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- ••The VALIANT study compared valsartanwith captopril and a combination of the two in 14,000 patients within 10 days of an AMI who had LV dysfunction or signs of heart failure. Results showed that valsartan had a similar effect in reducing mortality to captopril alone, but that the combination had no extra benefit but did have additional side effects.
- SALAM AM: Clinical trials evaluating angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the setting of acute myocardial infarction. Expert Opin. Investig. Drugs. (2003) 12(3):501–507.
- •A good review of clinical trials of ACE inhibitors and ARBs in AMI.
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- DICKSTEIN K, KJEKSHUS J: Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial. Lancet (2002) 360:752–60.
- ••An earlier trial comparing the ARBlosartan with captopril in the setting of AMI in patients with LV dysfunction, which showed a trend towards a better effect with captopril than with losartan.
- McMURRAY JJ, OSTERGREN J, SWEDBERG K et al: Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. Lancet (2003) 362:767–771.
- PITT B, POOLE-WILSON PA, SEGAL Ret al: Effect of losartan compared with captopril on mortality to patients with symptomatic heart failure: randomised trial the losartan heart failure survival study ELITE II. Lancet (2000) 355:1582–1587.
- COHN JN, TOGNONI G: Valsartan heartfailure trial investigators. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N EngL Med. (2001) 345(23):1667–1675. Affiliation Amar M Salmi, MB, BS, MRCP (UK) Department of Cardiology and Cardiovascular Surgery, Hamad Medical Corporation, PO Box 3050, Doha, Qatar Tel: +974 4392642; Fax: +974 4392454; E-mail: [email protected]