347
Views
12
CrossRef citations to date
0
Altmetric
Original Article

Peppermint (Mentha Xpiperita)

An Evidence-Based Systematic Review by the Natural Standard Research Collaboration

, , , , , , , & show all
Pages 91-143 | Published online: 20 Aug 2009

References

  • McKay D. L., Blumberg J. B. A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). Phytother Res 2006; 20(8)619–633, View Abstract
  • Schelz Z., Molnar J., Hohmann J. Antimicrobial and antiplasmid activities of essential oils. Fitoterapia 2006; 77(4)279–285, View Abstract
  • Vidal F., Vidal J. C, Gadelha A. P., Lopes C. S., Coelho M. G., Monteiro-Leal L. H. Giardia lamb lia: the effects of extracts and fractions from Mentha X piperita Lin. (Lamiaceae) on trophozoites. Exp Parasitol 2007; 115(1)25–31, View Abstract
  • Asao T., Mochiki E., Suzuki H., Nakamura J., Hirayama I., Morinaga N., Shoji H., Shitara Y., Kuwano H. An easy method for the intraluminal administration of peppermint oil before colonoscopy and its effectiveness in reducing colonie spasm. Gastrointest. Endosc 2001; 53(2)172–177, View Abstract
  • Kligler B., Chaudhary S. Peppermint oil. Am Fam. Physician 4–1–2007; 75(7)1027–1030, View Abstract
  • Veal L. The potential effectiveness of essential oils as a treatment for headlice, Pediculus humanus capitis. Complement Ther Nurs. Midwifery 1996; 2(4)97–101, View Abstract
  • Eccles R., Jawad M. S., Morris S. The effects of oral administration of (-)-menthol on nasal resistance to airflow and nasal sensation of airflow in subjects suffering from nasal congestion associated with the common cold. J Pharm Pharmacol 1990; 42(9)652–654, View Abstract
  • Wilkinson J. M. What do we know about herbal morning sickness treatments? A literature survey. Midwifery 2000; 16(3)224–228, View Abstract
  • Shkurupii V. A., Odintsova O. A., Kazarinova N. V., Tkrachenko K. G [Use of essential oil of peppermint (Mentha piperita) in the complex treatment of patients with infiltrative pulmonary tuberculosis]. Probl. Tuberk. Bolezn. Legk 2006, 9: 43–45, View Abstract
  • Liu J. H., Chen G H., Yeh H. Z., Huang C. K., Poon S. K. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997; 32(6)765–768, View Abstract
  • May B., Kohier S., Schneider B. Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia. Aliment. Pharmacol Ther 2000; 14(12)1671–1677, View Abstract
  • Kline R. M., Kline J. J., Di Palma J., Barbero G. J. Enteric-coated, pH-de-pendent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 2001; 138(1)125–128, View Abstract
  • Lawson M. J., Knight R. E., Tran K, et al. Failure of enteric-coated peppermint oil in the irritable bowel syndrome: a randomized, double-blind crossover study. J. Gastroenterol Hepatol 1988; 3(3)235–238
  • Rees W. D., Evans B. K, Rhodes J. Treating irritable bowel syndrome with peppermint oil. Br Med J 6 10, 1979; 2(194)835–836, View Abstract
  • Pittler M. H., Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and meta-analysis. Am J Gastroenterol 1998; 93(7)1131–1135, View Abstract
  • Heng M. C. Local necrosis and interstitial nephritis due to topical methyl salicylate and menthol. Cutis 1987; 39(5)442–444, View Abstract
  • Wyllie J. P., Alexander F. W. Nasal instillation of ‘Olbas Oil’ in an infant. Arch Dis Child 1994; 70(4)357–358, View Abstract
  • Behrends M., Beiderlinden M., Peters J. Acute lung injury after peppermint oil injection. Anesth. Analg 2005; 101(4)1160–1162, View Abstract
  • Eickholt T. H., Box R. H. Toxicities of peppermint and Pycnanthemun albescens oils, fam. Labiateae. J Pharm Sei 1965; 54(7)1071–1072, View Abstract
  • Morice A. H., Marshall A. E., Higgins K. S., Grattan T. J. Effect of inhaled menthol on citric acid induced cough in normal subjects. Thorax 1994; 49(10)1024–1026, View Abstract
  • Giachetti D., Taddei E., Taddei I. Pharmacological Activity of Mentha piperita, Salvia officinalis and Rosmarinus officinalis Essences on Oddi's sphincter. Planta Med 1986; 52(6)543–544, View Abstract
  • Pimentel M., Bonorris G G, Chow E. J., Lin H. C. Peppermint oil improves the manometric findings in diffuse esophageal spasm. J Clin Gastroenterol 2001; 33(1)27–31, View Abstract
  • Hiki N., Kurosaka H., Tatsutomi Y., Shimoyama S., Tsuji E., Kojima J., Shimizu N., Ono H., Hirooka T., Noguchi C, Mafune K., Kaminishi M. Peppermint oil reduces gastric spasm during upper endoscopy: a randomized, double-blind, double-dummy controlled trial. Gastrointest. Endosc 2003; 57(4)475–482, View Abstract
  • Grigoleit H. G, Grigoleit P. Peppermint oil in irritable bowel syndrome. Phytomedicine 2005; 12(8)601–606, View Abstract
  • Gobel H., Fresenius J., Heinze A., Dworschak M., Soyka D. [Effectiveness of Oleum menthae piperitae and paracetamol in therapy of headache of the tension type]. Nervenarzt 1996; 67(8)672–681, View Abstract
  • Davies S. J., Harding L. M., Baranowski A. P. A novel treatment of postherpetic neuralgia using peppermint oil. Clin J Pain 2002; 18(3)200–202, View Abstract
  • Olsen P., Thorup I. Neurotoxicity in rats dosed with peppermint oil and pulegone. Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals 1984, 7: 408–409
  • Thorup I., Wurtzen G., Carstensen J., Olsen P. Short term toxicity study in rats dosed with peppermint oil. Toxicol Lett 1983; 19(3)211–215, View Abstract
  • Mengs U., Stotzem C. D. Toxicological evaluation of peppermint oil in rodents and dogs. Medical Science Research 1989; 17(ll)499–500
  • Spindler P., Madsen C. Subchronic toxicity study of peppermint oil in rats. Toxicol. Lett 1992; 62(2–3)215–220, View Abstract
  • Madsen C, Wurtzen G, Carstensen J. Short-term toxicity study in rats dosed with menthone. Toxicol Lett 1986; 32(l-2)147–152, View Abstract
  • McGowan E. M. Menthol urticaria. Arch Dermatol 1966; 94(1)62–63, View Abstract
  • Morton C. A., Garioch J., Todd P., Lamey P. J., Forsyth A. Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. Contact Dermatitis 1995; 32(5)281–284, View Abstract
  • Wilkinson S. M., Beck M. H. Allergic contact dermatitis from menthol in peppermint. Contact Dermatitis 1994; 30(1)42–43, View Abstract
  • Foti C, Conserva A., Antelmi A., Lospalluti L., Angelini G. Contact dermatitis from peppermint and menthol in a local action transcutaneous patch. Contact Dermatitis 2003; 49(6)312–313, View Abstract
  • Camarasa G., Alomar A. Menthol dermatitis from cigarettes. Contact Dermatitis 1978; 4(3)169–170, View Abstract
  • Papa C. M., Shelley W. B. Menthol hypersensitivity; diagnostic basophil response in a patient with chronic urticaria, flushing, and headaches. JAMA 8–17–1964; 189: 546–548, View Abstract
  • Anderson F. E. Chronic bullous eruptions of the skin. Aust. Fam. Physician 1978; 7(12)1516–4, View Abstract
  • Subiza J., Subiza J. L., Valdivieso R., Escribano P. M., Garcia R., Jerez M., Subiza E. Toothpaste flavor-induced asthma. J Allergy Clin Immunol 1992; 90(6 Pt 1)1004–1006, View Abstract
  • Calnan C. D., Bandmann H. J., Cronin E., Fregert S., Hjorth N., Magnusson B., Malten K., Meneghini C. L., Pirila V., Wilkinson D. S. Hand dermatitis in housewives. Br J Dermatol 1970; 82(6)543–548, View Abstract
  • Peltonen L., Wickstrom G, Vaahtoranta M. Occupational dermatoses in the food industry. Derm. Beruf. Umwelt 1985; 33(5)166–169, View Abstract
  • Moghadam B. K., Gier R., Thurlow T. Extensive oral mucosal ulcérations caused by misuse of a commercial mouthwash. Cutis 1999; 64(2)131–134, View Abstract
  • Nash P., Gould S. R., Bernardo D. E. Peppermint oil does not relieve the pain of irritable bowel syndrome. Br. J. Clin. Pract 1986; 40(7)292–293, View Abstract
  • Tamir S., Davidovich Z., Attal P., Eliashar R. Peppermint oil chemical burn. Otolaryngol. HeadNeck Surg 2005; 133(5)801–802, View Abstract
  • Nielsen J. B. Natural oils affect the human skin integrity and the percutaneous penetration of benzoic acid dose-dependently. Basic Clin Pharmacol Toxicol 2006; 98(6)575–581, View Abstract
  • Lech Y., Olesen K. M., Hey H., Rask-Pedersen E., Vilien M., Ostergaard O. [Treatment of irritable bowel syndrome with peppermint oil. A double-blind study with a placebo]. Ugeskr. Laeger 10–3–1988; 150(40)2388–2389, View Abstract
  • Weston C. F. Anal burning and peppermint oil. Postgrad Med J 1987; 63(742)717, View Abstract
  • Weston C. F. Eppermint oil. Lancet 7–9–1988; 2(8602)98–99, View Abstract
  • Javorka K., Tomori Z., Zavarska L. Protective and defensive airway reflexes in premature infants. Physiol Bohemoslov 1980; 29(1)29–35, View Abstract
  • Sadlo S., Szpyrka E., Rogozinska K., Rupar J. [Occurrence of some pesticides residues in peppermint Mentha piperita L. in 2003–2005]. Rocz. Panstw. Zakl. Hig 2006; 57(3)211–216, View Abstract
  • Abdullah D., Ping Q. N, Liu G. J. Enhancing effect of essential oils on the penetration of 5-fluorouracil through rat skin. Yao Xue. Xue. Bao. (Acta Pharmaceutica Sinica) 1996; 31(3)214–221, View Abstract
  • Inouye S., Uchida K., Nishiyama Y., Hasumi Y., Yamaguchi H., Abe S. Combined effect of heat, essential oils and salt on fungicidal activity against Trichophyton mentagrophytes in a foot bath. Nippon Ishinkin. Gakkai Zasshi 2007; 48(1)27–36, View Abstract
  • Laude E. A., Morice A. H., Grattan T. J. The antitussive effects of menthol, camphor and cineole in conscious guinea-pigs. Pulm. Pharmacol 1994; 7(3)179–184, View Abstract
  • Beesley A., Hardcastle J., Hardcastle P. T., Taylor C. J. Influence of peppermint oil on absorptive and secretory processes in rat small intestine. Gut 1996; 39(2)214–219, View Abstract
  • Wacher V. J., Wong S., Wong H. T. Peppermint oil enhances cyclo-sporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) andketoconazole. JPharmSci 2002; 91(1)77–90, View Abstract
  • Dresser G. K., Wacher V., Ramtoola Z., et al. Peppermint oil increases the oral bioavailability of felodipine and simvastatin. American Society for Clinical Pharmacology and Therapeutics Annual Meeting 24–27 March, 2002; TPII–95
  • Belanger J. T. Perillyl alcohol: applications in oncology. Altern Med Rev 1998; 3(6)448–457, View Abstract
  • Green B. G, McAuliffe B. L. Menthol desensitization of capsaicin irritation. Evidence of a short-term anti-nociceptive effect. Physiol Behav 2000; 68(5)631–639, View Abstract
  • Lundy R. F., Jr., Contreras R. J. Neural responses of thermal-sensitive lingual fibers to brief menthol stimulation. Brain Res 4–4–1994; 641(2)208–216, View Abstract
  • Eccles R., Griffiths D. H., Newton C. G, Tolley N. S. The effects of menthol isomers on nasal sensation of airflow. Clin Otolaryngol 1988; 13(1)25–29, View Abstract
  • Gobel H., Schmidt G, Soyka D. Effect of peppermint and eucalyptus oil preparations on neurophysiological and experimental algesimetric headache parameters. Cephalalgia 1994; 14(3)228–234, View Abstract
  • Green B. G. Menthol inhibits the perception of warmth. Physiol Behav 1986; 38(6)833–838, View Abstract
  • Shapiro S., Meier A., Guggenheim B. The antimicrobial activity of essential oils and essential oil components towards oral bacteria. Oral Microbiol.Immunol 1994; 9(4)202–208, View Abstract
  • Herrmann E. C, Jr., Kucera L. S. Antiviral substances in plants of the mint family (labiatae). 3. Peppermint (Mentha piperita) and other mint plants. Proc Soc Exp BiolMed 1967; 124(3)874–878, View Abstract
  • Bromm B., Scharein E., Darsow U., Ring J. Effects of menthol and cold on histamine-induced itch and skin reactions in man. Neurosci Lett 3–10–1995; 187(3)157–160, View Abstract
  • Green B. G The sensory effects of 1-menthol on human skin. Somatosens. Mot. Res 1992; 9(3)235–244, View Abstract
  • Yosipovitch G, Szolar C, Hui X. Y., Maibach H. Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin. Arch Dermatol Res 1996; 288(5–6)245–248, View Abstract
  • Grigoleit H. G, Grigoleit P. Pharmacology and preclinical pharmacokinetics of peppermint oil. Phytomedicine 2005; 12(8)612–616, View Abstract
  • Hansen B., Babiak G., Schilling M., et al. A mixture of volatile oils in treatment of common cold. Therapiewoche 1984; 34(13)2015–2019
  • Pasechnik I. K. [Study of choleretic properties of flavonoid compounds isolated from Folia Menthae piperitae]. Farmakol. Toksikol 1966; 29(6)735–737, View Abstract
  • Goerg K. J., Spilker T. Effect of peppermint oil and caraway oil on gastrointestinal motility in healthy volunteers: a pharmacodynamic study using simultaneous determination of gastric and gall-bladder emptying and orocaecal transit time. Aliment. Pharmacol. Ther 2003; 17(3)445–451, View Abstract
  • Adam B., Liebregts T., Best J., Bechmann L., Lackner C, Neumann J., Koehler S., Holtmann G. A combination of peppermint oil and caraway oil attenuates the post-inflammatory visceral hyperalgesia in a rat model. Scand J Gastroenterol 2006; 41(2)155–160, View Abstract
  • Burrow A., Eccles R., Jones A. S. The effects of camphor, eucalyptus and menthol vapour on nasal resistance to airflow and nasal sensation. Acta Otolaryngol 1983; 96(1-2)157–161, View Abstract
  • Eccles R., Jones A. S. The effect of menthol on nasal resistance to airflow. J Laryngol Otol 1983; 97(8)705–709, View Abstract
  • Eccles R., Griffiths D. H., Newton C. G., Tolley N. S. The effects of D and L isomers of menthol upon nasal sensation of airflow. J Laryngol Otol 1988; 102(6)506–508, View Abstract
  • Naito K., Ohoka E., Kato R., Kondo Y., Lwata S. The effect of L-menthol stimulation of the major palatine nerve on nasal patency. Auris Nasus Larynx 1991; 18(3)221–226, View Abstract
  • Naito K., Komori M., Kondo Y., Takeuchi M., Iwata S. The effect of L-menthol stimulation of the major palatine nerve on subjective and objective nasal patency. Auris Nasus Larynx 1997; 24(2)159–162, View Abstract
  • Green B. G. Menthol modulates oral sensations of warmth and cold. Physiol Behav 1985; 35(3)427–434, View Abstract
  • Nishino T., Tagaito Y., Sakurai Y. Nasal inhalation of l-menthol reduces respiratory discomfort associated with loaded breathing. Am J Respir Crit Care Med 1997; 156(1)309–313, View Abstract
  • Micklefield G. H., Greving I., May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother. Res 2000; 14(1)20–23, View Abstract
  • Hills J. M., Aaronson P. I. The mechanism of action of peppermint oil on gastrointestinal smooth muscle. An analysis using patch clamp electrophysiology and isolated tissue pharmacology in rabbit and guinea pig. Gastroenterology 1991; 101(1)55–65, View Abstract
  • Taylor B., Luscombe D., Duthie H. Inhibitory effect of peppermint oil on gastrointestinal smooth muscle. Gut 1983; 24: A992
  • Hawthorn M., Ferrante J., Luchowski E., Rutledge A., Wei X. Y., Triggle D. J. The actions of peppermint oil and menthol on calcium channel dependent processes in intestinal, neuronal and cardiac preparations. Aliment. Pharmacol Ther 1988; 2(2)101–118, View Abstract
  • Duthie H. L. The effect of peppermint oil on colonie motility in man. Br J Surg 1981; 68: 820
  • Täte S. Peppermint oil: a treatment for postoperative nausea. J Adv. Nurs 1997; 26(3)543–549, View Abstract
  • Giachetti D., Taddei E., Taddei I. Pharmacological activity of essential oils on Oddi's sphincter. Planta Med 1988; 54(5)389–392, View Abstract
  • Mascher H., Kikuta C, Schiel H. Pharmacokinetics of menthol and carvone after administration of an enteric coated formulation containing peppermint oil and caraway oil. Arzneimittelforschung 2001; 51(6)465–469, View Abstract
  • Somerville K. W., Richmond C. R., Bell G. D. Delayed release peppermint oil capsules (Colpermin) for the spastic colon syndrome: a pharmacokinetic study. Br. J Clin Pharmacol 1984; 18(4)638–640, View Abstract
  • White D. A., Thompson S. P., Wilson C. G., et al. A pharmacokinetic comparison of two delayed-release peppermint oil preparations, Colpermin and Mintec, for treatment of irritable bowel syndrome. Int J Pharm 1987; 40: 151–155
  • Leicester R. J., Hunt R. H. Peppermint oil to reduce colonie spasm during endoscopy. Lancet 10–30–1982; 2(8305)989, View Abstract
  • Briggs C. Peppermint: medicinal herb and flavouring agent. Can Pharm J 1993; 126(2)89–92
  • Sparks M. J., O'Sullivan P., Herrington A. A., Morcos S. K. Does peppermint oil relieve spasm during barium enema? Br. J Radiol 1995; 68(812)841–843, View Abstract
  • Asao T., Kuwano H., Ide M., Hirayama I., Nakamura J. I., Fujita K. I., Horiuti R. Spasmolytic effect of peppermint oil in barium during double-contrast barium enema compared with Buscopan. Clin Radiol 2003; 58(4)301–305, View Abstract
  • May B., Kuntz H. D., Kieser M., Kohier S. Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996; 46(12)1149–1153, View Abstract
  • Barnick C. G, Cardozo L. D. The treatment of abdominal distension and dyspepsia with enteric coated peppermint oil following routine gynaecological intraperitoneal surgery. J Obstet. Gynecol 1990; 10(5)423–424
  • Madisch A., Heydenreich C. J., Wieland V., Hufnagel R., Hotz J. Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled double-blind equivalence study. Arzneimittelforschung 1999; 49(ll)925–932, View Abstract
  • Freise J., Kohler S. [Peppermint oil-caraway oil fixed combination in non-ulcer dyspepsia-comparison of the effects of enteric preparations]. Pharmazie 1999; 54(3)210–215, View Abstract
  • Dalvi S. S., Nadkarni P. M., Pardesi R., Gupta K. C. Effect of peppermint oil on gastric emptying in man: a preliminary study using a radiolabelled solid test meal. Indian J Physiol Pharmacol 1991; 35(3)212–214, View Abstract
  • Carling L, Svedberg L, Hultsen S. Short term treatment of the irritable bowel syndrome: a placebo-controlled trial of peppermint oil against hyoscyamine. Opuscula Med 1989; 34: 55–57
  • Schneider M M, Otten M H. Efficacy of colpermin in the treatment of patients with irritable bowel syndrome (abstract). Gastroenterology 1990; 98(5)A389
  • Dew M. J., Evans B. K, Rhodes J. Peppermint oil for the irritable bowel syndrome: a multicentre trial. Br J Clin Pract 1984; 38(ll-12)394–398, View Abstract
  • Evans B. K, Le vine D. F., Mayberry J. F., et al. Multicentre trial of peppermint oil capsules in irritable bowel syndrome. Scand J Gastroenterol 1982; 17: 503
  • Rhodes J., Evans B. K, Rees W. D. Peppermint oil in enteric coated capsules for the treatment of irritable bowel syndrome: a double blind controlled trial. Hepato-Gastroenterology 1980; 27(Suppl)252
  • Shaw G., Srivastava E. D., Sadlier M., Swann P., James J. Y., Rhodes J. Stress management for irritable bowel syndrome: a controlled trial. Digestion 1991; 50(1)36–42, View Abstract
  • Logan A. C., Beaulne T. M. The treatment of small intestinal bacterial overgrowth with enteric-coated peppermint oil: A case report. Altern Med Rev 2002; 7(5)410–417, View Abstract
  • Mizuno S., Kato K., Ono Y., Yano K., Kurosaka H., Takahashi A., Abeta H., Kushiro T., Miyamoto S., Kurihara R., Hiki N., Kaminishi M., Iwasaki A., Arakawa Y. Oral peppermint oil is a useful antispasmodic for double-contrast barium meal examination. J Gastroenterol. Hepatol 2006; 21(8)1297–1301, View Abstract
  • Anderson L. A., Gross J. B. Aromatherapy with peppermint, isopropyl alcohol, or placebo is equally effective in relieving postoperative nausea. J Perianesth. Nurs 2004; 19(1)29–35, View Abstract
  • Shin B. C., Lee M. S. Effects of aromatherapy acupressure on hémiplégie shoulder pain and motor power in stroke patients: a pilot study. J Altern Complement Med 2007; 13(2)247–251, View Abstract
  • Sullivan T. E., Warm J. S., Schefft B. K., Dember W. N., O'Dell M. W., Peterson S. J. Effects of olfactory stimulation on the vigilance performance of individuals with brain injury. J Clin Exp Neuropsychol 1998; 20(2)227–236, View Abstract

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.