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Review

Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity

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Pages 1113-1122 | Published online: 24 Feb 2005

Bibliography

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  • •This study, as well as that of [24], was one of the first reports to describe the MCH–1R.
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  • •This study uses genetically modified mice to confirm and extend pharmacological evidence demonstrating that chronic central MCH signaling promotes obesity and insulin resistance in mice.
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  • ••This report describes the phenotype ofpmchl- mice.
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  • ••This paper, as well as that of [62], report onthe phenotype of mice lacking the MCH–1R.
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  • ••A study reporting the phenotype ofMCH-1R knockout mice. This study, as well as that of [61], provides support for targeting the MCH-1R for the treatment of obesity.
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  • •The first study reporting oral activity of a small molecular weight MCH-1R antagonist using a pharmacodynarnic feeding model.
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  • ••The first description of an efficacious smallmolecular weight MCH-1R antagonist using a model of rodent obesity. Efficacy in rodent models of anxiety and depression was also reported.
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