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Review Articles

Targeting the gut-brain axis for therapeutic adherence in patients with inflammatory bowel disease: a review on the role of psychotherapy

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Article: 2181101 | Received 13 Jun 2022, Accepted 10 Feb 2023, Published online: 28 Feb 2023

References

  • Zhang Y-Z, Li Y-Y. Inflammatory bowel disease: pathogenesis. WJG. 2014;20(1):91–99.
  • Garber A, Regueiro M. Extraintestinal manifestations of inflammatory bowel disease: epidemiology, etiopathogenesis, and management. Curr Gastroenterol Rep. 2019;21(7):31.
  • Oligschlaeger Y, Yadati T, Houben T, et al. Inflammatory bowel disease: a stressed “gut/feeling. Cells. 2019;8(7):659.
  • Torres J, Ellul P, Langhorst J, et al. European crohn’s and colitis organisation topical review on complementary medicine and psychotherapy in inflammatory bowel disease. J Crohns Colitis. 2019;13(6):673–685e.
  • Knowles SR, Monshat K, Castle DJ. The efficacy and methodological challenges of psychotherapy for adults with inflammatory bowel disease: a review. Inflamm Bowel Dis. 2013;19(12):2704–2715.
  • McCombie AM, Mulder RT, Gearry RB. Psychotherapy for inflammatory bowel disease: a review and update. J Crohns Colitis. 2013;7(12):935–949.
  • Kaplan GG. The global burden of IBD: from 2015 to 2025. Nat Rev Gastroenterol Hepatol. 2015;12(12):720–727.
  • Torres J, Bonovas S, Doherty G, et al. ECCO guidelines on therapeutics in Crohn’s disease: medical treatment. J Crohns Colitis. 2020;14(1):4–22.
  • Raine T, Bonovas S, Burisch J, et al. ECCO guidelines on therapeutics in ulcerative colitis: medical treatment. J Crohns Colitis. 2022;16(1):2–17.
  • Lakatos PL. Prevalence, predictors, and clinical consequences of medical adherence in IBD: how to improve it? WJG. 2009;15(34):4234–4239.
  • Watanabe C, Nagahori M, Fujii T, et al. Non-adherence to medications in pregnant ulcerative colitis patients contributes to disease flares and adverse pregnancy outcomes. Dig Dis Sci. 2021;66(2):577–586.
  • Bager P, Julsgaard M, Vestergaard T, et al. Adherence and quality of care in IBD. Scand J Gastroenterol. 2016;51(11):1326–1331.
  • Colonnello V, Agostini A. Disease course, stress, attachment, and mentalization in patients with inflammatory bowel disease. Med Hypotheses. 2020;140:109665.
  • Neuendorf R, Harding A, Stello N, et al. Depression and anxiety in patients with inflammatory bowel disease: a systematic review. J Psychosom Res. 2016;87:70–80.
  • Barberio B, Zamani M, Black CJ, et al. Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2021;6(5):359–370.
  • Sontakke S, Budania R, Bajait C, et al. Evaluation of adherence to therapy in patients of chronic kidney disease. Indian J Pharmacol. 2015;47(6):668–671.
  • Copeland LA, Zeber JE, Salloum IM, et al. Treatment adherence and illness insight in veterans with bipolar disorder. J Nerv Ment Dis. 2008;196(1):16–21.
  • Tong P, Bu P, Yang Y, et al. Group cognitive behavioural therapy can reduce stigma and improve treatment compliance in major depressive disorder patients. Early Interv Psychiatry. 2020;14(2):172–178.
  • Gracie DJ, Hamlin PJ, Ford AC. The influence of the brain-gut axis in inflammatory bowel disease and possible implications for treatment. Lancet Gastroenterol Hepatol. 2019;4(8):632–642.
  • Günther C, Rothhammer V, Karow M, et al. The gut-brain axis in inflammatory bowel disease-current and future perspectives. IJMS. 2021;22(16):8870.
  • Lewis JD, Chuai S, Nessel L, et al. Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis. Inflamm Bowel Dis. 2008;14:1660–1666.
  • Gracie DJ, Williams CJM, Sood R, et al. Poor correlation between clinical disease activity and mucosal inflammation, and the role of psychological comorbidity, in inflammatory bowel disease. Am J Gastroenterol. 2016;111(4):541–551.
  • Targownik LE, Sexton KA, Bernstein MT, et al. The relationship among perceived stress, symptoms, and inflammation in persons with inflammatory bowel disease. Am. J Gastroenterol. 2015;110(7):1001–1012. quiz 1013.
  • Fond G, Loundou A, Hamdani N, et al. Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis. Eur Arch Psychiatry Clin Neurosci. 2014;264(8):651–660.
  • Mayer EA, Labus J, Aziz Q, et al. Role of brain imaging in disorders of brain-gut interaction: a rome working team report. Gut. 2019;68(9):1701–1715.
  • Lee I-S, Wang H, Chae Y, et al. Functional neuroimaging studies in functional dyspepsia patients: a systematic review. Neurogastroenterol. Motil. 2016;28(6):793–805.
  • Jones MP, Tack J, Van Oudenhove L, et al. Mood and anxiety disorders precede development of functional gastrointestinal disorders in patients but not in the population. Clin Gastroenterol Hepatol. 2017;15(7):1014–1020.e4.
  • Banerjee R, Pal P, Adigopula B, et al. Impact of demographic, clinical and psychosocial variables on drug adherence and outcomes in indian patients with inflammatory bowel disease: cost is not the only factor. J Clin Gastroenterol. 2021;55(10):e92–e99.
  • Nahon S, Lahmek P, Durance C, et al. Risk factors of anxiety and depression in inflammatory bowel disease. Inflamm Bowel Dis. 2012;18:2086–2091.
  • Selinger CP, Robinson A, Leong RW. Clinical impact and drivers of non-adherence to maintenance medication for inflammatory bowel disease. Expert Opin Drug Saf. 2011;10(6):863–870.
  • Cushman GK, Shih S, Stolz MG, et al. Stressful life events, depression, and the moderating role of psychophysiological reactivity in patients with pediatric inflammatory bowel disease. J Psychosom Res. 2021;141:110323.
  • López-Sanromán A, Bermejo F. Review article: how to control and improve adherence to therapy in inflammatory bowel disease. Aliment Pharmacol Ther. 2006;24(s3):45–49.
  • Dolovich C, Bernstein CN, Singh H, et al. Anxiety and depression leads to anti-tumor necrosis factor discontinuation in inflammatory bowel disease. Clin Gastroenterol Hepatol. 2021;19(6):1200–1208.e1.
  • Araki M, Shinzaki S, Yamada T, et al. Psychologic stress and disease activity in patients with inflammatory bowel disease: a multicenter cross-sectional study. PLOS One. 2020;15(5):e0233365.
  • Shaw L, Ehrlich A. Relaxation training as a treatment for chronic pain caused by ulcerative colitis. Pain. 1987;29(3):287–293.
  • García-Vega E, Fernandez-Rodriguez C. A stress management programme for Crohn’s disease. Behav Res Ther. 2004;42(4):367–383.
  • Vogelaar L, Van’t Spijker A, Vogelaar T, et al. Solution focused therapy: a promising new tool in the management of fatigue in Crohn’s disease patients psychological interventions for the management of fatigue in Crohn’s disease. J Crohns Colitis. 2011;5(6):585–591.
  • Keefer L, Kiebles JL, Kwiatek MA, et al. The potential role of a self-management intervention for ulcerative colitis: a brief report from the ulcerative colitis hypnotherapy trial. Biol Res Nurs. 2012;14(1):71–77.
  • Grootenhuis MA, Maurice-Stam H, Derkx BH, et al. Evaluation of a psychoeducational intervention for adolescents with inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2009;21:340–345.
  • Timmer A, Preiss JC, Motschall E, et al. Psychological interventions for treatment of inflammatory bowel disease. Cochrane Database Syst Rev. 2011;(2):CD006913. doi: 10.1002/14651858.CD006913.pub2. PMID: 21328288
  • Oliveira S, Zaltman C, Elia C, et al. Quality-of-life measurement in patients with inflammatory bowel disease receiving social support. Inflamm Bowel Dis. 2007;13:470–474.
  • Smith GD, Watson R, Roger D, et al. Impact of a nurse-led counselling service on quality of life in patients with inflammatory bowel disease. J Adv Nurs. 2002;38(2):152–160.
  • Langhorst J, Mueller T, Luedtke R, et al. Effects of a comprehensive lifestyle modification program on quality-of-life in patients with ulcerative colitis: a twelve-month follow-up. Scand J Gastroenterol. 2007;42(6):734–745.
  • van den Brink G, Stapersma L, Bom AS, et al. Effect of cognitive behavioral therapy on clinical disease course in adolescents and young adults with inflammatory bowel disease and subclinical anxiety and/or depression: results of a randomized trial. Inflamm Bowel Dis. 2019;25(12):1945–1956.
  • Ewais T, Begun J, Kenny M, et al. Mindfulness based cognitive therapy for youth with inflammatory bowel disease and depression - Findings from a pilot randomised controlled trial. J Psychosom Res. 2021;149:110594.
  • Norton C, Czuber-Dochan W, Artom M, et al. Systematic review: interventions for abdominal pain management in inflammatory bowel disease. Aliment Pharmacol Ther. 2017;46(2):115–125.
  • Farrell D, Artom M, Czuber-Dochan W, et al. Interventions for fatigue in inflammatory bowel disease. Cochrane Database Syst Rev. 2020;4:CD012005.
  • Stapersma L, van den Brink G, van der Ende J, et al. Psychological outcomes of a cognitive behavioral therapy for youth with inflammatory bowel disease: results of the HAPPY-IBD randomized controlled trial at 6- and 12-month follow-up. J Clin Psychol Med Settings. 2020;27(3):490–506.
  • Chen J, Chen X, Sun Y, et al. The physiological and psychological effects of cognitive behavior therapy on patients with inflammatory bowel disease before COVID-19: a systematic review. BMC Gastroenterol. 2021;21(1):469.
  • Jantschek G, Zeitz M, Pritsch M, et al. Effect of psychotherapy on the course of Crohn’s disease. Results of the german prospective multicenter psychotherapy treatment study on Crohn’s disease. German study group on psychosocial intervention in Crohn’s disease. Scand J Gastroenterol. 1998;33:1289–1296.
  • Deter H-C, Keller W, von Wietersheim J, et al. Psychological treatment may reduce the need for healthcare in patients with Crohn’s disease. Inflamm Bowel Dis. 2007;13:745–752.
  • Hommel KA, Herzer M, Ingerski LM, et al. Individually tailored treatment of medication nonadherence. J Pediatr Gastroenterol Nutr. 2011;53(4):435–439.
  • Wenzel A. Basic strategies of cognitive behavioral therapy. Psychiatr Clin North Am. 2017;40(4):597–609.
  • Oar EL, Johnco C, Ollendick TH. Cognitive behavioral therapy for anxiety and depression in children and adolescents. Psychiatr Clin North Am. 2017;40(4):661–674.
  • Kaczkurkin AN, Foa EB. Cognitive-behavioral therapy for anxiety disorders: an update on the empirical evidence. Dialogues Clin Neurosci. 2015;17(3):337–346.
  • Hommel KA, Hente EA, Odell S, et al. Evaluation of a group-based behavioral intervention to promote adherence in adolescents with inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2012;24:64–69.
  • Keefer L, Doerfler B, Artz C. Optimizing management of Crohn’s disease within a project management framework: results of a pilot study. Inflamm Bowel Dis. 2012;18:254–260.
  • Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986;24:67–74.
  • Hommel KA, Hente E, Herzer M, et al. Telehealth behavioral treatment for medication nonadherence: a pilot and feasibility study. Eur J Gastroenterol Hepatol. 2013;25(4):469–473.
  • Antal-Uram D, Harsányi L, Perczel-Forintos D. [Low-intensity, evidence-based cognitive-behavioural therapy of a patient with Crohn’s disease]. Orv Hetil. 2018;159(9):363–369.
  • Ewais T, Begun J, Kenny M, et al. Protocol for a pilot randomised controlled trial of mindfulness-based cognitive therapy in youth with inflammatory bowel disease and depression. BMJ Open. 2019;9(4):e025568.
  • Abbott RA, Whear R, Rodgers LR, et al. Effectiveness of mindfulness-based stress reduction and mindfulness based cognitive therapy in vascular disease: a systematic review and meta-analysis of randomised controlled trials. J Psychosom Res. 2014;76(5):341–351.
  • Luders E, Clark K, Narr KL, et al. Enhanced brain connectivity in long-term meditation practitioners. Neuroimage. 2011;57(4):1308–1316.
  • Keefer L, Taft TH, Kiebles JL, et al. Gut-directed hypnotherapy significantly augments clinical remission in quiescent ulcerative colitis. Aliment Pharmacol Ther. 2013;38(7):761–771.
  • Peters SL, Yao CK, Philpott H, et al. Randomised clinical trial: the efficacy of gut-directed hypnotherapy is similar to that of the low FODMAP diet for the treatment of irritable bowel syndrome. Aliment Pharmacol Ther. 2016;44(5):447–459.
  • Peters SL, Muir JG, Gibson PR. Review article: gut-directed hypnotherapy in the management of irritable bowel syndrome and inflammatory bowel disease. Aliment Pharmacol Ther. 2015;41(11):1104–1115.
  • Calvert EL, Houghton LA, Cooper P, et al. Long-term improvement in functional dyspepsia using hypnotherapy. Gastroenterology. 2002;123(6):1778–1785.
  • Sharma RL. Functional dyspepsia: at least recommend hypnotherapy. BMJ. 2008;337:a1972.
  • Chiarioni G, Vantini I, De Iorio F, et al. Prokinetic effect of gut-oriented hypnosis on gastric emptying. Aliment Pharmacol Ther. 2006;23(8):1241–1249.
  • Hypnotherapy for duodenal ulcer. Lancet. 1988. 2:159–160.
  • Dorfman L, Nassar R, Binjamin Ohana D, et al. Pediatric inflammatory bowel disease and the effect of COVID-19 pandemic on treatment adherence and patients’ behavior. Pediatr Res. 2021;90(3):637–641.
  • Gomollón F. Treatment adherence is always worse than we think: an unresolved problem in inflammatory bowel disease. Gastroenterol Hepatol. 2016;39(Suppl 1):14–19.
  • Salehi C, Mansfield KJ, Lee T. Predictors of receptivity to psychotherapy in inflammatory bowel disease. J Gastroenterol Hepatol. 2016. 31:145.
  • D'Incà R, Bertomoro P, Mazzocco K, et al. Risk factors for non-adherence to medication in inflammatory bowel disease patients. Aliment Pharmacol Ther. 2008;27(2):166–172.
  • Magalhães J, Dias de Castro F, Boal Carvalho P, et al. Treatment of inflammatory bowel disease: is your patient at risk of non-adherence? Acta Med Port. 2014;27(5):576–580.
  • van der Have M, Oldenburg B, Kaptein AA, et al. Non-adherence to anti-TNF therapy is associated with illness perceptions and clinical outcomes in outpatients with inflammatory bowel disease: results from a prospective multicentre study. J Crohns Colitis. 2016;10(5):549–555.
  • Horne R, Parham R, Driscoll R, et al. Patients’ attitudes to medicines and adherence to maintenance treatment in inflammatory bowel disease. Inflamm Bowel Dis. 2009;15:837–844.
  • Lopez A, Billioud V, Peyrin-Biroulet C, et al. Adherence to anti-TNF therapy in inflammatory bowel diseases: a systematic review. Inflamm Bowel Dis. 2013;19(7):1528–1533.
  • Wentworth BJ, Buerlein RCD, Tuskey AG, et al. Nonadherence to biologic therapies in inflammatory bowel disease. Inflamm Bowel Dis. 2018;24(9):2053–2061.
  • Devlen J, Beusterien K, Yen L, et al. Barriers to mesalamine adherence in patients with inflammatory bowel disease: a qualitative analysis. J Manag Care Spec Pharm. 2014;20(3):309–314.
  • Greenley RN, Karazsia B, Schurman JV, et al. Trajectories of oral medication adherence in youth with inflammatory bowel disease. Health Psychol. 2015;34(5):514–521.
  • Herman ML, Kane SV. Treatment nonadherence in inflammatory bowel disease: identification, scope, and management strategies. Inflamm Bowel Dis. 2015;21(12):2979–2984.
  • Gray WN, Denson LA, Baldassano RN, et al. Treatment adherence in adolescents with inflammatory bowel disease: the collective impact of barriers to adherence and anxiety/depressive symptoms. J Pediatr Psychol. 2012;37(3):282–291.
  • Vangeli E, Bakhshi S, Baker A, et al. A systematic review of factors associated with non-adherence to treatment for immune-mediated inflammatory diseases. Adv Ther. 2015;32(11):983–1028.
  • Knowles SR, Alex G. Medication adherence across the life span in inflammatory bowel disease: implications and recommendations for nurses and other health providers. Gastroenterol Nurs. 2020;43(1):76–88.
  • Bhatt J, Patil S, Joshi A, et al. Self-reported treatment adherence in inflammatory bowel disease in indian patients. Indian J Gastroenterol. 2009;28(4):143–146.
  • Calvo-Arbeloa M, Insausti-Serrano AM, Arrondo-Velasco A, et al. Adherence to treatment with adalimumab, golimumab and ustekinumab in patients with inflammatory bowel disease. Farm Hosp. 2020;44:62–67.
  • Nguyen GC, LaVeist TA, Harris ML, et al. Patient trust-in-physician and race are predictors of adherence to medical management in inflammatory bowel disease. Inflamm Bowel Dis. 2009;15:1233–1239.
  • Nahon S, Lahmek P, Saas C, et al. Socioeconomic and psychological factors associated with nonadherence to treatment in inflammatory bowel disease patients: results of the ISSEO survey. Inflamm Bowel Dis. 2011;17(6):1270–1276.
  • Kim MC, Jung YS, Song YS, et al. Factors associated with anxiety and depression in korean patients with inactive inflammatory bowel disease. Gut Liver. 2016;10(3):399–405.
  • Greuter T, Manser C, Pittet V, , et al. Gender differences in inflammatory bowel disease. Digestion. 2020;101 Suppl 1(Suppl 1):98–104.
  • Andrade LD, Oliveira FA, Mariano VD, et al. Adherence to medical treatment in inflammatory bowel disease patients from a referral center in Bahia-Brazil. Biomed Res Int. 2020;2020:5269493. 2020:
  • Ribaldone DG, Vernero M, Astegiano M, et al. How ameliorate the adherence in patients with inflammatory bowel disease? Scand J Gastroenterol. 2018;53(8):938–939.
  • Tahri N. [Treatment adherence and chronic inflammatory bowel diseases]. Presse Med. 2007;36(9 Pt 2):1236–1243.
  • Jackson CA, Clatworthy J, Robinson A, et al. Factors associated with non-adherence to oral medication for inflammatory bowel disease: a systematic review. Am J Gastroenterol. 2010;105(3):525–539.
  • Robinson A. Review article: improving adherence to medication in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2008;27 Suppl 1:9–14.
  • Lai C, Sceats LA, Qiu W, et al. Patient decision-making in severe inflammatory bowel disease: the need for improved communication of treatment options and preferences. Colorectal Dis. 2019;21(12):1406–1414.