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Novel investigational adenosine A2A receptor antagonists for Parkinson's disease

Pages 1619-1631 | Published online: 04 Nov 2009

Bibliography

  • Obeso JA, Rodriguez-Oroz MC, Rodriguez M, Pathophysiology of the basal ganglia in Parkinson's disease. Trends Neurosci 2000;23:S8-19
  • Chaudhuri KR, Healy DG, Schapira AH; National Institute for Clinical Excellence. Non-motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurol 2006;5(3):235-45
  • Alves G, Forsaa EB, Pedersen KF, Epidemiology of Parkinson's disease. J Neurol 2008;255(Suppl 5):18-32
  • Jenner P, Olanow CW. The pathogenesis of cell death in Parkinson's disease. Neurology 2006;66:S24-36
  • Twelves D, Perkins KS, Counsell C. Systematic review of incidence studies of Parkinson's disease. Mov Disord 2003;18(1):19-31
  • von Campenhausen S, Bornschein B, Wick R, Prevalence and incidence of Parkinson's disease in Europe. Eur Neuropsychopharmacol 2005;15(4):473-90
  • Van Den Eeden SK, Tanner CM, Bernstein AL, Incidence of Parkinson's disease: variation by age, gender, and race/ethnicity. Am J Epidemiol 2003;157(11):1015-22
  • Weintraub D, Comella CL, Horn S. Parkinson's disease–Part 1: pathophysiology, symptoms, burden, diagnosis, and assessment. Am J Manag Care 2008;14:S40-8
  • Dorsey ER, Constantinescu R, Thompson JP, Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology 2007;68:384-86
  • Dowding CH, Shenton CL, Salek SS. A review of the health-related quality of life and economic impact of Parkinson's disease. Drugs Aging 2006;23(9):693-721
  • Olanow CW, Agid Y, Mizuno Y, Levodopa in the treatment of Parkinson's disease: current controversies. Mov Disord 2004;19(9):997-1005
  • Horstink M, Tolosa E, Bonuccelli U, Review of the therapeutic management of Parkinson's disease. Report of a joint task force of the European Federation of Neurological Societies and the Movement Disorder Society-European Section. Part I: early (uncomplicated) Parkinson's disease. Eur J Neurol 2006;13(11):1170-85
  • Horstink M, Tolosa E, Bonuccelli U, Review of the therapeutic management of Parkinson's disease. Report of a joint task force of the European Federation of Neurological Societies (EFNS) and the Movement Disorder Society-European Section (MDS-ES). Part II: late (complicated) Parkinson's disease. Eur J Neurol 2006;13(11):1186-202
  • Guttman M, Kish SJ, Furukawa Y. Current concepts in the diagnosis and management of Parkinson's disease. CMAJ 2003;168(3):293-301
  • Goetz CG, Poewe W, Rascol O, Sampaio C. Evidence-based medical review update: pharmacological and surgical treatments of Parkinson's disease: 2001 to 2004. Mov Disord 2005;20(5):523-39
  • Morelli M, Di Paolo T, Wardas J, Role of adenosine A2A receptors in parkinsonian motor impairment and l-DOPA-induced motor complications. Prog Neurobiol 2007;83(5):293-309
  • Xu K, Bastia E, Schwarzschild M. Therapeutic potential of adenosine A(2A) receptor antagonists in Parkinson's disease. Pharmacol Ther 2005;105:267-310
  • Schiffmann SN, Vanderhaeghen JJ. Adenosine A2 receptors regulate the gene expression of striatopallidal and striatonigral neurons. J Neurosci 1993;13:1080-7
  • Svenningsson P, Le Moine C, Aubert I, Cellular distribution of adenosine A2A receptor mRNA in the primate striatum. J Comp Neurol 1998;399:229-40
  • Simola N, Morelli M, Pinna A. Adenosine A2A receptor antagonists and Parkinson's disease: state of the art and future directions. Curr Pharm Des 2008;14(15):1475-89
  • Pinna A, Di Chiara G, Wardas J, Morelli M. Blockade of A2A adenosine receptors positively modulates turning behaviour and c-fos expression induced by D1 agonists in dopamine-denervated rats. Eur J Neurosci 1996;8:1176-81
  • Pollack AE, Fink JS. Synergistic interaction between an adenosine antagonist and a D1 dopamine agonist on rotational behaviour and striatal c-Fos induction in 6-hydroxydopamine-lesioned rats. Brain Res 1996;743:124-30
  • Jenner P, Mori A, Hauser R, Adenosine, adenosine A(2A) antagonists, and Parkinson's disease. Parkinsonism Relat Disord 2009, May 13. PubMed PMID: 19446490. [Epub ahead of print]
  • Fuxe K, Marcellino D, Genedani S, Agnati L. Adenosine A(2A) receptors, dopamine D(2) receptors and their interactions in Parkinson's disease. Mov Disord 2007;22(14):1990-2017
  • Ross GW, Abbott RD, Petrovitch H, Association of coffee and caffeine intake with the risk of Parkinson disease. JAMA 2000;283:2674-9
  • Ascherio A, Zhang SM, Hernán MA, Prospective study of caffeine consumption and risk of Parkinson's disease in men and women. Ann Neurol 2001;50:56-63
  • Chen JF, Xu K, Petzer JP, Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease. J Neurosci 2001;21:RC143
  • Kalda A, Yu L, Oztas E, Chen JF. Novel neuroprotection by caffeine and adenosine A(2A) receptor antagonists in animal models of Parkinson's disease. J Neurol Sci 2006;248(1-2):9-15
  • Barcia C, Sánchez Bahillo A, Fernández-Villalba E, Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure. Glia 2004;46:402-9
  • Hunot S, Hirsch EC. Neuroinflammatory processes in Parkinson's disease. Ann Neurol 2003;53:S49-58
  • McGeer PL, Itagaki S, Boyes BE, McGeer EG. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988;38:1285-91
  • Wu DC, Jackson-Lewis V, Vila M, Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci 2002;22:1763-71
  • Ikeda K, Kurokawa M, Aoyama S, Kuwana Y. Neuroprotection by adenosine A2A receptor blockade in experimental models of Parkinson's disease. J Neurochem 2002;80:262-70
  • Pierri M, Vaudano E, Sager T, Englund U. KW-6002 protects from MPTP induced dopaminergic toxicity in the mouse. Neuropharmacology 2005;48:517-24
  • Chen JF, Sonsalla PK, Pedata F, Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and “fine tuning” modulation. Prog Neurobiol 2007;83(5):310-31
  • Takahashi RN, Pamplona FA, Prediger RD. Adenosine receptor antagonists for cognitive dysfunction: a review of animal studies. Front Biosci 2008;13:2614-32
  • Kase H, Aoyama S, Ichimura M, Progress in pursuit of therapeutic A2A antagonists: the adenosine A2A receptor selective antagonist KW6002: research and development toward a novel nondopaminergic therapy for Parkinson's disease. Neurology 2003;61(11Suppl 6):S97-100
  • Jenner P. Istradefylline, a novel adenosine A2A receptor antagonist, for the treatment of Parkinson's disease. Expert Opin Investig Drugs 2005;14:729-38
  • FDA Issues Not Approvable Letter for Istradefylline. Available from: http://www.drugs.com/nda/kw_6002_080228.html [Last accessed 16 June 2009]
  • Hockemeyer J, Burbiel JC, Mueller CE. Multigram-scale syntheses, stability, and photoreactions of A2A adenosine receptor antagonists with 8-styrylxanthine structure: potential drugs for Parkinson's disease. J Org Chem 2004;69(10):3308-18
  • Johnston TH, Brotchie JM. Drug in development for Parkinson's disease: an update. Curr Opin Investig Drugs 2006;7(1):25-32
  • Weiss SM, Benwell K, Cliffe IA, Discovery of nonxanthine adenosine A2A receptor antagonists for the treatment of Parkinson's disease. Neurology 2003;61(11 Suppl 6):S101-6
  • Gillespie RJ, Bamford SJ, Botting R, Antagonists of the Human A2A Adenosine Receptor. 4. Design, Synthesis, and Preclinical Evaluation of 7-Aryltriazolo[4,5-d]pyrimidines. J Med Chem 2009;52(1):33-47
  • Product Pipeline of Vernalis. Parkinson's Disease: V2006. Available from: http://www.vernalis.com/ver/rdc2/neurology/v2006/ [Last accessed 16 June 2009]
  • Padfield A, Denny S, Merrett A, Pre-clinical drug metabolism and pharmacokinetic studies with BIIB014/V2006. Presented at International research conference “Targeting adenosine A2A receptors in PD and other CNS Disorders”, Boston, USA (17-19 May 2006). Available from: http://handle.dtic.mil/100.2/ADA452764 [Last accessed 16 June 2009]
  • Wade A, Bakhtyari A, Thomas R, BIIB014/V2006: Pharmacokinetics in young and elderly healthy subjects. Presented at International research conference “Targeting adenosine A2A receptors in PD and other CNS Disorders”, Boston, USA (17-19 May 2006). Available from: http://handle.dtic.mil/100.2/ADA452764 [Last accessed 16 June 2009]
  • An Open-Label, Positron Emission Tomography Study to Assess Adenosine A2A Brain Receptor Occupancy of BIIB014 at Multiple Dose Levels in Healthy Male Volunteers. ClinicalTrials.gov. NCT00531193. Available from: http://clinicaltrials.gov/ct2/show/NCT00531193 [Last accessed 16 June 2009]
  • Moresco RM, Todde S, Belloli S, In vivo imaging of adenosine A2A receptors in rat and primate brain using [11C]SCH442416. Eur J Nucl Med Mol Imaging 2005;32(4):405-13
  • Lightowler S, Knight AR, Upton R, Pharmacology of BIIB014/V2006, an A2A antagonist for the treatment of PD. Presented at International research conference “Targeting adenosine A2A receptors in PD and other CNS Disorders”, Boston, USA (17-19 May 2006). Available from: http://handle.dtic.mil/100.2/ADA452764 [Last accessed 16 June 2009]
  • A Randomized, Double-Blind, Placebo-Controlled, Dose Escalation Study of Single and Multiple Oral Dose Administration of BIIB014 in Subjects With Moderate to Late Stage Parkinson's Disease Who Are Also Receiving Treatment With Levodopa ClinicalTrials.gov. NCT00438607. Available from: http://clinicaltrials.gov/ct2/show/NCT00438607 [Last accessed 16 June 2009]
  • A Randomized, Double-Blind, Placebo-Controlled, Dose Escalation Study of Multiple Doses of BIIB014 Administered Orally in Subjects With Early Parkinson's Disease. ClinicalTrials.gov. NCT00442780. Available from: http://clinicaltrials.gov/ct2/show/NCT00442780 [Last accessed 16 June 2009]
  • Biogen Idec reports favourable data from Phase IIa Parkinson's Disease studies of BIIB014 (licensed from Vernalis). Available from: http://www.vernalis.com/ver/nc/latestreleases/releases2009/2009-03-27/ [Last accessed 16 June 2009]; Access the Biogen IDEC results of presentation from: http://library.corporate-ir.net/library/14/148/148682/items/329869/503E91BE-5BE4-47F0-A030-17858A19C307_6_BIIB014v2.pdf [Last accessed 16 June 2009]
  • Lightowler S. Progressing the A2A antagonist BIIB014/V2006 to the clinic for the treatment of PD. Presented at International research conference “Targeting adenosine A2A receptors in PD and other CNS Disorders”, Boston, USA (17-19 May 2006). Available from: http://handle.dtic.mil/100.2/ADA452764 [Last accessed 16 June 2009]
  • Neustadt BR, Hao J, Lindo N, Potent, selective, and orally active adenosine A2A receptor antagonists: Arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines. Bioorg Med Chem Lett 2007;17:1376-80
  • Ongini E, Dionisotti S, Gessi S, Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol 1999;359(1):7-10
  • Fenu S, Pinna A, Ongini E, Morelli M. Adenosine A2A receptor antagonism potentiates L-DOPA induced turning behavior and c-fos expression in 6-hydroxydopamine-lesioned rats. Eur J Pharmacol 1997;321:143-47
  • Svenningsson P, Nomikos GG, Ongini E, Fredholm BB. Antagonism of adenosine A2A receptors underlies the behavioural activating effect of caffeine and is associated with reduced expression of messenger RNA for NGFI-A and NGFI-B in caudate-putamen and nucleus accumbens. Neuroscience 1997;79(3):753-64
  • Wardas J, Konieczny J, Lorenc-Koci E. SCH 58261, an A(2A) adenosine receptor antagonist, counteracts parkinsonian-like muscle rigidity in rats. Synapse 2001;41(2):160-71
  • Carta AR, Pinna A, Tronci E, Morelli M. Adenosine A2A and dopamine receptor interactions in basal ganglia of dopamine denervated rats. Neurology 2003;61:S39-43
  • Simola N, Fenu S, Baraldi PG, Blockade of adenosine A2A receptors antagonizes parkinsonian tremor in the rat tacrine model by an action on specific striatal regions. Exp Neurol 2004;189:182-8
  • Pinna A, Pontis S, Borsini F, Morelli M. Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6-hydroxydopamine rat model of Parkinson's disease. Synapse 2007;61:606-14
  • Cutler DL, Tendolkar A, Hunter J. Effects of age and gender on preladenant pharmacokinetics in healthy subjects. Presented at Movement Disorder Society's 13th International Congress of Parkinson's Disease and Movements Disorders, Paris, France (7-11 June 2009). Abstract Mo-194
  • Brooks DJ, Warrington S, Tendolkar A, Positron emission tomography (PET) study of preladenant in healthy male subjects. Presented at Movement Disorder Society's 13th International Congress of Parkinson's Disease and Movements Disorders, Paris, France (7-11 June 2009). Abstract Mo-187
  • Hodgson RA, Bertorelli R, Varty GB, Characterization of the Potent and Highly Selective A2A Receptor Antagonists Preladenant and SCH 412348 in Rodent Models of Movement Disorders and Depression. J Pharmacol Exp Ther 2009 Mar 30. PubMed PMID: 19332567. [Epub ahead of print]
  • Hunter J. SCH 420814: a novel Adenosine A2a antagonist. Exploring Parkinson's Disease and beyond. Presented at International research conference “Targeting adenosine A2A receptors in PD and other CNS Disorders”, Boston, USA (17-19 May 2006). Available from: http://handle.dtic.mil/100.2/ADA452764
  • Phase 2, 12-Week, Double-Blind, Dose-Finding, Placebo-Controlled Study to Assess the Efficacy and Safety of a Range of SCH 420814 Doses in Subjects With Moderate to Severe Parkinson's Disease Experiencing Motor Fluctuations and Dyskinesias. ClinicalTrials.gov. NCT00406029. Available from: http://clinicaltrials.gov/ct2/show/NCT00406029 [Last accessed 18 June 2009]
  • Hauser RA, Pourcher E, Micheli F, Efficacy of preladenant, a novel A2A antagonist, as an adjunct to levodopa for the treatment of Parkinson's disease. Presented at Movement Disorder Society's 13th International Congress of Parkinson's Disease and Movements Disorders, Paris, France (7-11 June 2009). Abstract Tu-185
  • Huyck SB, Wolski K, Cantillon M. Impact of A2A receptor antagonist preladenant on dyskinesia in moderate to severe Parkinson's disease: Post-hoc analysis of dose-finding study. Presented at Movement Disorder Society's 13th International Congress of Parkinson's Disease and Movements Disorders, Paris, France (7-11 June 2009). Abstract Tu-187
  • A Phase 2, 36-Week, Open-Label, Uncontrolled Safety Follow-up Study Assessing SCH 420814 5 mg BID (Protocol No. P05175). ClinicalTrials.gov. NCT00406029. Available from: http://clinicaltrials.gov/ct2/show/NCT00537017 [Last accessed 18 June 2009]
  • Acute Effects of SCH 420814 on Dyskinesia and Parkinsonism in Levodopa Treated Patients. ClinicalTrials.gov. NCT00845000. Available from: http://clinicaltrials.gov/ct2/show/NCT00845000 [Last accessed 18 June 2009]
  • Pourcher E, Micheli F, Mok V, Safety and tolerability profile of preladenant as an adjunct to L-dopa in patients with Parkinson's disease. Presented at Movement Disorder Society's 13th International Congress of Parkinson's Disease and Movements Disorders, Paris, France (7-11 June 2009). Abstract We-187
  • Minetti P, Tinti MA, Carminati P, 2-n-Butyl-9-8-[1,2,3] triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. J Med Chem 2005;48:6887-96
  • Stasi MA, Borsini F, Varani K, ST1535: A preferential A2a adenosine receptor antagonist. Int J Neuropsychopharm 2006;9(5):575-84
  • Rose S, Ramsay Croft N, Jenner P. The novel adenosine A2a antagonist ST1535 potentiates the effects of a threshold dose of l-dopa in unilaterally 6-OHDA-lesioned rats. Brain Res 2007;1133:110-14
  • Tronci E, Simola N, Borsini F, Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats. Eur J Pharmacol 2007;566:94-102
  • Rose S, Jackson MJ, Smith LA, The novel adenosine A2a antagonist ST1535 potentiates the effects of a threshold dose of L-dopa in MPTP treated common marmosets. Eur J Pharmacol 2006;546(1-3):82-7
  • Galluzzo M, Pintor A, Pèzzola A, Behavioural and neurochemical characterization of the adenosine A2A receptor antagonist ST1535. Eur J Pharmacol 2008;579(1-3):149-52
  • Di Serio S, Danese V, Guaraldi D, The novel adenosine A2A receptor antagonist 2-butyl-9-methyl-8-(2H-1,2, 3-triazol-2-yl)-9H-purin-6-ylamine (ST1535) ameliorates memory disruption mediated by adenosine A1 receptor stimulation. Presented at 13th European Behavioural Pharmacology Society Biennial Meeting, Rome, Italy (4-7 September 2009)
  • Sigma-Tau communication about development of ST-1535. Available from: http://www.sigma-tau.it/eng/fasidisviluppo.asp [Last accessed 18 June 2009] with specific piece of information provide by Sigma-Tau Company
  • Schering Plough Corp. communication about preladenant clinical development program in PD. Available from: http://www.medicalnewstoday.com/articles/130623.php [Last accessed 18 June 2009]
  • Kanda T, Tashiro T, Kuwana Y, Jenner P. Adenosine A2A receptors modify motor function in MPTP-treated common marmosets. Neuroreport 1998;9:2857-60
  • Kanda T, Jackson MJ, Smith LA, Combined use of the adenosine A(2A) antagonist KW-6002 with L-DOPA or with selective D1 or D2 dopamine agonists increases antiparkinsonian activity but not dyskinesia in MPTP-treated monkeys. Exp Neurol 2000;162:321-27
  • Grondin R, Bedard PJ, Hadj Tahar A, Antiparkinsonian effect of a new selective adenosine A2A receptor antagonist in MPTP-treated monkeys. Neurology 1999;52:1673-7
  • Shiozaki S, Ichikawa S, Nakamura J, Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP. Psychopharmacology 1999;147:90-5
  • Bara-Jimenez W, Sherzai A, Dimitrova T, Adenosine A(2A) receptor antagonist treatment of Parkinson's disease. Neurology 2003;61:293-6
  • Levin BE, Katzen HL. Early cognitive changes and nondementing behavioral abnormalities in Parkinson's disease. Adv Neurol 2005;96:84-94
  • El Yacoubi M, Ledent C, Parmentier M, Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice. Br J Pharmacol 2001;134:68-77
  • Gessi S, Varani K, Merighi S, A(2A) adenosine receptors in human peripheral blood cells. Br J Pharmacol 2000;129:2-11
  • Haskó G, Pacher P. A2A receptors in inflammation and injury: lessons learned from transgenic animals. J Leukoc Biol 2008;83(3):447-55
  • Ohta A, Sitkovsky M. Role of G-protein-coupled adenosine receptors in down regulation of inflammation and protection from tissue damage. Nature 2001;414:916-20
  • Ohta A, Lukashev D, Jackson EK, 1,3,7-trimethylxanthine (caffeine) may exacerbate acute inflammatory liver injury by weakening the physiological immunosuppressive mechanism. J Immunol 2007;179(11):7431-8
  • Thiel M, Chouker A, Ohta A, Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury. PLoS Biol 2005;3(6):e174
  • Mihara T, Mihara K, Yarimizu J, Pharmacological characterization of a novel, potent adenosine A1 and A2A receptor dual antagonist, 5-[5-amino-3-(4-fluorophenyl)pyrazin- 2-yl]-1-isopropylpyridine-2(1H)-one(ASP5854), in models of Parkinson's disease and cognition. J Pharmacol Exp Ther 2007;323(2):708-19

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