123
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

A pilot study examining BDNF Val66Met polymorphism and biological sex: Relationships with baseline cognitive functioning in adolescent athletes

, , , , & ORCID Icon

References

  • Barbey, A. K., Colom, R., Paul, E., Forbes, C., Krueger, F., Goldman, D., & Grafman, J. (2014). Preservation of general intelligence following traumatic brain injury: Contributions of the Met66 brain-derived neurotrophic factor. PLOS One, 9(2), e88733. https://doi.org/10.1371/journal.pone.0088733
  • Bath, K. G., & Lee, F. S. (2006). Variant BDNF (Val66Met) impact on brain structure and function. Cognitive, Affective & Behavioral Neuroscience, 6(1), 79–85. https://doi.org/10.3758/cabn.6.1.79
  • Brooks, B. L., Iverson, G. L., Atkins, J. E., Zafonte, R., & Berkner, P. D. (2016). Sex differences and self-reported attention problems during baseline concussion testing. Applied Neuropsychology. Child, 5(2), 119–126. https://doi.org/10.1080/21622965.2014.1003066
  • Broshek, D. K., Kaushik, T., Freeman, J. R., Erlanger, D., Webbe, F., & Barth, J. T. (2005). Sex differences in outcome following sports-related concussion. Journal of Neurosurgery, 102(5), 856–863. https://doi.org/10.3171/jns.2005.102.5.0856
  • Chan, C. B., & Ye, K. (2017). Sex differences in brain-derived neurotrophic factor signaling and functions. Journal of Neuroscience Research, 95(1–2), 328–335. https://doi.org/10.1002/jnr.23863
  • Covassin, T., Elbin, R. J., 3rd, Larson, E., & Kontos, A. P. (2012). Sex and age differences in depression and baseline sport-related concussion neurocognitive performance and symptoms. Clinical Journal of Sport Medicine, 22(2), 98–104. https://doi.org/10.1097/JSM.0b013e31823403d2
  • Covassin, T., Savage, J. L., Bretzin, A. C., & Fox, M. E. (2018). Sex differences in sport-related concussion long-term outcomes. International Journal of Psychophysiology, 132(Pt A), 9–13. https://doi.org/10.1016/j.ijpsycho.2017.09.010
  • DePadilla, L., Miller, G. F., Jones, S. E., Peterson, A. B., & Breiding, M. J. (2018). Self-reported concussions from playing a sport or being physically active among high school students – United States, 2017. MMWR. Morbidity and Mortality Weekly Report, 67(24), 682–685. https://doi.org/10.15585/mmwr.mm6724a3
  • Dollé, J.-P., Jaye, A., Anderson, S. A., Ahmadzadeh, H., Shenoy, V. B., & Smith, D. H. (2018). Newfound sex differences in axonal structure underlie differential outcomes from in vitro traumatic axonal injury. Experimental Neurology, 300, 121–134.
  • Echemendia, R. J., Iverson, G. L., McCrea, M., Macciocchi, S. N., Gioia, G. A., Putukian, M., & Comper, P. (2013). Advances in neuropsychological assessment of sport-related concussion. British Journal of Sports Medicine, 47(5), 294–298.
  • Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., Lu, B., & Weinberger, D. R. (2003). The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell, 112(2), 257–269. https://doi.org/10.1016/S0092-8674(03)00035-7
  • Finan, J. D., Udani, S. V., Patel, V., & Bailes, J. E. (2018). The influence of the Val66Met polymorphism of brain-derived neurotrophic factor on neurological function after traumatic brain injury. Journal of Alzheimer’s Disease, 65(4), 1055–1064. https://doi.org/10.3233/JAD-180585
  • Freeman, B., Smith, N., Curtis, C., Huckett, L., Mill, J., & Craig, I. W. (2003). DNA from buccal swabs recruited by mail: Evaluation of storage effects on long-term stability and suitability for multiplex polymerase chain reaction genotyping. Behavior Genetics, 33(1), 67–72. https://doi.org/10.1023/a:1021055617738
  • French, J., Huber, P., McShane, J., Holland, C. L., Elbin, R. J., & Kontos, A. P. (2019). Influence of test environment, age, sex, and sport on baseline computerized neurocognitive test performance. The American Journal of Sports Medicine, 47(13), 3263–3269.
  • Hariri, A. R., Goldberg, T. E., Mattay, V. S., Kolachana, B. S., Callicott, J. H., Egan, M. F., & Weinberger, D. R. (2003). Brain-derived neurotrophic factor Val66Met polymorphism affects human memory-related hippocampal activity and predicts memory performance. The Journal of Neuroscience, 23(17), 6690–6694. https://doi.org/10.1523/JNEUROSCI.23-17-06690.2003
  • Havelka Mestrovic, A., Tudor, L., Nedic Erjavec, G., Nikolac Perkovic, M., Svob Strac, D., Kovacic Petrovic, Z., & Pivac, N. (2020). The impact of BDNF Val66Met on cognitive skills in veterans with posttraumatic stress disorder. Neuroscience Letters, 735, 135235. https://doi.org/10.1016/j.neulet.2020.135235
  • Houck, Z. M., Asken, B. M., Bauer, R. M., Caccese, J. B., Buckley, T. A., McCrea, M. A., McAllister, T. W., Broglio, S. P., & Clugston, J. R. (2020). Academic aptitude mediates the relationship between socioeconomic status and race in predicting ImPACT scores in college athletes. The Clinical Neuropsychologist, 34(3), 561–579. https://doi.org/10.1080/13854046.2019.1666923
  • Iverson, G. L., Silverberg, N. D., Mannix, R., Maxwell, B. A., Atkins, J. E., Zafonte, R., & Berkner, P. D. (2015). Factors associated with concussion-like symptom reporting in high school athletes. JAMA Pediatrics, 169(12), 1132–1140. https://doi.org/10.1001/jamapediatrics.2015.2374
  • Kerr, Z. Y., Register-Mihalik, J. K., Marshall, S. W., Evenson, K. R., Mihalik, J. P., & Guskiewicz, K. M. (2014). Disclosure and non-disclosure of concussion and concussion symptoms in athletes: Review and application of the socio-ecological framework. Brain Injury, 28(8), 1009–1021. https://doi.org/10.3109/02699052.2014.904049
  • Khoury, S., Segal, J., Parisien, M., Noreau, A., Dion, P., Benavides, R., Giguère, J.-F., Denis, R., Belfer, I., Diatchenko, L., Rouleau, G. A., & Lavigne, G. J. (2017). Post-concussion symptoms and chronic pain after mild traumatic brain injury are modulated by multiple locus effect in the BDNF gene through the expression of antisense: A pilot prospective control study. Canadian Journal of Pain, 1(1), 112–126. https://doi.org/10.1080/24740527.2017.1362942
  • Koerte, I. K., Schultz, V., Sydnor, V. J., Howell, D. R., Guenette, J. P., Dennis, E., Kochsiek, J., Kaufmann, D., Sollmann, N., Mondello, S., Shenton, M. E., & Lin, A. P. (2020). Sex-related differences in the effects of sports-related concussion: A review. Journal of Neuroimaging, 30(4), 387–409. https://doi.org/10.1111/jon.12726
  • Kroshus, E., Baugh, C. M., Stein, C. J., Austin, S. B., & Calzo, J. P. (2017). Concussion reporting, sex, and conformity to traditional gender norms in young adults. Journal of Adolescence, 54, 110–119.
  • Krueger, F., Pardini, M., Huey, E. D., Raymont, V., Solomon, J., Lipsky, R. H., Hodgkinson, C. A., Goldman, D., & Grafman, J. (2011). The role of the Met66 brain-derived neurotrophic factor allele in the recovery of executive functioning after combat-related traumatic brain injury. The Journal of Neuroscience, 31(2), 598–606. https://doi.org/10.1523/JNEUROSCI.1399-10.2011
  • Lovell, M. R. (2016). Administration and interpretation manual. ImPACT Applications.
  • Maerlender, A., Flashman, L., Kessler, A., Kumbhani, S., Greenwald, R., Tosteson, T., & McAllister, T. (2010). Examination of the construct validity of ImPACT™ computerized test, traditional, and experimental neuropsychological measures. The Clinical Neuropsychologist, 24(8), 1309–1325.
  • McAllister, T. W., Tyler, A. L., Flashman, L. A., Rhodes, C. H., McDonald, B. C., Saykin, A. J., Tosteson, T. D., Tsongalis, G. J., & Moore, J. H. (2012). Polymorphisms in the brain-derived neurotrophic factor gene influence memory and processing speed one month after brain injury. Journal of Neurotrauma, 29(6), 1111–1118. https://doi.org/10.1089/neu.2011.1930
  • McCrory, P., Meeuwisse, W., Dvorak, J., Aubry, M., Bailes, J., Broglio, S., Cantu, R. C., Cassidy, D., Echemendia, R. J., Castellani, R. J., Davis, G. A., Ellenbogen, R., Emery, C., Engebretsen, L., Feddermann-Demont, N., Giza, C. C., Guskiewicz, K. M., Herring, S., Iverson, G. L., … Vos, P. E. (2017). Consensus statement on concussion in sport-the 5(th) international conference on concussion in sport held in Berlin, October 2016. British Journal of Sports Medicine, 51(11), bjsports-2017-097699-847. https://doi.org/10.1136/bjsports-2017-097699
  • Mihalik, J. P., Ondrak, K. S., Guskiewicz, K. M., & McMurray, R. G. (2009). The effects of menstrual cycle phase on clinical measures of concussion in healthy college-aged females. Journal of Science and Medicine in Sport, 12(3), 383–387.
  • Miranda, M., Morici, J. F., Zanoni, M. B., & Bekinschtein, P. (2019). Brain-derived neurotrophic factor: A key molecule for memory in the healthy and the pathological brain. Frontiers in Cellular Neuroscience, 13, 363. https://doi.org/10.3389/fncel.2019.00363
  • Mollayeva, T., Mollayeva, S., & Colantonio, A. (2018). Traumatic brain injury: Sex, gender and intersecting vulnerabilities. Nature Reviews. Neurology, 14(12), 711–722.
  • Moran, L. M., Taylor, H. G., Ganesalingam, K., Gastier-Foster, J. M., Frick, J., Bangert, B., Dietrich, A., Nuss, K. E., Rusin, J., Wright, M., & Yeates, K. O. (2009). Apolipoprotein E4 as a predictor of outcomes in pediatric mild traumatic brain injury. Journal of Neurotrauma, 26(9), 1489–1495. https://doi.org/10.1089/neu.2008.0767
  • Moser, R. S., Iverson, G. L., Echemendia, R. J., Lovell, M. R., Schatz, P., Webbe, F. M., Ruff, R. M., & Barth, J. T. (2007). Neuropsychological evaluation in the diagnosis and management of sports-related concussion. Archives of Clinical Neuropsychology, 22(8), 909–916. https://doi.org/10.1016/j.acn.2007.09.004
  • Moser, R. S., Olek, L., & Schatz, P. (2019). Gender differences in symptom reporting on baseline sport concussion testing across the youth age span. Archives of Clinical Neuropsychology, 34(1), 50–59. https://doi.org/10.1093/arclin/acy007
  • Narayanan, V., Veeramuthu, V., Ahmad-Annuar, A., Ramli, N., Waran, V., Chinna, K., Bondi, M. W., Delano-Wood, L., & Ganesan, D. (2016). Missense mutation of brain derived neurotrophic factor (BDNF) alters neurocognitive performance in patients with mild traumatic brain injury: A longitudinal study. PLOS One, 11(7), e0158838. https://doi.org/10.1371/journal.pone.0158838
  • Riegler, K. E., Guty, E. T., Thomas, G. A., & Arnett, P. A. (2021). Sleep deprived or concussed? The acute impact of self-reported insufficient sleep in college athletes. Journal of the International Neuropsychological Society, 27(1), 35–46. https://doi.org/10.1017/S135561772000065X
  • Solomito, M. J., Reuman, H., & Wang, D. H. (2019). Sex differences in concussion: A review of brain anatomy, function, and biomechanical response to impact. Brain Injury, 33(2), 105–110.
  • Thomas, G. A., Guty, E. T., Riegler, K. E., & Arnett, P. A. (2021). Comorbid affective symptomatology and neurocognitive performance in college athletes. Journal of the International Neuropsychological Society, 28, 177–187. https://doi.org/10.1017/S135561772100134X
  • Treble-Barna, A., Wade, S. L., Pilipenko, V., Martin, L. J., Yeates, K. O., Taylor, H. G., & Kurowski, B. G. (2022). Brain-derived neurotrophic factor Val66Met and neuropsychological functioning after early childhood traumatic brain injury. Journal of the International Neuropsychological Society. https://doi.org/10.1017/S1355617722000194
  • Tuminello, E. R., & Han, S. D. (2011). The apolipoprotein e antagonistic pleiotropy hypothesis: Review and recommendations. International Journal of Alzheimer’s Disease, 2011, 726197. https://doi.org/10.4061/2011/726197
  • Veliz, P., McCabe, S. E., Eckner, J. T., & Schulenberg, J. E. (2017). Prevalence of concussion among US adolescents and correlated factors. JAMA, 318(12), 1180–1182. https://doi.org/10.1001/jama.2017.9087
  • Weaver, S. M., Chau, A., Portelli, J. N., & Grafman, J. (2012). Genetic polymorphisms influence recovery from traumatic brain injury. The Neuroscientist, 18(6), 631–644. https://doi.org/10.1177/1073858411435706
  • Wunderle, K., Hoeger, K. M., Wasserman, E., & Bazarian, J. J. (2014). Menstrual phase as predictor of outcome after mild traumatic brain injury in women. The Journal of Head Trauma Rehabilitation, 29(5), E1–E8.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.