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Modern Rheumatology Case Reports Volume 5, 2021 - Issue 2
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Case Reports

IgG4-related disease presenting as a paraneoplastic syndrome: report of two cases and literature review

Mitsuteru Akahoshia Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, JapanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3556-4709
ORCID Icon,
Yojiro Arinobua Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
,
Yusuke Kashiwadoa Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
,
Aya Omotoa Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
,
Masahiro Ayanoa Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
,
Hiroki Mitomaa Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
,
Yasutaka Kimotob Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Oita, Japan
,
Nobuyuki Onoa Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
,
Takahiko Horiuchib Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Oita, Japan
&
Hiroaki Niiroc Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
 show all
Pages 371-376 | Received 14 Jan 2021, Accepted 05 Feb 2021, Published online: 15 Mar 2021

References

  • Kamisawa T, Zen Y, Pillai S, et al. IgG4-related disease. Lancet. 2015;385(9976):1460–1471.
  • Yamamoto M, Takahashi H, Tabeya T, et al. Risk of malignancies in IgG4-related disease. Mod Rheumatol. 2012;22(3):414–418.
  • Shiokawa M, Kodama Y, Yoshimura K, et al. Risk of cancer in patients with autoimmune pancreatitis. Am J Gastroenterol. 2013;108(4):610–617.
  • Huggett MT, Culver EL, Kumar M, Hurst JM, et al. Type 1 autoimmune pancreatitis and IgG4-related sclerosing cholangitis is associated with extrapancreatic organ failure, malignancy, and mortality in a prospective UK cohort. Am J Gastroenterol. 2014;109(10):1675–1683.
  • Asano J, Watanabe T, Oguchi T, et al. Association between immunoglobulin g4-related disease and malignancy within 12 years after diagnosis: an analysis after longterm followup. J Rheumatol. 2015;42(11):2135–2142.
  • Tang H, Yang H, Zhang P, et al. Malignancy and IgG4-related disease: the incidence, related factors and prognosis from a prospective cohort study in China. Sci Rep. 2020;10(1):4910.
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  • Lekakis L, Tryfonopoulos D, Fakinos G, et al. A case of paraneoplastic autoimmune pancreatitis: mini-review of paraneoplastic syndromes in breast cancer. Anticancer Res. 2012;32(8):3311–3314.
  • Krause ML, Yi ES, Warrington KJ. Pulmonary IgG4-related disease and colon adenocarcinoma: possible paraneoplastic syndrome. Int J Rheum Dis. 2017;20(5):654–656.
  • Ghazale A, Chari ST, Smyrk TC, et al. Value of serum IgG4 in the diagnosis of autoimmune pancreatitis and in distinguishing it from pancreatic cancer. Am J Gastroenterology. 2007;102(8):1646–1653.
  • Raina A, Krasinskas AM, Greer JB, et al. Serum immunoglobulin G fraction 4 levels in pancreatic cancer: elevations not associated with autoimmune pancreatitis. Arch Pathol Lab Med. 2008;132(1):48–53.
  • Hamano H, Kawa S, Horiuchi A, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med. 2001;344(10):732–738.
  • Oseini AM, Chaiteerakij R, Shire AM, et al. Utility of serum immunoglobulin G4 in distinguishing immunoglobulin G4-associated cholangitis from cholangiocarcinoma. Hepatology. 2011;54(3):940–948.
  • Hirano K, Tada M, Sasahira N, et al. Incidence of malignancies in patients with IgG4-related disease. Intern Med. 2014;53(3):171–176.
  • Inoue D, Yoshida K, Yoneda N, et al. IgG4-related disease: dataset of 235 consecutive patients. Medicine. 2015;94(15):e680.
  • Takahashi N, Ghazale AH, Smyrk TC, et al. Possible association between IgG4-associated systemic disease with or without autoimmune pancreatitis and non-Hodgkin lymphoma. Pancreas. 2009;38(5):523–526.
  • Bernatsky S, Ramsey-Goldman R, Clarke A. Malignancy and autoimmunity. Curr Opin Rheumatol. 2006;18(2):129–134.
  • Miyatani K, Saito H, Murakami Y, et al. A high number of IgG4-positive cells in gastric cancer tissue is associated with tumor progression and poor prognosis. Virchows Arch. 2016;468(5):549–557.

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