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Research Article

Chimeric antigens displaying GPR65 extracellular loops on a soluble scaffold enabled the discovery of antibodies, which recognized native receptor

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Article: 2299522 | Received 26 Sep 2023, Accepted 21 Dec 2023, Published online: 07 Jan 2024

References

  • Dougados M, Baeten D. Spondyloarthritis. Lancet. 2011;377(9783):2127–12. doi: 10.1016/S0140-6736(11)60071-8
  • Navarro-Compán V, Sepriano A, El-Zorkany B, et al. Axial spondyloarthritis. Ann Rheum Dis. Ann Rheumatic Dis. 2021;80(12):1511–1521. doi: 10.1136/annrheumdis-2021-221035
  • Lambert RG, Salonen D, Rahman P, et al. Adalimumab significantly reduces both spinal and sacroiliac joint inflammation in patients with ankylosing spondylitis: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2007;56(12):4005–4014. doi: 10.1002/art.23044
  • van der Heijde D, Gensler LS, Deodhar A, et al. Dual neutralisation of interleukin-17A and interleukin-17F with bimekizumab in patients with active ankylosing spondylitis: results from a 48-week phase IIb, randomised, double-blind, placebo-controlled, dose-ranging study. Ann Rheum Dis. 2020;79(5):595–604. doi: 10.1136/annrheumdis-2020-216980
  • Cortes A, et al. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet. 2013;45(7):730–738. doi:10.1038/ng.2667
  • Ellinghaus D, Baurecht H, Esparza-Gordillo J, et al. High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. Nat Genet. 2013;45(7):808–12. doi: 10.1038/ng.2642
  • Choi JW, Lee SY, Choi Y. Identification of a putative G protein-coupled receptor induced during activation-induced apoptosis of T cells. Cell Immunol. 1996;168(1):78–84. doi: 10.1006/cimm.1996.0051
  • Wang JQ, Kon J, Mogi C, et al. TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor. J Biol Chem. 2004;279(44):45626–33. doi: 10.1074/jbc.M406966200
  • Kyaw H, ZENG Z, SU K, et al. Cloning, characterization, and mapping of human homolog of mouse T-cell death-associated gene. DNA Cell Biol. 1998;17(6):493–500. doi: 10.1089/dna.1998.17.493
  • Hauser AS, Attwood MM, Rask-Andersen M, et al. Trends in GPCR drug discovery: new agents, targets and indications. Nat Rev Drug Discov. 2017;16(12):829–842. doi: 10.1038/nrd.2017.178
  • Hutchings CJ. Mini-review: antibody therapeutics targeting G protein-coupled receptors and ion channels. Antib Ther. 2020;3(4):257–264. doi: 10.1093/abt/tbaa023
  • King CT, Gegg CV, Hu SN-Y, et al. Discovery of the migraine prevention therapeutic aimovig (erenumab), the first FDA-Approved antibody against a G-Protein-coupled receptor. ACS Pharmacol Transl Sci. 2019;2(6):485–490. doi: 10.1021/acsptsci.9b00061
  • Niwa R, Shoji-Hosaka E, Sakurada M, et al. Defucosylated chimeric anti-CC chemokine receptor 4 IgG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T-cell leukemia and lymphoma. Cancer Res. 2004;64(6):2127–33. doi: 10.1158/0008-5472.CAN-03-2068
  • Ishida T, Iida S, Akatsuka Y, et al. The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-Cell leukemia/lymphoma. Clin Cancer Res. 2004;10(22):7529–39. doi: 10.1158/1078-0432.CCR-04-0983
  • Correia BE, Bates JT, Loomis RJ, et al. Proof of principle for epitope-focused vaccine design. Nature. 2014;507(7491):201–6. doi: 10.1038/nature12966
  • Chan CE, Lim APC, MacAry PA, et al. The role of phage display in therapeutic antibody discovery. Int Immunol. 2014;26(12):649–657. doi: 10.1093/intimm/dxu082
  • Kumar R, Parray HA, Shrivastava T, et al. Phage display antibody libraries: a robust approach for generation of recombinant human monoclonal antibodies. Int j biol macromol. 2019;135:907–918. doi: 10.1016/j.ijbiomac.2019.06.006
  • Koksal AC, et al. Functional mimetic of the G-protein coupled receptor CXCR4 on a soluble antibody scaffold. Mabs. 2019;11(4):725–734. doi: 10.1080/19420862.2019.1596703
  • Stephenson E, Reynolds G, Botting RA, et al. Single-cell multi-omics analysis of the immune response in COVID-19. Nat Med. 2021;27(5):904–916. doi: 10.1038/s41591-021-01329-2
  • Buccitelli C, Selbach M. mRnas, proteins and the emerging principles of gene expression control. Nat Rev Genet. 2020;21(10):630–644. doi: 10.1038/s41576-020-0258-4
  • Liu Y, Beyer A, Aebersold R. On the dependency of cellular protein levels on mRNA abundance. Cell. 2016;165(3):535–550. doi: 10.1016/j.cell.2016.03.014
  • Zhu C, Dukhovlinova E, Council O, et al. Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies. Nat Commun. 2019;10(1):948. doi: 10.1038/s41467-019-08876-w
  • Marks JD, Hoogenboom HR, Bonnert TP, et al. By-passing immunization. Human antibodies from V-gene libraries displayed on phage. J Mol Biol. 1991;222(3):581–97. doi: 10.1016/0022-2836(91)90498-U