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Review

Novel pharmacological therapies for the treatment of AIDS-related Kaposi’s sarcoma

, &
Pages 501-513 | Published online: 02 Mar 2005

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  • •Important Phase III trial confirming significant activity of liposomal daunorubicin leading to approval of the drug in the US.
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  • •Phase III trial supporting the approval of doxorubicin in the US for the treatment of advanced KS.
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  • •A comprehensive review of the activity of paclitaxel in KS.
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  • •Although this is a small study it is the first to demonstrate the regression of KS during HAART.
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  • •The study reports the highest remission rate of KS under HAART after a median follow up of 22 months.
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  • LITTLE RE PLUDA JM, WYVILL K, LIETZAU J, SHEARER G, TOSATO G: Interleukin 12 (IL-12) appears to be active in AIDS-associated Kaposi's sarcoma (KS): early results of a pilot study. 7th Conference on Retrovirus and Opportunistic Infections. San Francisco, USA (2000) (Abstract 5).
  • IM862 (Investigator's brochure) 6th Edition. WA Kirland (Ed.), Cytran Inc., USA (1998).
  • TULPULE A, SCADDEN DT, ESPINA BM et al: Results of a randomized study of IM862 nasal solution in the treatment of AIDS-related Kaposi's sarcoma. Clin. Oncol. (2000) 18:716–723.
  • •Phase II clinical trial describing encouraging activity and low toxicities of IM-862 in KS therapy.
  • NOY A, GILL P, SCADDEN D, LEE J et al.: Angiogenesis inhibitor IM862 is effective against AIDS-KS in a randomized, placebo controlled trial. 6th International Conference on Malignancies in AIDS and Other Immunodeficiencies. Bethesda, MD, USA (2002).
  • FONG TA, SHAWVER LK, SUN L et al.: 5U5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flkl/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res. (1999) 59:99–106.
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  • VIA LE, GORE-LANGTON RE, PLUDA JM: Clinical trials referral resource. Current clinical trials administering the antiangiogenesis agent 5U5416. Oncology (2000) 14:1321–1323.
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  • ••Well-written review on the role of MMPsas antiangiogenetic agents in KS.
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  • GILL PS, McLAUGHLIN T, ESPINA BM et al.: Phase I study of a preparation of human chorionic gonadotropin given subcutaneously to patients with AIDS-related Kaposi's sarcoma. Natl. Cancer Inst. (1997) 89:1797–1802.
  • TAVIO M, NASTI G, SIMONELLI C et al.: Human chorionic gonadotropin in the treatment of HIV-related Kaposi's sarcoma. Ear. I. Cancer (1998) 34:1643–1647.
  • KROWN SE : Highly active antiretroviral therapy in AIDS-associated Kaposi's sarcoma: implications for the design of therapeutic trials in patients with advanced, symptomatic Kaposi's sarcoma. J. Oncol ( 2004) 22:399–402.
  • STEBBING J, GAZZARD B, PATTERSON S et al.: Antibody-targeted MHC complex-directed expansion of HIV-1 and KSHV-specific CD8+ lymphocytes: a new approach to therapeutic vaccination. Blood( 2004) 103:1791-1795. Affiliation Anna Maria Cattelan MDtl, Marco Trevenzoli MD1 & Savina Maria Lucia Aversa MD2 -rAuthor for correspondence -r1 Department of Infectious Diseases, University of Padua, Via Giustiniani 2, 35128 Padova, Italy Tel: +39 049 821 3741; Fax: +39 049 8213768 E-mail: [email protected] or [email protected] 2 Oncology Division, General Hospital, University of Padua, Italy

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