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Meeting Report

Ion Channels in Drug Discovery and Development

Pages 1861-1865 | Published online: 02 Mar 2005

Bibliography

  • XU J, WANG X, ENSIGN B et al: Ion-channel assay technologies: quo vadis? Drug Disc. Today (2001) 6:1278–1287.
  • TERSTAPPEN GC: Functional analysis of native and recombinant ion channels using a high capacity nonradioactive rubidium efflux assay. Anal. Biochern (1999) 272:149–155.
  • NETZER R, EBNETH A, BISCHOFF U, PONG 0: Screening lead compounds for QT interval prolongation. Drug Disc. Today (2001) 6:78–84.
  • SCHROEDER K, NEAGLE B, TREZISE DJ et Ionworks HT: a new high-throughput electrophysiology measurement platform. J. Biornolec. Screening (2003) 8:50-64. In this review the Ionworks HT patch-clamp platform, one of the most used currently, is well described and put in the context of other HT ion-channel technologies.
  • PARDO LA, DEL CAMINO D, SANCHEZ A et al.: Oncogenic potential of EAG K(+) channels. EMBOJ (1999) 18:5540–5547.
  • GOPALAKRISHNAN M, BUCKNER SA,WHITEAKER KL et al: () (9S) 9 (3 Bromo-4-fluoropheny1)-2,3,5,6,7,9-hexahydrothieno [3,2-b] quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterisation. Pharm. Exp. Ther. (2002) 303:379–386.
  • SPLAWSKI I, SHEN J, TIMOTHY KV et al: Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation (2000) 102:1178–1185.
  • •An excellent review of the multiple types of ion channels involved in long QT syndrome besides the most famous HERG.

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