61
Views
9
CrossRef citations to date
0
Altmetric
Review

Prevention of perinatal HIV transmission: a review of novel strategies

&
Pages 1535-1544 | Published online: 02 Mar 2005

Bibliography

  • MANDELBROT L, LECHENADEC J, delivery in the French Perinatal Cohort. JAMA (1998) 280:55–60.
  • LALLEMANT M, JOURDAIN G, LE COEUR S et al.: A trial of shortened zidovudine regimens to prevent mother-to-child transmission of human immunodeficiency virus Type 1. N Engl. Med. (2000) 343:982–991.
  • KIND C, RUDIN C, SIEGRIST CA et Prevention of vertical HIV transmission: additive protective effect of elective cesareansection and zidovudine prophylaxis. AIDS (1998) 12:205–210.
  • WORKING GROUP ON MOTHER-TO-CHILD TRANSMISSION OF HIV: Rates of mother-to-child HIV in Africa, America and Europe: results from 13 perinatal studies. I AIDS Hum. Retrovirol. (1995) 8:506–510.
  • DECOCK KM, FOWLER MG, MERCIER E et al: Prevention of mother-to-child HIV transmission in resource-poor countries: translating research into policy and practice. JAMA (2000) 283:1175–1182.
  • ARBONA SI, MELVILLE SK, HANSON C et al.: Mother-to-child transmission of the human immunodeficiency virus in Texas. Pediatr. Infect. Dis. (2001) 20:602–606.
  • DECOCK K: Heterogeneity and Public Health in the Global HIV/AIDS Epidemic Top. HIV Med. (2001) 9(3):15–19.
  • CONNOR EM, SPERLING R, GELBER R et al: Reduction of maternal-infant transmission of HIV Type 1 with zidovudine treatment. N Engl. J. Med. (1994) 311:1173–1180.
  • •Seminal first trial that showed efficacy of zidovudine in reducing perinatal transmission of HIV-1.
  • SPERLING RS, SHAPIRO ED, COOMBS RW et al.: Maternal viral load, zidovudine treatment, and the risk of transmission of HIV-1 from mother to infant. N Engl. J. Med. (1996) 335:1621–1629.
  • BLANCHE S, TARDIEU M, RUSTIN P et al: Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues. Lancet (1999) 354:1084–1089.
  • PERINATAL SAFETY REVIEW WORKING GROUP: Nucleoside exposure in the children of HIV-infected women receiving antiretroviral drugs. J. Acquit: Immune Defic. Syndr: (2000) 15:261–268.
  • SHIRAMIZU B, SHIKUMA KM, KAMEMOTO L et al.: Brief report: placenta and cord blood mitochondrial DNA toxicity in HIV-1 infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy. I Acquir: Immune Defic. Syndr: (2003) 32:370–374.
  • EASTMAN PS, SHAPIRO DE, COOMBS RW et al.: Maternal viral genotypic resistance and infrequent failure of zidovudine therapy to prevent perinatal transmission of HIV-1 in pediatric AIDS Clinical Trials Group../. Infect. Dis. (1998) 177:557–564.
  • PALUMBO P, HOLLAND B, DOBBS T et al.: Antiretroviral resistance mutations among pregnant human immunodeficiency virus type-1 infected women and their newborns in the United States: vertical transmission and clades. J. Infect. Dis. (2001) 184:1120–1126.
  • WELLES SL, PITT J, COLGROVE R et al.: HIV-1 genotypic zidovudine drug resistance and the risk of maternal-infant transmission in the women and infants transmission study. The Women and Infants Transmission Study Group. AIDS (2000) 14:263–271.
  • COOPER ER, NUGENT RP, DIAZ C et al: After AIDS clinical trial 076: The changing pattern of zidovudine use during pregnancy, and the subsequent reduction in vertical transmission of HIV in a cohort of infected women and their infants. Infect. Dis. (1996) 174:1207–1211.
  • MATHESON PB, ABRAMS EJ, THOMAS PA et al: Efficacy of antenatal zidovudine in reducing perinatal transmission of HIV-1. J. Infect. Dis. (1995) 172:353–358.
  • EUROPEAN COLLABORATIVE STUDY: HIV-infected pregnant women and vertical transmission in Europe since 1986. AIDS(2001) 15:761–770.
  • CENTERS FOR DISEASE CONTROL AND PREVENTION: US Public Health Service Task Force recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United States. MMWR (2002) 51 (RR18):1–38.
  • ••Comprehensive review of pharmacologyand current guidelines for prevention of HIV-1 transmission strategies from mother to infant.
  • SHAFFER N, CHUACHOOWONG R, MOCK P et al.: Short-course zidovudine for perinatal HIV-1 transmission in Bangkok, Thailand: a randomised controlled trial. Lancet (1999) 353:773–780.
  • WIKTOR S, EKPINI E, KARON J et al.: Short-course oral zidovudine for prevention of mother to child tranmission of HIV-1 in Abidjan, Cote d'Ivoire: a randomised trial. Lancet (1999) 353:781–785.
  • DABIS F, MSELLATI P, MEDA N etal.: 6 month efficacy, tolerance, and acceptability of a short regimen of oral zidovudine to reduce vertical transmission of HIV in breastfed children in Cote d'Ivoire and Burkina Faso: a double blind placebo controlled multicentre trial. Lancet (1999) 353:786–792.
  • LEROY V, NEWELL ML, DABIS F etal.: International multicentre pooled analysis of late postnatal mother to child transmission of HIV-1 infection. Lancet (1998) 352:597–600.
  • FISCUS S, ADIMORA A, SCHOENBACH V et al: Trends in HIV counseling, testing and antiretroviral treatment of HIV-infected women and perinatal transmission in North Carolina. J. Infect. Dis. (1999) 180(1):99–105.
  • WADE N, BIRKHEAD G, WARREN B et al.: Abbreviated regimens of zidovudine prophylaxis and perinatal transmission of the human immunodeficiency virus. N. Engl. J. Med. (1998) 339:1409–1414.
  • WADE NA, BIRKHEAD GS, WARREN BL et al.: Short courses of zidovudine and perinatal transmission of HIV (letter). N Engl. J. Med. (1999) 340:1042–1043.
  • BULTERYS M, ORLOFF S, ABRAMS E et al.: for the Perinatal AIDS Collaborative Transmission Study. Impact of zidovudine post-perinatal exposure prophylaxis on vertical HIV-1 transmission: A prospective cohort study in 4 US cities. 2nd Conference on Global Strategies for the Prevention of HIV Transmission from Mothers to Infants Montreal, Canada (1999) (Abstract 015).
  • BARDSLEY-ELLIOT A, PERRY CM: Nevirapine: A review of its use in the prevention and treatment of paediatric HIV infection. Paediatr. Drugs (2000) 5:373–407.
  • GUAY L, MUSOKE P, FLEMING T et al: Intrapartum and neonatal single dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomized trial. Lancet (1999) 354(9181):795–801.
  • •Important trial showing efficacy of a very simple nevirapine regimen.
  • MOODLEY D, MOODLEY J, COOVADIA H et al.: A multicenter randomized controlled trial of nevirapine versus a combination of zidovudine and lamivudine to reduce intrapartum and early postpartum mother-to-child transmission of HIV-1. J. Infect. Dis. (2003) 187:725–735.
  • DORENBAUM A, CUNNINGHAM CK, GELBER RD et al.: Two-dose intrapartum/ newborn nevirapine and standard antiretroviral thepapy to reduce perinatal HIV-1 transmission: a randomized trial. JAMA (2002) 288:189–198.
  • ESHLEMAN SH, MRACNA M, GUAY LA et al: Selection and fading of resistance mutations in women and infants 1542 Expert Op/n. lnvestig. Drugs (2003) 12(9) receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012). AIDS (2001) 15:1951–1957.
  • CUNNINGHAM CK, CHAIX ML, REKACEWICZ C et al.: Development of resistance mutations in women receiving standard antiretroviral therapy who received intrapartum nevirapine to prevent perinatal HIV-1 transmission: a substudy of pediatric AIDS clinical trials group protocol 316. Infect. Dis. (2002) 186:181–188.
  • STRINGER JS, SINKALA M, STOUT JP et al.: Comparison of two strategies for administering nevirapine to prevent perinatal HIV transmission in high-prevalence, resource-poor settings. Acquir. Immune Defic. Syndr. Hum. Retrovirol. (2003) 32:506–513.
  • THE PETRA STUDY TEAM: Efficacy of three short-course regimens of zidovudine and lamivudine in preventing early and late transmission of HIV-1 from mother to child in Tanzania, South Africa, and Uganda (Petra study): a randomized, double-blind, placebo-controlled trial. Lancet (2002) 359:1178–1186.
  • MANDELBROT L, LANDREAU-MASCARO A, REKACEWICZ C et al.: Lamivudine-Zidovudine combination for prevention of maternal-infant transmission of HIV-1. JAMA (2001) 285:2083–2093.
  • CLARKE JR, BRAGANZA R, MIRZA A et al.: Rapid development of genotypic resistance to lamivudine when combined with zidovudine in pregnancy. I Med. Virol. (1999) 59:364–368.
  • DABIS F, LEROY V, BEQUET L et al.: Effectiveness of a short course of zidovudine + nevirapine to prevent mother to child transmission (PMTCT) of HIV-1: The Ditrame Plus, ANRS 1201 Project in Abidjan, Cote d'Ivoire. XIV International AIDS Conference, Barcelona, Spain (2002) (Abstract 1428).
  • HELFGOTT AW, ERIKSEN N, LEWIS S et al: Highly active antiretroviral therapy for the prevention of perinatal HIV. Am.j Obstet. Cynecol. (2000) (Suppl., Part 2):100 (Abstract).
  • BLATTNER W, COOPER E, CHARURAT M et al.: Effectiveness of potent antiretroviral therapies on reducing perinatal transmission of HIV-1. XIII International AIDS Conference, Durban, South Africa (2000) (Abstract LbOr4).
  • BRYSON Y, STEK A, MIROCHNICK M et al.: Pharmacokinetics, antiviral activity, and safety of nelfinavir (NFV) with ZDV/ 3TC in pregnant HIV-1 infected women and their infants: PACTG 353 Cohort 2. 9th Conference on Retroviruses and Opportunistic Infections, Seattle, WA, USA (2002) (Abstract 795–W).
  • THE EUROPEAN COLLABORATIVE STUDY AND THE SWISS MOTHER CHILD HIV COHORT STUDY: Combination antiretroviral therapy and duration of pregnancy. AIDS(2000) 14:2913–2920.
  • SHAPIRO D, TUOMALA R, SAMELSON R et al.: Antepartum antiretroviral therapy and pregnancy outcomes in 462 HIV-infected women in 1998–1999 (PACTG 367). 7th Conference on Retroviruses and Opportunistic Infections, San Francisco, CA, USA (2000) (Abstract 664).
  • JUNGMANN EM, MERCEY D, DERUITER A et al.: Is first trimester exposure to the combination of antiretroviral therapy and folate antagonists a risk factor for congenital abnormalities? Sex Transm. Infect. (2001) 77:441–443.
  • MANDELBROT L, MSELLATI P, MEDA N et al.: 15 month follow up of African children following vaginal cleansing with benzalconium chloride of their HIV-1 infected mothers during late pregnancy and delivery. Sex Transm. Infect. (2002) 78:267–270.
  • BIGGAR RJ, MIOTTI PG, TAHA TE et al.: Perinatal intervention trial in Africa: effect of a birth canal cleansing intervention to prevent HIV-1 transmission. Lancet (1996) 347: 1647-1650.
  • GAILLARD P, MWANYUMBA F, VERHOFSTEDE C et al.: Vaginal lavage with chlorhexidine during labour to reduce mother to child HIV-1 transmission: clinical trial in Mombasa, Kenya. AIDS (2001) 15:389–396.
  • FAWZI WW, MSAMANGA GI, HUNTER D et al.: Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality. AIDS(2002) 16: 1935-1944.
  • STOLZFUS RJ, HUMPHREYS JH: Vitamin A and the nursing mother-infant dyad: evidence for intervention. Adv. Exp. Med. Biol. (2002) 503:39–47.
  • PILLAY C, GRAY G, STEVENS G et al.:Emergence of resistance mutations in children treated with ddI plus d4T after treatment to prevent mother to child transmission. XIV International AIDS Conference, Barcelona, Spain (2002) (Abstract B4583).
  • ZORILLA CD, VAN DYKE R, BARDEGUEZ A et al.: Clinical response, safety, and tolerability to saquinavir-SCG with low-dose ritonavir boosting in combination with zidovudine and lamivudine in HIV-1 infected pregnant women: preliminary results of PACTG 386. 10th Conference on Retroviruses and Opportunistic Infections, Boston, MA, USA (2003) (Abstract 887).
  • SCOTT G, RODMAN J, SCOTT W et al.: Pharmacokinetics and virologic response to ritonavir in combination with zidovudine and lamivudine in HIV-1 infected pregnant women and their infants. 9th Conference on Retroviruses and Opportunistic Infections, Seattle, WA, USA (2002) (Abstract 794–W).
  • LALLEMANT MC, THAINEUA V, JOURDAN G et al.: PHPT-2: Nevirapine plus zidovudine for the prevention of perinatal HIV-1. XIV International AIDS Conference, Barcelona, Spain (2002) (Abstract C10914).
  • SILVERMAN MS, THISTLE P, ARBESS G et al: Superiority of an 'ultra-short' zidovudine regimen in the prevention of perinatal HIV-1 transmission in rural Zimbabwe. XIV International AIDS Conference, Barcelona, Spain (2002) (Abstract D3680).
  • SAEZ-LLORENS X, VIOLARI A, DEETZ CO et al.: Forty-eight week evaluation of lopinavir/ritonavir, a new protease inhibitor, in HIV-1 infected children. Pediatr. Infect. Dis. I (2003) 22:216–224.
  • LALEZARI JP, HENRY K, O'HEARN Met al: Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV-1 infection in North and South America. N Engl. Med. (2003) 348:2175–2185.
  • VAN ROMPAY K, MILLER MD, MARTHAS ML et al: Prophylactic and therapeutic benefits of short-term 9- [2-(R)-(phosphonomethoxy)propylladenine (PMPA) administration to newborn macaques following oral inoculation with SIV with reduced susceptibility to PMPA. Virol. (2000) 74:1767–1774.
  • DEEKS S, BARDITCH-CROVOP, LIETMAN P et al.: Safety, pharmacokinetics and antiretroviral activity of intravenous 9-[2-(A)-(phosphonomethoxy)propylladenine, a novel anit-HIV-1 therapy, in HIV-1-1543 infected adults. Antimicrob. Agents Cliemother. (1998) 42:2380–2384.
  • BARDITCH-CROVO P, DEEKS SG, COLLIER A et al: Phase I/II trial of the pharmacokinetics, safety, and antiretroviral activity of tenofovir disoproxil fumarate in HIV-1 infected adults. Antimicrob. Agents Cliemother. (2001) 45:2733–2739.
  • PALMER S, MARGOT N, GILBERT H et al.: Tenofovir, adefovir, and zidovudine susceptibilities of primary HIV-1 isolates with non-B subtypes or nucleoside resistance. AIDS Res. Hum. Retrovjruses (2001) 17:1167–1173.
  • TARANTAL AF, MARTHAS ML, SHAW JP et al.: Administration of 9-[2-(R)-(phosphonomethoxy)propyll adenine (PMPA) to gravid and infant rhesus macaques (macaca mulatta): safety and efficacy studies. I Acquir: Immune Defic. Syndr: Hum. Retrovirol (1999) 20:323–333.
  • MIOTTI PG, TAHA TE, KUMWENDA N et al: HIV transmission through breastfeeding. A study in Malawi. JA/VIA (1999) 282:744–749.
  • NDUATI RW, JOHN GC, RICHARDSON BA et al.: HIV-1 infected cells in breast milk: association with immunosuppression and vitamin A deficiency." Infect. Dis. (1995) 172:1461–1468.
  • COUTSOUDIS A, PILLAY K, KUHN L et al.: Method of feeding and transmission of HIV-1 from mothers to children by 15 months of age: prospective cohort study from Durban, South Africa. AIDS(2001) 15:379–387.
  • FOWLER MG, NEWELL ML: Breast-feeding and HIV-1 transmission in resource-limited settings." Acquir. Immune Defic. Syndr. Hum. Retrovirol (2002) 30:230–239.
  • •Comprehensive review of breastfeeding transmission of HIV-1.
  • SAVARINO A, GENNERO L, CHEN HC et al.: Anti-HIV-1 effects of chloroquine: mechanisms of inhibition and spectrum of activity. AIDS (2001) 23:2221–2229.
  • BOELAERT JR, YARO S, AUGUSTIJNS P et al.: Chloroquine accumulates in breast milk cells: potential impact in the prophylaxis of postnatal mother to child transmission of HIV-1. AIDS (2001) 15:2205–2207.
  • SEMBA RD, KUMWENDA N, HOOVER DR et al: HIV load in breast milk, mastitis, and mother-to-child transmission of HIV Type 1.1 Infect. Dis. (1999) 180:93–98.
  • BORKOWSKY W: Immunotherapy for pregnant women and newborns. Ann. NY Acad. Sci. (2000) 918:313–317.
  • WRIGHT PF, LAMBERT JS, GORSE GJ et al: Immunization with envelope MN rgp 120 vaccine in HIV-infected pregnant women." Infect. Dis. (1999) 180:1080–1085.
  • FERRANTELLI F, HOFMANN-LEHMANN R, RASMUSSEN R et al: Post-exposure prophylaxis with human monoclonal antibodies prevented SHIV 89.6P infection or disease in neonatal macaques. AIDS (2003) 17:301–309.
  • WATANABE ME: Sceptical scientists skewer VaxGen statistics. Nat. Med. (2003) 9:376.
  • JOHNSON D, MCFARLAND E, MURESAN P et al.: PACTG 326: A Phase I/II study to evaluate the safety and immunogenicity of Alvac HIV-1 vaccines alone and with AIDSVax B/B in children born to HIV-1-infected mothers: preliminary results. 10th Conference on Retro viruses and Opportunistic Infections, Boston, MA, USA (2003) (Abstract 404).
  • MCFARLAND E, JOHNSON D, FENTON T et al: A Phase I/II study of the safety and immunogenicity of an HIV-1-1 ALVAC vaccine in infants born to HIV-1-infected mothers. 10th Conference on Retro viruses and Opportunistic Infections, Boston, MA, USA (2003) (Abstract 99).
  • SUSMAN E: Vaccine trials begin. Notes and quotes. AIDS(2003) 17:N5.
  • CHUACHOOWONG R, SHAFFER N, VANCOTT TC et al: Lack of association between human HIV antibody in cervicovaginal lavage fluid and plasma and perinatal transmission, in Thailand. Infect. Dis. (2000) 181:1957–1963.
  • STIEHM ER, LAMBERT JS, MOFENSON LM et al: Efficacy of zidovudine and HIV hyperimmune immunoglobulin for reducing perinatal HIV transmission from HIV-infected women with advanced disease : results of Pediatric AIDS Clinical Trials Group protocol 185. J. Infect. Dis. (1999) 179:567–575.
  • GUAY LA, MUSOKE P, HOM DL et al.:Phase I/II trial of HIV-1 hyperimmune globulin for the prevention of HIV-1 vertical transmission in Uganda. AIDS (2002) 16:1391–1400.
  • SHEARER WT, DULIEGE AM, KLINE MW et al.: Transport of recombinant human CD4-immunoglobulin G across the human placenta: pharmacokinetics and safety in six mother-infant pairs in AIDS clinical trial group protocol 146. Clin. Diag. Lab. Immunol (1995) 2:281–285.

Websites

  • http://www.hptn.org/research_studies/ study_details.asp?Protoco1+%23=HIVNET +024 HIVNET 024: Phase III trial of antibiotics to reduce chorioamnionitis-related perinatal HIV-1 transmission. HPTN study details (2003).
  • http://pactg.s-3.com SPECTOR S: Presentation of PACTG Winter 2002 meeting (2003).
  • http://www.iavi.org/iavireport/0103/ babies.htm INTERNATIONAL AIDS VACCINE INITIATIVE (IAVI) REPORT: Are babies in a blind spot? Pediatric workshop highlights barriers to neonatal HIV vaccine development (2003).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.