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A literature review of severity scores for adults with influenza or community-acquired pneumonia – implications for influenza vaccines and therapeutics

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Pages 5460-5474 | Received 02 Aug 2021, Accepted 02 Oct 2021, Published online: 10 Nov 2021

References

  • Iuliano AD, Roguski KM, Chang HH, Muscatello DJ, Palekar R, Tempia S, Cohen C, Gran JM, Schanzer D, Cowling BJ, et al. Estimates of global seasonal influenza-associated respiratory mortality: a modelling study. Lancet. 2018 Mar 31;391(10127):1285–300. doi:10.1016/S0140-6736(17)33293-2.
  • Belongia EA, Simpson MD, King JP, Sundaram ME, Kelley NS, Osterholm MT, McLean HQ. Variable influenza vaccine effectiveness by subtype: a systematic review and meta-analysis of test-negative design studies. Lancet Infect Dis. 2016 Aug;16(8):942–51. doi:10.1016/S1473-3099(16)00129-8.
  • Arriola C, Garg S, Anderson EJ, Ryan PA, George A, Zansky SM, Bennett N, Reingold A, Bargsten M, Miller L, et al. Influenza vaccination modifies disease severity among community-dwelling adults hospitalized with influenza. Clin Infect Dis. 2017 Oct 15;65(8):1289–97. doi:10.1093/cid/cix468.
  • Lee N, Choi KW, Chan PK, Hui DSC, Lui GCY, Wong BCK, Wong RYK, Sin WY, Hui WM, Ngai KLK, et al. Outcomes of adults hospitalised with severe influenza. Thorax. 2010 June;65(6):510–15. doi:10.1136/thx.2009.130799.
  • Treanor JJ, Hayden FG, Vrooman PS, Barbarash R, Bettis R, Riff D, Singh S, Kinnersley N, Ward P, Mills RG, et al. Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial. US oral neuraminidase study group. JAMA. 2000 Feb 23;283(8):1016–24. doi:10.1001/jama.283.8.1016.
  • Chaves SS, Perez A, Miller L, Bennett NM, Bandyopadhyay A, Farley MM, Fowler B, Hancock EB, Kirley PD, Lynfield R, et al. Impact of prompt influenza antiviral treatment on extended care needs after influenza hospitalization among community-dwelling older adults. Clin Infect Dis. 2015 Dec 15;61(12):1807–14. doi:10.1093/cid/civ733.
  • Oboho IK, Reed C, Gargiullo P, Leon M, Aragon D, Meek J, Anderson EJ, Ryan P, Lynfield R, Morin C, et al. Benefit of early initiation of influenza antiviral treatment to pregnant women hospitalized with laboratory-confirmed influenza. J Infect Dis. 2016 Aug 15;214(4):507–15. doi:10.1093/infdis/jiw033.
  • Arriola CS, Anderson EJ, Baumbach J, Bennett N, Bohm S, Hill M, Lindegren ML, Lung K, Meek J, Mermel E, et al. Does influenza vaccination modify influenza severity? Data on older adults hospitalized with influenza during the 2012-2013 season in the United States. J Infect Dis. 2015 Oct 15;212(8):1200–08. doi:10.1093/infdis/jiv200.
  • Thompson MG, Pierse N, Sue Huang Q, Prasad N, Duque J, Claire Newbern E, Baker MG, Turner N, McArthur C. Influenza vaccine effectiveness in preventing influenza-associated intensive care admissions and attenuating severe disease among adults in New Zealand 2012–2015. Vaccine. 2018 Sept 18;36(39):5916–25. doi:10.1016/j.vaccine.2018.07.028.
  • Guidance for Industry Influenza: developing drugs for treatment and/or prophylaxis. U.S. Department of Health and Human Services, Food and Drug Administration; 2011.
  • King JC, Beigel JH, Ison MG, Rothman RE, Uyeki TM, Walker RE, Neaton JD, Tegeris JS, Zhou JA, Armstrong KL, et al. Clinical development of therapeutic agents for hospitalized patients with influenza: challenges and innovations. Open Forum Infect Dis. 2019 Apr;6(4):ofz137. doi:10.1093/ofid/ofz137.
  • Jennings LC, Anderson TP, Beynon KA, Chua A, Laing RTR, Werno AM, Young SA, Chambers ST, Murdoch DR. Incidence and characteristics of viral community-acquired pneumonia in adults. Thorax. 2008 Jan;63(1):42–48. doi:10.1136/thx.2006.075077.
  • Adeniji KA, Cusack R. The simple triage scoring system (STSS) successfully predicts mortality and critical care resource utilization in H1N1 pandemic flu: a retrospective analysis. Crit Care. 2011;15(1):R39. doi:10.1186/cc10001.
  • Agapakis DI, Tsantilas D, Psarris P, MASSA EV, KOTSAFTIS P, TZIOMALOS K, HATZITOLIOS AI. Coagulation and inflammation biomarkers may help predict the severity of community-acquired pneumonia. Respirology (Carlton, Vic). 2010 July;15(5):796–803. doi:10.1111/j.1440-1843.2010.01773.x.
  • Ahn JH, Choi EY. Expanded A-DROP score: a new scoring system for the prediction of mortality in hospitalized patients with community-acquired pneumonia. Sci Rep. 2018 Oct 1;8(1):14588. doi:10.1038/s41598-018-32750-2.
  • Ahnert P, Creutz P, Horn K, Schwarzenberger F, Kiehntopf M, Hossain H, Bauer M, Brunkhorst FM, Reinhart K, Völker U, et al. Sequential organ failure assessment score is an excellent operationalization of disease severity of adult patients with hospitalized community acquired pneumonia – results from the prospective observational PROGRESS study. Crit Care (London, England). 2019 Apr 4;23(1):110. doi:10.1186/s13054-019-2316-x.
  • Alan M, Grolimund E, Kutz A, Christ-Crain M, Thomann R, Falconnier C, Hoess C, Henzen C, Zimmerli W, Mueller B, et al. Clinical risk scores and blood biomarkers as predictors of long-term outcome in patients with community-acquired pneumonia: a 6-year prospective follow-up study. J Intern Med. 2015 Aug;278(2):174–84. doi:10.1111/joim.12341.
  • Aliberti S, Ramirez J, Cosentini R, Brambilla AM, Zanaboni AM, Rossetti V, Tarsia P, Peyrani P, Piffer F, Blasi F, et al. Low CURB-65 is of limited value in deciding discharge of patients with community-acquired pneumonia. Respir Med. 2011 Nov;105(11):1732–38. doi:10.1016/j.rmed.2011.07.006.
  • Andersen SB, Baunbaek Egelund G, Jensen AV, Petersen PT, Rohde G, Ravn P. Failure of CRP decline within three days of hospitalization is associated with poor prognosis of Community-acquired Pneumonia. Infect Dis (London, England). 2017 Apr;49(4):251–60. doi:10.1080/23744235.2016.1253860.
  • Andrijevic I, Matijasevic J, Andrijevic L, Kovacevic T, Zaric B. Interleukin-6 and procalcitonin as biomarkers in mortality prediction of hospitalized patients with community acquired pneumonia. Ann Thorac Med. 2014 July;9(3):162–67. doi:10.4103/1817-1737.134072.
  • Angus DC, Marrie TJ, Obrosky DS, Clermont G, Dremsizov TT, Coley C, Fine MJ, Singer DE, Kapoor WN. Severe community-acquired pneumonia: use of intensive care services and evaluation of American and British thoracic society diagnostic criteria. Am J Respir Crit Care Med. 2002 Sept 1;166(5):717–23. doi:10.1164/rccm.2102084.
  • Arminanzas C, Velasco L, Calvo N, Portilla R, Riancho JA, Valero C. CURB-65 as an initial prognostic score in Internal Medicine patients. Eur J Intern Med. 2013 July;24(5):416–19. doi:10.1016/j.ejim.2013.01.004.
  • Asai N, Watanabe H, Shiota A, Kato H, Sakanashi D, Hagihara M, Koizumi Y, Yamagishi Y, Suematsu H, Mikamo H, et al. Efficacy and accuracy of qSOFA and SOFA scores as prognostic tools for community-acquired and healthcare-associated pneumonia. Int J Infect Dis. 2019 Apr 24;84:89–96. 10.1016/j.ijid.2019.04.020
  • Bello S, Lasierra AB, Minchole E, Fandos S, Ruiz MA, Vera E, De Pablo F, Ferrer M, Menendez R, Torres A, et al. Prognostic power of proadrenomedullin in community-acquired pneumonia is independent of aetiology. Eur Respir J. 2012 May;39(5):1144–55. doi:10.1183/09031936.00080411.
  • Bloos F, Marshall JC, Dellinger RP, Vincent J-L, Gutierrez G, Rivers E, Balk RA, Laterre P-F, Angus DC, Reinhart K, et al. Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study. Crit Care. 2011;15(2):R88. doi:10.1186/cc10087.
  • Buising KL, Thursky KA, Black JF, MacGregor L, Street AC, Kennedy MP, Brown GV. Identifying severe community-acquired pneumonia in the emergency department: a simple clinical prediction tool. Emerg Med Australas. 2007 Oct;19(5):418–26. doi:10.1111/j.1742-6723.2007.01003.x.
  • Capelastegui A, Espana PP, Quintana JM, Areitio I, Gorordo I, Egurrola M, Bilbao A. Validation of a predictive rule for the management of community-acquired pneumonia. Eur Respir J. 2006 Jan;27(1):151–57. doi:10.1183/09031936.06.00062505.
  • Chalmers JD, Singanayagam A, Hill AT. Predicting the need for mechanical ventilation and/or inotropic support for young adults admitted to the hospital with community-acquired pneumonia. Clin Infect Dis. 2008 Dec 15;47(12):1571–74. doi:10.1086/593195.
  • Chen JH, Chang SS, Liu JJ, Chan R-C, Wu J-Y, Wang W-C, Lee S-H, Lee -C-C. Comparison of clinical characteristics and performance of pneumonia severity score and CURB-65 among younger adults, elderly and very old subjects. Thorax. 2010 Nov;65(11):971–77. doi:10.1136/thx.2009.129627.
  • Chen L, Han X, Li YL, Zhang C, Xing X. FluA-p score: a novel prediction rule for mortality in influenza A-related pneumonia patients. Respir Res. 2020 May 8;21(1):109. doi:10.1186/s12931-020-01379-z.
  • Chiang TY, Yu YL, Lin CW, Tsao SM, Yang SF, Yeh CB. The circulating level of MMP-9 and its ratio to TIMP-1 as a predictor of severity in patients with community-acquired pneumonia. Clin Chim Acta. 2013 Sept 23;424:261–66. doi:10.1016/j.cca.2013.06.013.
  • Cho WH, Yeo HJ, Yoon SH, Lee SE, Jeon DS, Kim YS, Lee SJ, Jo EJ, Mok JH, Kim MH, et al. Lysophosphatidylcholine as a prognostic marker in community-acquired pneumonia requiring hospitalization: a pilot study. Eur J Clin Microbiol Infect Dis. 2015 Feb;34(2):309–15. doi:10.1007/s10096-014-2234-4.
  • Choi WI, Yim JJ, Park J, Kim SC, Na MJ, Lee WY, et al. Clinical characteristics and outcomes of H1N1-associated pneumonia among adults in South Korea. Int J Tuberc Lung Dis. 2011Feb, 15(2), 270–5, i.
  • Chou SC, Ko HW, Lin YC. CRP/IL-6/IL-10 single-nucleotide polymorphisms correlate with the susceptibility and severity of community-acquired pneumonia. Genet Test Mol Biomarkers. 2016 Dec;20(12):732–40. doi:10.1089/gtmb.2016.0156.
  • Christ-Crain M, Morgenthaler NG, Stolz D, Müller C, Bingisser R, Harbarth S, Tamm M, Struck J, Bergmann A, Müller B, et al. Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397]. Crit Care. 2006;10(3):R96. doi:10.1186/cc4955.
  • Christ-Crain M, Breidthardt T, Stolz D, Zobrist K, Bingisser R, Miedinger D, Leuppi J, Tamm M, Mueller B, Mueller C, et al. Use of B-type natriuretic peptide in the risk stratification of community-acquired pneumonia. J Intern Med. 2008 Aug;264(2):166–76. doi:10.1111/j.1365-2796.2008.01934.x.
  • Courtais C, Kuster N, Dupuy AM, Folschveiller M, Jreige R, Bargnoux A-S, Guiot J, Lefebvre S, Cristol J-P, Sebbane M, et al. Proadrenomedullin, a useful tool for risk stratification in high pneumonia severity index score community acquired pneumonia. Am J Emerg Med. 2013 Jan;31(1):215–21. doi:10.1016/j.ajem.2012.07.017.
  • Davis JS, Cross GB, Charles PG, Currie BJ, Anstey NM, Cheng AC. Pneumonia risk stratification in tropical Australia: does the SMART-COP score apply? Med J Aust. 2010 Feb 1;192(3):133–36. doi:10.5694/j.1326-5377.2010.tb03450.x.
  • Dwyer R, Hedlund J, Henriques-Normark B, Kalin M. Improvement of CRB-65 as a prognostic tool in adult patients with community-acquired pneumonia. BMJ Open Respir Res. 2014;1(1):e000038. doi:10.1136/bmjresp-2014-000038.
  • Ehsanpoor B, Vahidi E, Seyedhosseini J, Jahanshir A. Validity of SMART-COP score in prognosis and severity of community acquired pneumonia in the emergency department. Am J Emerg Med. 2019 Aug;37(8):1450–54. doi:10.1016/j.ajem.2018.10.044.
  • Espana PP, Capelastegui A, Gorordo I, Esteban C, Oribe M, Ortega M, Bilbao A, Quintana JM. Development and validation of a clinical prediction rule for severe community-acquired pneumonia. Am J Respir Crit Care Med. 2006 Dec 1;174(11):1249–56. doi:10.1164/rccm.200602-177OC.
  • Espana PP, Capelastegui A, Bilbao A, Diez R, Izquierdo F, Lopez De Goicoetxea MJ, Gamazo J, Medel F, Salgado J, Gorostiaga I, et al. Utility of two biomarkers for directing care among patients with non-severe community-acquired pneumonia. Eur J Clin Microbiol Infect Dis. 2012 Dec;31(12):3397–405. doi:10.1007/s10096-012-1708-5.
  • Espana PP, Capelastegui A, Mar C, Bilbao A, Quintana JM, Diez R, Esteban C, Bereciartua E, Unanue U, Uranga A, et al. Performance of pro-adrenomedullin for identifying adverse outcomes in community-acquired pneumonia. J Infect. 2015 May;70(5):457–66. doi:10.1016/j.jinf.2014.12.003.
  • Flanders WD, Tucker G, Krishnadasan A, Martin D, Honig E, McClellan WM. Validation of the pneumonia severity index. Importance of study-specific recalibration. J Gen Intern Med. 1999 June;14(6):333–40. doi:10.1046/j.1525-1497.1999.00351.x.
  • Fukuyama H, Ishida T, Tachibana H, Nakagawa H, Iwasaku M, Saigusa M, Yoshioka H, Arita M, Hashimoto T. Validation of scoring systems for predicting severe community-acquired pneumonia. Int Med (Tokyo, Japan). 2011;50(18):1917–22. doi:10.2169/internalmedicine.50.5279.
  • Gearhart AM, Furmanek S, English C, Ramirez J, Cavallazzi R. Predicting the need for ICU admission in community-acquired pneumonia. Respir Med. 2019 Aug;155:61–65. doi:10.1016/j.rmed.2019.07.007.
  • Golcuk Y, Golcuk B, Bilge A, Irik M, Dikmen O. Combination of mean platelet volume and the CURB-65 score better predicts 28-day mortality in patients with community-acquired pneumonia. Am J Emerg Med. 2015 May;33(5):648–52. doi:10.1016/j.ajem.2015.02.001.
  • Gordo-Remartinez S, Calderon-Moreno M, Fernandez-Herranz J, Castuera-Gil A, Gallego-Alonso-Colmenares M, Puertas-López C, Nuevo-González JA, Sánchez-Sendín D, García-Gámiz M, Sevillano-Fernández JA, et al. Usefulness of midregional proadrenomedullin to predict poor outcome in patients with community acquired pneumonia. PloS One. 2015;10(6):e0125212. doi:10.1371/journal.pone.0125212.
  • Grudzinska FS, Aldridge K, Hughes S, Nightingale P, Parekh D, Bangash M, Dancer R, Patel J, Sapey E, Thickett DR, et al. Early identification of severe community-acquired pneumonia: a retrospective observational study. BMJ Open Respir Res. 2019;6(1):e000438. doi:10.1136/bmjresp-2019-000438.
  • Gunaydin S, Kucuk M, Gunaydin UM. The role of Endocan as a Prognostic Biomarker in community-acquired pneumonia. Pak J Med Sci. 2019 Jan-Feb;35(1):117–23. doi:10.12669/pjms.35.1.280.
  • Guo Q, Li HY, Zhou YP, Li M, Chen X-K, Liu H, Peng H-L, Yu H-Q, Chen X, Liu N, et al. CURB-65 score predicted mortality in community-acquired pneumonia better than IDSA/ATS minor criteria in a low-mortality-rate setting. Eur J Clin Microbiol Infect Dis. 2012 Dec;31(12):3281–86. doi:10.1007/s10096-012-1693-8.
  • Gwak MH, Jo S, Jeong T, Lee JB, Jin YH, Yoon J, Park B. Initial serum lactate level is associated with inpatient mortality in patients with community-acquired pneumonia. Am J Emerg Med. 2015 May;33(5):685–90. doi:10.1016/j.ajem.2015.03.002.
  • Hamaguchi S, Suzuki M, Sasaki K, Abe M, Wakabayashi T, Sando E, Yaegashi M, Morimoto S, Asoh N, Hamashige N, et al. Six underlying health conditions strongly influence mortality based on pneumonia severity in an ageing population of Japan: a prospective cohort study. BMC Pulm Med. 2018 May 23;18(1):88. doi:10.1186/s12890-018-0648-y.
  • Huaman MA, Diaz-Kuan A, Hegab S, Brar I, Kaatz S. CURB-65 and SMRT-CO in the prediction of early transfers to the intensive care unit among patients with community-acquired pneumonia initially admitted to a general ward. J Hosp Med. 2011 Nov;6(9):513–18. doi:10.1002/jhm.921.
  • Huang DT, Weissfeld LA, Kellum JA, Yealy DM, Kong L, Martino M, Angus DC. Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia. Ann Emerg Med. 2008 July;52(1):48–58.e2. doi:10.1016/j.annemergmed.2008.01.003.
  • Huang DT, Angus DC, Kellum JA, Pugh NA, Weissfeld LA, Struck J, Delude RL, Rosengart MR, Yealy DM. Midregional proadrenomedullin as a prognostic tool in community-acquired pneumonia. Chest. 2009 Sept;136(3):823–31. doi:10.1378/chest.08-1981.
  • Ito A, Ishida T, Tokumasu H, Washio Y, Yamazaki A, Ito Y, Tachibana H. Prognostic factors in hospitalized community-acquired pneumonia: a retrospective study of a prospective observational cohort. BMC Pulm Med. 2017 May 2;17(1):78. doi:10.1186/s12890-017-0424-4.
  • Jain S, Benoit SR, Skarbinski J, Bramley AM, Finelli L. Pandemic Influenza AVHIT. Influenza-associated pneumonia among hospitalized patients with 2009 pandemic influenza A (H1N1) virus–United States, 2009. Clin Infect Dis. 2012 May;54(9):1221–29. doi:10.1093/cid/cis197.
  • Jeong BH, Jeon EJ, Yoo H, Koh W-J, Suh GY, Chung MP, Kwon OJ, Jeon K. Comparison of severe healthcare-associated pneumonia with severe community-acquired pneumonia. Lung. 2014 Apr;192(2):313–20. doi:10.1007/s00408-013-9541-x.
  • Jo S, Jeong T, Lee JB, Jin Y, Yoon J, Park B. Validation of modified early warning score using serum lactate level in community-acquired pneumonia patients. The national early warning score-lactate score. Am J Emerg Med. 2016 Mar;34(3):536–41. doi:10.1016/j.ajem.2015.12.067.
  • Justel M, Socias L, Almansa R, Ramírez P, Gallegos MC, Fernandez V, Gordon M, Andaluz-Ojeda D, Nogales L, Rojo S, et al. IgM levels in plasma predict outcome in severe pandemic influenza. J Clin Virol. 2013 Nov;58(3):564–67. doi:10.1016/j.jcv.2013.09.006.
  • Kasamatsu Y, Yamaguchi T, Kawaguchi T, TANAKA N, Oka H, NAKAMURA T, YAMAGAMI K, YOSHIOKA K, Imanishi M. Usefulness of a semi-quantitative procalcitonin test and the A-DROP Japanese prognostic scale for predicting mortality among adults hospitalized with community-acquired pneumonia. Respirology (Carlton, Vic). 2012 Feb;17(2):330–36. doi:10.1111/j.1440-1843.2011.02101.x.
  • Katsoulis K, Kontakiotis T, Baltopoulos G, Kotsovili A, Legakis IN. Total antioxidant status and severity of community-acquired pneumonia: are they correlated? Respiration. 2005 July-Aug;72(4):381–87. doi:10.1159/000086252.
  • Kim JW, Hong DY, Lee KR, Kim SY, Baek KJ, Park SO. Usefulness of plasma neutrophil gelatinase-associated lipocalin concentration for predicting the severity and mortality of patients with community-acquired pneumonia. Clin Chim Acta. 2016 Nov 1;462:140–45. doi:10.1016/j.cca.2016.09.011.
  • Kim MW, Lim JY, Oh SH. Mortality prediction using serum biomarkers and various clinical risk scales in community-acquired pneumonia. Scand J Clin Lab Invest. 2017 Nov;77(7):486–92. doi:10.1080/00365513.2017.1344298.
  • Ko CP, Yu YL, Hsiao PC, Yang SF, Yeh CB. Plasma levels of soluble Axl correlate with severity of community-acquired pneumonia. Mol Med Rep. 2014 Apr;9(4):1400–04. doi:10.3892/mmr.2014.1933.
  • Kolditz M, Halank M, Schulte-Hubbert B, Hoffken G. Adrenal function is related to prognosis in moderate community-acquired pneumonia. Eur Respir J. 2010 Sept;36(3):615–21. doi:10.1183/09031936.00191709.
  • Lee JH, Kim J, Kim K, Jo YH, Rhee J, Kim TY, Na SH, Hwang SS. Albumin and C-reactive protein have prognostic significance in patients with community-acquired pneumonia. J Crit Care. 2011 June;26(3):287–94. doi:10.1016/j.jcrc.2010.10.007.
  • Lee SM, Lee JH, Kim K, Jo YH, Lee J, Kim J, Hwang JE, Ko YS, Ha C, Jang S, et al. The clinical significance of changes in red blood cell distribution width in patients with community-acquired pneumonia. Clin Exp Emerg Med. 2016 Sept;3(3):139–47. doi:10.15441/ceem.15.081.
  • Leroy O, Georges H, Beuscart C, Guery B, Coffinier C, Vandenbussche C, Thevenin D, Beaucaire G. Severe community-acquired pneumonia in ICUs: prospective validation of a prognostic score. Intensive Care Med. 1996 Dec;22(12):1307–14. doi:10.1007/BF01709543.
  • Li HY, Guo Q, Song WD, Li M, Chen X-K, Liu H, Peng H-L, Yu H-Q, Chen X, Liu N, et al. CUR-65 score for community-acquired pneumonia predicted mortality better than CURB-65 score in low-mortality rate settings. Am J Med Sci. 2015 Sept;350(3):186–90. doi:10.1097/maj.0000000000000545.
  • Li HY, Guo Q, Song WD, Zhou Y-P, Li M, Chen X-K, Liu H, Peng H-L, Yu H-Q, Chen X, et al. Modified IDSA/ATS minor criteria for severe community-acquired pneumonia best predicted mortality. Medicine. 2015 Sept;94(36):e1474. doi:10.1097/md.0000000000001474.
  • Liapikou A, Ferrer M, Polverino E, Balasso V, Esperatti M, Piñer R, Mensa J, Luque N, Ewig S, Menendez R, et al. Severe community-acquired pneumonia: validation of the Infectious diseases society of America/American thoracic society guidelines to predict an intensive care unit admission. Clin Infect Dis. 2009 Feb 15;48(4):377–85. doi:10.1086/596307.
  • Lim WS, van der Eerden MM, Laing R, Boersma WG, Karalus N, Town GI, Lewis SA, Macfarlane JT. Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study. Thorax. 2003 May;58(5):377–82. doi:10.1136/thorax.58.5.377.
  • Liu B, Yin Q, Chen YX, Zhao YZ, Li CS. Role of Presepsin (sCD14-ST) and the CURB65 scoring system in predicting severity and outcome of community-acquired pneumonia in an emergency department. Respir Med. 2014 Aug;108(8):1204–13. doi:10.1016/j.rmed.2014.05.005.
  • Liu JL, Xu F, Zhou H, Wu X-J, Shi L-X, Lu R-Q, Farcomeni A, Venditti M, Zhao Y-L, Luo S-Y, et al. Expanded CURB-65: a new score system predicts severity of community-acquired pneumonia with superior efficiency. Sci Rep. 2016 Mar 18;6:22911. 10.1038/srep22911
  • Luo Q, He X, Ning P, Zheng Y, Yang D, Xu Y, Shang Y, Gao Z. Admission pentraxin-3 level predicts severity of community-acquired pneumonia independently of etiology. Proteomics Clin Appl. 2018 Dec 17:e1800117. doi:10.1002/prca.201800117.
  • Mahendra M, Jayaraj BS, Limaye S, Chaya SK, Dhar R, Mahesh PA. Factors influencing severity of community-acquired pneumonia. Lung India. 2018 July-Aug;35(4):284–89. doi:10.4103/lungindia.lungindia_334_17.
  • Mamani M, Muceli N, Ghasemi Basir HR, Vasheghani M, Poorolajal J. Association between serum concentration of 25-hydroxyvitamin D and community-acquired pneumonia: a case-control study. Int J Gen Med. 2017;10:423–29. doi:10.2147/ijgm.S149049.
  • Masia M, Gutierrez F, Shum C, Padilla S, Navarro JC, Flores E, Hernández I. Usefulness of procalcitonin levels in community-acquired pneumonia according to the patients outcome research team pneumonia severity index. Chest. 2005 Oct;128(4):2223–29. doi:10.1378/chest.128.4.2223.
  • Meier MA, Ottiger M, Vogeli A, Steuer C, Bernasconi L, Thomann R, Christ-Crain M, Henzen C, Hoess C, Zimmerli W, et al. Activation of the tryptophan/serotonin pathway is associated with severity and predicts outcomes in pneumonia: results of a long-term cohort study. Clin Chem Lab Med. 2017 June 27;55(7):1060–69. doi:10.1515/cclm-2016-0912.
  • Mendez R, Menendez R, Amara-Elori I, Feced L, Piró A, Ramírez P, Sempere A, Ortega A, Bermejo-Martín JF, Torres A, et al. Lymphopenic community-acquired pneumonia is associated with a dysregulated immune response and increased severity and mortality. J Infect. 2019 June;78(6):423–31. doi:10.1016/j.jinf.2019.04.006.
  • Menendez R, Martinez R, Reyes S, Mensa J, Filella X, Marcos MA, Martinez A, Esquinas C, Ramirez P, Torres A, et al. Biomarkers improve mortality prediction by prognostic scales in community-acquired pneumonia. Thorax. 2009 July;64(7):587–91. doi:10.1136/thx.2008.105312.
  • Miller AC, Subramanian RA, Safi F, Sinert R, Zehtabchi S, Elamin EM, Influenza A. 2009 (H1N1) virus in admitted and critically ill patients. J Intensive Care Med. 2012 Feb;27(1):25–31. doi:10.1177/0885066610393626.
  • Miyazaki H, Nagata N, Akagi T, Takeda S, Harada T, Ushijima S, Aoyama T, Yoshida Y, Yatsugi H, Fujita M, et al. Comprehensive analysis of prognostic factors in hospitalized patients with pneumonia occurring outside hospital: serum albumin is not less important than pneumonia severity assessment scale. J Infect Chemother. 2018 Aug;24(8):602–09. doi:10.1016/j.jiac.2018.03.006.
  • Muller B, Suess E, Schuetz P, Müller C, Bingisser R, Bergmann A, Stolz D, Tamm M, Morgenthaler NG, Christ-crain M, et al. Circulating levels of pro-atrial natriuretic peptide in lower respiratory tract infections. J Intern Med. 2006 Dec;260(6):568–76. doi:10.1111/j.1365-2796.2006.01722.x.
  • Muller B, Morgenthaler N, Stolz D, Schuetz P, Müller C, Bingisser R, Bergmann A, Tamm M, Christ-Crain M. Circulating levels of copeptin, a novel biomarker, in lower respiratory tract infections. Eur J Clin Invest. 2007 Feb;37(2):145–52. doi:10.1111/j.1365-2362.2007.01762.x.
  • Murcia J, Llorens P, Sanchez-Paya J, Reus S, Boix V, Merino E, Laghzaoui F, Portilla J. Functional status determined by Barthel Index predicts community acquired pneumonia mortality in general population. J Infect. 2010 Dec;61(6):458–64. doi:10.1016/j.jinf.2010.08.006.
  • Naderi HR, Sheybani F, Sarvghad M, Nooghabi MJ. Can procalcitonin add to the prognostic power of the severity scoring system in adults with pneumonia? Tanaffos. 2015;14:95–106.
  • Nastasijevic Borovac D, Radjenovic Petkovic T, Pejcic T, Stankovic I, Jankovic I, Ciric Z, Rancic M. Role of D-dimer in predicting mortality in patients with community-acquired pneumonia. Med Glas. 2014Feb, 11(1), 37–43.
  • Nicolini A, Ferrera L, Rao F, Senarega R, Ferrari-Bravo M. Chest radiological findings of influenza A H1N1 pneumonia. Rev Port Pneumol. 2012 May-June;18(3):120–27. doi:10.1016/j.rppneu.2011.12.008.
  • Nowak A, Breidthardt T, Christ-Crain M, Bingisser R, Meune C, Tanglay Y, Heinisch C, Reiter M, Drexler B, Arenja N, et al. Direct comparison of three natriuretic peptides for prediction of short- and long-term mortality in patients with community-acquired pneumonia. Chest. 2012 Apr;141(4):974–82. doi:10.1378/chest.11-0824.
  • Oh WS, Lee SJ, Lee CS, Hur J-A, Hur A-C, Park YS, Heo S-T, Bae I-G, Park SW, Kim ES, et al. A prediction rule to identify severe cases among adult patients hospitalized with pandemic influenza A (H1N1) 2009. J Korean Med Sci. 2011 Apr;26(4):499–506. doi:10.3346/jkms.2011.26.4.499.
  • Papadimitriou-Olivgeris M, Gkikopoulos N, Wüst M, Ballif A, Simonin V, Maulini M, Nusbaumer C, Bertaiola Monnerat L, Tschopp J, Kampouri -E-E, et al. Predictors of mortality of influenza virus infections in a Swiss Hospital during four influenza seasons: role of quick sequential organ failure assessment. Eur J Intern Med. 2020 Apr;74:86–91. doi:10.1016/j.ejim.2019.12.022.
  • Parsonage M, Nathwani D, Davey P, Barlow G. Evaluation of the performance of CURB-65 with increasing age. Clin Microbiol Infect. 2009 Sept;15(9):858–64. doi:10.1111/j.1469-0691.2009.02908.x.
  • Phua J, See KC, Chan YH, Widjaja LS, Aung NW, Ngerng WJ, Lim TK. Validation and clinical implications of the IDSA/ATS minor criteria for severe community-acquired pneumonia. Thorax. 2009 July;64(7):598–603. doi:10.1136/thx.2009.113795.
  • Querol-Ribelles JM, Tenias JM, Grau E, Querol-Borras JM, Climent JL, Gomez E, Martinez I. Plasma d-dimer levels correlate with outcomes in patients with community-acquired pneumonia. Chest. 2004 Oct;126(4):1087–92. doi:10.1378/chest.126.4.1087.
  • Remmelts HH, van de Garde EM, Meijvis SC, Peelen ELGCA, Damoiseaux JGMC, Grutters JC, Biesma DH, Bos WJW, Rijkers GT. Addition of vitamin D status to prognostic scores improves the prediction of outcome in community-acquired pneumonia. Clin Infect Dis. 2012 Dec;55(11):1488–94. doi:10.1093/cid/cis751.
  • Renaud B, Schuetz P, Claessens YE, Labarere J, Albrich W, Mueller B. Proadrenomedullin improves Risk of Early Admission to ICU score for predicting early severe community-acquired pneumonia. Chest. 2012 Dec;142(6):1447–54. doi:10.1378/chest.11-2574.
  • Richards G, Levy H, Laterre PF, Feldman C, Woodward B, Bates BM, Qualy RL. CURB-65, PSI, and APACHE II to assess mortality risk in patients with severe sepsis and community acquired pneumonia in PROWESS. J Intensive Care Med. 2011 Jan-Feb;26(1):34–40. doi:10.1177/0885066610383949.
  • Robins-Browne KL, Cheng AC, Thomas KA, Palmer DJ, Currie BJ, Davis JS. The SMART-COP score performs well for pneumonia risk stratification in Australia’s Tropical Northern Territory: a prospective cohort study. Trop Med Int Health. 2012 July;17(7):914–19. doi:10.1111/j.1365-3156.2012.03006.x.
  • Ronan D, Nathwani D, Davey P, Barlow G. Predicting mortality in patients with community-acquired pneumonia and low CURB-65 scores. Eur J Clin Microbiol Infect Dis. 2010 Sept;29(9):1117–24. doi:10.1007/s10096-010-0970-7.
  • Salluh JIF, Rabello L, Rosolem MM, Soares M, Bozza FA, Verdeal JCR, Mello GW, Castro Faria Neto HC, Lapa e Silva JR, Bozza PT, et al. The impact of coagulation parameters on the outcomes of patients with severe community-acquired pneumonia requiring intensive care unit admission. J Crit Care. 2011 Oct;26(5):496–501. doi:10.1016/j.jcrc.2011.02.001.
  • Schuetz P, Koller M, Christ-Crain M, STEYERBERG E, STOLZ D, MÜLLER C, BUCHER H, Bingisser R, TAMM M, MÜLLER B, et al. Predicting mortality with pneumonia severity scores: importance of model recalibration to local settings. Epidemiol Infect. 2008 Dec;136(12):1628–37. doi:10.1017/s0950268808000435.
  • Schuetz P, Stolz D, Mueller B, Morgenthaler NG, Struck J, Mueller C, Bingisser R, Tamm M, Christ-Crain M. Endothelin-1 precursor peptides correlate with severity of disease and outcome in patients with community acquired pneumonia. BMC Infect Dis. 2008 Feb 28;8(1):22. doi:10.1186/1471-2334-8-22.
  • Schuetz P, Wolbers M, Christ-Crain M, Thomann R, Falconier C, Widmer I, Neidert S, Fricker T, Blum C, Schild U, et al. Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections. Crit Care. 2010;14(3):R106. doi:10.1186/cc9055.
  • Shindo Y, Sato S, Maruyama E, OHASHI T, OGAWA M, IMAIZUMI K, HASEGAWA Y. Comparison of severity scoring systems A-DROP and CURB-65 for community-acquired pneumonia. Respirology (Carlton, Vic). 2008 Sept;13(5):731–35. doi:10.1111/j.1440-1843.2008.01329.x.
  • Siljan WW, Holter JC, Nymo SH, Husebye E, Ueland T, Aukrust P, Mollnes TE, Heggelund L. Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia. Eur J Clin Invest. 2018 Jan;48(1):e12865. doi:10.1111/eci.12865.
  • Song H, Moon HG, Kim SH. Efficacy of quick Sequential Organ Failure Assessment with lactate concentration for predicting mortality in patients with community-acquired pneumonia in the emergency department. Clin Exp Emerg Med. 2019 Mar;6(1):1–8. doi:10.15441/ceem.17.262.
  • Spoorenberg SM, Vestjens SM, Rijkers GT, Meek B, van Moorsel CHM, Grutters JC, Bos WJW. YKL-40, CCL18 and SP-D predict mortality in patients hospitalized with community-acquired pneumonia. Respirology (Carlton, Vic). 2017 Apr;22(3):542–50. doi:10.1111/resp.12924.
  • Talmor D, Jones AE, Rubinson L, Howell MD, Shapiro NI. Simple triage scoring system predicting death and the need for critical care resources for use during epidemics. Crit Care Med. 2007 May;35(5):1251–56. doi:10.1097/01.Ccm.0000262385.95721.Cc.
  • Valencia M, Badia JR, Cavalcanti M, Ferrer M, Agustí C, Angrill J, García E, Mensa J, Niederman MS, Torres A, et al. Pneumonia severity index class v patients with community-acquired pneumonia: characteristics, outcomes, and value of severity scores. Chest. 2007 Aug;132(2):515–22. doi:10.1378/chest.07-0306.
  • Vecchiarino P, Bohannon RW, Ferullo J, Maljanian R. Short-term outcomes and their predictors for patients hospitalized with community-acquired pneumonia. Heart Lung. 2004 Sept-Oct;33(5):301–07. doi:10.1016/j.hrtlng.2004.03.007.
  • Vicco MH, Ferini F, Rodeles L, Scholtus P, Long AK, Musacchio HM. In-hospital mortality risk factors in community acquired pneumonia: evaluation of immunocompetent adult patients without comorbidities. Revista Da Associacao Medica Brasileira (1992). 2015 Mar-Apr;61(2):144–49. doi:10.1590/1806-9282.61.02.144.
  • Wang HL, Hsiao PC, Tsai HT, Yeh CB, Yang SF. Usefulness of plasma YKL-40 in management of community-acquired pneumonia severity in patients. Int J Mol Sci. 2013 Nov 19;14(11):22817–25. doi:10.3390/ijms141122817.
  • Wang X, Jiao J, Wei R, Feng Y, Ma X, Li Y, Du Y. A new method to predict hospital mortality in severe community acquired pneumonia. Eur J Intern Med. 2017 May;40:56–63. doi:10.1016/j.ejim.2017.02.013.
  • Wu HP, Chen CK, Chung K, Jiang BY, Yu TJ, Chuang DY. Plasma transforming growth factor-beta1 level in patients with severe community-acquired pneumonia and association with disease severity. J Formosan Med Assoc = Taiwan Yi Zhi. 2009 Jan;108(1):20–27. doi:10.1016/s0929-6646(09)60028-0.
  • Yang SQ, Qu JX, Wang C, Yu XM, Liu YM, Cao B. Influenza pneumonia among adolescents and adults: a concurrent comparison between influenza A (H1N1) pdm09 and A (H3N2) in the post-pandemic period. Clin Respir J. 2014 Apr;8(2):185–91. doi:10.1111/crj.12056.
  • Yeon Lee S, Cha SI, Seo H, Oh S, Choi K-J, Yoo -S-S, Lee J, Lee S-Y, Kim C-H, Park J-Y, et al. Multimarker prognostication for hospitalized patients with community-acquired pneumonia. Int Med (Tokyo, Japan). 2016;55(8):887–93. doi:10.2169/internalmedicine.55.5764.
  • Yin Q, Liu B, Chen Y, Zhao Y, Li C. Soluble thrombomodulin to evaluate the severity and outcome of community-acquired pneumonia. Inflammation. 2014 Aug;37(4):1271–79. doi:10.1007/s10753-014-9854-9.
  • Zhang ZX, Yong Y, Tan WC, Shen L, Ng HS, Fong KY. Prognostic factors for mortality due to pneumonia among adults from different age groups in Singapore and mortality predictions based on PSI and CURB-65. Singapore Med J. 2018 Apr;59(4):190–98. doi:10.11622/smedj.2017079.
  • Zhou J, To KK, Dong H, Cheng Z-S, Lau CCY, Poon VKM, Fan Y-H, Song Y-Q, Tse H, Chan K-H, et al. A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection. J Infect Dis. 2012 Aug 15;206(4):495–503. doi:10.1093/infdis/jis378.
  • Zhou H, Guo S, Lan T, Ma S, Zhang F, Zhao Z. Risk stratification and prediction value of procalcitonin and clinical severity scores for community-acquired pneumonia in ED. Am J Emerg Med. 2018 Dec;36(12):2155–60. doi:10.1016/j.ajem.2018.03.050.
  • Zhu L, Liu L, Zhang Y, Pu L, Liu J, Li X, Chen Z, Hao Y, Wang B, Han J, et al. High level of neutrophil extracellular traps correlates with poor prognosis of severe influenza a infection. J Infect Dis. 2018 Jan 17;217(3):428–37. doi:10.1093/infdis/jix475.
  • Zimmerman O, Rogowski O, Aviram G, Mizrahi M, Zeltser D, Justo D, Dahan E, Arad R, Touvia O, Tau L, et al. C-reactive protein serum levels as an early predictor of outcome in patients with pandemic H1N1 influenza A virus infection. BMC Infect Dis. 2010 Oct 4;10(1):288. doi:10.1186/1471-2334-10-288.
  • de Jager CP, Wever PC, Gemen EF, Kusters R, van Gageldonk-Lafeber AB, Van Der Poll T, Laheij RJF. The neutrophil-lymphocyte count ratio in patients with community-acquired pneumonia. PloS One. 2012;7(10):e46561. doi:10.1371/journal.pone.0046561.
  • Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985 Oct;13(10):818–29. doi:10.1097/00003246-198510000-00009.
  • Miyashita N, Matsushima T, Oka M, Japanese Respiratory S. The JRS guidelines for the management of community-acquired pneumonia in adults: an update and new recommendations. Int Med (Tokyo, Japan). 2006;45(7):419–28. doi:10.2169/internalmedicine.45.1691.
  • Yanagihara K, Kohno S, Matsusima T. Japanese guidelines for the management of community-acquired pneumonia. Int J Antimicrob Agents. 2001;18(Suppl 1):S45–8. doi:10.1016/s0924-8579(01)00402-2.
  • Pereira JM, Moreno RP, Matos R, Rhodes A, Martin-Loeches I, Cecconi M, Lisboa T, Rello J. Severity assessment tools in ICU patients with 2009 influenza A (H1N1) pneumonia. Clin Microbiol Infect. 2012 Oct;18(10):1040–48. doi:10.1111/j.1469-0691.2011.03736.x.
  • Neill AM, Martin IR, Weir R, Anderson R, Chereshsky A, Epton MJ, Jackson R, Schousboe M, Frampton C, Hutton S, et al. Community acquired pneumonia: aetiology and usefulness of severity criteria on admission. Thorax. 1996 Oct;51(10):1010–16. doi:10.1136/thx.51.10.1010.
  • Qureshi KN, Hodkinson HM. Evaluation of a ten-question mental test in the institutionalized elderly. Age Ageing. 1974 Aug;3(3):152–57. doi:10.1093/ageing/3.3.152.
  • Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, Dowell SF, File TM, Musher DM, Niederman MS, et al. Infectious diseases society of America/American thoracic society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007 Mar 1;44(Suppl 2):S27–72. doi:10.1086/511159.
  • Jones M. NEWSDIG: the national early warning score development and implementation group. Clin Med (Lond). 2012 Dec;12(6):501–03. doi:10.7861/clinmedicine.12-6-501.
  • Wang HL, Tsao SM, Yeh CB, Chou YE, Yang SF. Circulating level of high mobility group box1 predicts the severity of community acquired pneumonia: regulation of inflammatory responses via the cJun Nterminal signaling pathway in macrophages. Mol Med Rep. 2017 Sept;16(3):2361–66. doi:10.3892/mmr.2017.6892.
  • Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, Coley CM, Marrie TJ, Kapoor WN. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med. 1997 Jan 23;336(4):243–50. doi:10.1056/NEJM199701233360402.
  • Ferreira FL, Bota DP, Bross A, Melot C, Vincent JL. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA. 2001 Oct 10;286(14):1754–58. doi:10.1001/jama.286.14.1754.
  • Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the working group on sepsis-related problems of the European society of intensive care med. Intensive Care Med. 1996 July;22(7):707–10. doi:10.1007/BF01709751.
  • Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, Rubenfeld G, Kahn JM, Shankar-Hari M, Singer M, et al. Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016 Feb 23;315(8):762–74. doi:10.1001/jama.2016.0288.
  • Subbe CP, Jishi F, Hibbs RA. The simple clinical score: a tool for benchmarking of emergency admissions in acute internal medicine. Clin Med (Lond). 2010 Aug;10(4):352–57. doi:10.7861/clinmedicine.10-4-352.
  • Kellett J, Deane B. The simple clinical score predicts mortality for 30 days after admission to an acute medical unit. QJM. 2006 Nov;99(11):771–81. doi:10.1093/qjmed/hcl112.
  • Le Gall JR, Loirat P, Alperovitch A, Glaser P, GRANTHIL C, MATHIEU D, MERCIER P, Thomas R, Villers D. A simplified acute physiology score for ICU patients. Crit Care Med. 1984 Nov;12(11):975–77. doi:10.1097/00003246-198411000-00012.
  • Patel MM, York IA, Monto AS, Thompson MG, Fry AM. Immune-mediated attenuation of influenza illness after infection: opportunities and challenges. Lancet Microbe. 2021. doi:10.1016/S2666-5247(21)00180-4.
  • Le Gall JR, Lemeshow S, Saulnier F. A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. JAMA. 1993 Dec 22-29;270(24):2957–63. doi:10.1001/jama.270.24.2957.
  • Charles PG, Wolfe R, Whitby M, Fine M, Fuller A, Stirling R, Wright A, Ramirez J, Christiansen K, Waterer G, et al. SMART-COP: a tool for predicting the need for intensive respiratory or vasopressor support in community-acquired pneumonia. Clin Infect Dis. 2008 Aug 1;47(3):375–84. doi:10.1086/589754.
  • Ferdinands JM, Thompson MG, Blanton L, Spencer S, Grant L, Fry AM. Does influenza vaccination attenuate the severity of breakthrough infections? A narrative review and recommendations for further research. Vaccine. 2021 June 23;39(28):3678–95. doi:10.1016/j.vaccine.2021.05.011.
  • Muthuri SG, Venkatesan S, Myles PR, Leonardi-Bee J, Al Khuwaitir TSA, Al Mamun A, Anovadiya AP, Azziz-Baumgartner E, Báez C, Bassetti M, et al. Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data. Lancet Respir Med. 2014 May;2(5):395–404. doi:10.1016/S2213-2600(14)70041-4.
  • Tenforde MW, Chung J, Smith ER, Talbot HK, Trabue CH, Zimmerman RK, Silveira FP, Gaglani M, Murthy K, Monto AS, et al. Influenza vaccine effectiveness in inpatient and outpatient settings in the United States, 2015-2018. Clin Infect Dis. 2020 Apr 9. doi:10.1093/cid/ciaa407.
  • Feng S, Cowling BJ, Sullivan SG. Influenza vaccine effectiveness by test-negative design - Comparison of inpatient and outpatient settings. Vaccine. 2016 Mar 29;34(14):1672–79. doi:10.1016/j.vaccine.2016.02.039.
  • Venkatesan S, Myles PR, Bolton KJ, Muthuri SG, Al Khuwaitir T, Anovadiya AP, Azziz-Baumgartner E, Bajjou T, Bassetti M, Beovic B. Neuraminidase inhibitors and hospital length of stay: a meta-analysis of individual participant data to determine treatment effectiveness among patients hospitalized with nonfatal 2009 pandemic influenza A(H1N1) virus infection. J Infect Dis. 2020 Jan 14;221(3):356–66. doi:10.1093/infdis/jiz152.
  • Jefferson T, Jones M, Doshi P, Spencer EA, Onakpoya I, Heneghan CJ. Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments. BMJ. 2014 Apr 9;348:g2545. doi:10.1136/bmj.g2545.
  • Patel MM, Glass R, Desai R, Tate JE, Parashar UD. Fulfilling the promise of rotavirus vaccines: how far have we come since licensure? Lancet Infect Dis. 2012 July;12(7):561–70. doi:10.1016/S1473-3099(12)70029-4.
  • Preziosi MP, Halloran ME. Effects of pertussis vaccination on disease: vaccine efficacy in reducing clinical severity. Clin Infect Dis. 2003 Sept 15;37(6):772–79. doi:10.1086/377270.
  • Evans SR, Rubin D, Follmann D, Pennello G, Huskins WC, Powers JH, Schoenfeld D, Chuang-Stein C, Cosgrove SE, Fowler VG, et al. Desirability of outcome ranking (DOOR) and response adjusted for duration of antibiotic risk (RADAR). Clin Infect Dis. 2015 Sept 1;61(5):800–06. doi:10.1093/cid/civ495.
  • Lees C, Godin J, McElhaney JE, McNeil SA, Loeb M, Hatchette TF, LeBlanc J, Bowie W, Boivin G, McGeer A, et al. Frailty hinders recovery from influenza and acute respiratory illness in older adults. J Infect Dis. 2020 July 6;222(3):428–37. doi:10.1093/infdis/jiaa092.
  • Linden D, Guo-Parke H, Coyle PV, Fairley D, McAuley D, Taggart CC, Kidney J. Respiratory viral infection: a potential “missing link” in the pathogenesis of COPD. Eur Respir Rev. 2019 Mar 31;28(151):180063. doi:10.1183/16000617.0063-2018.

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