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Expert Opinion on Investigational Drugs Volume 18, 2009 - Issue 5
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Reviews

Pharmacological approaches to the treatment of obstructive sleep apnoea

Malcolm Kohler University Hospital of Zurich, Sleep Disorders Centre and Pulmonary Division, Raemistrasse 100, Zurich 8091, Switzerland +41 44 255 97 51; +41 44 255 44 51; [email protected]
,
Konrad E Bloch University Hospital of Zurich, Sleep Disorders Centre and Pulmonary Division, Raemistrasse 100, Zurich 8091, Switzerland +41 44 255 97 51; +41 44 255 44 51; [email protected]
&
John R Stradling Churchill Hospital, Sleep Unit, Oxford Centre for Respiratory Medicine, Old Road, Headington, Oxford OX3 7LJ, UK
Pages 647-656 | Published online: 24 Apr 2009

Bibliography

  • Schwab RJ, Pasirstein M, Pierson R, et al. Identification of upper airway anatomic risk factors for obstructive sleep apnea with volumetric MRI. Am J Respir Crit Care Med 2003;168:522-30
  • Kushida CA, Efron B, Guilleminault C. A predictive model for the obstructive sleep apnea syndrome. Ann Intern Med 1997;127:581-7
  • Issa FG, Sullivan CE. Upper airway closing pressures in obstructive sleep apnea. J Appl Physiol 1984;57:520-7
  • Redline S, Tishler PV, Tosteson TD, et al. The familial aggregation of obstructive sleep apnea. Am J Respir Crit Care Med 1995;151:682-7
  • Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 2002;165:1217-39
  • George CF. Reduction in motor vehicle collisions following treatment of sleep apnoea with nasal CPAP. Thorax 2001;56:508-12
  • Peker Y, Hedner J, Norum J, et al. Increased incidence of cardiovascular disease in middle-aged men with obstructive sleep apnea: a 7-year follow-up. Am J Respir Crit Care Med 2002;166:159-65
  • Marin JM, Carrizo SJ, Vicente E, et al. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 2005;365:1046-53
  • Kohler M, Craig S, Nicoll D, et al. Endothelial function and arterial stiffness in minimally symptomatic obstructive sleep apnea. Am J Respir Crit Care Med 2008;178:984-8
  • Somers VK, Kyken ME, Clary MP, et al. Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 1995;96:1897-904
  • Shamsuzzaman AS, Winnicki M, Lanfranchi P, et al. Elevated C-reactive protein in patients with obstructive sleep apnea. Circulation 2002;105:2462-64
  • Ip MSM, Tse HF, Lam B, et al. Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med 2004;169:348-53
  • Kohler M, Pepperell JCT, Casadei B, et al. CPAP and measures of cardiovascular risk in males with OSAS. Eur Respir J 2008;32:1488-96
  • Somers VK, White DP, Amin R, et al. Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation scientific statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing. J Am Coll Cardiol 2008;52:686-717
  • Smith I, Lasserson TJ, Wright J. Drug therapy for obstructive sleep apnoea in adults. Cochrane Database Syst Rev 2006;(2):CD003002
  • Hedner J, Grote L, Zou D. Pharmacological treatment of sleep apnea: current situation and future strategies. Sleep Medicine Rev 2008;12:33-47
  • Sullivan CE, Berthon-Jones M, Issa FG, et al. Reversal of obstructive sleep apnea by continuous positive airway pressure applied trough the nares. Lancet 1981;1:862-5
  • Engleman HM, Martin SE, Deary IJ, et al. Effect of continuous positive airway pressure treatment on daytime function in sleep apnoe/hypopnoe syndrome. Lancet 1994;343:572-5
  • Jenkinson C, Davies RJO, Mullins R, et al. Comparison of therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised prospective parallel trial. Lancet 1999;353:2100-5
  • Chervin RD, Theut S, Bassetti C, et al. Compliance with nasal CPAP can be improved by simple interventions. Sleep 1997;20:284-9
  • Kaplan V, Bingisser R, Li Y, et al. Compliance with nasal positive pressure (CPAP) in obstructive sleep apnea syndrome. Swiss Med Weekly 1996;130:15-22
  • Engleman HM, Kingshott RN, Wraith PK, et al. Randomized placebo-controlled crossover trial of continuous positive airway pressure for mild sleep apnea/hypopnea syndrome. Am J Respir Crit Care Med 1999;159:461-7
  • Bloch KE, Iseli A, Zhang JN, et al. Randomized, controlled trial of two oral appliances for sleep apnea treatment. Am J Respir Crit Care Med 2000;162:246-1
  • Bloch KE, Senn O, Iseli A. Oral appliances for the treatment of snoring and obstructive sleep apnea. In: Fabiani M, editor. Surgery for snoring and obstructive sleep apnea syndrome. The Hague, Netherlands: Kugler Publications, 2003
  • Fritsch K, Iseli A, Russi EW, et al. Side effects of manidubular advancement devices for sleep apnea treatment. Am J Respir Crit Care Med 2001;164:813-18
  • Scherler MR. Surgical options for treatment of snoring and sleep apnea. Ther Umsch 2000;57:454-7
  • Punjabi NM, Newman AB, Young TB, et al. Sleep-disordered breathing and cardiovascular disease: an outcome-based definition of hypopneas. Am J Respir Crit Care Med 2008;177:1150-5
  • Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 1991;14:540-5
  • Carskadon MA, Dement WC, Mitler MM, et al. Guidelines for the multiple sleep latency test (MSLT): a standard measure of sleepiness. Sleep 1986;9:519-24
  • Poceta JS, Timms RM, Jeong DU, et al. Maintenance of wakefulness test in obstructive sleep apnea syndrome. Chest 1992;101:893-7
  • Bennett LS, Stradling JR, Davies RJ. A behavioural test to assess daytime sleepiness in obstructive sleep apnoea. J Sleep Res 1997;6:142-5
  • Carley DW, Olopade C, Ruigt GS, et al. Efficacy of mirtazapine in obstructive sleep apnea syndrome. Sleep 2007;30:35-41
  • Hollister LE. Tricyclic antidepressants. N Engl J Med 1978;299:1106-9
  • Bonora M, St John WMBT. Differential elevation by protriptyline and depression by diazepam of upper airway respiratory motor activity. Am Rev Respir Dis 1985;131:41-5
  • Brownell L, West P, et al. Protriptyline in obstructive sleep apnoea: a double blind trial. N Engl J Med 1982;307:1037-42
  • Stepanski E, Conway W, Young D, et al. A double-blind trial of protriptyline in the treatment of sleep apnoea syndrome. Henry Ford Hospital Medical Journal 1988;36:5-8
  • Whyte K, Gould G, Airlie A, et al. Role of protriptyline and acetazolomide in the sleep apnea/hypopnea syndrome. Sleep 1988;11:463-72
  • Sunderram J, Parisi RA, Strobel RJ. Serotonergic stimulation of the genioglossus and the response to nasal continuous positive airway pressure. Am J Respir Crit Care Med 2000;162:925-9
  • Kraiczi H, Hedner J, Dahlof P, et al. Effect of serotonin uptake inhibition on breathing during sleep and daytime symptoms in obstructive sleep apnea. Sleep 1999;22:61-7
  • Berry RB, Koch GL, Hayward LF. Low-dose mirtazapine increases genioglossus activity in the anesthetized rat. Sleep 2005;28:78-84
  • Carley DW, Radulovacki M. Mirtazapine, a mixed-profile serotonin agonist/antagonist, suppresses sleep apnea in the rat. Am J Respir Crit Care Med 1999;160:1824-9
  • Marshall NS, Yee BJ, Deasi AV, et al. Two randomized placebo-controlled trials to evaluate the efficacy and tolerability of mirtazapine for the treatment of obstructive sleep apnea. Sleep 2008;31:824-31
  • Veasey SC, Chachkes J, Fenik P, et al. The effects of ondansetron on sleep-disordered breathing in the English bulldog. Sleep 2001;24:155-60
  • Stradling JR, Smith D, Radulovacki M, et al. Effect of ondansetron on moderate obstructive sleep apnoea, a single night, placebo-controlled trial. J Sleep Res 2003;12:169-70
  • Faris PL, Kim SW, Meller WH, et al. Effect of decreasing afferent vagal activity with ondansetron on symptoms of bulimia nervosa: a randomised, double-blind trial. Lancet 2000;355:792-7
  • Garner SJ, Eldridge FL, Wagner PG, et al. Buspirone, an anxiolytic drug that stimulates respiration. Am Rev Respir Dis 1989;139:945-50
  • Mendelson WB, Maczaj M, Holt J. Buspirone administration to sleep apnea patients. J Clin Psychopharmacol 1991;11:71-2
  • Bellingham MC, Ireland MF. Contribution of cholinergic systems to state dependent modulation of respiratory control. Respir Physiol Neurobiol 2002;131:135-44
  • Gilman S, Chervin RD, Koeppe RA, et al. Obstructive sleep apnea is related to a thalamic cholinergic deficit in MSA. Neurology 2003;61:35-9
  • Hedner J, Kraiczi H, Peker Y, et al. Reduction of sleep-disordered breathing after physostigmine. Am J Respir Crit Care Med 2003;168:1246-51
  • Moraes W, Poyares D, Sukys-Claudino L, et al. Donepezil improves obstructive sleep apnea in Alzheimer disease. Chest 2008;133:677-83
  • Hedner J, Kraiczi H, Peker Y, et al. Reduction of sleep apnea after the orally available cholinesterase inhibitor donepezil. Sleep Medicine 2005;6:S54-55
  • Espinoza H, Antic R, Thornton AT, et al. The effects of aminophylline on sleep and sleep-disordered breathing in patients with obstructive sleep apnea syndrome. Am Rev Respir Dis 1987;136:80-4
  • Hein H, Behnke G, Jorres RA, et al. The therapeutic effect of theophylline in mild obstructive sleep apnea/hypopnea syndrome: results of repeated measurements with portable recording devices at home. Eur J Med Res 2000;5:391-9
  • Mulloy E, Mcnicholas WT. Theophylline in obstructive sleep apnea: a double-blind evaluation. Chest 1992;101:753-7
  • Atkinson RL, Suratt PM, Wilhoit SC, et al. Naloxone improves sleep apnea in obese humans. Int J Obesity 1985;9:233-9
  • Ferber C, Duclaux R, Mouret J. Naltrexone improves blood gas patterns in obstructive sleep apnoea syndrome through its influence on sleep. J Sleep Res 1993;2:149-55
  • Suratt PM, Wilhoit SC, Brown ED, et al. Effect of doxapram on obstructive sleep apnea. Bulletin Europeen de Physiopathologie Respiratoire 1986;22:127-31
  • Mangin P, Krieger J, Kurtz D. Effect of oral almitrine on the sleep apnea syndrome. Revue Francaise des Maladies Respiratoires 1983;11:899-906
  • Kiely JL, Nolan P, Mcnicholas WT. Intranasal corticosteroid therapy for obstructive sleep apnoea in patients with co-existing rhinitis. Thorax 2004;59:50-5
  • Clarenbach CF, Kohler M, Senn O, et al. Does nasal decongestion improve obstructive sleep apnea? J Sleep Res 2008;17:444-9
  • Jokic R, Klimaszewski A, Mink J, et al. Surface tension forces in sleep apnea: the role of a soft tissue lubricant. Am J Respir Crit Care Med 1998;157:1522-5
  • Rasche K, Duchna HW, Lauer J, et al. Obstructive sleep apnea and hypopnea efficacy and safety of a long-acting beta2-agonist. Sleep and Breathing 1999;3:125-9
  • Widdicombe JG, Davies A. The effects of a mixture of surface-active agents (Sonarex) on upper airways resistance and snoring in anaesthetized dogs. Eur Respir J 1988;1:785-91
  • Morrell MJ, Arabi Y, Zahn BR, et al. Effect of surfactant on pharyngeal mechanics in sleeping humans: implications for sleep apnoea. Eur Respir J 2002;20:451-7
  • Schwartz AR, Rowley JA, O'donnell C, et al. Effect of hypertension on upper airway function and sleep apnoea. J Sleep Res 1995;4:83-8
  • Carley DW, Trbovic SM, Radulovacki M. Hydralazine reduces elevated sleep apnea index in spontaneously hypertensive (SHR) rats to equivalence with normotensive Wistar-Kyoto rats. Sleep 1996;19:363-6
  • Grote L, Wutkewicz K, Knaack L, et al. Association between blood pressure reduction with antihypertensive treatment and sleep apnea activity. Am J Hypertens 2000;13:1280-7
  • Issa FG. Effect of clonidine in obstructive sleep apnea. Am Rev Respir Dis 1992;145:435-9
  • Heitmann J, Grote L, Knaack L, et al. Cardiovascular effects of mibefradil in hypertensive patients with obstructive sleep apnea. Eur J Clin Pharmacol 1998;54:691-6
  • Mcmanigle JE, Panico WH, Dasilva AM, et al. Respiratory effects produced by microinjection of L-glutamate and an uptake inhibitor of L-glutamate into the caudal subretrofacial area of the medulla. Eur J Pharmacol 1995;280:257-75
  • Pauwels P, Van Assouw H, Peeters L, et al. Chronic treatment with sabeluzole protects cultured rat brain neurones from the neurotoxic effects of excitatory amino acids. Synapse 1992;12:271-80
  • Hedner J, Grunstein R, Eriksson B, et al. A double-blind, randomized trial of sabeluzole - a putative glutamate antagonist - in obstructive sleep apnea. Sleep 1996;19:287-9
  • Torvaldsson S, Grote L, Peker Y, et al. A randomized placebo-controlled trial of an NMDA receptor antagonist in sleep-disordered breathing. J Sleep Res 2005;14:149-55
  • Popovic RM, White DP. Upper airway muscle activity in normal women: influence of hormonal status. J Appl Physiol 1998;84:1055-62
  • Manber R, Kuo TF, Cataldo N, et al. The effects of hormone replacement therapy on sleep-disordered breathing in postmenopausal women: a pilot study. Sleep 2003;2:163-8
  • Cook WR, Benich JJ, Wooten SA. Indices of severity of obstructive sleep apnea syndrome do not change during medroxyprogesterone acetate therapy. Chest 1989;96:262-6
  • Suurna MV, Welge J, Surdulescu V, et al. Randomized placebo-controlled trial of pantoparzole for daytime sleepiness in GERD and obstructive sleep disordered breathing. Otolaryng Head Neck 2008;139:286-90
  • Resta O, Foschino-Barbaro MP, Legari G, et al. Sleep-related breathing disorders, loud snoring and excessive daytime sleepiness in obese subjects. Int J Obes Relat Metab Disord 2001;25:669-75
  • Peppard PE, Young T, Palta M, et al. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA 2000;284:3015-21
  • Yee BJ, Phillips CL, Banerjee D, et al. The effect of sibutramine-assisted weight loss in men with obstructive sleep apnoea. Int J Obesity 2007;31:161-8

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