Therapeutic potential of matrix metalloprotease inhibitors in neuropathic pain

Bibliography

• Ro LS, Chang KH. Neuropathic pain: mechanisms and treatments. Chang Gung Med J 2005;28(9):597-605
   PubMedGoogle Scholar
• Ossipov MH, Porreca F. Challenges in the development of novel treatment strategies for neuropathic pain. NeuroRx 2005;2(4):650-61
   PubMedGoogle Scholar
• Verma S, Estanislao L, Simpson D. HIV associated neuropathic pain: epidemiology, pathophysiology and management. CNS Drugs 2005;19:325-34
   PubMed Web of Science ®Google Scholar
• Torrance N, Smith BH, Bennett MI, Lee AJ. The epidemiology of chronic pain of predominantly neuropathic origin. Results from a general population survey. J Pain 2006;7(4):281-9
   PubMed Web of Science ®Google Scholar
• Turk DC. Clinical effectiveness and cost-effectiveness of treatments for patients with chronic pain. Clin J Pain 2002;18(6):355-65
   PubMed Web of Science ®Google Scholar
• Taylor BK. Pathophysiologic mechanisms of neuropathic pain. Curr Pain Headache Rep 2001;5(2):151-61
   PubMedGoogle Scholar
• Wall PD, Gutnick M. Ongoing activity in peripheral nerves: the physiology and pharmacology of impulses originating from a neuroma. Exp Neurol 1974;43(3):580-93
   PubMed Web of Science ®Google Scholar
• England JD, Happel LT, Kline DG, Sodium channel accumulation in humans with painful neuromas. Neurology 1996;47(1):272-6
   PubMed Web of Science ®Google Scholar
• Devor M, Keller CH, Deerinck TJ, Na+ channel accumulation on axolemma of afferent endings in nerve end neuromas in Apteronotus. Neurosci Lett 1989;102(2-3):149-54
   PubMed Web of Science ®Google Scholar
• Waxman SG, Kocsis JD, Black JA. Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy. J Neurophysiol 1994;72(1):466-70
   PubMed Web of Science ®Google Scholar
• Dib-Hajj S, Black JA, Felts P, Waxman SG. Down-regulation of transcripts for Na channel alpha-SNS in spinal sensory neurons following axotomy. Proc Natl Acad Sci USA 1996;93(25):14950-4
   PubMed Web of Science ®Google Scholar
• Dib-Hajj SD, Fjell J, Cummins TR, Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain. Pain 1999;83(3):591-600
   PubMed Web of Science ®Google Scholar
• Bridges D, Thompson SW, Rice AS. Mechanisms of neuropathic pain. Br J Anaesth 2001;87(1):12-26
   PubMedGoogle Scholar
• Baccei ML, Kocsis JD. Voltage-gated calcium currents in axotomized adult rat cutaneous afferent neurons. J Neurophysiol 2000;83(4):2227-38
   PubMed Web of Science ®Google Scholar
• Catterall WA. Structure and regulation of voltage-gated Ca2+ channels. Annu Rev Cell Dev Biol 2000;16:521-55
   PubMed Web of Science ®Google Scholar
• Xiao WH, Bennett GJ. Synthetic omega-conopeptides applied to the site of nerve injury suppress neuropathic pains in rats. J Pharmacol Exp Ther 1995;274(2):666-72
   PubMed Web of Science ®Google Scholar
• Ji RR, Strichartz G. Cell signaling and the genesis of neuropathic pain. Sci STKE 2004;2004(252):reE14
   PubMedGoogle Scholar
• Pertwee RG. Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol Ther 1997;74(2):129-80
   PubMed Web of Science ®Google Scholar
• Gregg JM. Studies of traumatic neuralgias in the maxillofacial region: surgical pathology and neural mechanisms. J Oral Maxillofac Surg 1990;48(3):228-37; discussion 38-9
   PubMed Web of Science ®Google Scholar
• McLachlan EM, Janig W, Devor M, Michaelis M. Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia. Nature 1993;363(6429):543-6
   PubMed Web of Science ®Google Scholar
• Yen LD, Bennett GJ, Ribeiro-da-Silva A. Sympathetic sprouting and changes in nociceptive sensory innervation in the glabrous skin of the rat hind paw following partial peripheral nerve injury. J Comp Neurol 2006;495(6):679-90
   PubMed Web of Science ®Google Scholar
• Grelik C, Bennett GJ, Ribeiro-da-Silva A. Autonomic fibre sprouting and changes in nociceptive sensory innervation in the rat lower lip skin following chronic constriction injury. Eur J Neurosci 2005;21(9):2475-87
   PubMed Web of Science ®Google Scholar
• Ruocco I, Cuello AC, Ribeiro-Da-Silva A. Peripheral nerve injury leads to the establishment of a novel pattern of sympathetic fibre innervation in the rat skin. J Comp Neurol 2000;422(2):287-96
   PubMed Web of Science ®Google Scholar
• Janig W, Levine JD, Michaelis M. Interactions of sympathetic and primary afferent neurons following nerve injury and tissue trauma. Prog Brain Res 1996;113:161-84
   PubMed Web of Science ®Google Scholar
• Woolf CJ, Mannion RJ. Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet 1999;353(9168):1959-64
   PubMed Web of Science ®Google Scholar
• Urban MO, Gebhart GF. Supraspinal contributions to hyperalgesia. Proc Natl Acad Sci USA 1999;96(14):7687-92
   PubMed Web of Science ®Google Scholar
• Kawamata M, Omote K. Involvement of increased excitatory amino acids and intracellular Ca2+ concentration in the spinal dorsal horn in an animal model of neuropathic pain. Pain 1996;68(1):85-96
   PubMed Web of Science ®Google Scholar
• Davar G, Hama A, Deykin A, MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathy. Brain Res 1991;553(2):327-30
   PubMed Web of Science ®Google Scholar
• Mao J, Price DD, Mayer DJ, Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy. Brain Res 1992;576(2):254-62
   PubMed Web of Science ®Google Scholar
• Sotgiu ML, Biella G. Differential effects of MK-801, a N-methyl-D-aspartate non-competitive antagonist, on the dorsal horn neuron hyperactivity and hyperexcitability in neuropathic rats. Neurosci Lett 2000;283(2):153-6
   PubMed Web of Science ®Google Scholar
• Rabben T, Skjelbred P, Oye I. Prolonged analgesic effect of ketamine, an N-methyl-D-aspartate receptor inhibitor, in patients with chronic pain. J Pharmacol Exp Ther 1999;289(2):1060-6
   PubMed Web of Science ®Google Scholar
• Chizh BA, Headley PM. Thyrotropin-releasing hormone facilitates spinal nociceptive responses by potentiating NMDA receptor-mediated transmission. Eur J Pharmacol 1996;300(3):183-9
   PubMed Web of Science ®Google Scholar
• Wallace MS. Pain Management and End-of-Life Care CME Program. 2007 Available from: www.csahq.org/pdf/bulletin/pain_cme044.pdf. [Last accessed 31 Dec 2009]
   Google Scholar
• Dogrul A, Ossipov MH, Lai J, Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR(5)) antagonist, in experimental neuropathic pain in rats. Neurosci Lett 2000;292(2):115-8
   PubMed Web of Science ®Google Scholar
• Walker K, Reeve A, Bowes M, mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia. Neuropharmacology 2001;40(1):10-9
   PubMed Web of Science ®Google Scholar
• Bhave G, Karim F, Carlton SM, Gereau RWT. Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Nat Neurosci 2001;4(4):417-23
   PubMed Web of Science ®Google Scholar
• Jones CK, Eberle EL, Peters SC, Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing. Neuropharmacology 2005;49(Suppl 1):206-18
   PubMedGoogle Scholar
• Hudson LJ, Bevan S, McNair K, Metabotropic glutamate receptor 5 upregulation in A-fibers after spinal nerve injury: 2-methyl-6- (phenylethynyl)-pyridine (MPEP) reverses the induced thermal hyperalgesia. J Neurosci 2002;22(7):2660-8
   PubMed Web of Science ®Google Scholar
• Sung B, Lim G, Mao J. Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats. J Neurosci 2003;23(7):2899-910
   PubMed Web of Science ®Google Scholar
• Osikowicz M, Mika J, Makuch W, Przewlocka B. Glutamate receptor ligands attenuate allodynia and hyperalgesia and potentiate morphine effects in a mouse model of neuropathic pain. Pain 2008;139(1):117-26
   PubMed Web of Science ®Google Scholar
• Prescott SA, De Koninck Y. Gain control of firing rate by shunting inhibition: roles of synaptic noise and dendritic saturation. Proc Natl Acad Sci USA 2003;100(4):2076-81
   PubMed Web of Science ®Google Scholar
• Sivilotti L, Woolf CJ. The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord. J Neurophysiol 1994;72(1):169-79
   PubMed Web of Science ®Google Scholar
• Yaksh TL. Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists. Pain 1989;37(1):111-23
   PubMed Web of Science ®Google Scholar
• Smith GD, Harrison SM, Birch PJ, Increased sensitivity to the antinociceptive activity of (+/-)-baclofen in an animal model of chronic neuropathic, but not chronic inflammatory hyperalgesia. Neuropharmacology 1994;33(9):1103-8
   PubMed Web of Science ®Google Scholar
• Watkins LR, Milligan ED, Maier SF. Glial activation: a driving force for pathological pain. Trends Neurosci 2001;24(8):450-5
   PubMed Web of Science ®Google Scholar
• Scholz J, Woolf CJ. The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci 2007;10(11):1361-8
   PubMed Web of Science ®Google Scholar
• Milligan ED, Watkins LR. Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci 2009;10(1):23-36
   PubMed Web of Science ®Google Scholar
• Allen NJ, Barres BA. Signaling between glia and neurons: focus on synaptic plasticity. Curr Opin Neurobiol 2005;15(5):542-8
   PubMed Web of Science ®Google Scholar
• Garrison CJ, Dougherty PM, Kajander KC, Carlton SM. Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury. Brain Res 1991;565(1):1-7
   PubMed Web of Science ®Google Scholar
• Garrison CJ, Dougherty PM, Carlton SM. GFAP expression in lumbar spinal cord of naive and neuropathic rats treated with MK-801. Exp Neurol 1994;129(2):237-43
   PubMed Web of Science ®Google Scholar
• Agrawal SK, Theriault E, Fehlings MG. Role of group I metabotropic glutamate receptors in traumatic spinal cord white matter injury. J Neurotrauma 1998;15(11):929-41
   PubMed Web of Science ®Google Scholar
• Bruno V, Battaglia G, Casabona G, Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta. J Neurosci 1998;18(23):9594-600
   PubMed Web of Science ®Google Scholar
• Taylor DL, Diemel LT, Cuzner ML, Pocock JM. Activation of group II metabotropic glutamate receptors underlies microglial reactivity and neurotoxicity following stimulation with chromogranin A, a peptide up-regulated in Alzheimer's disease. J Neurochem 2002;82(5):1179-91
   PubMed Web of Science ®Google Scholar
• Osikowicz M, Skup M, Mika J, Glial inhibitors influence the mRNA and protein levels of mGlu2/3, 5 and 7 receptors and potentiate the analgesic effects of their ligands in a mouse model of neuropathic pain. Pain 2009;147(1-3):175-86
   PubMed Web of Science ®Google Scholar
• Watkins LR, Maier SF. The pain of being sick: implications of immune-to-brain communication for understanding pain. Annu Rev Psychol 2000;51:29-57
   PubMed Web of Science ®Google Scholar
• Watkins LR, Milligan ED, Maier SF. Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain. Adv Exp Med Biol 2003;521:1-21
   PubMed Web of Science ®Google Scholar
• Zhuang ZY, Wen YR, Zhang DR, A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. J Neurosci 2006;26(13):3551-60
   PubMed Web of Science ®Google Scholar
• Jin SX, Zhuang ZY, Woolf CJ, Ji RR. p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci 2003;23(10):4017-22
   PubMed Web of Science ®Google Scholar
• Zhuang ZY, Gerner P, Woolf CJ, Ji RR. ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain 2005;114(1-2):149-59
   PubMed Web of Science ®Google Scholar
• Ji RR, Xu ZZ, Wang X, Lo EH. Matrix metalloprotease regulation of neuropathic pain. Trends Pharmacol Sci 2009;30(7):336-40
   PubMed Web of Science ®Google Scholar
• Raghavendra V, Tanga F, DeLeo JA. Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy. J Pharmacol Exp Ther 2003;306(2):624-30
   PubMed Web of Science ®Google Scholar
• Sindrup SH, Jensen TS. Pharmacologic treatment of pain in polyneuropathy. Neurology 2000;55(7):915-20
   PubMed Web of Science ®Google Scholar
• Galer BS. Neuropathic pain of peripheral origin: advances in pharmacologic treatment. Neurology 1995;45(12 Suppl 9):S17-25; discussion S35-6
   PubMed Web of Science ®Google Scholar
• Watson CP, Vernich L, Chipman M, Reed K. Nortriptyline versus amitriptyline in postherpetic neuralgia: a randomized trial. Neurology 1998;51(4):1166-71
   PubMed Web of Science ®Google Scholar
• Max MB, Kishore-Kumar R, Schafer SC, Efficacy of desipramine in painful diabetic neuropathy: a placebo-controlled trial. Pain 1991;45(1):3-9; discussion 1-2
   PubMed Web of Science ®Google Scholar
• Faber TS, Zehender M, Just H. Drug-induced torsade de pointes. Incidence, management and prevention. Drug Saf 1994;11(6):463-76
   PubMed Web of Science ®Google Scholar
• Max MB, Lynch SA, Muir J, Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. N Engl J Med 1992;326(19):1250-6
   PubMed Web of Science ®Google Scholar
• Sindrup SH, Jensen TS. Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action. Pain 1999;83(3):389-400
   PubMed Web of Science ®Google Scholar
• Kingery WS. A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes. Pain 1997;73(2):123-39
   PubMed Web of Science ®Google Scholar
• McQuay H, Carroll D, Jadad AR, Anticonvulsant drugs for management of pain: a systematic review. BMJ 1995;311(7012):1047-52
   PubMed Web of Science ®Google Scholar
• Chabal C, Russell LC, Burchiel KJ. The effect of intravenous lidocaine, tocainide, and mexiletine on spontaneously active fibers originating in rat sciatic neuromas. Pain 1989;38(3):333-8
   PubMed Web of Science ®Google Scholar
• Challapalli V, Tremont-Lukats IW, McNicol ED, Systemic administration of local anesthetic agents to relieve neuropathic pain. Cochrane Database Syst Rev 2005;(4):CD003345
   Google Scholar
• Dellemijn PL, Vanneste JA. Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain. Lancet 1997;349(9054):753-8
   PubMed Web of Science ®Google Scholar
• Watson CP, Babul N. Efficacy of oxycodone in neuropathic pain: a randomized trial in postherpetic neuralgia. Neurology 1998;50(6):1837-41
   PubMed Web of Science ®Google Scholar
• Harati Y, Gooch C, Swenson M, Double-blind randomized trial of tramadol for the treatment of the pain of diabetic neuropathy. Neurology 1998;50(6):1842-6
   PubMed Web of Science ®Google Scholar
• Watson CP, Evans RJ, Watt VR. Post-herpetic neuralgia and topical capsaicin. Pain 1988;33(3):333-40
   PubMed Web of Science ®Google Scholar
• McCawley LJ, Matrisian LM. Matrix metalloproteinases: they're not just for matrix anymore! Curr Opin Cell Biol 2001;13(5):534-40
   PubMed Web of Science ®Google Scholar
• Lynch CC, Matrisian LM. Matrix metalloproteinases in tumor-host cell communication. Differentiation 2002;70(9-10):561-73
   PubMed Web of Science ®Google Scholar
• Bode W, Gomis-Ruth FX, Stockler W. Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the ‘metzincins’. FEBS Lett 1993;331(1-2):134-40
   PubMed Web of Science ®Google Scholar
• Gomis-Ruth FX. Structural aspects of the metzincin clan of metalloendopeptidases. Mol Biotechnol 2003;24(2):157-202
   PubMed Web of Science ®Google Scholar
• Sato H, Takino T, Okada Y, A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature 1994;370(6484):61-5
   PubMed Web of Science ®Google Scholar
• Tsuda M, Inoue K, Salter MW. Neuropathic pain and spinal microglia: a big problem from molecules in ‘small’ glia. Trends Neurosci 2005;28(2):101-7
   PubMed Web of Science ®Google Scholar
• Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet 2006;367(9522):1618-25
   PubMed Web of Science ®Google Scholar
• Parks WC, Wilson CL, Lopez-Boado YS. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol 2004;4(8):617-29
   PubMed Web of Science ®Google Scholar
• Chattopadhyay S, Myers RR, Janes J, Shubayev V. Cytokine regulation of MMP-9 in peripheral glia: implications for pathological processes and pain in injured nerve. Brain Behav Immun 2007;21(5):561-8
   PubMed Web of Science ®Google Scholar
• Coleman MP, Conforti L, Buckmaster EA, An 85-kb tandem triplication in the slow Wallerian degeneration (Wlds) mouse. Proc Natl Acad Sci USA 1998;95(17):9985-90
   PubMed Web of Science ®Google Scholar
• La Fleur M, Underwood JL, Rappolee DA, Werb Z. Basement membrane and repair of injury to peripheral nerve: defining a potential role for macrophages, matrix metalloproteinases, and tissue inhibitor of metalloproteinases-1. J Exp Med 1996;184(6):2311-26
   PubMed Web of Science ®Google Scholar
• Hughes PM, Wells GM, Perry VH, Comparison of matrix metalloproteinase expression during Wallerian degeneration in the central and peripheral nervous systems. Neuroscience 2002;113(2):273-87
   PubMed Web of Science ®Google Scholar
• Siebert H, Dippel N, Mader M, Matrix metalloproteinase expression and inhibition after sciatic nerve axotomy. J Neuropathol Exp Neurol 2001;60(1):85-93
   PubMed Web of Science ®Google Scholar
• Shubayev VI, Myers RR. Endoneurial remodeling by TNFalpha- and TNFalpha-releasing proteases. A spatial and temporal co-localization study in painful neuropathy. J Peripher Nerv Syst 2002;7(1):28-36
   PubMed Web of Science ®Google Scholar
• Noble LJ, Donovan F, Igarashi T, Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J Neurosci 2002;22(17):7526-35
   PubMed Web of Science ®Google Scholar
• Wells JE, Rice TK, Nuttall RK, An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice. J Neurosci 2003;23(31):10107-15
   PubMed Web of Science ®Google Scholar
• Maeda T, Kiguchi N, Kobayashi Y, Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation. Proc Natl Acad Sci USA 2009;106(31):13076-81
   PubMed Web of Science ®Google Scholar
• Shubayev VI, Myers RR. Upregulation and interaction of TNF-alpha and gelatinases A and B in painful peripheral nerve injury. Brain Res 2000;855(1):83-9
   PubMed Web of Science ®Google Scholar
• Kawasaki Y, Xu ZZ, Wang X, Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. Nat Med 2008;14(3):331-6
   PubMed Web of Science ®Google Scholar
• Nishida K, Kuchiiwa S, Oiso S, Up-regulation of matrix metalloproteinase-3 in the dorsal root ganglion of rats with paclitaxel-induced neuropathy. Cancer Sci 2008;99(8):1618-25
   PubMed Web of Science ®Google Scholar
• Ramer MS, Murphy PG, Richardson PM, Bisby MA. Spinal nerve lesion-induced mechanoallodynia and adrenergic sprouting in sensory ganglia are attenuated in interleukin-6 knockout mice. Pain 1998;78(2):115-21
   PubMed Web of Science ®Google Scholar
• Milligan ED, O'Connor KA, Nguyen KT, Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines. J Neurosci 2001;21(8):2808-19
   PubMed Web of Science ®Google Scholar
• Covey WC, Ignatowski TA, Knight PR, Spengler RN. Brain-derived TNFalpha: involvement in neuroplastic changes implicated in the conscious perception of persistent pain. Brain Res 2000;859(1):113-22
   PubMed Web of Science ®Google Scholar
• Sweitzer S, Martin D, DeLeo JA. Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain. Neuroscience 2001;103(2):529-39
   PubMed Web of Science ®Google Scholar
• Laughlin TM, Bethea JR, Yezierski RP, Wilcox GL. Cytokine involvement in dynorphin-induced allodynia. Pain 2000;84(2-3):159-67
   PubMed Web of Science ®Google Scholar
• Tadano T, Namioka M, Nakagawasai O, Induction of nociceptive responses by intrathecal injection of interleukin-1 in mice. Life Sci 1999;65(3):255-61
   PubMed Web of Science ®Google Scholar
• Arruda JL, Sweitzer S, Rutkowski MD, DeLeo JA. Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain. Brain Res 2000;879(1-2):216-25
   PubMed Web of Science ®Google Scholar
• Murphy PG, Ramer MS, Borthwick L, Endogenous interleukin-6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice. Eur J Neurosci 1999;11(7):2243-53
   PubMed Web of Science ®Google Scholar
• Stoll G, Jander S, Myers RR. Degeneration and regeneration of the peripheral nervous system: from Augustus Waller's observations to neuroinflammation. J Peripher Nerv Syst 2002;7(1):13-27
   PubMed Web of Science ®Google Scholar
• Empl M, Renaud S, Erne B, TNF-alpha expression in painful and nonpainful neuropathies. Neurology 2001;56(10):1371-7
   PubMed Web of Science ®Google Scholar
• Gearing AJ, Beckett P, Christodoulou M, Processing of tumour necrosis factor-alpha precursor by metalloproteinases. Nature 1994;370(6490):555-7
   PubMed Web of Science ®Google Scholar
• Hooper NM, Karran EH, Turner AJ. Membrane protein secretases. Biochem J 1997;321(Pt 2):265-79
   PubMedGoogle Scholar
• Williams LM, Gibbons DL, Gearing A, Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures. J Clin Invest 1996;97(12):2833-41
   PubMed Web of Science ®Google Scholar
• Shubayev VI, Angert M, Dolkas J, TNF-alpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve. Mol Cell Neurosci 2006;31(3):407-15
   PubMed Web of Science ®Google Scholar
• Sommer C, Lalonde A, Heckman HM, Quantitative neuropathology of a focal nerve injury causing hyperalgesia. J Neuropathol Exp Neurol 1995;54(5):635-43
   PubMed Web of Science ®Google Scholar
• Saren P, Welgus HG, Kovanen PT. TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages. J Immunol 1996;157(9):4159-65
   PubMed Web of Science ®Google Scholar
• Nagase H. Activation mechanisms of matrix metalloproteinases. Biol Chem 1997;378(3-4):151-60
   PubMed Web of Science ®Google Scholar
• Singer CF, Marbaix E, Lemoine P, Local cytokines induce differential expression of matrix metalloproteinases but not their tissue inhibitors in human endometrial fibroblasts. Eur J Biochem 1999;259(1-2):40-5
   PubMedGoogle Scholar
• Genersch E, Hayess K, Neuenfeld Y, Haller H. Sustained ERK phosphorylation is necessary but not sufficient for MMP-9 regulation in endothelial cells: involvement of Ras-dependent and -independent pathways. J Cell Sci 2000;113(Pt 23):4319-30
   PubMed Web of Science ®Google Scholar
• McGeehan GM, Becherer JD, Bast RC Jr, Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitor. Nature 1994;370(6490):558-61
   PubMed Web of Science ®Google Scholar
• Schonbeck U, Mach F, Libby P. Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 beta processing. J Immunol 1998;161(7):3340-6
   PubMed Web of Science ®Google Scholar
• Sommer C, Petrausch S, Lindenlaub T, Toyka KV. Neutralizing antibodies to interleukin 1-receptor reduce pain associated behavior in mice with experimental neuropathy. Neurosci Lett 1999;270(1):25-8
   PubMed Web of Science ®Google Scholar
• Schafers M, Brinkhoff J, Neukirchen S, Combined epineurial therapy with neutralizing antibodies to tumor necrosis factor-alpha and interleukin-1 receptor has an additive effect in reducing neuropathic pain in mice. Neurosci Lett 2001;310(2-3):113-6
   PubMed Web of Science ®Google Scholar
• Komori K, Nonaka T, Okada A, Absence of mechanical allodynia and Abeta-fiber sprouting after sciatic nerve injury in mice lacking membrane-type 5 matrix metalloproteinase. FEBS Lett 2004;557(1-3):125-8
   PubMed Web of Science ®Google Scholar
• Folgueras AR, Valdes-Sanchez T, Llano E, Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation. Proc Natl Acad Sci USA 2009;106(38):16451-6
   PubMed Web of Science ®Google Scholar
• Sommer C, Schmidt C, George A, Toyka KV. A metalloprotease-inhibitor reduces pain associated behavior in mice with experimental neuropathy. Neurosci Lett 1997;237(1):45-8
   PubMed Web of Science ®Google Scholar
• Leppert D, Hughes P, Huber S, Matrix metalloproteinase upregulation in chronic inflammatory demyelinating polyneuropathy and nonsystemic vasculitic neuropathy. Neurology 1999;53(1):62-70
   PubMed Web of Science ®Google Scholar
• Hsu JY, McKeon R, Goussev S, Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. J Neurosci 2006;26(39):9841-50
   PubMed Web of Science ®Google Scholar
• Mika J, Osikowicz M, Makuch W, Przewlocka B. Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain. Eur J Pharmacol 2007;560(2-3):142-9
   PubMed Web of Science ®Google Scholar
• Cui Y, Liao XX, Liu W, A novel role of minocycline: attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia. Brain Behav Immun 2008;22(1):114-23
   PubMed Web of Science ®Google Scholar
• Bendszus M, Stoll G. Caught in the act: in vivo mapping of macrophage infiltration in nerve injury by magnetic resonance imaging. J Neurosci 2003;23(34):10892-6
   PubMed Web of Science ®Google Scholar
• Kobayashi H, Chattopadhyay S, Kato K, MMPs initiate Schwann cell-mediated MBP degradation and mechanical nociception after nerve damage. Mol Cell Neurosci 2008;39(4):619-27
   PubMed Web of Science ®Google Scholar
• Coleman WB, Tsongalis GJ. The molecular basis for human cancer. Humana, Totowa, NJ; 2002
   Google Scholar