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Drug Evaluation

Anidulafungin: an echinocandin antifungal

Pages 1183-1197 | Published online: 24 Feb 2005

Bibliography

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  • ••A comprehensive review of allechinocandins, including anidulafungin, includes in vitro activity and in vivo studies as well as tolerability and pharmacokinetic data.
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  • •A useful in vitro comparison of anidulafungin and caspofungin against a broad range of fungi.
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  • ••An important study demonstrating thatthe efficacy of caspofungin was similar to B with reduced toxicity.
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  • •The first documented resistance to caspofungin in a clinical isolate of. albicans.
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  • ••An excellent in vivo study documentingthe efficacy of anidulafungin in treating disseminated candiasis and pulmonary aspergillosis in neutropenic rabbits.
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  • •A very well done study of the in vivo activity of anidulafungin against aspergillosis.
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  • •Demonstration of dosage-dependent antifungal activity against fluconazole-resistant candidiasis.
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