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Research Article

Substitution of gp120 C4 region compensates for V3 loss-of-fitness mutations in HIV-1 CRF01_AE co-receptor switching

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Article: e2169196 | Received 29 Aug 2022, Accepted 11 Jan 2023, Published online: 28 Feb 2023

References

  • Orloff GM, Orloff SL, Kennedy MS, et al. Penetration of CD4 T cells by HIV-1. The CD4 receptor does not internalize with HIV, and CD4-related signal transduction events are not required for entry. J Immunol (Baltimore, MD: 1950). 1991;146(8):2578–2587. Epub 1991/04/15. PubMed PMID: 1673142.
  • Hartley O, Klasse PJ, Sattentau QJ, et al. V3: HIV's switch-hitter. AIDS Res Hum Retroviruses. 2005;21(2):171–189. Epub 2005/02/24. doi:10.1089/aid.2005.21.171. PubMed PMID: 15725757.
  • Hwang SS, Boyle TJ, Lyerly HK, et al. Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. Science (New York, NY). 1991;253(5015):71–74. Epub 1991/07/05. doi:10.1126/science.1905842. PubMed PMID: 1905842.
  • Rizzuto CD, Wyatt R, Hernández-Ramos N, et al. A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. Science (New York, NY). 1998;280(5371):1949–1953. Epub 1998/06/25. doi:10.1126/science.280.5371.1949. PubMed PMID: 9632396.
  • Bleul CC, Farzan M, Choe H, et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature. 1996;382(6594):829–833. Epub 1996/08/29. doi:10.1038/382829a0. PubMed PMID: 8752280.
  • Connor RI, Sheridan KE, Ceradini D, et al. Change in coreceptor use correlates with disease progression in HIV-1–infected individuals. J Exp Med 1997;185(4):621–628. Epub 1997/02/17. doi:10.1084/jem.185.4.621. PubMed PMID: 9034141; PubMed Central PMCID: PMCPmc2196142.
  • Coakley E, Petropoulos CJ, Whitcomb JM. Assessing chemokine co-receptor usage in HIV. Curr Opin Infect Dis. 2005;18(1):9–15. doi:10.1097/00001432-200502000-00003. PubMed PMID: 15647694.
  • Bentwich Z, Maartens G, Torten D, et al. Concurrent infections and HIV pathogenesis. AIDS (London, England). 2000;14(14):2071–2081. Epub 2000/11/04. doi:10.1097/00002030-200009290-00002. PubMed PMID: 11061647.
  • Shioda T, Levy JA, Cheng-Mayer C. Small amino acid changes in the V3 hypervariable region of gp120 can affect the T-cell-line and macrophage tropism of human immunodeficiency virus type 1. Proc Natl Acad Sci USA 1992;89(20):9434–9438. Epub 1992/10/15. doi:10.1073/pnas.89.20.9434. PubMed PMID: 1409653; PubMed Central PMCID: PMCPmc50146.
  • Suphaphiphat P, Essex M, Lee TH. Mutations in the V3 stem versus the V3 crown and C4 region have different effects on the binding and fusion steps of human immunodeficiency virus type 1 gp120 interaction with the CCR5 coreceptor. Virology. 2007;360(1):182–190. doi:10.1016/j.virol.2006.10.019. PubMed PMID: 17101166; PubMed Central PMCID: PMC2014721.
  • Korber B, Gnanakaran S. The implications of patterns in HIV diversity for neutralizing antibody induction and susceptibility. Curr Opin HIV AIDS. 2009;4(5):408–417. doi:10.1097/COH.0b013e32832f129e. PubMed PMID: 20048705; PubMed Central PMCID: PMC6426297.
  • Pastore C, Ramos A, Mosier DE. Intrinsic obstacles to human immunodeficiency virus type 1 coreceptor switching. J Virol 2004;78(14):7565–7574. Epub 2004/06/29. doi: 10.1128/jvi.78.14.7565-7574.2004. PubMed PMID: 15220431; PubMed Central PMCID: PMCPmc434079.
  • Pastore C, Nedellec R, Ramos A, et al. Human immunodeficiency virus type 1 coreceptor switching: V1/V2 gain-of-fitness mutations compensate for V3 loss-of-fitness mutations. J Virol 2006;80(2):750–758. doi: 10.1128/JVI.80.2.750-758.2006. PubMed PMID: 16378977; PubMed Central PMCID: PMC1346864.
  • Moore JP, Thali M, Jameson BA, et al. Immunochemical analysis of the gp120 surface glycoprotein of human immunodeficiency virus type 1: probing the structure of the C4 and V4 domains and the interaction of the C4 domain with the V3 loop. J Virol 1993;67(8):4785–4796. Epub 1993/08/01. doi: 10.1128/jvi.67.8.4785-4796.1993. PubMed PMID: 7687303; PubMed Central PMCID: PMCPmc237865.
  • Carrillo A, Ratner L. Human immunodeficiency virus type 1 tropism for T-lymphoid cell lines: role of the V3 loop and C4 envelope determinants. J Virol 1996;70(2):1301–1309. Epub 1996/02/01. doi: 10.1128/jvi.70.2.1301-1309.1996. PubMed PMID: 8551600; PubMed Central PMCID: PMCPMC189948.
  • Wyatt R, Thali M, Tilley S, et al. Relationship of the human immunodeficiency virus type 1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved region. J Virol 1992;66(12):6997–7004. Epub 1992/12/01. doi:10.1128/jvi.66.12.6997-7004.1992. PubMed PMID: 1279195; PubMed Central PMCID: PMCPmc240347.
  • Lasky LA, Nakamura G, Smith DH, et al. Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor. Cell. 1987;50(6):975–985. Epub 1987/09/11. doi:10.1016/0092-8674(87)90524-1. PubMed PMID: 2441877.
  • Zheng Y, Han GW, Abagyan R, et al. Structure of CC chemokine receptor 5 with a potent chemokine antagonist reveals mechanisms of chemokine recognition and molecular mimicry by HIV. Immunity. 2017;46(6):1005–1017 e5. doi: 10.1016/j.immuni.2017.05.002. PubMed PMID: 28636951; PubMed Central PMCID: PMC5572563.
  • Doi N, Yokoyama M, Koma T, et al. Concomitant enhancement of HIV-1 replication potential and neutralization-resistance in concert With three adaptive mutations in Env V1/C2/C4 domains. Front Microbiol. 2019;10:2. doi:10.3389/fmicb.2019.00002. PubMed PMID: 30705669; PubMed Central PMCID: PMC6344430.
  • Moseri A, Biron Z, Arshava B, et al. The C4 region as a target for HIV entry inhibitors - NMR mapping of the interacting segments of T20 and gp120. FEBS J 2015;282(24):4643–4657. Epub 2015/10/04. doi:10.1111/febs.13541. PubMed PMID: 26432362; PubMed Central PMCID: PMCPmc4715528.
  • Li X, Xue Y, Zhou L, et al. Evidence that HIV-1 CRF01_AE Is associated with Low CD4+T cell count and CXCR4 Co-receptor usage in recently infected young Men Who have Sex with Men (MSM) in Shanghai, china. PloS one. 2014;9(2):e89462. Epub 2014/03/04. doi:10.1371/journal.pone.0089462. PubMed PMID: 24586795; PubMed Central PMCID: PMCPmc3931781.
  • Chu M, Zhang W, Zhang X, et al. HIV-1 CRF01_AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China. Sci Rep. 2017;7(1):1570. Epub 2017/05/10. doi:10.1038/s41598-017-01858-2. PubMed PMID: 28484257; PubMed Central PMCID: PMCPmc5431509.
  • Song H, Ou W, Feng Y, et al. Disparate impact on CD4 T cell count by two distinct HIV-1 phylogenetic clusters from the same clade. Proc Natl Acad Sci USA 2019;116(1):239–244. doi:10.1073/pnas.1814714116. PubMed PMID: 30559208; PubMed Central PMCID: PMC6320496.
  • Mosier DE. Virus and target cell evolution in human immunodeficiency virus type 1 infection. Immunol Res 2000;21(2-3):253–258. Epub 2000/06/14. doi:10.1385/IR:21:2-3:253. PubMed PMID: 10852125.
  • Scarlatti G, Tresoldi E, Björndal A, et al. In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression. Nat Med 1997;3(11):1259–1265. Epub 1997/11/14. doi:10.1038/nm1197-1259. PubMed PMID: 9359702.
  • Vodros D, Tscherning-Casper C, Navea L, et al. Quantitative evaluation of HIV-1 coreceptor Use in the GHOST(3) cell assay. Virology. 2001;291(1):1–11. doi: 10.1006/viro.2001.1163. PubMed PMID: 11878871.
  • Shaik MM, Peng H, Lu J, et al. Structural basis of coreceptor recognition by HIV-1 envelope spike. Nature. 2019;565(7739):318–323. doi:10.1038/s41586-018-0804-9. PubMed PMID: 30542158; PubMed Central PMCID: PMC6391877.
  • Foda M, Harada S, Maeda Y. Role of V3 independent domains on a dualtropic human immunodeficiency virus type 1 (HIV-1) envelope gp120 in CCR5 coreceptor utilization and viral infectivity. Microbiol Immunol 2001;45(7):521–530. Epub 2001/09/01. doi:10.1111/j.1348-0421.2001.tb02653.x. PubMed PMID: 11529558.
  • Labrosse B, Treboute C, Brelot A, et al. Cooperation of the V1/V2 and V3 domains of human immunodeficiency virus type 1 gp120 for interaction with the CXCR4 receptor. J Virol 2001;75(12):5457–5464. doi: 10.1128/JVI.75.12.5457-5464.2001. PubMed PMID: 11356952; PubMed Central PMCID: PMC114257.
  • Keller R, Peden K, Paulous S, et al. Amino acid changes in the fourth conserved region of human immunodeficiency virus type 2 strain HIV-2ROD envelope glycoprotein modulate fusion. J Virol 1993;67(10):6253–6258. Epub 1993/10/01. doi: 10.1128/jvi.67.10.6253-6258.1993. PubMed PMID: 8371358; PubMed Central PMCID: PMCPmc238048.
  • Suphaphiphat P, Thitithanyanont A, Paca-Uccaralertkun S, et al. Effect of amino acid substitution of the V3 and bridging sheet residues in human immunodeficiency virus type 1 subtype C gp120 on CCR5 utilization. J Virol 2003;77(6):3832–3837. doi: 10.1128/jvi.77.6.3832-3837.2003. PubMed PMID: 12610158; PubMed Central PMCID: PMC149532.
  • Huang CC, Lam SN, Acharya P, et al. Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4. Science (New York, NY). 2007;317(5846):1930–1934. Epub 2007/09/29. doi:10.1126/science.1145373. PubMed PMID: 17901336; PubMed Central PMCID: PMCPmc2278242.
  • Yamaguchi-Kabata Y. [Sequence variation of HIV and bioinformatics]. Uirusu. 2004;54(1):33–38. Epub 2004/09/29. doi:10.2222/jsv.54.33. PubMed PMID: 15449902.
  • Cashin K, Sterjovski J, Harvey KL, et al. Covariance of charged amino acids at positions 322 and 440 of HIV-1 Env contributes to coreceptor specificity of subtype B viruses, and can be used to improve the performance of V3 sequence-based coreceptor usage prediction algorithms. PLoS one. 2014;9(10):e109771. doi:10.1371/journal.pone.0109771. PubMed PMID: 25313689; PubMed Central PMCID: PMC4196930.
  • Du Y, Wu E, Gao X, et al. Evolution of multiple domains of the HIV-1 envelope glycoprotein during coreceptor switch with CCR5 antagonist therapy. Microbiol Spectr. 2022;10(4):e0072522. doi:10.1128/spectrum.00725-22. PubMed PMID: 35727047; PubMed Central PMCID: PMC9431240.
  • Zhang J, Gao X, Martin J, et al. Evolution of coreceptor utilization to escape CCR5 antagonist therapy. Virology. 2016;494:198–214. doi:10.1016/j.virol.2016.04.010. PubMed PMID: 27128349; PubMed Central PMCID: PMC4913893.
  • Kwong PD, Wyatt R, Robinson J, et al. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature. 1998;393(6686):705–759. Epub 1998/06/26. doi: 10.1038/31405. PubMed PMID: 9641677; PubMed Central PMCID: PMCPmc5629912.
  • Nakamura GR, Byrn R, Wilkes DM, et al. Strain specificity and binding affinity requirements of neutralizing monoclonal antibodies to the C4 domain of gp120 from human immunodeficiency virus type 1. J Virol. 1993;67(10):6179–6191. Epub 1993/10/01. doi: 10.1128/jvi.67.10.6179-6191.1993. PubMed PMID: 7690420; PubMed Central PMCID: PMCPmc238040.