199
Views
42
CrossRef citations to date
0
Altmetric
Drug Evaluation

Dronedarone: an amiodarone analogue

&
Pages 415-426 | Published online: 02 Mar 2005

Bibliography

  • CARDIAC ARRHYTHMIA SUPPRESSION TRIAL (CAST) INVESTIGATORS: Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. iN Eng]. I Med. (1989) 321:406–412.
  • ECHT DS, LIEBSON PR, MITCHELL LB, CAST INVESTIGATORS: Mortality and morbidity in patients receiving encainide, flecainide or placebo: The Cardiac Arrhythmia Suppression Trial. iN Eng]. Med. (1991) 324:781–788.
  • THE CARDIAC ARRHYTHMIA SUPPRESSION TRIAL II INVESTIGATORS: Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction. iN Eng]. I Med. (1992) 327:227–233.
  • NACCARELLI GV, WOLBRETTE DL, LUCK JC: Results of clinical trials. In: Cardiac electrophysiology from cell to bedside iOld edition) Zipes EP, Jalife J (Eds) (1999):791–798.
  • VISKIN S: Long QT syndromes and torsade de pointes. iLancet (1999) 354:1625–1633.
  • WALDO AL, CAMM AJ, DERUYTER H iet al.: Effects of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. (The SWORD investigators). iLancet (1996) 348:7–12.
  • MOUNSEY JP, DIMARCO JP: Cardiovascular drugs. Dofetilide. iCirculation (2000) 102:2665–2670.
  • RODEN DM: Ibutilide and the treatment of atrial arrhythmias. A new drug-almost unheralded-is now available to US physicians. iCirculation (1996) 94:1499–1502.
  • HONDEGHEM LM, SNYDERS DJ: Class III antiarrhythmic agents have a lot of potential but a long way to go. iCirculation (1990) 81:686–690.
  • GRANT AO: Mechanisms of action of antiarrhythmic drugs: from ion channel blockade to arrhythmia termination. iPacing Clin. Electrophysiol. (1997) 20:432–444.
  • CAMM AJ, YAP YG: What should we expect from the next generation of antiarrhythmic drugs? I iCardiovas. Electrophys. (1999) 10:307–317.
  • NATTEL S: The molecular and ionic specificity of antiarrhythmic drug actions. iCardiovas. Electrophys. (1999) 10:272–282.
  • JANUARY CT, RIDDLE JM: Early afterdepolarizations: Mechanism of induction and block. A role for L-type Ca2+ current. iCirc. Res. (1989) 64:977–990.
  • ZHOU Z, STUDENIK C, JANUARY CT: Properties of E-4031-induced early afterdepolarizations in rabbit ventricular myocytes: Studies using a perforated patch method. In: Potassium channels in normal and abnormal conditions. J Vereecke, PP van Bogaert, F Verdonck (Eds), Leuven University Press, Belgium (1995) 375–379.
  • MAKIELSKI JC, JANUARY CT: Proarrhythmia related to prolongation of repolarization: mechanisms, monitoring, prevention and management. iCardiac Electrophysiol. Rev. (1998) 2:132–135.
  • LIU DW, ANTZELEVITCH C: Characteristics of the delayed rectifier current UK, and IK) in canine ventricular epicardial, mid myocardial and endocardial myocytes. A weaker ILK, contributes to the longer action potential of the M cell. iCirc. Res. (1995) 76:351–365.
  • ANTZELEVITCH C, SICOURI S: Clinical relevance of cardiac arrhythmias generated by afterdepolarisations. Role of M cells in the generation of U waves, triggered activity and torsade de pointes. I iAm. Coll Cardiol. (1994) 23:259–277.
  • ANTZELEVITCH C: Repolarizing currents in canine ventricular myocardium. Regional differences and similarities. In: Potassium channels M normal and ipathological conditions. J Vereecke, PP van Bogaert, F Verdonck (Eds) Leuven University Press, Belgium (1995) 256–259.
  • GINTANT GA: Regional differences in IKdensity in canine left ventricle: role of I in electrical heterogeneity. iAm.' Physiol. (1995) 268:H604–H613.
  • SANGUINETTI MC, CURRAN ME, SPECTOR PS: Block of delayed rectifier K+ channels as an antiarrhythmic mechanism. In: Potassium channels in normal and pathological conditions. VereeckeJ, van Bogaert PP, Verdonck F (Eds) Leuven University Press, Belgium (1995):151–166.
  • SAGER PT: New advances in class III antiarrhythmic drug therapy. iCarr. Opin. Cardiol. (2000) 15:41–53.
  • BRIL A, FOREST MC, CHEVAL B, FAIVRE JF: Combined potassium and calcium channel antagonistic activities as a basis for neutral frequency dependent increase in action potential duration: comparison between BRL-32872 and azimilide. iCardiovasc. Res. (1998) 37:130–140
  • BRIL A, GOUT B, BONHOMME M iet al.: Combined potassium and calcium channel blocking activities as a basis for antiarrhythmic efficacy with low proarrhythmic risk: experimental profile of BRL-32872. I iPharmacol. Exp. Ther. (1996) 276:637–646.
  • KODAMA I, KAMIYA K, TOYAMA J: Cellular electropharmacology of amiodarone. iCardiovasc. Res. (1997) 35:13–29.
  • DOGGRELL SA: Amiodarone - waxed andwaned and waxed again. iExpert Opin. Pharmacother, (2001) 2:1877–1890.
  • •Recent comprehensive review of amiodarone. H.WATANABE Y, KIMURA J: Inhibitory effect of amiodarone on Na+/Ca2+ exchange current in guinea-pig cardiac myocytes. iBr. Pharmacol. (2000) 131:80–84.
  • KADISH AH, CHEN RF, SCHMALTZ S, MORADY F: Magnitude and time course of beta-adrenergic antagonism during oral amiodarone therapy. I iAm. Coll Cardiol. (1990) 16:1240–1245.
  • BJORNERHEIM R, FROYSAKER T, HANSSON V: Effects of chronic amiodarone treatment on human myocardium beta adrenoceptor density and 424 adenylate cyclase response. iCardiovasc. Res. (1991) 25:503–509.
  • BUDU CE, BALAS N, NAWRATH H, WEGENER JW, SHAINBERG A: Increased cardiac alpha-l-adrenoceptor density in rats following treatment with amiodarone. I iBasic Clin. PhysioL Pharmacol (2001) 12:33–47.
  • HOHNSLOSER SH, KLINGENHEBEN T, SINGH BN: Amiodarone-associated proarrhythmic effects. A review with special reference to torsade de pointes tachycardia. iAnn. Intern. Med. (1994) 121:529–535.
  • SUNDERJI R, KANJI Z, GIN K: Pulmonary effects of low dose amiodarone: a review of the risks and recommendations for surveillance. iCan. Cardiol (2000) 16:1435–1440.
  • ERDOGAN MF, GULEC S, TUTAR E, BASKAL N, ERFOGAN G: A stepwise approach to the treatment of amiodarone-induced thyrotoxicosis. iThyroid (2003) 13:205–209.
  • DOVAL HC, NUL DR, GRANCELLI HO iet al.: Randomised trial of low-dose amiodarone in severe congestive heart failure. Grupo de Estudio de la Sobrevida en Isuficiencia Cardiaca en Argentina (GESICA). iLancet (1994) 344:493–498.
  • GARGUICHEVICH JJ, RAMOS JL, GAMBARTE A iet al.: Effect of amiodarone therapy on mortality in patients with left ventricular dysfunction and asymptomatic complex ventricular arrhythmias: Argentine Pilot Study of Sudden Death and Amiodarone (EPAMSA). iAm. Heart (1995) 130:494–500.
  • SINGH SN, FLETCHER RD, FISHER SG iet al.: Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmias. Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure. iN Engl. I Med. (1995) 333:77–82.
  • SINGH BN, JEWITT DE, DOWNEY JM, KIRK ES, SONNENBLICK EH: Effects of amiodarone and L8040, novel antianginal and antiarrhythmic drugs, on cardiac and coronary haemodynamics and on cardiac intracellular potentials. iClin. Exp. Pharmacol PhysioL (1976) 3:427–442.
  • VALENZUELA C, BENNETT PB: Voltage- and use-dependent modulation of calcium channel current in guinea pig ventricular cells by amiodarone and des-oxo-amiodarone. I iCardiovasc. Pharmacol (1991) 17:894–902.
  • RAATIKAINEN MJ, NAP OLITANO CA, DRUZGALA P, DENNIS DM: Electrophysiological effects of a novel, short-acting and potent ester derivative of amiodarone, ATI-2001, in guinea pig isolated heart. J iPharmacolExp Ther. (1996) 277:1454–1463.
  • •First bdescription bof bthe bshort bacting ATI analogues of amiodarone.
  • MOREY TE, SEUBERT CN, RAATIKAINEN MJ iet al.: Structure-activity relationships and electrophysiological effects of short-acting amiodarone homologs in guinea pig isolated heart. iJ. Pharmacol Exp. Ther. (2001) 297:260–266.
  • RAATIKAINEN MJ, MOREY TE, DRUZGALA P iet al.: Potent and reversible effects of ATI-2001 on atrial and atrioventricular nodal electrophysiological properties in guinea pig isolated perfused heart. iJ Pharmacol Exp. Ther. (2000) 295:779–785.
  • KULIER AH, NOVALIJA E, HOGAN Q iet al.: The effects of the new antiarrhythmic E 047/1 on postoperative ischemia-induced arrhythmias in dogs. iAnesth. Analg. (1999) 89:1393–1399.
  • DOMANOVITS H, SCHILLINGER M, LERCHER P iet al.: E 047/1: a new class III antiarrhythmic agent. iCardiovasc. Pharmacol (2000) 35:716–722.
  • GOMBOTA H, VICENZI M, MAHLA E, REHAK P, METZLER H: First clinical experience with the rapid, short-acting amiodarone derivative E 047/1 after cardiac surgery. iEui: Anasethesiol (2002) 19:23–31.
  • HA HR, STIEGER B, GRASSI G, ALTORFER HR, FOLLATH F: Structure-effect relationships of amiodarone analogues on the inhibition of thyroxine deiodination. iEur. Clin. Pharmacol (2000) 55:807–814.
  • SPANIOL M, BRACHER R, HA HR, FOLLATH F, KRAHENBUHL S: Toxicity of amiodarone and amiodarone analogues on isolated rat liver mitochondria. iHepatol. (2001) 35:628–636.
  • CARLSSON B, SINGH BN, TEMCIUC M iet al.: Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone. I iMed. Chem. (2002) 45:623–630.
  • •First bdescription bof bthe bthyroid breceptor bantagonist KB-130015.
  • MACIANSKIENE R, VIAPPIANI S, SIPIDO KR, MUBAGWA K: Slowing of the inactivation of cardiac voltage-dependent sodium channels by the amiodarone derivative 2-methy1-3-(3,5-diiodocarboxymethoxybenzyl)benzofuran (KB130015). I iPharmacol Exp. Ther: (2003) 304:130–138.
  • MACIANSKIENE R, BITO V, RAEYMAEKERS L iet al.: Action potential changes associated with a slowed inactivation of cardiac voltage-gated sodium channels by KB130015. iBr: J. PharmacoL (2003) 139:1469–1479.
  • BRANDTS B, ROLF B, MACIANSKIENE R iet al.: Inhibition of G protein coupled and ATP sensitive potassium currents by 2-methy1-3-(3,5-diiodo-4-carboxymethoxybenzyl) benzofuran (KB130015), an amiodarone derivative. I iPharmacoL Exp. Ther. (2004) 308:134–142.
  • AIMOND F, BECK L, GAUTIER P iet al.:Cellular and iin vivo electrophysiological effects of dronedarone in normal and postmyocardial infarcted rats. I iPharmacol Exp. Ther (2000) 292:415–424.
  • •Initial description of the electrophysiology of dronedarone in rats.
  • HIMMEL HM, WETTWER E, LI Q, RAVENS U: Four different components contribute to outward current in rat ventricular myocytes. iAm. I PhysioL (1999) 277:H107–H118.
  • WICKENDEN AD, JEGLA TJ, KAPRIELIAN R, BACKX PH: Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle. iAm. I Physiol (1999) 276:H1599–H1607.
  • VARRO A, TAKACS J, NEMETH M iet al.: Electrophysiological effects of dronedarone (SR 33589), a noniodinated amiodarone derivative in the canine heart: comparison with amiodarone. iBr. Pharmacol (2001) 133:625–634.
  • •Detailed study of electrophysiology of dronedarone at cellular, tissue and intact heart levels in dog.
  • GAUTIER P, GUILLEMARE E, MARION A iet al.: Electrophysiologic characterization of dronedarone in guinea pig ventricular cells." iCardiovasc. Pharmacol (2003) 41:191–202.
  • •Detailed study of cellular electrophysiology of dronedarone in guinea-pig.
  • THOMAS D, KATHOFER S, ZHANG W iet al.: Acute effects of dronedarone on both Expert Op/n. lnvestig. Drugs (2004) 13(4) components of the cardiac delayed rectifier K+ current, HERG and KvLQT1/minK potassium channels. iBr. J. Phannacol. (2003) 140:996–1002.
  • •Study providing insight into molecular basis of repolarising K+ current pharmacology of dronedarone.
  • WEERAPURA M, NATTEL S, CHARTIER D, CABALLERO R, HEBERT TE: A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link?' iPhysiol (2002) 540:15–27.
  • WITCHEL HJ, MILNES JT, MITCHESON JS, HANCOX JC: Troubleshooting problems with iin vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes. iPhannacol Toxicol Methods (2003) 48:65–80.
  • LALEVEE N, NARGEOT J, BARRERE-LEMAIRE S, GAUTIER P, RICHARD S: Effects of amiodarone and dronedarone on voltage-dependent sodium current in human cardiomyocytes. iCardiovasc. Electrophysiol (2003) 14:885–890.
  • •Study providing direct evidence for action of dronedarone on cardiac Na+ channels.
  • PITT AD, FERNANDES C, BE WICK NL iet al.: Chronic amiodarone-induced inhibition of the Na+-K+ pump in rabbit cardiac myocytes is thyroid-dependent: comparison with dronedarone. iCardiovasc. Res. (2003) 57:101–108.
  • SUN W, SARMA JS, SINGH BN: Chronic and acute effects of dronedarone on the action potential of rabbit atrial muscle preparations: comparison with amiodarone. iCardiovasc. Phannacol (2002) 39:677–684.
  • GUILLEMARE E, MARION A, NISATO D, GAUTIER P: Inhibitory effects of dronedarone on muscarinic K+ current in guinea pig atrial cells." iCardiovasc. Phannacol (2000) 36:802–805.
  • •Study providing evidence for potent action of dronedarone on atrial muscarinic K+ current.
  • ALTOMARE C, BARBUTI A, VISCOMI C, BARUSCOTTI M, DIFRANCESCO D: Effects of dronedarone on acetylcholine-activated current in rabbit SAN cells. iBr. J. Phannacol (2000) 130:1315–1320.
  • CHATELAIN P, MEYSMANS L, MATEAZZI JR, BEAUFORT P, CLINIET M: Interaction of the antiarrhythmic agents SR 33589 and amiodarone with the 13-adrenoceptor and adenylate cyclase in rat heart. iBr. J. Phannacol (1995) 116:1949–1956.
  • HODEIGE D, HEYNDRICKZ JP, CHATELAIN P, MANNING A: SR 33589, a new amiodarone-like antiarrhythmic agent: anti-adrenoceptor activity in anaesthetized and conscious dogs. iEur. Phannacol (1995) 279:25–32.
  • PANTOS C, MOUROUZIS I, DELBRUYERE M iet al: Effects of dronedarone and amiodarone on plasma thyroid hormones and on the basal and postischemic performance of the isolated rat heart. iEur. Phannacol (2002) 444:191–196.
  • VAN BEEREN HC, JONG WM, KAPTEIN E iet al.: Dronedarone acts as a selective inhibitor of 3,5, 3'-tritodothyronine binding to thyroid hormone receptor-alphal : iin vitro and iin vivo evidence. iEndocrinology (2003) 144:552–558.
  • MANNING A, THISSE V, HODEIGE D iet al: SR 33589, a new amiodarone-like antiarrhythmic agent: electrophysiological effects in anesthetized dogs. iCardiovasc. Phannacol (2000) 25:252–261.
  • MANNING AS, BRUYNINCKX C, RAMBOUXJ, CHATELAIN P: SR 33589, a new amiodarone-like agent:: effect on ischemic- and reperfusion-induced arrhythmias in anaesthetized rats. iCardiovasc. Phannacol (1995) 26:453–461.
  • •First description of the effects of dronedarone in an animal model of ischaemic- and reperfusion-induced arrhythmias.
  • ROCHETAING A, BARBE C, KREHER P: Beneficial effects of amiodarone and dronedarone (SR 33589) when applied during low-flow ischemia, on arrhythmia and functional parameters assessed during reperfusion in isolated rat hearts. iJ. Cardiovasc. Phannacol (2001) 38:500–511.
  • FINANCE 0, MANNING A, CHATELAIN P: Effects of a new amiodarone-like agent, SR 33589, in comparison to amiodarone, D,L-sotalol, and lignocaine, on ischemia-induced ventricular arrhythmias in anesthetized pigs. iCardiovasc. Phannacol (1995) 26:570–576.
  • VERDUN SC, VOS MA, LEUNISSEN HD, VAN OPSTAL JM, WELLENS HJ: Evaluation of the acute electrophysiological effects of intravenous dronedarone, an amiodarone-like agent, with special emphasis on ventricular repolarization and acquired torsade de pointes arrhythmias. I iCardiovasc. Phannacol (1995) 33:212–222.
  • VAN OPSTAL JM, SCHOENMAKERS M, VERDUYN SC iet al.: Chronic amiodarone evokes no torsade de pointes arrhythmia despite QT lengthening in an animal model of acquired long-QT syndrome. iCirculation (2001) 104:2722–2727.
  • DJANDJIGHIAN L, PLANCHENAULT J, FINANCE 0 iet al.: Hemodynamic and antiadrenergic effects of dronedarone and amiodarone in animal with a healed myocardial infarction. iCardiovasc. Phannacol (2000) 36:376–383.
  • TOUBOUL P, BRUGADA J, CAPUCCI A iet al.: Dronedarone for prevention of atrial fibrillation: a dose-ranging study. iEur: Heart J. (2003) 24:1481–1487.
  • •Clinical trial showing dronedarone prevents atrial fibrillation relapses after cardioversion. Websites

Websites

  • http://www.sanofi-synthelabous.com/news/ 192003/20030117.html Sanofi-sythelabous press release (2003).
  • http://es.sanofi-synthelabo.com/Images/ 143_22613.pdf Sanofi-sythelabous research and development presentation for the Merrill Lynch Global Pharmaceutical Conference (2003).
  • http://www.arrhythmia.org/newsite/ clinical_trials.html St Luke's-Roosavelt Hospital Centre clinical trials.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.