1,223
Views
0
CrossRef citations to date
0
Altmetric
Ebola

RNA binding motif 4 inhibits the replication of ebolavirus by directly targeting 3′-leader region of genomic RNA

, , , , , , , , , , , , , & show all
Article: 2300762 | Received 29 Sep 2023, Accepted 26 Dec 2023, Published online: 07 Jan 2024

References

  • Di Paola N, Sanchez-Lockhart M, Zeng X, et al. Viral genomics in Ebola virus research. Nat Rev Microbiol. 2020;18(7):365–378. doi:10.1038/s41579-020-0354-7
  • Malvy D, McElroy AK, de Clerck H, et al. Ebola virus disease. Lancet. 2019;393(10174):936–948. doi:10.1016/S0140-6736(18)33132-5
  • Jacob ST, Crozier I, Fischer WA, 2nd, et al. Ebola virus disease. Nat Rev Dis Primers. 2020;6(1):13. doi:10.1038/s41572-020-0147-3
  • Rojas M, Monsalve DM, Pacheco Y, et al. Ebola virus disease: an emerging and re-emerging viral threat. J Autoimmun. 2020;106:102375. doi:10.1016/j.jaut.2019.102375
  • Hoenen T, Groseth A, Feldmann H. Therapeutic strategies to target the ebola virus life cycle. Nat Rev Microbiol. 2019;17(10):593–606. doi:10.1038/s41579-019-0233-2
  • Liu CH, Hu YT, Wong SH, et al. Therapeutic strategies against Ebola virus infection. Viruses. 2022;14(3):579.
  • Baseler L, Chertow DS, Johnson KM, et al. The pathogenesis of Ebola virus disease. Annu Rev Pathol Mech Dis. 2017;12:387–418. doi:10.1146/annurev-pathol-052016-100506
  • Jain S, Martynova E, Rizvanov A, et al. Structural and functional aspects of ebola virus proteins. Pathogens. 2021;10(10):1330.
  • Bach S, Biedenkopf N, Grünweller A, et al. Hexamer phasing governs transcription initiation in the 3'-leader of ebola virus. RNA. 2020;26(4):439–453.
  • Mühlberger E. Filovirus replication and transcription. Future Virol. 2007;2(2):205–215. doi:10.2217/17460794.2.2.205
  • Pereira B, Billaud M, Almeida R. RNA-binding proteins in cancer: old players and new actors. Trends Cancer. 2017;3(7):506–528. doi:10.1016/j.trecan.2017.05.003
  • Qin H, Ni H, Liu Y, et al. RNA-binding proteins in tumor progression. J Hematol Oncol. 2020;13(1):90. doi:10.1186/s13045-020-00927-w
  • Seufert L, Benzing T, Ignarski M, et al. RNA-binding proteins and their role in kidney disease. Nat Rev Nephrol. 2022;18(3):153–170. doi:10.1038/s41581-021-00497-1
  • Li Z, Guo Q, Zhang J, et al. The RNA-binding motif protein family in cancer: friend or foe? Front Oncol. 2021;11:757135. doi:10.3389/fonc.2021.757135
  • Christopoulou N, Granneman S. The role of RNA-binding proteins in mediating adaptive responses in gram-positive bacteria. FEBS J. 2022;289(7):1746–1764. doi:10.1111/febs.15810
  • Corley M, Burns MC, Yeo GW. How RNA-binding proteins interact with RNA: molecules and mechanisms. Mol Cell. 2020;78(1):9–29. doi:10.1016/j.molcel.2020.03.011
  • Li Z, Nagy PD. Diverse roles of host RNA binding proteins in RNA virus replication. RNA Biol. 2011;8(2):305–315. doi:10.4161/rna.8.2.15391
  • Zhu J, Gopinath K, Murali A, et al. RNA-binding proteins that inhibit RNA virus infection. Proc Natl Acad Sci USA. 2007;104(9):3129–3134. doi:10.1073/pnas.0611617104
  • Yong H, Zhao W, Zhou X, et al. RNA-binding motif 4 (RBM4) suppresses tumor growth and metastasis in human gastric cancer. Med Sci Monit Int Med J Exp Clin Res. 2019;25:4025–4034.
  • Yang L, Wang ZA, Zuo H, et al. The LARK protein is involved in antiviral and antibacterial responses in shrimp by regulating humoral immunity. Dev Comp Immunol. 2021;114:103826. doi:10.1016/j.dci.2020.103826
  • Watanabe T, Watanabe, T, Noda, T, et al. Production of novel Ebola virus-like particles from cDNAs: an alternative to ebola virus generation by reverse genetics. J Virol. 2003;78(2):999–1005.
  • Wang ZY, Guo ZD, Li JM, et al. Genome-wide search for competing endogenous RNAs responsible for the effects induced by Ebola virus replication and transcription using a trVLP system. Front Cell Infect Microbiol. 2017;7:479. doi:10.3389/fcimb.2017.00479
  • Galão RP, Wilson H, Schierhorn KL, et al. TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction. PLoS Pathog. 2022;18(5):e1010530. doi:10.1371/journal.ppat.1010530
  • Gonzalez JP, Pourrut X, Leroy E. Ebola virus and other filoviruses. Curr Top Microbiol Immunol. 2007;315:363–387.
  • Batra J, Hultquist JF, Liu D, et al. Protein interaction mapping identifies RBBP6 as a negative regulator of Ebola virus replication. Cell. 2018;175(7):1917–1930.e13. doi:10.1016/j.cell.2018.08.044
  • Markus MA, Morris BJ. RBM4: a multifunctional RNA-binding protein. Int J Biochem Cell Biol. 2009;41(4):740–743. doi:10.1016/j.biocel.2008.05.027
  • Chi YL, Lin JC. RBM4a modulates the impact of PRDM16 on development of brown adipocytes through an alternative splicing mechanism. Biochim Biophys Acta Mol Cell Res. 2018;1865(11):1515–1525. doi:10.1016/j.bbamcr.2018.08.001
  • Lin JC, Tarn WY. RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing. J Cell Biol. 2011;193(3):509–520. doi:10.1083/jcb.201007131
  • Ahmad A, Tigabu B, Ivanov A, et al. Ebola Virus NP Binding to Host Protein Phosphatase-1 Regulates Capsid Formation. Res Sq [Preprint]. 2023:rs.3.rs-2963943. doi:10.21203/rs.3.rs-2963943/v1.
  • Chen J, He Z, Yuan Y, et al. Host factor SMYD3 is recruited by Ebola virus nucleoprotein to facilitate viral mRNA transcription. Emerg Microbes Infect. 2019;8(1):1347–1360. doi:10.1080/22221751.2019.1662736
  • Brandt J, Wendt L, Bodmer BS, et al. The cellular protein CAD is recruited into Ebola virus inclusion bodies by the nucleoprotein NP to facilitate genome replication and transcription. Cells. 2020;9(5):1126. doi:10.3390/cells9051126
  • Rasmussen AL. Host factors in ebola infection. Annu Rev Genomics Hum Genet. 2016;17:333–351. doi:10.1146/annurev-genom-083115-022446
  • Halder AK, Dutta P, Kundu M, et al. Review of computational methods for virus-host protein interaction prediction: a case study on novel ebola-human interactions. Brief Funct Genomics. 2018 Nov;17(6):381–391.
  • Sun X, Hu Y, Wu J, et al. RBMS2 inhibits the proliferation by stabilizing P21 mRNA in breast cancer. J Exp Clin Cancer Res. 2018;37(1):298. doi:10.1186/s13046-018-0968-z
  • Yao Y, Yang B, Chen Y, et al. RNA-binding motif protein 38 (RBM38) mediates HBV pgRNA packaging into the nucleocapsid. Antiviral Res. 2022;198:105249. doi:10.1016/j.antiviral.2022.105249
  • Ganaie SS, Chen AY, Huang C, et al. RNA binding protein RBM38 regulates expression of the 11-kilodalton protein of parvovirus B19, which facilitates viral DNA replication. J Virol. 2018;92(8):e02050-17. doi:10.1128/JVI.02050-17
  • Duff MO, Olson S, Wei X, et al. Genome-wide identification of zero nucleotide recursive splicing in Drosophila. Nature. 2015;521(7552):376–379. doi:10.1038/nature14475
  • Foroushani AK, Chim B, Wong M, et al. Posttranscriptional regulation of human endogenous retroviruses by RNA-binding motif protein 4, RBM4. Proc Natl Acad Sci USA. 2020;117(42):26520–26530. doi:10.1073/pnas.2005237117
  • Morvan JM, Deubel V, Gounon P, et al. Identification of Ebola virus sequences present as RNA or DNA in organs of terrestrial small mammals of the Central African Republic. Microbes Infection. 1999;1(14):1193–1201. doi:10.1016/S1286-4579(99)00242-7
  • Leroy EM, Kumulungui B, Pourrut X, et al. Fruit bats as reservoirs of Ebola virus. Nature. 2005;438(7068):575–576. doi:10.1038/438575a
  • Koyama S, Ishii KJ, Coban C, et al. Innate immune response to viral infection. Cytokine. 2008;43(3):336–341.
  • Han H, Lin T, Wang Z, et al. RNA-binding motif 4 promotes angiogenesis in HCC by selectively activating VEGF-A expression. Pharmacol Res. 2023;187:106593. doi:10.1016/j.phrs.2022.106593
  • Wang K, Huang C, Jiang T, et al. RNA-binding protein RBM47 stabilizes IFNAR1 mRNA to potentiate host antiviral activity. EMBO Rep. 2021;22(8):e52205. doi:10.15252/embr.202052205