131
Views
7
CrossRef citations to date
0
Altmetric
Review

Developing curcumin into a viable therapeutic for lymphoma

, &
Pages 57-67 | Published online: 03 Dec 2008

Bibliography

  • Hansmann ML, Küppers R. Pathology and ‘molecular histology’ of Hodgkin's disease and the border to non-Hodgkin's lymphomas. Baillieres Clin Haematol 1996;9:459-77
  • Harris NL. Hodgkin's disease: classification and differential diagnosis. Mod Pathol 1999;12:159-75
  • Küppers R, Schwering I, Bräuninger A, et al. Biology of Hodgkin's lymphoma. Ann Oncol 2002;13(Suppl 1):11-8
  • Bräuninger A, Hansmann ML, Strickler JG, et al. Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma. N Engl J Med 1999;340:1239-47
  • Coffey J, Hodgson DC, Gospodarowicz MK. Therapy of non-Hodgkin's lymphoma. Eur J Nucl Med Mol Imaging 2003;(Suppl 1):S28-36
  • Jiménez-Zepeda VH, Jiménez-Zepeda RJ. Non-Hodgkin's lymphoma: biologic classification, diagnosis and treatment. Gac Med Mex 1998;134:443-63
  • Thomas RK, Kallenborn A, Wickenhauser C, et al. Constitutive expression of c-FLIP in Hodgkin and Reed-Sternberg cells. Am J Pathol 2002;160:1521-8
  • Davis RE, Brown KD, Siebenlist U, et al. Constitutive nuclear factor κB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells. J Exp Med 2001;194:1861-74
  • Plumas J, Jacob MC, Chaperot L, et al. Tumor B cells from non-Hodgkin's lymphoma are resistant to CD95 (Fas/Apo-1)-mediated apoptosis. Blood 1998;91:2875-85
  • Krammer PH. CD95's deadly mission in the immune system. Nature 2000;407:789-95
  • Kuppers R, Rajewsky K. The origin of Hodgkin and Reed/Sternberg cells in Hodgkin's disease. Annu Rev Immunol 1998;16:471-93
  • Thomas RK, Re D, Wolf J, et al. Part I. Hodgkin's lymphoma–molecular biology of Hodgkin and Reed-Sternberg cells. Lancet Oncol 2004;5:11-8
  • Lodha R, Bagga A. Traditional Indian systems of medicine. Ann Acad Med Singapore 2000;29:37-41
  • Chen H, Zhang ZS, Zhang YL, et al. Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing apoptosis in colon carcinoma cells. Anticancer Res 1999;19:3675-80
  • Li L, Aggarwal BB, Shishodia S, et al. Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. Cancer 2004;101:2351-62
  • Syng-Ai C, Kumari AL, Khar A. Effect of curcumin on normal and tumor cells: role of glutathione and bcl-2. Mol Cancer Ther 2004;3:1101-08
  • Limtrakul P, Lipigorngoson S, Namwong O, et al. Inhibitory effect of dietary curcumin on skin carcinogenesis in mice. Cancer Lett 24;116:197-203
  • Huang MT, Lou YR, Xie JG, et al. Effect of dietary curcumin and dibenzoylmethane on formation of 7,12-dimethylbenz [a] anthracene-induced mammary tumors and lymphomas/leukemias in Sencar mice. Carcinogenesis 1998;19:1697-700
  • Kawamori T, Lubet R, Steele VE, et al. Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Res 1999;59:597-601
  • Chuang SE, Kuo ML, Hsu CH, et al. Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. Carcinogenesis 2000;21:331-5
  • Su CC, Yang JS, Lin SY, et al. Curcumin inhibits WEHI-3 leukemia cells in BALB/c mice in vivo. In vivo 2008;22:63-8
  • Aggarwal BB, Banerjee S, Bharadwaj U, et al. Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines. Biochem Pharmacol 2007;73:1024-32
  • Srivastava RK, Chen Q, Siddiqui I, et al. Linkage of curcumin-induced cell cycle arrest and apoptosis by cyclin-dependent kinase inhibitor p21(/WAF1/CIP1). Cell Cycle 2007;6:2953-61
  • Anand P, Sundaram C, Jhurani S, et al. Curcumin and cancer: an “old-age” disease with an “age-old” solution. Cancer Lett 2008;18(267):133-64
  • Uddin S, Hussain AR, Manogaran PS, et al. Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma. Oncogene 2005;24:7022-30
  • Hussain A, Al-Rasheed M, Manogaran PS, et al. Curcumin induced apoptosis in acute T cell leukemias. Apoptosis 2006;11:245-54
  • Ranjan D, Johnston TD, Reddy KS, et al. Enhanced apoptosis mediates inhibition of EBV-transformed lymphoblastoid cell line proliferation by curcumin. J Surg Res 1999;87:1-5
  • Han SS, Chung ST, Robertson DA, et al. Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53. Clin Immunol 1999;93:152-61
  • Tomita M, Kawakami H, Uchihara JN, et al. Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells. Int J Cancer 2006;118:765-72
  • Tomita M, Kawakami H, Uchihara JN, et al. Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines. Leuk Res 2006;30:313-21
  • Huang MT, Lou YR, Ma W, et al. Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice. Cancer Res 1994;54:5841-7
  • Kelloff GJ, Boone CW, Crowell JA, et al. Chemopreventive drug development: perspectives and progress. Cancer Epidemiol Biomarkers Prev 1994;3:85-98
  • Somasundaram S, Edmund NA, Moore DT, et al. Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res 2002;62:3868-75
  • Jaiswal AS, Marlow BP, Gupta N, et al. Beta-cateninmediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene 2002;21:8414-27
  • Bhaumik S, Anjum R, Rangaraj N, et al. Curcumin mediated apoptosis in AK-5 tumor cells involves the production of reactive oxygen intermediates. FEBS Lett 1999;456:311-14
  • Woo JH, Kim YH, Choi YJ, et al. Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis 2003;24:1199-208
  • Simon HU, Haj-Yehia A, Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 2002;5:415-18
  • Hussain AR, Ahmed M, Al-Jomah N, et al. Curcumin required Bax to induce cell death in Burkitt's lymphoma. Mol Cancer Ther 2008;7 [Epub]
  • Jung EM, Lim JH, Lee TJ, et al. Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5). Carcinogenesis 2005;26:1905-13
  • Wang X, Chen W, Zeng W, et al. Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells. Mol Cancer Ther 2008;7:1156-63
  • Fantin VR, Loboda A, Paweletz CP, et al. Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma. Cancer Res 2008;68:3785-94
  • Fan Y, Dutta J, Gupta N, et al. Regulation of programmed cell death by NF-kappaB and its role in tumorigenesis and therapy. Adv Exp Med Biol 2008;615:223-50
  • Marzo I, Naval J. Bcl-2 family members as molecular targets in cancer therapy. Biochem Pharmacol 2008 [Epub ahead of print]
  • Uddin S, Hussain A, Manogaran PS, et al. Inhibition of phosphatidylinositol 3′-kinase/AKT-signaling promotes apoptosis of primary effusion lymphoma cells. Clin Cancer Res 2005;11:3102-8
  • Matthews CP, Colburn NH, Young MR. AP-1 a target for cancer prevention. Curr Cancer Drug Targets 2007;7:317-24
  • Steelman LS, Abrams SL, Whelan J, et al. Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia. Leukemia 2008;22:686-707
  • Verde P, Casalino L, Talotta F, et al. Deciphering AP-1 function in tumorigenesis: fra-ternizing on target promoters. Cell Cycle 2007;6:2633-9
  • Lee TL, Yeh J, Friedman J, et al. A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas. Int J Cancer 2008;122:1987-98
  • Borgés S, Moudilou E, Vouyovitch C, et al. Involvement of a JAK/STAT pathway inhibitor: cytokine inducible SH2 containing protein in breast cancer. Adv Exp Med Biol 2008;617:321-9
  • Chang YM, Bai L, Liu S, et al. Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530. Oncogene 2008 [Epub ahead of print]
  • Bharti AC, Donato N, Singh S, et al. Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 2003;101:1053-62
  • Bharti AC, Donato N, Aggarwal BB. Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. J Immunol 2003;171:3863-71
  • Bharti AC, Shishodia S, Reuben JM, et al. Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. Blood 2004;103:3175-84
  • Li L, Aggarwal BB, Shishodia S, et al. Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. Cancer 2004;101:2351-62
  • Mukhopadhyay A, Bueso-Ramos C, Chatterjee D, et al. Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines Oncogene 2001;20:7597-609
  • Bush JA, Cheung KJ Jr, Li G. Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53. Exp Cell Res 2001;271:305-14
  • Anto RJ, Mukhopadhyay A, Denning K, et al. Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl. Carcinogenesis 2002;23:143-50
  • Jones KD, Aoki Y, Chang Y, et al. Involvement of interleukin-10 (IL-10) and viral IL-6 in the spontaneous growth of Kaposi's sarcoma herpesvirus-associated infected primary effusion lymphoma cells. Blood 1999;94:2871-9
  • Sredni B, Weil M, Khomenok G, et al. Ammonium trichloro(dioxoethylene-o,o′)tellurate (AS101) sensitizes tumors to chemotherapy by inhibiting the tumor interleukin 10 autocrine loop. Cancer Res 2004;64:1843-52
  • Aoki Y, Feldman GM, Tosato G. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood 2003;101:1535-42
  • Deveraux QL, Reed JC. IAP family proteins–suppressors of apoptosis. Genes Dev 1999;13:239-52
  • Deveraux QL, Roy N, Stennicke HR, et al. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J 1998;17:2215-23
  • Hallek M, Bergsagel PL, Anderson KC. Multiple myeloma: increasing evidence for a multistep transformation process. Blood 1998;91:3-21
  • Ferrajoli A, Faderl S, Ravandi F, et al. The JAK-STAT pathway: a therapeutic target in hematological malignancies. Curr Cancer Drug Targets 2006;6:671-9
  • Catlett-Falcone R, Landowski TH, Oshiro MM, et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 1999;10:105-15
  • Sun ZW, Andersson R. NF-kappa b activation and inhibition: A review. Shock 2002;18:99-106
  • Chen CL, Edelstein, LC, Gelinas C. The Rel/NF-kappa B family directly activates expression of the apoptosis inhibitor Bcl-x(L). Mol Cell Biol 2000;20:2687-95
  • Lin MT, Chang CC, Chen ST, et al. Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappa B-dependent XIAP up-regulation. Biol Chem 2004;279:24015-23
  • Shukla S, Gupta S. Suppression of constitutive and tumor necrosis factor alpha-induced nuclear factor (NF)-kappa B activation and induction of apoptosis by apigenin in human prostate carcinoma PC-3 cells: Correlation with down-regulation of NF-kappa B-responsive genes. Clin Cancer Res 2004;10:3169-78
  • Pham LV, Tamayo AT, Yoshimura LC, et al. Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis. J Immunol 2003;171:88-95
  • Cho JW, Lee KS, Kim CW. Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets. Int J Mol Med 2007;19:469-74
  • Baichwal and Baeuerie Activate NF-kappa B or die? Curr Biol 1997;1(7):R94-6
  • Bhardwaj A, Sethi G, Vadhan-Raj S, et al. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood 2007;109:2293-302
  • Shishodia S, Amin HM, Lai R, et al. Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol 2005;70:700-13
  • Bertoniand F, Ponzoni M. The cellular origin of mantle cell lymphoma. Int J Biochem Cell Biol 2007;39:1747-53
  • Shakir R, Ngo N, Naresh KN. Correlation of cyclin D1 transcript levels, transcript type and protein expression with proliferation and histology among mantle cell lymphoma. J Clin Pathol 2008;61:920-7
  • Rummel MJ, de Vos S, Hoelzer D, et al. Altered apoptosis pathways in mantle cell lymphoma. Leuk Lymphoma 2004;45:49-54
  • Tracey L, Pérez-Rosado A, Artiga MJ, et al. Expression of the NF-B targets BCL2 and BIRC5/Survivin characterizes small B-cell and aggressive B-cell lymphomas, respectively. J Pathol 2005;206:123-34
  • Baldwin AS. The transcription factor NF-κB and human disease. J Clin Invest 2001;107:3-6
  • Wang CY, Guttridge DC, Mayo MW, et al. NF-κB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol Cell Biol 1999;19:5923-9
  • Dummer R, Willers J, Kamarashev J, et al. Pathogenesis of cutaneous lymphomas. Semin Cutan Med Surg 2000;9:78-86
  • Dummer R, Cozzio A, Meier S, et al. Standard and experimental therapy in cutaneous T cell lymphomas. J Cutan Pathol 2006;33(Suppl No 1):52-57
  • Döbbeling U. Transcription factor profiling shows new ways towards new treatment options of cutaneous T cell lymphomas. Curr Drug Discov Technol 2007;4:24-30
  • Krejsgaard T, Vetter-Kauczok CS, Woetmann A, et al. Jak3- and JNK-dependent vascular endothelial growth factor expression in cutaneous T-cell lymphoma Leukemia 2006;20:1759-66
  • Thomas RK, Sos ML, Zander T, et al. Inhibition of nuclear translocation of nuclear factor-κB despite lack of functional IκBα protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies. Clinical Cancer Res 2005;11:8186-94
  • Mackenzie GG, Queisser N, Wolfson ML, et al. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. Int J Cancer 2008;123:56-65
  • Cleary ML, Smith SD, Sklar J, Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 1986;47:19-28
  • Hockenbery D, Nunez G, Milliman C, et al. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990;22:334-6
  • Gandhi MK, Marcus RE. Follicular lymphoma: time for a re-think? Blood Rev 2005;19:1655-78
  • Hiddemann W, Buske C, Dreyling M, Treatment strategies in follicular lymphomas: current status and future perspectives, J Clin Oncol 2005;23:6394-9
  • Skommer J, Wlodkowic D, Pelkonen J. Cellular foundation of curcumin-induced apoptosis in follicular lymphoma cell lines. Exp Hematol 2006;34:463-74
  • Skommer J, Wlodkowic D, Pelkonen J. Gene-expression profiling during curcumin-induced apoptosis reveals downregulation of CXCR4. Exp Hematol 2007;35:84-95
  • Deutsch AJ, Aigelsreiter A, Steinbauer E, et al. Distinct signatures of B-cell homeostatic and activation-dependent chemokine receptors in the development and progression of extragastric MALT lymphomas. J Pathol 2008;215:431-44
  • Liu HL, Chen Y, Cui GH, et al. Curcumin, a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-NHL cell line Raji proliferation. Acta Pharmacol Sin 2005;26:603-9
  • Chen Y, Shu W, Chen W, et al. Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells. Basic Clin Pharmacol Toxicol 2007;101:427-33
  • Wu Q, Chen Y, Li X. HDAC1 expression and effect of curcumin on proliferation of Raji cells. J Huazhong Univ Sci Technolog Med Sci 2006;26:199-201
  • Wu Q, Chen Y, Li XG, et al. Regulatory effect of curcumin on p300 and HDAC1 in B-NHL cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2006;14:293-7
  • Li XG, Chen Y, Wu Q, et al. Effect of curcumin on acetylation of histone H3 in human lymphoma cell line Raji. Ai Zheng 2006;25:582-6
  • Gururajan M, Dasu T, Shahidain S, et al. Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth. J Immunol 2007;178:111-21
  • Kunnumakkara AB, Guha S, Krishnan S, et al. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer Res 2007;67:3853-61
  • Cheng AL, Hsu CH, Lin JK, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 2001;21:2895-900
  • Garcea G, Jones DJ, Singh R, et al. Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration. Br J Cancer 2004;90:1011-15
  • Li L, Ahmed B, Mehta K, et al. Liposomal curcumin with and without oxaliplatin: effects on cell growth, apoptosis, and angiogenesis in colorectal cancer. Mol Cancer Ther 2007;6:1276-82
  • Li L, Braiteh FS, Kurzrock R. Liposome-encapsulated curcumin: In vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer 2005;104:1322-31
  • Wang D, Veena MS, Stevenson K, et al. Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor κB by an AKT-independent pathway. Clin Cancer Res 2008;14:6228-36

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.