018.11.001 Epub 2018/12/05 PubMed PMID: 30509563.
   PubMed Web of Science ®Google Scholar
• Janciauskiene S, Welte T. Well-known and less well-known functions of alpha-1 antitrypsin. Its role in chronic obstructive pulmonary disease and other disease developments. Ann Am Thoracic Soc. 2016;13(Supplement_4):S280–S8. doi: 10.1513/AnnalsATS.201507-468KV PubMed PMID: 27564662.
   PubMedGoogle Scholar
• Miravitlles M. Alpha-1-antitrypsin and other proteinase inhibitors. Curr Opin Pharmacol. 2012;12(3):309–14. doi: 10.1016/j.coph.2012.02.004 PubMed PMID: 22365503.
   PubMed Web of Science ®Google Scholar
• Lewis EC. Expanding the clinical indications for α1-antitrypsin therapy. Mol Med. 2012;18(6):957–970. doi: 10.2119/molmed.2011.00196 Epub 2012/05/29 PubMed PMID: 22634722; PubMed Central PMCID: PMC3459478.
   PubMed Web of Science ®Google Scholar
• Jonigk D, Al-Omari M, Maegel L, et al. Anti-inflammatory and immunomodulatory properties of alpha1-antitrypsin without inhibition of elastase. Proc Natl Acad Sci U S A. 2013;110(37):15007–15012. doi: 10.1073/pnas.1309648110 PubMed PMID: 23975926; PubMed Central PMCID: PMC3773761.
   PubMed Web of Science ®Google Scholar
• Wewers MD, Crystal RG. Alpha-1 antitrypsin augmentation therapy. COPD: J Chronic Obstructive Pulmonary Dis. 2013;10 Suppl 1(sup1):64–67. doi: 10.3109/15412555.2013.764402 PubMed PMID: 23527997.
   Google Scholar
• Magenau JM, Goldstein SC, Peltier D, et al. alpha1-antitrypsin infusion for treatment of steroid-resistant acute graft-versus-host disease. Blood. 2018;131(12):1372–1379. doi: 10.1182/blood-2017-11-815746 Epub 2018/02/14 PubMed PMID: 29437593; PubMed Central PMCID: PMC5865235.
   PubMed Web of Science ®Google Scholar
• Marcondes AM, Hockenbery D, Lesnikova M, et al. Response of steroid-refractory acute GVHD to alpha1-antitrypsin. Biol Blood Marrow Transplant. 2016;22(9):1596–1601. doi: 10.1016/j.bbmt.2016.05.011 Epub 2016/05/26 PubMed PMID: 27223109.
   PubMed Web of Science ®Google Scholar
• Matzaraki V, Gresnigt MS, Jaeger M, et al. An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility. PloS One. 2017;12(7):e0180824. doi: 10.1371/journal.pone.0180824 Epub 2017/07/21 PubMed PMID: 28727728; PubMed Central PMCID: PMC5519064.
   PubMed Web of Science ®Google Scholar
• Bruno M, Dewi IMW, Matzaraki V, et al. Comparative host transcriptome in response to pathogenic fungi identifies common and species-specific transcriptional antifungal host response pathways. Comput Struct Biotechnol J. 2021;19:647–663. doi: 10.1016/j.csbj.2020.12.036 Epub 2021/01/30 PubMed PMID: 33510868; PubMed Central PMCID: PMC7817431.
   PubMed Web of Science ®Google Scholar
• Gross O, Gewies A, Finger K, et al. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature. 2006;442(7103):651–6. doi: 10.1038/nature04926. Epub 2006/07/25 PubMed PMID: 16862125.
   PubMed Web of Science ®Google Scholar
• Kayagaki N, Stowe IB, Lee BL, et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 2015;526(7575):666–71. doi: 10.1038/nature15541
   PubMed Web of Science ®Google Scholar
• Gillum AM, Tsay EY, Kirsch DR. Isolation of the Candida albicans gene for orotidine-5’-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Mol Gen Genet. 1984;198(2):179–182. doi: 10.1007/BF00328721 Epub 1984/01/01 PubMed PMID: 6394964.
   PubMedGoogle Scholar
• Zakikhany K, Naglik JR, Schmidt-Westhausen A, et al. In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination. Cell Microbiol. 2007;9(12):2938–54. doi: 10.1111/j.1462-5822.2007.01009.x PubMed PMID: 17645752.
   PubMed Web of Science ®Google Scholar
• Wartenberg A, Linde J, Martin R, et al. Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant. PLoS Genet. 2014;10(12):e1004824. doi: 10.1371/journal.pgen.1004824
   PubMed Web of Science ®Google Scholar
• Zheng X, Wang Y, Wang Y. Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis. EMBO J. 2004;23(8):1845–56. doi: 10.1038/sj.emboj.7600195 Epub 2004/04/09 PubMed PMID: 15071502; PubMed Central PMCID: PMC394249.
   PubMed Web of Science ®Google Scholar
• Moyes DL, Wilson D, Richardson JP, et al. Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature. 2016;532(7597):64–8. doi: 10.1038/nature17625. PubMed PMID: 27027296; PubMed Central PMCID: PMC4851236.
   PubMed Web of Science ®Google Scholar
• Bates S, Bleddyn Hughes H, Munro CA, et al. Outer chain N-glycans are required for cell wall integrity and virulence of Candida albicans. J Biol Chem. 2006;281(1):90–8. doi: 10.1074/jbc.M510360200
   PubMed Web of Science ®Google Scholar
• Uwamahoro N, Verma-Gaur J, Shen HH, et al. The pathogen Candida albicans hijacks pyroptosis for escape from macrophages. MBio. 2014;5(2):e00003–14. doi: 10.1128/mBio.00003-14. Epub 2014/03/29 PubMed PMID: 24667705; PubMed Central PMCID: PMC3977349.
   PubMed Web of Science ®Google Scholar
• Schindelin J, Arganda-Carreras I, Frise E, et al. Fiji: an open-source platform for biological-image analysis. Nat Methods. 2012;9(7):676–82. doi: 10.1038/nmeth.2019. Epub 2012/06/30 PubMed PMID: 22743772; PubMed Central PMCID: PMC3855844.
   PubMed Web of Science ®Google Scholar
• Wachtler B, Wilson D, Haedicke K, et al. From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells. PloS One. 2011;6(2):e17046. doi: 10.1371/journal.pone.0017046 Epub 2011/03/17 PubMed PMID: 21407800; PubMed Central PMCID: PMC3044159.
   PubMed Web of Science ®Google Scholar
• Luttich A, Brunke S, Hube B. Isolation and amplification of fungal RNA for microarray analysis from host samples. Methods Mol Biol. 2012;845:411–421. doi: 10.1007/978-1-61779-539-8_28. PubMed PMID: 22328391.
   PubMedGoogle Scholar
• Hebecker B, Vlaic S, Conrad T, et al. Dual-species transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions. Sci Rep. 2016;6:36055. doi: 10.1038/srep36055 PubMed PMID: 27808111; PubMed Central PMCID: PMC5093689.
   PubMed Web of Science ®Google Scholar
• Huber W, Carey VJ, Gentleman R, et al. Orchestrating high-throughput genomic analysis with Bioconductor. Nat Methods. 2015;12(2):115–21. doi: 10.1038/nmeth.3252. Epub 2015/01/31 PubMed PMID: 25633503; PubMed Central PMCID: PMC4509590.
   PubMed Web of Science ®Google Scholar
• Ritchie ME, Phipson B, Wu D, et al. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47. doi: 10.1093/nar/gkv007 Epub 2015/01/22 PubMed PMID: 25605792; PubMed Central PMCID: PMC4402510.
   PubMed Web of Science ®Google Scholar
• Kolde R. Pheatmap: pretty heatmaps. R package. 2015;1(7):790
   Google Scholar
• Skrzypek MS, Binkley J, Binkley G, et al. The Candida Genome Database (CGD): incorporation of assembly 22, systematic identifiers and visualization of high throughput sequencing data. Nucleic Acids Res. 2017;45(D1):D592–D6. doi: 10.1093/nar/gkw924 Epub 20161013 PubMed PMID: 27738138; PubMed Central PMCID: PMC5210628.
   PubMed Web of Science ®Google Scholar
• Nogueira MF, Istel F, Jenull S, et al. Quantitative analysis of candida cell wall components by flow cytometry with triple-fluorescence staining. J Microbiol Modern Tech. 2017;2(1). doi: 10.15744/2575-5498.2.101
   Google Scholar
• Santos EO, Azzolini AE, Lucisano-Valim YM. Optimization of a flow cytometric assay to evaluate the human neutrophil ability to phagocytose immune complexes via fcgamma and complement receptors. J Pharmacol Toxicol Methods. 2015;72:67–71. doi: 10.1016/j.vascn.2014.10.005. PubMed PMID: 25450839.
   PubMed Web of Science ®Google Scholar
• Netea MG, Joosten LA, van der Meer JW, et al. Immune defence against Candida fungal infections. Nat Rev Immunol. 2015;15(10):630–642. doi: 10.1038/nri3897 PubMed PMID: 26388329.
   PubMed Web of Science ®Google Scholar
• Ter Horst R, Jaeger M, Smeekens SP, et al. Host and environmental factors influencing individual human cytokine responses. Cell. 2016;167(4):1111–24 e13. doi: 10.1016/j.cell.2016.10.018 Epub 2016/11/05 PubMed PMID: 27814508; PubMed Central PMCID: PMC5787854.
   PubMed Web of Science ®Google Scholar
• Kasper L, Konig A, Koenig PA, et al. The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. Nat Commun. 2018;9(1):4260. doi: 10.1038/s41467-018-06607-1. Epub 2018/10/17 PubMed PMID: 30323213; PubMed Central PMCID: PMC6189146.
   PubMedGoogle Scholar
• Ding X, Kambara H, Guo R, et al. Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages. Nat Commun. 2021;12(1):6699. doi: 10.1038/s41467-021-27034-9. Epub 20211118 PubMed PMID: 34795266.
   PubMed Web of Science ®Google Scholar
• Olivier FAB, Hilsenstein V, Weerasinghe H, et al. The escape of Candida albicans from macrophages is enabled by the fungal toxin candidalysin and two host cell death pathways. Cell Rep. 2022;40(12):111374. doi: 10.1016/j.celrep.2022.111374 PubMed PMID: 36130496.
   PubMed Web of Science ®Google Scholar
• Hopke A, Brown AJP, Hall RA, et al. Dynamic fungal cell wall architecture in stress adaptation and immune evasion. Trends Microbiol. 2018;26(4):284–95. doi: 10.1016/j.tim.2018.01.007
   PubMed Web of Science ®Google Scholar
• Behrens NE, Lipke PN, Pilling D, et al. Serum amyloid P component binds fungal surface amyloid and decreases human macrophage phagocytosis and secretion of inflammatory cytokines. MBio. 2019;10(2). doi: 10.1128/mBio.00218-19 Epub 2019/03/14 PubMed PMID: 30862745; PubMed Central PMCID: PMC6414697.
   PubMed Web of Science ®Google Scholar
• Pinsky M, Roy U, Moshe S, et al. Human serum albumin facilitates heme-iron utilization by Fungi. MBio. 2020;11(2). doi: 10.1128/mBio.00607-20 Epub 2020/04/23 PubMed PMID: 32317324; PubMed Central PMCID: PMC7175094.
   Web of Science ®Google Scholar
• Luo S, Poltermann S, Kunert A, et al. Immune evasion of the human pathogenic yeast Candida albicans: Pra1 is a factor H, FHL-1 and plasminogen binding surface protein. Mol Immunol. 2009;47(2–3):541–50. doi: 10.1016/j.molimm.2009.07.017 Epub 2009/10/24 PubMed PMID: 19850343.
   PubMed Web of Science ®Google Scholar
• Lopez CM, Wallich R, Riesbeck K, et al. Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin. PloS One. 2014;9(3):e90796. doi: 10.1371/journal.pone.0090796 Epub 20140313 PubMed PMID: 24625558; PubMed Central PMCID: PMC3953207.
   PubMed Web of Science ®Google Scholar
• Martin R, Albrecht-Eckardt D, Brunke S, et al. A core filamentation response network in Candida albicans is restricted to eight genes. PloS One. 2013;8(3):e58613. doi: 10.1371/journal.pone.0058613 Epub 2013/03/22 PubMed PMID: 23516516; PubMed Central PMCID: PMC3597736.
   PubMed Web of Science ®Google Scholar
• Hnisz D, Majer O, Frohner IE, et al. The Set3/Hos2 histone deacetylase complex attenuates cAMP/PKA signaling to regulate morphogenesis and virulence of Candida albicans. PLOS Pathog. 2010;6(5):e1000889. doi: 10.1371/journal.ppat.1000889 Epub 20100513 PubMed PMID: 20485517; PubMed Central PMCID: PMC2869326.
   PubMed Web of Science ®Google Scholar
• Braun BR, Johnson AD. Control of filament formation in Candida albicans by the transcriptional repressor TUP1. Science. 1997;277(5322):105–9. doi: 10.1126/science.277.5322.105 Epub 1997/07/04 PubMed PMID: 9204892.
   PubMed Web of Science ®Google Scholar
• Kaneko A, Umeyama T, Utena-Abe Y, et al. Tcc1p, a novel protein containing the tetratricopeptide repeat motif, interacts with Tup1p to regulate morphological transition and virulence in Candida albicans. Eukaryot Cell. 2006;5(11):1894–905. doi: 10.1128/EC.00151-06. Epub 2006/09/26 PubMed PMID: 16998076; PubMed Central PMCID: PMC1694794.
   PubMedGoogle Scholar
• Mogavero S, Sauer FM, Brunke S, et al. Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by Candida albicans. Cell Microbiol. 2021;23(10):e13378. doi: 10.1111/cmi.13378 Epub 20210720 PubMed PMID: 34245079; PubMed Central PMCID: PMC8460606.
   PubMed Web of Science ®Google Scholar
• Lo HJ, Kohler JR, DiDomenico B, et al. Nonfilamentous C. albicans mutants are avirulent. Cell. 1997;90(5):939–949. doi: 10.1016/S0092-8674(00)80358-X PubMed PMID: 9298905.
   PubMed Web of Science ®Google Scholar
• Tucey TM, Verma J, Harrison PF, et al. Glucose homeostasis is important for immune cell viability during Candida Challenge and Host survival of systemic fungal infection. Cell Metab. 2018;27(5):988–1006 e7. doi: 10.1016/j.cmet.2018.03.019 PubMed PMID: 29719235.
   PubMed Web of Science ®Google Scholar
• McKenzie CG, Koser U, Lewis LE, et al. Contribution of Candida albicans cell wall components to recognition by and escape from murine macrophages. Infect Immun. 2010;78(4):1650–8. doi: 10.1128/IAI.00001-10. Epub 2010/02/04 PubMed PMID: 20123707; PubMed Central PMCID: PMC2849426.
   PubMed Web of Science ®Google Scholar
• Ghosh S, Navarathna DH, Roberts DD, et al. Arginine-induced germ tube formation in Candida albicans is essential for escape from murine macrophage line RAW 264.7. Infect Immun. 2009;77(4):1596–1605. doi: 10.1128/IAI.01452-08 Epub 2009/02/04 PubMed PMID: 19188358; PubMed Central PMCID: PMC2663133.
   PubMed Web of Science ®Google Scholar
• O’Meara TR, Duah K, Guo CX, et al. High-throughput screening identifies genes required for Candida albicans induction of macrophage pyroptosis. MBio. 2018;9(4). doi: 10.1128/mBio.01581-18 Epub 20180821 PubMed PMID: 30131363; PubMed Central PMCID: PMC6106084.
   PubMed Web of Science ®Google Scholar
• Wellington M, Koselny K, Sutterwala FS, et al. Candida albicans triggers NLRP3-mediated pyroptosis in macrophages. Eukaryot Cell. 2014;13(2):329–40. doi: 10.1128/EC.00336-13. Epub 2014/01/01 PubMed PMID: 24376002; PubMed Central PMCID: PMC3910967.
   PubMedGoogle Scholar
• Westman J, Moran G, Mogavero S, et al. Candida albicans hyphal expansion causes phagosomal membrane damage and luminal alkalinization. MBio. 2018;9(5). doi: 10.1128/mBio.01226-18 Epub 2018/09/13 PubMed PMID: 30206168; PubMed Central PMCID: PMC6134096.
   PubMed Web of Science ®Google Scholar
• Ebrahimi T, Rust M, Kaiser SN, et al. alpha1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid beta1-42-stimulated murine astrocytes. J Neuroinflammation. 2018;15(1):282. doi: 10.1186/s12974-018-1319-x Epub 20180927 PubMed PMID: 30261895; PubMed Central PMCID: PMC6158809.
   PubMedGoogle Scholar
• Shi J, Zhao Y, Wang K, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526(7575):660–5. doi: 10.1038/nature15514. Epub 2015/09/17 PubMed PMID: 26375003.
   PubMed Web of Science ®Google Scholar
• Lowman DW, Greene RR, Bearden DW, et al. Novel structural features in Candida albicans hyphal glucan provide a basis for differential innate immune recognition of hyphae versus yeast. J Biol Chem. 2014;289(6):3432–43. doi: 10.1074/jbc.M113.529131 Epub 2013/12/18 PubMed PMID: 24344127; PubMed Central PMCID: PMC3916545.
   PubMed Web of Science ®Google Scholar
• Yadav B, Mora-Montes HM, Wagener J, et al. Differences in fungal immune recognition by monocytes and macrophages: N-mannan can be a shield or activator of immune recognition. Cell Surf. 2020;6:100042. doi: 10.1016/j.tcsw.2020.100042 Epub 20200721 PubMed PMID: 33364531; PubMed Central PMCID: PMC7750734.
   PubMedGoogle Scholar
• Navarro-Garcia F, Alonso-Monge R, Rico H, et al. A role for the MAP kinase gene MKC1 in cell wall construction and morphological transitions in Candida albicans. Microbiology. 1998;144(Pt 2):411–424. doi: 10.1099/00221287-144-2-411 Epub 1998/03/11 PubMed PMID: 9493378.
   PubMedGoogle Scholar
• Nakamata K, Kurita T, Bhuiyan MS, et al. KEG1/YFR042w encodes a novel Kre6-binding endoplasmic reticulum membrane protein responsible for beta-1,6-glucan synthesis in Saccharomyces cerevisiae. J Biol Chem. 2007;282(47):34315–34324. doi: 10.1074/jbc.M706486200 Epub 2007/09/26 PubMed PMID: 17893149.
   PubMed Web of Science ®Google Scholar
• Bain JM, Louw J, Lewis LE, et al. Candida albicans hypha formation and Mannan Masking of β-glucan inhibit macrophage phagosome maturation. MBio. 2014;5(6):e01874. doi: 10.1128/mBio.01874-14 Epub 2014/12/04 PubMed PMID: 25467440; PubMed Central PMCID: PMC4324242.
   PubMed Web of Science ®Google Scholar
• Goodridge HS, Wolf AJ, Underhill DM. Beta-glucan recognition by the innate immune system. Immunol Rev. 2009;230(1):38–50. doi: 10.1111/j.1600-065X.2009.00793.x PubMed PMID: 19594628; PubMed Central PMCID: PMC6618291.
   PubMed Web of Science ®Google Scholar
• Reid DM, Gow NA, Brown GD. Pattern recognition: recent insights from dectin-1. Curr Opin Immunol. 2009;21(1):30–7. doi: 10.1016/j.coi.2009.01.003 Epub 20090214 PubMed PMID: 19223162; PubMed Central PMCID: PMC2684021.
   PubMed Web of Science ®Google Scholar
• Wheeler RT, Fink GR. A drug-sensitive genetic network masks fungi from the immune system. PLOS Pathog. 2006;2(4):e35. doi: 10.1371/journal.ppat.0020035 Epub 2006/05/03.
   PubMed Web of Science ®Google Scholar
• O’Meara TR, Veri AO, Ketela T, et al. Global analysis of fungal morphology exposes mechanisms of host cell escape. Nat Commun. 2015;6:6741. doi: 10.1038/ncomms7741. Epub 20150331 PubMed PMID: 25824284; PubMed Central PMCID: PMC4382923.
   PubMed Web of Science ®Google Scholar
• Drummond RA, Swamydas M, Oikonomou V, et al. CARD9(+) microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment. Nat Immunol. 2019;20(5):559–570. doi: 10.1038/s41590-019-0377-2 Epub 2019/04/19 PubMed PMID: 30996332; PubMed Central PMCID: PMC6494474.
   PubMed Web of Science ®Google Scholar
• Ganesan S, Rathinam VAK, Bossaller L, et al. Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans. J Immunol. 2014;193(5):2519–2530. doi: 10.4049/jimmunol.1400276 Epub 2014/07/27 PubMed PMID: 25063877; PubMed Central PMCID: PMC4134963.
   PubMed Web of Science ®Google Scholar
• Gringhuis SI, Kaptein TM, Wevers BA, et al. Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome. Nat Immunol. 2012;13(3):246–54. doi: 10.1038/ni.2222. Epub 2012/01/24 PubMed PMID: 22267217.
   PubMed Web of Science ®Google Scholar
• Malik A, Sharma D, Malireddi RKS, et al. SYK-CARD9 signaling axis promotes gut fungi-mediated inflammasome activation to restrict colitis and colon cancer. Immunity. 2018;49(3):515–30.e5. doi: 10.1016/j.immuni.2018.08.024 Epub 2018/09/21 PubMed PMID: 30231985; PubMed Central PMCID: PMC6541497.
   PubMed Web of Science ®Google Scholar
• Rhoads JP, Lukens JR, Wilhelm AJ, et al. Oxidized low-density lipoprotein immune complex priming of the Nlrp3 inflammasome involves TLR and FcγR cooperation and is dependent on CARD9. J Immunol. 2017;198(5):2105–14. doi: 10.4049/jimmunol.1601563 Epub 2017/01/29 PubMed PMID: 28130494; PubMed Central PMCID: PMC5318843.
   PubMed Web of Science ®Google Scholar
• Lewis LE, Bain JM, Lowes C, et al. Stage specific assessment of Candida albicans phagocytosis by macrophages identifies cell wall composition and morphogenesis as key determinants. PLOS Pathog. 2012;8(3):e1002578. doi: 10.1371/journal.ppat.1002578 Epub 2012/03/23 PubMed PMID: 22438806; PubMed Central PMCID: PMC3305454.
   PubMed Web of Science ®Google Scholar
• Maxson ME, Naj X, O’Meara TR, et al. Integrin-based diffusion barrier separates membrane domains enabling the formation of microbiostatic frustrated phagosomes. Elife. 2018;7:e34798. doi: 10.7554/eLife.34798 Epub 2018/03/20.
   PubMed Web of Science ®Google Scholar
• Gow NAR, van de Veerdonk FL, Brown AJP, et al. Candida albicans morphogenesis and host defence: discriminating invasion from colonization. Nature Rev Microbiol. 2012;10(2):112–22. doi: 10.1038/nrmicro2711
   Web of Science ®Google Scholar
• Brown GD, Taylor PR, Reid DM, et al. Dectin-1 is a Major β-glucan receptor on macrophages. J Exp Med. 2002;196(3):407–412. doi: 10.1084/jem.20020470
   PubMed Web of Science ®Google Scholar
• Pradhan A, Avelar GM, Bain JM, et al. Non-canonical signalling mediates changes in fungal cell wall PAMPs that drive immune evasion. Nat Commun. 2019;10(1):5315. doi: 10.1038/s41467-019-13298-9. Epub 2019/11/24 PubMed PMID: 31757950; PubMed Central PMCID: PMC6876565.
   PubMedGoogle Scholar
• Thornton BP, Vetvicka V, Pitman M, et al. Analysis of the sugar specificity and molecular location of the beta-glucan-binding lectin site of complement receptor type 3 (CD11b/CD18). J Immunol. 1996;156(3):1235–46. doi: 10.4049/jimmunol.156.3.1235
   PubMed Web of Science ®Google Scholar
• Brunke S, Hube B. Adaptive prediction as a strategy in microbial infections. PLOS Pathog. 2014;10(10):e1004356. doi: 10.1371/journal.ppat.1004356 Epub 2014/10/03.
   PubMed Web of Science ®Google Scholar
• Mitchell A, Romano GH, Groisman B, et al. Adaptive prediction of environmental changes by microorganisms. Nature. 2009;460(7252):220–4. doi: 10.1038/nature08112. Epub 2009/06/19 PubMed PMID: 19536156.
   PubMed Web of Science ®Google Scholar
• Rodaki A, Bohovych IM, Enjalbert B, et al. Glucose promotes stress resistance in the fungal pathogen Candida albicans. Mol Biol Cell. 2009;20(22):4845–4855. doi: 10.1091/mbc.E09-01-0002 Epub 2009/09/18 PubMed PMID: 19759180; PubMed Central PMCID: PMC2777113.
   PubMed Web of Science ®Google Scholar
• Kalo-Klein A, Witkin SS. Prostaglandin E2 enhances and Gamma Interferon inhibits germ tube formation in Candida albicans infection and immunity. Infect Immun. 1989;58(1):260–262. doi: 10.1128/iai.58.1.260-262.1990
   Web of Science ®Google Scholar
• Zelante T, Iannitti RG, De Luca A, et al. Sensing of mammalian IL-17A regulates fungal adaptation and virulence. Nat Commun. 2012;3:683. doi: 10.1038/ncomms1685 PubMed PMID: 22353714.
   PubMed Web of Science ®Google Scholar
• Case NT, Duah K, Larsen B, et al. The macrophage-derived protein PTMA induces filamentation of the human fungal pathogen Candida albicans. Cell Rep. 2021;36(8):109584. doi: 10.1016/j.celrep.2021.109584 Epub 2021/08/26 PubMed PMID: 34433036; PubMed Central PMCID: PMC8454912.
   PubMed Web of Science ®Google Scholar