Intravital characterization of tumor cell migration in pancreatic cancer

References

• Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, Hruban RH, Rustgi AK, Chang S, Tuveson DA. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 2005; 7:469-83; PMID:15894267; http://dx.doi.org/10.1016/j.ccr.2005.04.023
   PubMed Web of Science ®Google Scholar
• Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009; 324:1457-61; PMID:19460966; http://dx.doi.org/10.1126/science.1171362
   PubMed Web of Science ®Google Scholar
• Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi AK, Vonderheide RH, et al. EMT and dissemination precede pancreatic tumor formation. Cell 2012; 148:349-61; PMID:22265420; http://dx.doi.org/10.1016/j.cell.2011.11.025
   PubMed Web of Science ®Google Scholar
• Zheng X, Carstens JL, Kim J, Scheible M, Kaye J, Sugimoto H, Wu CC, LeBleu VS, Kalluri R. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature 2015; 527:525-30; PMID:26560028; http://dx.doi.org/10.1038/nature16064
   PubMed Web of Science ®Google Scholar
• Ellenbroek SI, van Rheenen J. Imaging hallmarks of cancer in living mice. Nat Rev Cancer 2014; 14:406-18; PMID:24854083; http://dx.doi.org/10.1038/nrc3742
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID:21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013
   PubMed Web of Science ®Google Scholar
• Beerling E, Ritsma L, Vrisekoop N, Derksen PW, van Rheenen J. Intravital microscopy: new insights into metastasis of tumors. J Cell Sci 2011; 124:299-310; PMID:21242309; http://dx.doi.org/10.1242/jcs.072728
   PubMed Web of Science ®Google Scholar
• Fein MR, Egeblad M. Caught in the act: revealing the metastatic process by live imaging. Dis Model Mech 2013; 6:580-93; PMID:23616077; http://dx.doi.org/10.1242/dmm.009282
   PubMed Web of Science ®Google Scholar
• Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell 2011; 147:275-92; PMID:22000009; http://dx.doi.org/10.1016/j.cell.2011.09.024
   PubMed Web of Science ®Google Scholar
• Sahai E. Mechanisms of cancer cell invasion. Curr Opin Genet Dev 2005; 15:87-96; PMID:15661538; http://dx.doi.org/10.1016/j.gde.2004.12.002
   PubMed Web of Science ®Google Scholar
• Friedl P, Locker J, Sahai E, Segall JE. Classifying collective cancer cell invasion. Nat Cell Biol 2012; 14:777-83; PMID:22854810; http://dx.doi.org/10.1038/ncb2548
   PubMed Web of Science ®Google Scholar
• Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA. Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev 2006; 20:1218-49; PMID:16702400; http://dx.doi.org/10.1101/gad.1415606
   PubMed Web of Science ®Google Scholar
• Rosenblum WI. Histopathologic clues to the pathways of neuronal death following ischemia/hypoxia. J Neurotrauma 1997; 14:313-26; PMID:9199397; http://dx.doi.org/10.1089/neu.1997.14.313
   PubMed Web of Science ®Google Scholar
• Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988; 53:549-54; PMID:2453289; http://dx.doi.org/10.1016/0092-8674(88)90571-5
   PubMed Web of Science ®Google Scholar
• Oosterom I, van Amersfoort M, Szuhai K, Lockley M, Offerhaus JG, Voest E, et al. Gemcitabine-induced invasion of pancreatic ductal adenocarcinoma in an accelerated genetically engineered Kras/P53 mouse model. submitted
   Google Scholar
• Ritsma L, Steller EJ, Ellenbroek SI, Kranenburg O, Borel Rinkes IH, van Rheenen J. Surgical implantation of an abdominal imaging window for intravital microscopy. Nat Protoc 2013; 8:583-94; PMID:23429719; http://dx.doi.org/10.1038/nprot.2013.026
   PubMed Web of Science ®Google Scholar
• Scheele CLGJ, Maynard C, Van Rheenen J. Intravital insights into heterogeneity, metastasis, and therapy response. Trends in Cancer in press
   Google Scholar
• Condeelis J, Singer RH, Segall JE. The great escape: when cancer cells hijack the genes for chemotaxis and motility. Ann Rev Cell Dev Biol 2005; 21:695-718; PMID:16212512; http://dx.doi.org/10.1146/annurev.cellbio.21.122303.120306
   PubMed Web of Science ®Google Scholar
• Beerling E, Seinstra D, de Wit E, Kester L, van der Velden D, Maynard C, Schäfer R, van Diest P, Voest E, van Oudenaarden A, et al. Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity. Cell Rep 2016; 14(10):2281-8; PMID:26947068; http://dx.doi.org/10.1016/j.celrep.2016.02.034
   PubMed Web of Science ®Google Scholar
• Pegtel DM, Ellenbroek SI, Mertens AE, van der Kammen RA, de Rooij J, Collard JG. The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity. Curr Biol 2007; 17:1623-34; PMID:17825562; http://dx.doi.org/10.1016/j.cub.2007.08.035
   PubMed Web of Science ®Google Scholar
• Giampieri S, Manning C, Hooper S, Jones L, Hill CS, Sahai E. Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat Cell biol 2009; 11:1287-96; PMID:19838175; http://dx.doi.org/10.1038/ncb1973
   PubMed Web of Science ®Google Scholar
• Wyckoff JB, Jones JG, Condeelis JS, Segall JE. A critical step in metastasis: in vivo analysis of intravasation at the primary tumor. Cancer Res 2000; 60:2504-11; PMID:10811132
   PubMed Web of Science ®Google Scholar
• Condeelis J, Segall JE. Intravital imaging of cell movement in tumours. Nat Rev Cancer 2003; 3:921-30; PMID:14737122; http://dx.doi.org/10.1038/nrc1231
   PubMed Web of Science ®Google Scholar
• Bzymek R, Horsthemke M, Isfort K, Mohr S, Tjaden K, Muller-Tidow C, Thomann M, Schwerdtle T, Bähler M, Schwab A, et al. Real-time two- and three-dimensional imaging of monocyte motility and navigation on planar surfaces and in collagen matrices: roles of Rho. Sci Rep 2016; 6:25016; PMID:27122054; http://dx.doi.org/10.1038/srep25016
   PubMed Web of Science ®Google Scholar
• Zanier ER, Fumagalli S, Perego C, Pischiutta F, De Simoni MG. Shape descriptors of the “never resting” microglia in three different acute brain injury models in mice. Intensive Care Med Exp 2015; 3:39; PMID:26215806; http://dx.doi.org/10.1186/s40635-015-0039-0
   PubMedGoogle Scholar
• Yu H, Tay CY, Leong WS, Tan SC, Liao K, Tan LP. Mechanical behavior of human mesenchymal stem cells during adipogenic and osteogenic differentiation. Biochem Biophys Res Commun 2010; 393:150-5; PMID:20117089; http://dx.doi.org/10.1016/j.bbrc.2010.01.107
   PubMed Web of Science ®Google Scholar
• Zaman MH, Trapani LM, Sieminski AL, Mackellar D, Gong H, Kamm RD, Wells A, Lauffenburger DA, Matsudaira P. Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proc Natl Acad Sci U S A 2006; 103:10889-94; PMID:16832052; http://dx.doi.org/10.1073/pnas.0604460103
   PubMed Web of Science ®Google Scholar
• Sanz-Moreno V, Gadea G, Ahn J, Paterson H, Marra P, Pinner S, Sahai E, Marshall CJ. Rac activation and inactivation control plasticity of tumor cell movement. Cell 2008; 135:510-23; PMID:18984162; http://dx.doi.org/10.1016/j.cell.2008.09.043
   PubMed Web of Science ®Google Scholar
• Huang YL, Tung CK, Zheng A, Kim BJ, Wu M. Interstitial flows promote amoeboid over mesenchymal motility of breast cancer cells revealed by a three dimensional microfluidic model. Integr Biol 2015; 7:1402-11; PMID:26235230; http://dx.doi.org/10.1039/C5IB00115C
   PubMedGoogle Scholar
• Wolf K, Mazo I, Leung H, Engelke K, von Andrian UH, Deryugina EI, Strongin AY, Bröcker EB, Friedl P. Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol 2003; 160:267-77; PMID:12527751; http://dx.doi.org/10.1083/jcb.200209006
   PubMed Web of Science ®Google Scholar
• Friedl P, Hegerfeldt Y, Tusch M. Collective cell migration in morphogenesis and cancer. Int J Dev Biol 2004; 48:441-9; PMID:15349818; http://dx.doi.org/10.1387/ijdb.041821pf
   PubMed Web of Science ®Google Scholar
• Hirata E, Park D, Sahai E. Retrograde flow of cadherins in collective cell migration. Nat Cell Biol 2014; 16:621-3; PMID:24981633; http://dx.doi.org/10.1038/ncb2995
   PubMed Web of Science ®Google Scholar
• Wormann SM, Song L, Ai J, Diakopoulos KN, Gorgulu K, Ruess D, Campbell A, Doglioni C, Jodrell D, Neesse A, et al. Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and is Associated With Patient Survival. Gastroenterology 2016; 151:180-93.e12; http://dx.doi.org/10.1053/j.gastro.2016.03.010
   Web of Science ®Google Scholar
• Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 2012; 21:418-29; PMID:22439937; http://dx.doi.org/10.1016/j.ccr.2012.01.007
   PubMed Web of Science ®Google Scholar