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Coronaviruses

Genetic diversity and molecular epidemiology of Middle East Respiratory Syndrome Coronavirus in dromedaries in Ethiopia, 2017–2020

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Article: e2164218 | Received 28 Sep 2022, Accepted 28 Dec 2022, Published online: 27 Jan 2023

References

  • Zaki AM, van Boheemen S, Bestebroer TM, et al. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012 Nov 8;367(19):1814–1820.
  • WHO. MERS Situation Update| June 2022; 2022.
  • Azhar EI, El-Kafrawy SA, Farraj SA, et al. Evidence for camel-to-human transmission of MERS coronavirus. N Engl J Med. 2014 Jun 26;370(26):2499–2505.
  • https://www.fao.org/statistics/eni [Internet]; 2020.
  • Sikkema RS, Farag E, Islam M, et al. Global status of Middle East respiratory syndrome coronavirus in dromedary camels: a systematic review. Epidemiol Infect. 2019 Jan;147:e84.
  • Muller MA, Corman VM, Jores J, et al. MERS coronavirus neutralizing antibodies in camels, Eastern Africa, 1983-1997. Emerg Infect Dis. 2014 Dec;20(12):2093–2095.
  • Miguel E, Chevalier V, Ayelet G, et al. Risk factors for MERS coronavirus infection in dromedary camels in Burkina Faso, Ethiopia, and Morocco, 2015. Euro Surveill. 2017 Mar 30;22(13).
  • Ali M, El-Shesheny R, Kandeil A, et al. Cross-sectional surveillance of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels and other mammals in Egypt, August 2015 to January 2016. Euro Surveill. 2017 Mar 16;22(11).
  • Hemida MG, Chu DK, Poon LL, et al. MERS coronavirus in dromedary camel herd, Saudi Arabia. Emerg Infect Dis. 2014 Jul;20(7):1231–1234.
  • Ki M. MERS outbreak in Korea: hospital-to-hospital transmission. Epidemiol Health. 2015;2015(37):e2015033.
  • Korea Centers for Disease C, Prevention. Middle East Respiratory Syndrome Coronavirus Outbreak in the Republic of Korea. (2015). Osong Public Health Res Perspect. 2015 Aug;6(4):269–278.
  • Balkhy HH, Alenazi TH, Alshamrani MM, et al. Notes from the field: nosocomial outbreak of Middle East Respiratory Syndrome in a large tertiary care hospital–Riyadh, Saudi Arabia, 2015. MMWR Morb Mortal Wkly Rep. 2016 Feb 19;65(6):163–164.
  • Chu DKW, Hui KPY, Perera R, et al. MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3144–3149.
  • Zhou Z, Hui KPY, So RTY, et al. Phenotypic and genetic characterization of MERS coronaviruses from Africa to understand their zoonotic potential. Proc Natl Acad Sci USA. 2021 Jun 22;118(25): e2103984118.
  • Liljander A, Meyer B, Jores J, et al. MERS-CoV antibodies in humans, Africa, 2013-2014. Emerg Infect Dis. 2016 Jun;22(6):1086–1089.
  • Farag E, Sikkema RS, Mohamedani AA, et al. MERS-CoV in camels but not camel handlers, Sudan, 2015 and 2017. Emerg Infect Dis. 2019 Dec;25(12):2333–2335.
  • So RT, Perera RA, Oladipo JO, et al. Lack of serological evidence of Middle East respiratory syndrome coronavirus infection in virus exposed camel abattoir workers in Nigeria, 2016. Eurosurveillance 2018;23(32):1800175.
  • Alshukairi AN, Zheng J, Zhao J, et al. High prevalence of MERS-CoV infection in camel workers in Saudi Arabia. mBio. 2018 Oct 30;9(5): e01985-18.
  • Muller MA, Meyer B, Corman VM, et al. Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study. Lancet Infect Dis. 2015 May;15(5):559–564.
  • Choe PG, Perera R, Park WB, et al. MERS-CoV antibody responses 1 year after symptom onset, South Korea, 2015. Emerg Infect Dis. 2017 Jul;23(7):1079–1084.
  • Mok CKP, Zhu A, Zhao J, et al. T-cell responses to MERS coronavirus infection in people with occupational exposure to dromedary camels in Nigeria: an observational cohort study. Lancet Infect Dis. 2021 Mar;21(3):385–395.
  • Munyua PM, Ngere I, Hunsperger E, et al. Low-level Middle East Respiratory Syndrome Coronavirus among Camel Handlers, Kenya, 2019. Emerg Infect Dis. 2021;27(4):1201–1205.
  • Ngere I, Hunsperger EA, Tong S, et al. Outbreak of Middle East Respiratory Syndrome Coronavirus in camels and probable spillover infection to humans in Kenya. Viruses. 2022 Aug 9;14(8):1743.
  • WHO. Laboratory testing for Middle East Respiratory Syndrome Coronavirus.
  • Corman VM, Eckerle I, Bleicker T, et al. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Euro Surveill. 2012 Sep 27;17(39):20285.
  • Hemida MG, Chu DKW, Chor YY, et al. Phylogenetic analysis of MERS-CoV in a Camel Abattoir, Saudi Arabia, 2016–2018. Emerg Infect Dis. 2020 Dec;26(12):3089–3091.
  • Ithete NL, Stoffberg S, Corman VM, et al. Close relative of human Middle East respiratory syndrome coronavirus in bat, South Africa. Emerg Infect Dis. 2013 Oct;19(10):1697–1699.
  • El-Kafrawy SA, Corman VM, Tolah AM, et al. Enzootic patterns of Middle East respiratory syndrome coronavirus in imported African and local Arabian dromedary camels: a prospective genomic study. Lancet Planet Health. 2019 Dec;3(12):e521–e528.
  • Shirato K, Melaku SK, Kawachi K, et al. Middle East Respiratory Syndrome Coronavirus in dromedaries in Ethiopia is antigenically different from the Middle East isolate EMC. Front Microbiol. 2019;10:1326.
  • MERS coronavirus database [Internet]. (2022). Available from: https://www.ncbi.nlm.nih.gov/genomes/VirusVariation/Database/nph-select.cgi?cmd = database&taxid = 1335626.
  • Lamers MM, Raj VS, Shafei M, et al. Deletion variants of Middle East respiratory syndrome Coronavirus from Humans, Jordan, 2015. Emerg Infect Dis. 2016 Apr;22(4):716–719.
  • Faye B. Camel meat and meat products 2013.
  • Adney DR, van Doremalen N, Brown VR, et al. Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels. Emerg Infect Dis. 2014 Dec;20(12):1999–2005.
  • Oudshoorn D, Rijs K, Limpens R, et al. Expression and cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 polyprotein induce the formation of double-membrane vesicles that mimic those associated with Coronaviral RNA replication. mBio. 2017 Nov 21;8(6): e01658-17.
  • Yang X, Chen X, Bian G, et al. Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease. J Gen Virol. 2014 Mar;95(Pt 3):614–626.
  • Lei J, Kusov Y, Hilgenfeld R. Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein. Antiviral Res. 2018 Jan;149:58–74.
  • Freundt EC, Yu L, Goldsmith CS, et al. The open reading frame 3a protein of severe acute respiratory syndrome-associated coronavirus promotes membrane rearrangement and cell death. J Virol. 2010 Jan;84(2):1097–1109.
  • Ren Y, Shu T, Wu D, et al. The ORF3a protein of SARS-CoV-2 induces apoptosis in cells. Cell Mol Immunol. 2020 Aug;17(8):881–883.
  • Zhou Y, Zheng R, Liu S, et al. Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation. J Biol Chem. 2022 Feb;298(2):101584.
  • Menachery VD, Mitchell HD, Cockrell AS, et al. MERS-CoV accessory ORFs play key role for infection and pathogenesis. mBio. 2017 Aug 22;8(4): e00665-17.
  • McBride R, van Zyl M, Fielding BC. The coronavirus nucleocapsid is a multifunctional protein. Viruses. 2014 Aug 7;6(8):2991–3018.
  • Chang CK, Hou MH, Chang CF, et al. The SARS coronavirus nucleocapsid protein–forms and functions. Antiviral Res. 2014 Mar;103:39–50.
  • Szelazek B, Kabala W, Kus K, et al. Structural characterization of human coronavirus NL63 N protein. J Virol. 2017 Jun 1;91(11): e02503-16.
  • Chang CY, Liu HM, Chang MF, et al. Middle East Respiratory Syndrome Coronavirus nucleocapsid protein suppresses type I and type III interferon induction by targeting RIG-I signaling. J Virol. 2020 Jun 16;94(13): e00099-20.
  • Zhu L, Gao T, Fu Y, et al. The MERS-CoV N protein regulates host cytokinesis and protein translation via interaction with EF1A. Front Microbiol. 2021;12:551602.
  • Guan Y, Zheng BJ, He YQ, et al. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science. 2003 Oct 10;302(5643):276–288.
  • Sabir JS, Lam TT, Ahmed MM, et al. Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia. Science. 2016 Jan 1;351(6268):81–84.