Diquafosol tetrasodium: a novel dry eye therapy

Bibliography

• LEMP MA: Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. CLAW. (1995) 21:221–232.
   PubMedGoogle Scholar
• ••This paper details group recommendationsfor the definition and classification for dry eye disease, and reviews available diagnostic tests.
   Google Scholar
• SCHAUMBERG DA, SULLIVAN DA, BURING JE et al.: Prevalence of dry eye syndrome among US women. Am. J. Ophthalmol (2003) 136:318–326.
   PubMed Web of Science ®Google Scholar
• SCHEIN OD, TIELSCH JM, MUNOZ Bet al.: Relation between signs and symptoms of dry eye in the elderly. A population-based perspective. Ophthalmology (1997) 104:1395–1401.
   Google Scholar
• •A thorough discussion of dry eye in the elderly population can be found in this paper.
   Google Scholar
• NICHOLS KK, NICHOLS JJ, ZADNIK K: Frequency of dry eye diagnostic test procedures used in various modes of ophthalmic practice. Cornea (2000) 19:477–482.
   PubMed Web of Science ®Google Scholar
• •While many diagnostic tests are available, not all are used in clinical practice. Chart audits were used to determine testing procedures used.
   Google Scholar
• KORB DR: Survey of preferred tests for diagnosis of the tear film and dry eye. Cornea (2000) 19:483–486.
   PubMed Web of Science ®Google Scholar
• •When asked, eye care providers often prefer dry eye diagnostic tests that are often left out of dry eye clinical examinations.
   Google Scholar
• NICHOLS KK, ZADNIK K: The repeatability of diagnostic tests and surveys in dry eye. Adv. Exp. Med. Biol. (2002) 506:1171-1175. Expert Op/n. lnvestig. Drugs (2004) 13(1)53
   Google Scholar
• WEN Q, KUANG K, YERXA B et al: Effects of P2Y2 agonists on lipid secretion by cultured rabbit meibocytes. Invest. Ophthalmol Vis. Sci. (2002) 43(Suppl.) (Abstract 3146).
   Google Scholar
• PENDERGAST W, YERXA BR, DOUGLASS JG 3rd et al.: Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates. Bioorg. Med. Chem. Lett. (2001) 11:157–160.
   Google Scholar
• BIDET M, DE RENZIS G, MARTIAL S et al.: Extracellular ATP increases [Ca(211(i) in distal tubule cells. I. Evidence for a P2Y2 purinoceptor. Am. I Physiol Rena] Physiol (2000) 279:F92–F101.
   Google Scholar
• •This paper provides evidence that P2Y2 receptor activation causes calcium release.
   Google Scholar
• BURRELL HE, BOWLER WB, GALLAGHER JA et al: Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.' Invest. Dermatol (2003) 120:440–447.
   PubMed Web of Science ®Google Scholar
• GALLAGHER CJ, SALTER MW: Differential properties of astrocyte calcium waves mediated by P2Y1 and P2Y2 receptors. Neurosci. (2003) 23:6728–6739.
   PubMed Web of Science ®Google Scholar
• SUGAMOTO Y, HIRAI K, TOKORO T: P2Y2 receptor elevates intracellular calcium concentration in rabbit eye suprachoroid. Med. Dent. Sci. (1999) 46:83–92.
   PubMedGoogle Scholar
• WERRY TD, WILKINSON GE WILLARS GB: Crosstalk between P2Y2 nucleotide receptors and CXCR2 resulting in enhanced Ca2' signalling involves enhancement of phospholipase C activity, and is enabled by incremental Ca2' release in HEK cells. I Pharmacol Exp. Ther. (2003) 307(2):661–669.
   PubMed Web of Science ®Google Scholar
• •This paper provides additional evidence that P2Y2 receptor activation causes calcium release.
   Google Scholar
• PINTOR J, PERAL A, HOYLE CH et al.:Effects of diadenosine polyphosphates on tear secretion in New Zealand white rabbits. Pharmacol Exp. Ther. (2002) 300:291–297.
   PubMed Web of Science ®Google Scholar
• LI Y, KUANG K, YERXA B et at Rabbit conjunctival epithelium transports fluid, and P2Y2 (2) receptor agonists stimulate Cl() and fluid secretion. Am. I Physiol Physiol (2001) 281:C595–C602.
   PubMed Web of Science ®Google Scholar
• ••The mechanism of chloride ion and fluidsecretion on the ocular surface is discussed in this pivotal paper.
   Google Scholar
• JUMBLATT JE, JUMBLATT MM: Regulation of ocular mucin secretion by P2Y2 nucleotide receptors in rabbit and human conjunctiva. Exp. Eye. Res. (1998) 67:341–346.
   PubMed Web of Science ®Google Scholar
• ••This is the first description of mucinsecretion and regulation through P2Y2 receptor stimulation.
   Google Scholar
• FUJIHARA T, MURAKAMI T, FUJITA H et al.: Improvement of corneal barrier function by the P2Y(2) agonist IN5365 in a rat dry eye model. Invest. Ophthalmol Vis. ScL (2001) 42:96–100.
   PubMed Web of Science ®Google Scholar
• PICHER M, BOUCHER RC: Biochemical evidence for an ecto alkaline phosphodiesterase I in human airways. Am. I Respir. Cell. MM. Biol. (2000) 23:255–261.
   PubMed Web of Science ®Google Scholar
• GUKASYAN HJ, YERXA BR, PENDERGAST W et al.: Metabolism and transport of purinergic receptor agonists in rabbit conjunctival epithelial cells. Adv. Exp. Med. Biol. (2002) 506:255–259.
   PubMed Web of Science ®Google Scholar
• YERXA B, GUKASYAN HJ, PENDERGAST W et al.: Ecto-metabolism and transport efficiency of P2Y receptor agonists by rabbit ocular surface epithelial Cells. Invest. Ophthalmol Vis. Sci. (2001) 42(Suppl.) (Abstract 4889).
   Google Scholar
• KELLERMAN D, SALL K, BOKOSKY Jet al.: Diquafosol tetrasodium (IN5365) ophthalmic solution is not absorbed systemically in patients with dry eye. Invest. Ophthalmol Vis. Sci. (2003) 44(Suppl.) (Abstract 3740).
   Google Scholar
• MUNDASAD MV, NOVACK GD, ALLGOOD VE et al.: Ocular safety of IN5365 ophthalmic solution: a P2Y(2) agonist in healthy subjects. Pharmacol Ther. (2001) 17:173–179.
   Web of Science ®Google Scholar
• YERXA BR, MUNDASAD M, SYLVESTER RN et at Ocular safety of IN5365 ophthalmic solution, a P2Y2 agonist, in patients with mild to moderate dry eye disease. Adv. Exp. Med. Biol. (2002) 506:1251–1257.
   PubMed Web of Science ®Google Scholar
• FOULKS G, SALL K, GREENBERG M et al.: Phase II dose ranging efficacy trial of IN5365 ophthalmic solution a p2y2 agonist in patients with dry eye. Invest. Ophthalmol Vis. ScL (2001) 43(Suppl.) (Abstract 3839).
   Google Scholar
• TAUBER J, DAVITT WF, BOKOSKY JE et al.: Double masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (IN5365) ophthalmic solution for the treatment of dry eye. Invest. Ophthalmol Vis. Sci. (2003) 45 (Abstract 3738).
   Google Scholar
• ••The preliminary Phase III data waspresented at the annual Association for Research in Vision and Opthalmology meeting and can be found in this abstract.
   Google Scholar
• SULLIVAN DA, SULLIVAN BD, EVANS JE et al.: Androgen deficiency, Meibomian gland dysfunction, and evaporative dry eye. Ann. NY Acad. ScL (2002) 966:211–222.
   PubMed Web of Science ®Google Scholar
• SULLIVAN DA, ROCHA EM, ULLMAN MD et al.: Androgen regulation of the meibomian gland. Adv. Exp. Med. Biol. (1998) 438:327–331.
   PubMed Web of Science ®Google Scholar
• •This is an excellent overview of the role of hormonal regulation of the ocular surface.
   Google Scholar
• JUMBLATT JE, JUMBLATT MM: Detection and quantification of conjunctival mucins. Adv. Exp. Med. Biol. (1998) 438:239–246.
   PubMed Web of Science ®Google Scholar
• PFLUGFELDER SC, LIU Z, MONROY D et al.: Detection of sialomucin complex (MUC4) in human ocular surface epithelium and tear fluid. Invest. Ophthalmol Vis. ScL (2000) 41:1316–1326.
   PubMed Web of Science ®Google Scholar
• WATANABE H: Significance of mucin onthe ocular surface. Cornea (2002) 21:S17–S22.
   PubMedGoogle Scholar
• GOTO E, TSENG SC: Differentiation of lipid tear deficiency dry eye by kinetic analysis of tear interference images. Arch. Ophthalmol (2003) 121:173–180.
   PubMed Web of Science ®Google Scholar
• KELLERMAN D, EVANS R, MATHEWS D et al.: Inhaled P2Y2 receptor agonists as a treatment for patients with Cystic Fibrosis lung disease. Adv. Drug Deli v. Rev (2002) 54:1463–1474.
   PubMed Web of Science ®Google Scholar
• •Further application of the P2Y2 receptor technology is discussed with regard to cystic fibrosis.
   Google Scholar
• RAMMINGER SJ, COLLETT A, BAINES DL et al.: P2Y2 receptor-mediated inhibition of ion transport in distal lung epithelial cells. Br. Pharmacol (1999) 128:293–300.
   PubMed Web of Science ®Google Scholar
• WEISMAN GA, GARRAD RC, ERB LJ et al.: Structure and function of P2Y2 nucleotide receptors in cystic fibrosis (CF) epithelium. Adv. Exp. Med. Biol. (1998) 431:417–424.
   PubMed Web of Science ®Google Scholar