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Brief Report

Unfolded protein response suppression potentiates LPS-induced barrier dysfunction and inflammation in bovine pulmonary artery endothelial cells

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Article: 2232245 | Received 22 Apr 2023, Accepted 27 Jun 2023, Published online: 12 Jul 2023

References

  • Claesson-Welsh L, Dejana E, McDonald DM. Permeability of the endothelial barrier: identifying and reconciling controversies. Trends Mol Med. 2021;27(4):1–6. doi:10.1016/j.molmed.2020.11.006.
  • Sukriti S, Tauseef M, Yazbeck P, Mehta D. Mechanisms regulating endothelial permeability. Pulm Circ. 2014;4(4):535–551. doi:10.1086/677356.
  • Komarova Y, Malik AB. Regulation of endothelial permeability via paracellular and transcellular transport pathways. Annu Rev Physiol. 2010;72(1):463–493. doi:10.1146/annurev-physiol-021909-135833.
  • Barabutis N. Unfolded protein response in the COVID-19 context. Aging Health Res. 2021;1(1):100001. doi:10.1016/j.ahr.2020.100001.
  • Akhter MS, Uddin MA, Kubra K-T, Barabutis N. Autophagy, unfolded protein response and lung disease. Curr Res Cell Biol. 2020;1:1. doi:10.1016/j.crcbio.2020.100003.
  • Barabutis N. Unfolded protein response supports endothelial barrier function. Biochimie. 2019;165:206–209. doi:10.1016/j.biochi.2019.08.007.
  • Barabutis N. Unfolded protein response in acute respiratory distress syndrome. Lung. 2019;197(6):827–828. doi:10.1007/s00408-019-00279-4.
  • Barabutis N. Unfolded protein response: a regulator of the endothelial barrier. Endocr Metab Sci. 2021;3:3. doi:10.1016/j.endmts.2021.100092.
  • Kubra KT, Uddin MA, Barabutis N. Tunicamycin protects against LPS-Induced lung injury. Pharmaceuticals (Basel). 2022;15(2):134. doi:10.3390/ph15020134.
  • Xia T, Liao Y-Q, Li L, Sun L-Y, Ding N-S, Wu Y-L, Lu K-L. 4-PBA attenuates fat accumulation in cultured spotted seabass fed high-fat-diet via regulating endoplasmic reticulum stress. Metabolites. 2022;12(12):1197. doi:10.3390/metabo12121197.
  • Dong Y, Li L, Xia T, Wang L, Xiao L, Ding N, Wu Y, Lu K. Oxidative stress can be attenuated by 4-PBA caused by high-fat or ammonia nitrogen in cultured spotted seabass: the mechanism is related to endoplasmic reticulum stress. Antioxid (Basel). 2022;11(7):1276. doi:10.3390/antiox11071276.
  • Rubenstein RC, Zeitlin PL. Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR. Am J Physiol Cell Physiol. 2000;278(2):C259–67. doi:10.1152/ajpcell.2000.278.2.C259.
  • Kubra KT, Akhter MS, Saini Y, Kousoulas KG, Barabutis N. Activating transcription factor 6 protects against endothelial barrier dysfunction. Cell Signal. 2022;99:110432. doi:10.1016/j.cellsig.2022.110432.
  • Kubra KT, Barabutis N. P53 in endothelial function and unfolded protein response regulation. Cell Biol Int. 2022;46(12):2257–2261. doi:10.1002/cbin.11891.
  • Barabutis N, Verin A, Catravas JD. Regulation of pulmonary endothelial barrier function by kinases. Am J Physiol Lung Cell Mol Physiol. 2016;311(5):L832–L845. doi:10.1152/ajplung.00233.2016.
  • Fang M, Zhong W-H, Song W-L, Deng Y-Y, Yang D-M, Xiong B, Zeng H-K, Wang H-D. Ulinastatin ameliorates pulmonary capillary endothelial permeability induced by sepsis through protection of tight junctions via inhibition of TNF-α and related pathways. Front Pharmacol. 2018;9:823. doi:10.3389/fphar.2018.00823.
  • Barabutis N, Akhter MS, Kubra KT, Jackson K. Growth Hormone-Releasing Hormone in Endothelial Inflammation. Endocrinology. 2022;164(2):bqac209. doi:10.1210/endocr/bqac209.
  • Barabutis N. Unfolded protein response in lung health and disease. Front Med. 2020;7:344. doi:10.3389/fmed.2020.00344.
  • Barabutis N. Heat shock protein 90 inhibition in the inflamed lungs. Cell Stress Chaperones. 2020;25(2):195–197. doi:10.1007/s12192-020-01069-1.
  • Barabutis N, Akhter MS, Kubra K-T, Jackson K. Growth hormone–releasing hormone in endothelial inflammation. Endocrinology. 2022;164(2). doi:10.1210/endocr/bqac209.
  • Barabutis N, Kubra KT, Akhter MS. Growth hormone-releasing hormone antagonists protect against hydrochloric acid-induced endothelial injury in vitro. Environ Toxicol Pharmacol. 2023;99:104113. doi:10.1016/j.etap.2023.104113.
  • Akhter MS, Uddin MA, Kubra K-T, Barabutis N. Elucidation of the molecular pathways involved in the protective effects of AUY-922 in LPS-Induced inflammation in mouse lungs. Pharmaceuticals (Basel). 2021;14(6):522. doi:10.3390/ph14060522.
  • Akhter MS, Uddin MA, Schally AV, Kubra K-T, Barabutis N. Involvement of the unfolded protein response in the protective effects of growth hormone releasing hormone antagonists in the lungs. J Cell Commun Signal. 2021;15(1):125–129. doi:10.1007/s12079-020-00593-0.
  • Uddin MA, Kubra K-T, Sonju JJ, Akhter MS, Seetharama J, Barabutis N. Effects of heat shock protein 90 inhibition in the lungs. Med Drug Discov. 2020;6:6. doi:10.1016/j.medidd.2020.100046.
  • Barabutis N. Unfolded protein response in endothelial injury. Cell Cycle. 2022;21(19):2009–2012. doi:10.1080/15384101.2022.2082024.
  • Barabutis N, Schally AV. Growth hormone-releasing hormone: extrapituitary effects in physiology and pathology. Cell Cycle. 2010;9(20):4110–4116. doi:10.4161/cc.9.20.13787.
  • Uddin MA, Akhter MS, Singh SS, Kubra K-T, Schally AV, Jois S, Barabutis N. GHRH antagonists support lung endothelial barrier function. Tissue Barriers. 2019;7(4):1669989. doi:10.1080/21688370.2019.1669989.
  • Barabutis N, Akhter MS, Uddin MA, Kubra K-T, Schally AV. GHRH antagonists protect against hydrogen peroxide-induced breakdown of brain microvascular endothelium integrity. Horm Metab Res. 2020;52(5):336–339. doi:10.1055/a-1149-9347.
  • Kubra KT, Akhter MS, Apperley K, Barabutis N. Growth hormone-releasing hormone antagonist JV-1-36 suppresses reactive oxygen species generation in A549 lung cancer cells. Endocrines. 2022;3(4):813–820. doi:10.3390/endocrines3040067.
  • Du L, Ho BM, Zhou L, Yip YWY, He JN, Wei Y, Tham CC, Chan SO, Schally AV, Pang CP, et al. Growth hormone releasing hormone signaling promotes Th17 cell differentiation and autoimmune inflammation. Nat Commun. 2023;14(1):3298. doi:10.1038/s41467-023-39023-1.
  • Zhang C, Cai R, Lazerson A, Delcroix G, Wangpaichitr M, Mirsaeidi M, Griswold AJ, Schally AV, Jackson RM. Growth hormone-releasing hormone receptor antagonist modulates lung inflammation and fibrosis due to bleomycin. Lung. 2019;197(5):541–549. doi:10.1007/s00408-019-00257-w.
  • Akhter MS, Kubra K-T, Uddin MA, Jois S, Barabutis N. An antagonist of growth hormone-releasing hormone protects against LPS-induced increase of bronchoalveolar lavage fluid protein concentration. Inflamm Res. 2022;71(2):183–185. doi:10.1007/s00011-021-01531-5.
  • Kubra KT, Uddin MA, Akhter MS, Barabutis N. Luminespib counteracts the Kifunensine-induced lung endothelial barrier dysfunction. Curr Res Toxicol. 2020;1:111–115. doi:10.1016/j.crtox.2020.09.003.
  • Maehana T, Tanaka T, Hashimoto K, Kobayashi K, Kitamura H, Masumori N. Heat shock protein 90 is a new potential target of anti-rejection therapy in allotransplantation. Cell Stress Chaperones. 2022;27(4):337–351. doi:10.1007/s12192-022-01272-2.
  • Kubra KT, Barabutis N. Brefeldin a and kifunensine modulate LPS-induced lung endothelial hyperpermeability in human and bovine cells. Am J Physiol Cell Physiol. 2021;321(2):C214–C220. doi:10.1152/ajpcell.00142.2021.
  • Akhter MS, Kubra K-T, Uddin MA, Barabutis N. Kifunensine compromises lung endothelial barrier function. Microvasc Res. 2020;132:104051. doi:10.1016/j.mvr.2020.104051.
  • Barabutis N. P53 in RhoA regulation. Cytoskeleton (Hoboken). 2020;77(5–6):197–201. doi:10.1002/cm.21604.
  • Barabutis N, Dimitropoulou C, Birmpas C, Joshi A, Thangjam G, Catravas JD. P53 protects against LPS-induced lung endothelial barrier dysfunction. Am J Physiol Lung Cell Mol Physiol. 2015;308(8):L776–87. doi:10.1152/ajplung.00334.2014.
  • Barabutis N, Dimitropoulou C, Gregory B, Catravas JD. Wild-type p53 enhances endothelial barrier function by mediating RAC1 signalling and RhoA inhibition. J Cell Mol Med. 2018;22(3):1792–1804. doi:10.1111/jcmm.13460.
  • Pham TH, Park H-M, Kim J, Hong JT, Yoon D-Y. STAT3 and p53: dual Target for Cancer Therapy. Biomedicines. 2020;8(12):637. doi:10.3390/biomedicines8120637.
  • Liu X, Kwak D, Lu Z, Xu X, Fassett J, Wang H, Wei Y, Cavener DR, Hu X, Hall J, et al. Endoplasmic reticulum stress sensor protein kinase R–Like endoplasmic reticulum kinase (PERK) protects against pressure overload–induced heart failure and lung remodeling. Hypertension. 2014;64(4):738–744. doi:10.1161/HYPERTENSIONAHA.114.03811.
  • Leonard A, Paton AW, El-Quadi M, Paton JC, Fazal F. Preconditioning with endoplasmic reticulum stress ameliorates endothelial cell inflammation. PLoS One. 2014;9(10):e110949. doi:10.1371/journal.pone.0110949.