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Review

From chemoprevention to chemotherapy: common targets and common goals

, &
Pages 1327-1338 | Published online: 24 Feb 2005

Bibliography

  • GORMAN C, PARK A: The fires within. Time (2004) 42–46.
  • COUSSENS LM, WERB Z: Inflammation and cancer. Nature (2002) 420(6917):860–867.
  • ••This article reviews various evidence thatinflammation is closely linked to tumourigenesis.
  • BALK WILL F, MANTOVANI A: Inflammation and cancer: back to Virchow? Lancet (2001) 357(9255):539–545.
  • YUSPA SH: Overview of carcinogenesis: past, present and future. Carcinogenesis (2000) 21(3):341–344.
  • •Reviews the fight against cancer.
  • HONG WK, SPORN MB: Recent advances in chemoprevention of cancer. Science (1997) 278(5340):1073–1077.
  • Prevention of cancer in the next millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research. Cancer Res. (1999) 59(19):4743–4758.
  • SPORN MB, SUH N: Chemoprevention of cancer. Carrinogenesis (2000) 21(3):525–530.
  • •Reviews the conceptual basis for chemoprevention of cancer.
  • KELLOFF GJ: Perspectives on cancer chemoprevention research and drug development. Adv. Cancer Res. (2000) 78:199–334.
  • CRAIG WJ: Phytochemicals: guardians of our health. Am. Diet. Assoc. (1997) 97(10 Suppl. 2):S199–204.
  • CRAIG WJ: Health-promoting properties of common herbs. Am.j Clin. Num. (1999) 70(3 Suppl.):491S–499S.
  • SURH YJ: Cancer chemoprevention with dietary phytochemicals. Nat. Rev Cancer (2003) 3(10):768–780.
  • •This article suggests that the consumption of fruits and vegetables can help fight cancer.
  • NEWMAN DJ, CRAGG GM, SNADER KM: Natural products as sources of new drugs over the period 1981-2002. Nat. Prod. (2003) 66(7):1022–1037.
  • ••This article reviews the source of mostdrugs.
  • KELLOFF GJ, BOONE CW, CROWELL JA et al: New agents for cancer chemoprevention.Biochem. Sapp].(1996) 26:1–28.
  • GARG A, AGGARWAL BB: Nuclear transcription factor-icB as a target for cancer drug development. Leukemia (2002) 16(6):1053–1068.
  • •This article provides evidence that NF-x13 can be targeted to discover new drugs for cancer.
  • AGGARWAL BB, TAKADA Y, SHISHODIA S et al: Nuclear transcription factor NF-k B: Role in biology and medicine. Indian,/ Exp. Biol. (2004) 42:341–353.
  • KARALIS KP, VENIHAKI M, ZHAO J,VAN VLERKEN LE, CHANDRAS C: NF-icB participates in the corticotropin- releasing, hormone-induced regulation of the pituitary proopiomelanocortin gene. J. Biol. Chem. (2004) 279(12):10837–10840.
  • YEH SH, LIN CH, LEE CF, GEAN PW: A requirement of nuclear factor-KB activation in fear-potentiated startle. Biol. Chem. (2002) 277(48):46720–46729.
  • KUMAR A, DHAWAN S, HARDEGEN NJ, AGGARWAL BB: Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-lcB activation. Biochem. Pharmacol (1998) 55(6):775–783.
  • LIN YL, LIN JK: 0-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-KB. Mol Pharmacol (1997) 52(3):465–472.
  • MANNA SK, MUKHOPADHYAY A, VAN NT, AGGARWAL BB: Silymarin suppresses TNF-induced activation of c-Jun N-terminal kinase and apoptosis. Immunol (1999) 163(12):6800–6809.
  • NATARAJAN K, MANNA SK, CHATURVEDI MM, AGGARWAL BB: Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-KB, degradation of IlcBa, nuclear translocation of p65 and subsequent gene expression. Arch. Biochem. Biophys. (1998) 352(1):59–70.
  • NATARAJAN K, SINGH S, BURKE TR Jr, GRUNBERGER D, AGGARWAL BB: Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor Proc Nati Arad SciUSA (1996) 93(17):9090–9095.
  • CHAINY GB, MANNA SK, CHATURVEDI MM, AGGARWAL BB: Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-icB, AP-1, JNK, MAPKK and apoptosis. Oncogene (2000) 19(25):2943–2950.
  • SINGH S, NATARAJAN K, AGGARWAL BB: Capsaicin (8-methyl-N-vanilly1-6-nonenamide) is a potent inhibitor of nuclear transcription factor-KB activation by diverse agents. Immunol. (1996) 157(10):4412–4420.
  • MANNA SK, MUKHOPADHYAY A, AGGARWAL BB: Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-icB, activator protein-1 and apoptosis: potential role of reactive oxygen intermediates and lipid perwddation. I Immunol. (2000) 164(12):6509–6519.
  • SHAULIAN E, KARIN M: AP-1 as a regulator of cell life and death. Nat. Cell Biol. (2002) 4(5):E131–136.
  • •This article shows the role of AP-1 in tumorigenesis.
  • YOUNG MR, YANG HS, COLBURN NH: Promising molecular targets for cancer prevention: AP-1, NF-icB and Pdcd4. Trends Mol. Med. (2003) 9(1):36–41.
  • SHAULIAN E, KARIN M: AP-1 in cell proliferation and survival. Oncogene (2001) 20(19):2390–2400.
  • BIERHAUS A, ZHANG Y, QUEHENBERGER P et al.: The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-icB. Thromb. Haemost. (1997) 77(4):772–782.
  • SATO T, KOIKE L, MIYATA Yet al.: Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells. Cancer Res. (2002) 62(4):1025–1029.
  • DONG Z, MA W, HUANG C, YANG CS: Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, epigallocatechin gallate and theaflavins. Cancer Res. (1997) 57(19):4414–4419.
  • CHUNG JY, HUANG C, MENG X, DONG Z, YANG CS: Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved. Cancer Res. (1999) 59(18):4610–4617.
  • DING M, LU Y, BOWMAN L et al: Inhibition of AP-1 and neoplastic transformation by fresh apple peel extract. Biol. Chem. (2004) 279(11):10670–10676.
  • AGGARWAL BB, KUMAR A, BHARTI AC: Anticancer potential of curcumin: preclinical and clinical studies. Anti-Cancer Res. (2003) 23(1A):363–398.
  • ANTO RJ, MUKHOPADHYAY A, DENNING K, AGGARWAL BB: Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bc1-2 and Bcl-xl. Carcinogenesis (2002) 23(1):143–150.
  • JANA NR, DIKSHIT P, GOSWAMI A, NUKINA N: Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway. J. Biol. Chem. (2004) 279(12):11680–11685.
  • AGGARWAL BB, BHARDWAJ A, AGGARWAL RS et al.: Role of reweratrol in prevention and therapy of cancer: preclinical and Clinical Studies. Anti-Cancer Res. (2004)
  • GUPTA S, HASTAK K, AFAQ F, AHMAD N, MUKHTAR H: Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor KB and induction of apoptosis. Oncogene (2004) 23(14):2507–2522
  • SHISHODIA S, AGGARWAL BB: Nuclear factor-KB activation: a question of life and death. Biochem. Mol. Biol. (2002) 35:28–40.
  • ESTEVE PO, CHICOINE E, ROBLEDO 0 et al.: Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-a in glioma cells via NF-icB. Biol. Chem. (2002) 277(38):35150–35155.
  • YAMAMOTO K, ARAKAWA T, UEDA N, YAMAMOTO S: Transcriptional roles of nuclear factor lcB and nuclear factor-interleukin-6 in the tumor necrosis factor a-dependent induction of cyclooxygenase-2 in MC3T3-El cells. J. Biol Chem. (1995) 270(52):31315–31320.
  • GUTTRIDGE DC, ALBANESE C, REUTHER JY, PESTELL RG, BALDWIN AS, JR.: NF-icB controls cell growth and differentiation through transcriptional regulation of cyclin Dl. Mol. Cell. Biol. (1999) 19(8):5785–5799.
  • ZHU L, FUKUDA S, CORDIS G, DAS DK, MAULIK N: Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning. FEBS Lett. (2001) 508(3):369–374.
  • CHU ZL, McKINSEY TA, LIU L et al.: Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-icB control. Proc. Nati Acad. Sci. USA (1997) 94(19):10057–10062.
  • YOU M, KU PT, HRDLICKOVA R, BOSE HR, JR.: Ch-IAP1, a member of the inhibitor-of-apoptosis protein family, is a mediator of the antiapoptotic activity of the v-Rel oncoprotein. Mol. Cell. Biol. (1997) 17(12):7328–7341.
  • TAMATANI M, CHE YH, MATSUZAKI H et al.: Tumor necrosis factor induces Bc1-2 and Bcl-x expression through NFicB activation in primary hippocampal neurons. Biol. Chem. (1999) 274(13):8531–8538.
  • GRUMONT RJ, ROURKE IJ, GERONDAKIS S: Rel-dependent induction of Al transcription is required to protect B cells from antigen receptor ligation-induced apoptosis. Genes Dev. (1999) 13(4):400–411.
  • ZONG WX, EDELSTEIN LC, CHEN C, BASH J, GELINAS C: The prosurvival Bc1-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-icB that blocks TNFa-induced apoptosis. Genes Dev. (1999) 13(4):382–387.
  • SCHWENZER R, SIEMIENSKI K, LIPTAY S et al.: The human tumor necrosis factor (TNF) receptor-associated factor 1 gene (TRAF1) is up-regulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-icB and c- Jun N-terminal kinase. J. Biol. Chem. (1999) 274(27):19368–19374.
  • KREUZ S, SIEGMUND D, SCHEURICH P, WAJANT H: NF-icB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Ma Cell Biol. (2001) 21(12):3964–3973.
  • BHARTI AC, DONATO N, SINGH S, AGGARWAL BB: Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-KB and IicBa kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood(2003) 101(3):1053–1062.
  • •This article provides evidence that curcumin, a pharmacologically safe agent, can be used for the treatment of multiple myeloma.
  • AGGARWAL S, TAKADA Y, SINGH S, MYERS J, AGGARWAL BB: Inhibition of growth and survival of human head neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kB signalling. Int. J. Cancer (2004) 111(5):679–692
  • FULDA S, DEBATIN KM: Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol. Cancer Res. (2004) 64(1):337–346.
  • HAYASHIBARA T, YAMADA Y, NAKAYAMA S et al.: Resveratrol induces downregulation in survivin expression and apoptosis in HTLV-1-infected cell lines: a prospective agent for adult T cell leukemia chemotherapy. Nutr. Cancer (2002) 44(2):193–201.
  • •This article shows that resveratrol can downregulate survival, a cell-survival protein.
  • TYAGI AK, SINGH RP, AGARWAL C, CHAN DC, AGARWAL R: Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth Inhibition, G2-M arrest and apoptosis. Clin. Cancer Res. (2002) 8(11):3512–3519.
  • MASUDA M, SUZUI M, WEINSTEIN IB: Effects of epigallocatechin-3-gallate on growth, epidermal growth factor receptor signaling pathways, gene expression and chemosensitivity in human head and neck squamous cell carcinoma cell lines. Clin. Cancer Res. (2001) 7(12):4220–4229.
  • CARPENTER G: The EGF receptor: a nexus for trafficking and signaling. Bioessays (2000) 22(8):697–707.
  • YARDEN Y, SLIWKOWSKI MX: Untangling the ErbB signalling network. Nat. Rev Ma Cell Biol. (2001) 2(2):127–137.
  • SCHLESSINGER J: Signal transduction. Autoinhibition control. Science (2003) 300(5620):750–752.
  • RUSCH V, KLIMSTRA D, VENKATRAMAN E et al.: Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor a is frequent in resectable non-small cell lung cancer but does not predict tumor progression. Clin. Cancer Res. (1997) 3(4):515–522.
  • DANCEY JE: Predictive factors for epidermal growth factor receptor inhibitors-the bull's-eye hits the arrow. Cancer Cell (2004) 5(5):411–415.
  • GAUR U, AGGARWAL BB: Regulation of proliferation, survival and apoptosis by members of the TNF superfamily. Biochem. Pharmacol (2003) 66(8):1403–1408.
  • ESTROV Z, SHISHODIA S, FADERL S et al.: Resveratrol blocks interleukin-113-induced activation of the nuclear transcription factor NF-icB, inhibits proliferation, causes S-phase arrest and induces apoptosis of acute myeloid leukemia cells. Blood (2003) 102(3):987–995.
  • ••This article shows that resveratrol has therapeutic potential against of acute myeloid leukemia.
  • BHARTI AC, DONATO N, AGGARWAL BB: Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. J. Immunol (2003) 171(7):3863–3871.
  • DORAI T, GEHANI N, KATZ A: Therapeutic potential of curcumin in human prostate cancer. II. Curcumin inhibits tyrosine kinase activity of epidermal growth factor receptor and depletes the protein. Ma Urol. (2000) 4(1):1–6.
  • HONG RL, SPOHN WH, HUNG MC: Curcumin inhibits tyrosine kinase activity of p185neu and also depletes p185neu. Gin. Cancer Res. (1999) 5(7):1884–1891.
  • SAH JF, BALASUBRAMANIAN S, ECKERT RL, RORKE EA: Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway: Evidence for direct inhibition of ERK1/2 and AKT kinases. J Biol. Chem. (2004) 279(13):12755–12762.
  • CHUNG JY, PARK JO, PHYU H, DONG Z, YANG CS: Mechanisms of inhibition of the Ras-MAP kinase signaling pathway in 30.76 Ras 12 cells by tea polyphenols (-)-epigallocatechin-3-gallate and theaflavin-3,3'-digallate. FASEB J. (2001) 15(11):2022–2024.
  • DARNELL JE, JR., KERR IM, STARK GR: Jak-STAT pathways and transcriptional activation in response to IENs and other extracellular signaling proteins. Science (1994) 264(5164):1415–1421.
  • TURKS ON J, JOVE R: STAT proteins: novel molecular targets for cancer drug discovery. Oncogene (2000) 19(56):6613–6626.
  • NATARAJAN C, BRIGHT JJ: Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes. J Immunol (2002) 168(12):6506–6513.
  • KIM HY, PARK EJ, JOE EH, JOU I: Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia. J. Immunol (2003) 171(11):6072–6079.
  • BHARTI AC, SHISHODIA S, REUBEN JM et al.: Nuclear factor-{K}B and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients and their suppression leads to apoptosis. Blood (2003).
  • ••This article shows curcumin as atherapeutic agent.
  • ZHOU G, KUO MT: NE-KB-mediated induction of mdrlb expression by insulin in rat hepatoma cells. Biol. Chem. (1997) 272(24):15174–15183.
  • ANUCHAPREEDA S, LEECHANACHAI P, SMITH MM, AMBUDKAR SV, LIMTRAKUL PN: Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells. Biochem. Pharmacol (2002) 64(4):573–582.
  • HONG J, LAMBERT JD, LEE SH, SINKO PJ, YANG CS: Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites. Biochem. Biophys. Res. Commun. (2003) 310(1):222–227.
  • JODOIN J, DEMEULE M, BELIVEAU R: Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols. Biochim. Biophys. Acta (2002) 1542(1-3):149–159.
  • GASPARINI G, LONGO R, SARMIENTO R, MORABITO A: Inhibitors of cyclo-oxygenase 2: a new class of anticancer agents? Lancet Oncol (2003) 4(10):605–615.
  • ANTO RJ, MUKHOPADHYAY A, SHISHODIA S, GAIROLA CG, AGGARWAL BB: Cigarette smoke condensate activates nuclear transcription factor-KB through phosphorylation and degradation of ficB(a): correlation with induction of cyclooxygenase-2. Carcinogenesis (2002) 23(9):1511–1518.
  • •This article shows how cigarettes can induce carcinogenesis.
  • KUWANO T, NAKAO S, YAMAMOTO H et al.: Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis. FASEB 1. (2004) 18(2):300–310.
  • FLOWER RJ: The development of COX2 inhibitors. Nat. Rev Drug Discov. (2003) 2(3):179–191.
  • PLUMMER SM, HOLLOWAY KA, MANSON MM et al.: Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-icB activation via the NIK/ IKK signalling complex. Oncogene (1999) 18(44):6013–6020.
  • SUBBARAMAIAH K, CHUNG WJ, MICHALUART P et al.: Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J. Biol. Chem. (1998) 273(34):21875–21882.
  • ••This article illustrates the regulation ofCOX-2 by resveratrol.
  • SHISHODIA S, MAJUMDAR S, BANERJEE S, AGGARWAL BB: Ursolic acid inhibits nuclear factor-KB activation induced by carcinogenic agents through suppression of IicBa kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9 and cyclin Dl. Cancer Res. (2003) 63(15):4375–4383.
  • •This article shows the potential of ursolic acid in the suppression of turnorigenesis and inflammation.
  • TAKADA Y, AGGARWAL BB: Flavopiridol inhibits NF-icB activation induced by various carcinogens and inflammatory agents through inhibition of IicBa kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2 and matrix metalloprotease-9. j. Biol. Chem. (2004) 279(6):4750–4759.
  • ••This article shows a novel mechanism ofaction of flavopiridol.
  • TAKADA Y, AGGARWAL BB: Betulinic acid suppresses carcinogen-induced NF-icB activation through inhibition of ficBa kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9. Immunol. (2003) 171(6):3278–3286.
  • FOLKMAN J, KAIPAINEN A: Genes tell lymphatics to sprout or not. Nat. Immunol (2004) 5(1):11–12.
  • ARBISERJL, KLAUBER N, ROHAN R et al.: Curcumin is an in vivo inhibitor of angiogenesis. Mol Med. (1998) 4(6):376–383.
  • MOHAN R, SIVAK J, ASHTON P et al.: Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase gelatinase B. j. Biol Chem. (2000) 275(14):10405–10412.
  • KIM JH, SHIM JS, LEE SK et al: Microarray-based analysis of anti-angiogenic activity of demethoxycurcumin on human umbilical vein endothelial cells: crucial involvement of the down-regulation of matrix metalloproteinase.1pn Cancer Res. (2002) 93(12):1378–1385.
  • TSENG SH, LIN SM, CHEN JC et al: Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats. Clin. Cancer Res. (2004) 10(6):2190–2202.
  • UN MT, YEN ML, UN CY, KUO ML: Inhibition of vascular endothelial growth factor-induced angiogenesis by resveratrol through interruption of Src-dependent vascular endothelial cadherin tyrosine phosphorylation. MM. Pharmacol (2003) 64(5):1029–1036.
  • BRAKENHIELM E, CAO R, CAO Y: Suppression of angiogenesis, tumor growth and wound healing by resveratrol, a natural compound in red wine and grapes. FASEB 1 (2001) 15(10):1798–1800.
  • LEE YK, BONE ND, STREGE AK, JELINEK DF, KAY NE: VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG) in B cell chronic lymphocytic leukemia. Blood (2004) 104(3):788–794.
  • LAMY S, GIN GRAS D, BELIVEAU R: Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation. Cancer Res. (2002) 62(2):381–385.
  • MOTOKURA T, BLOOM T, KIM HG et al: A novel cyclin encoded by a bc11-linked candidate oncogene. Nature (1991) 350(6318):512–515.
  • MUKHOPADHYAY A, BANERJEE S, STAFFORD LJ et al.: Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene (2002) 21(57):8852–8861.
  • SHISHODIA S, POTDAR P, GAIROLA CG, AGGARWAL BB: Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-icB activation through inhibition of IKBa kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin Dl. Carcinogenesis (2003) 24(7):1269–1279.
  • ••This article shows how cigarettes can induce carcinogenesis, and the way to prevent it using curcumin.
  • AHMAD N, ADHAMI VM, AFAQ F, FEYES DK, MUKHTAR H: Resveratrol causes WAF-1/p21-mediated G(1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells. Clin. Cancer Res. (2001) 7(5):1466–1473.
  • WOLTER F, AKOGLU B, CLAUSNITZER A, STEIN J: Downregulation of the cyclin Dl/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines. 1. Num (2001) 131(8):2197–2203.
  • JOE AK, LIU H, SUZUI M et al.: Resveratrol induces growth inhibition, S-phase arrest, apoptosis and changes in biomarker expression in several human cancer cell lines. Chit. Cancer Res. (2002) 8(3)893–903.
  • GUPTA S, HUSSAIN T, MUKHTAR H: Molecular pathway for 0-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells. Arch. Biochem. Biophys. (2003) 410(1):177–185.
  • ZI X, AGARWAL R: Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer intervention. Proc. Natl. Acad. Sd.USA (1999) 96(13):7490–7495.
  • DUVOIX A, SCHMITZ M, SCHNEKENBURGER M et al.: Transcriptional regulation of glutathione S-transferase P1-1 in human leukemia. Biofactors (2003) 17(1-4):131–138.
  • DUVOIX A, MORCEAU F, DELHALLE S et al: Induction of apoptosis by curcumin: mediation by glutathione S-transferase P1-1 inhibition. Biochem. Phannacol (2003) 66(8):1475–1483.
  • AWASTHI S, PANDYA U, SINGHAL SS et al.: Curcumin-glutathione interactions and the role of human glutathione S-transferase P1-1. Chem. Biol. Interact. (2000) 128(i):19–38.
  • KUBOTA T, UEMURA Y, KOBAYASHI M, TAGUCHI H: Combined effects of resveratrol and paclitaxel on lung cancer cells. Anti-Cancer Res. (2003) 23(5A):4039–4046.
  • JAZIREHI AR, BONAVIDA B: Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. MM. Cancer Ther. (2004) 3(1):71–84.
  • HARBOTTLE A, DALY AK, ATHERTON K, CAMPBELL FC: Role of glutathione S-transferase P1, P-glycoprotein and multidrug resistance-associated protein 1 in acquired doxorubicin resistance. Int. .1. Cancer (2001) 92(6):777–783.
  • SADZUKA Y, SUGIYAMA T, SONOBE T: Efficacies of tea components on doxorubicin induced antitumor activity and reversal of multidrug resistance. Toxicol Lett. (2000) 114(1-3):155–162.
  • SADZUKA Y, SUGIYAMA T, HIROTA S: Modulation of cancer chemotherapy by green tea. Clin. Cancer Res. (1998) 4(1):153–156.
  • DHANALAKSHMI S, AGARWAL P, GLODE LM, AGARWAL R: Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic death. Int. Cancer (2003) 106(5):699–705.
  • WANG CY, CUSACK JC Jr, LIU R, BALDWIN AS Jr: Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-icB. Nat. Med. (1999) 5(4):412–417.
  • CLEMENT MV, HIRPARA JL, CHAWDHURY SH, PERVAIZ S: Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells. Blood (1998) 92(3):996–1002.
  • CHEN X, SHEN B, XIA L etal.: Activation of nuclear factor lcB in radioresistance of TP53-inactive human keratinocytes. Cancer Res. (2002) 62(4):1213–1221.
  • •This article shows that NF-icB can mediate radioresistance.
  • TAMATANI T, AZUMA M, ASHIDA Y et al.: Enhanced radiosensitization and chemosensitization in NF-KB-suppressed human oral cancer cells via the inhibition of gamma-irradiation- and 5-FU-induced production of IL-6 and IL-8. Int. I Cancer (2004) 108(6):912–921.
  • CHENDIL D, RANGA RS, MEIGOONI D, SATHISHKUMAR S, AHMED MM: Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3. Oncogene (2004) 23(8):1599–1607.
  • CATALDI A, CENTURIONE L, DI PIETRO R et al.: Protein kinase nuclear translocation mediates the occurrence of radioresistance in friend erythroleukemia cells.Biochem. (2003) 88(i):144–151.
  • VARADKAR P, DUBEY P, KRISHNA M, VERIVIA N: Modulation of radiation-induced protein kinase C activity by phenolics. J. Radial. Prot (2001) 21(4):361–370.
  • BENOWITZ S: Technology Motivating Industry. Scientist (1996) 10:1–7.
  • BENOWITZ S, REYNOLD T: I Natl. Cancer Inst. (1991) 183:594.
  • SOMASUNDARAM S, EDMUND NA, MOORE DT et al.: Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res. (2002) 62(13):3868–3875.

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