533
Views
76
CrossRef citations to date
0
Altmetric
Review

FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis

, &
Pages 283-289 | Published online: 16 Feb 2007

Bibliography

  • ADACHI K, KOHARA T, NAKAO N, ARITA M, CHIBA K, MISHINA Z: Design, synthesis and structure-activity relationships of 2-substituted 2-amino-1,3-propandiols: discovery of a novel immunosuppressant, FTY720. Bioorg. Med. Chem. Lett. (1995) 5:853-856.
  • CHEN JK, LANE WS, SCHREIBER SL: The identification of myriocin-binding proteins. Chem. Biol. (1999) 6:221-235.
  • CHIBA K, YANAGAWA Y, MASUBUCHI Y et al.: FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J. Immunol. (1998) 160:5037-5044.
  • WATTENBERG BW, PITSON SM, RABEN DM: The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function. J. Lipid Res. (2006) 47:1128-1139.
  • SCHWAB SR, PEREIRA JP, MATLOUBIAN M, XU Y, HUANG Y, CYSTER JG: Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science (2005) 309:1735-1739.
  • SPIEGEL S, CUVILLIER O, EDSALL LC et al.: Sphingosine-1-phosphate in cell growth and cell death. Ann. NY Acad. Sci. (1998) 845:11-18.
  • SPIEGEL S, MILSTIEN S: Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat. Rev. Mol. Cell Biol. (2003) 4:397-407.
  • ALLENDE ML, YAMASHITA T, PROIA RL: G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood (2003) 102:3665-3667.
  • MIZUGISHI K, YAMASHITA T, OLIVERA A, MILLER GF, SPIEGEL S, PROIA RL: Essential role for sphingosine kinases in neural and vascular development. Mol. Cell Biol. (2005) 25:11113-11121.
  • HLA T: Physiological and pathological actions of sphingosine 1-phosphate. Semin. Cell Dev. Biol. (2004) 15:513-520.
  • PYNE S, PYNE NJ: Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors. Biochim. Biophys. Acta (2002) 1582:121-131.
  • BAUMRUKER T, BORNANCIN F, BILLICH A: The role of sphingosine and ceramide kinases in inflammatory responses. Immunol. Lett. (2005) 96:175-185.
  • GOETZL EJ, WANG W, MCGIFFERT C, HUANG MC, GRALER MH: Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory system. J. Cell Biochem. (2004) 92:1104-1114.
  • THEILMEIER G, SCHMIDT C, HERRMANN J et al.: High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. Circulation (2006) 114:1403-1409.
  • BRINKMANN V, DAVIS MD, HEISE CE et al.: The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J. Biol. Chem. (2002) 277:21453-21457.
  • MANDALA S, HAJDU R, BERGSTROM J et al.: Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science (2002) 296:346-349.
  • BILLICH A, BORNANCIN F, DEVAY P, MECHTCHERIAKOVA D, URTZ N, BAUMRUKER T: Phosphorylation of the imunomodulatory drug FTY720 by sphingosine kinases. J. Biol. Chem. (2003) 278:47408-47415.
  • ZEMANN B, KINZEL B, MULLER M et al.: Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. Blood (2006) 107:1454-1458.
  • CHUN J, ROSEN H: Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseases. Curr. Pharm. Des. (2006) 12:161-171.
  • GRAELER M, GOETZL EJ: Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells. FASEB J. (2002) 16:1874-1878.
  • MATLOUBIAN M, LO CG, CINAMON G et al.: Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature (2004) 427:355-360.
  • BRINKMANN V, CYSTER JG, HLA T: FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am. J. Transplant. (2004) 4:1019-1025.
  • SINGER II, TIAN M, WICKHAM LA et al.: Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes. J. Immunol. (2005) 175:7151-7161.
  • MCVERRY BJ, GARCIA JG: In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. Cell Signal. (2005) 17:131-139.
  • BRINKMANN V, BAUMRUKER T: Pulmonary and vascular pharmacology of sphingosine 1-phosphate. Curr. Opin. Pharmacol. (2006) 6:244-250.
  • SHIOW LR, ROSEN DB, BRDICKOVA N et al.: CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature (2006) 440:540-544.
  • ROSEN H, GOETZL EJ: Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat. Rev. Immunol. (2005) 5:560-570.
  • PENG X, HASSOUN PM, SAMMANI S et al.: Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. Am. J. Respir. Crit. Care Med. (2004) 169:1245-1251.
  • SANCHEZ T, ESTRADA-HERNANDEZ T, PAIK JH et al.: Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J. Biol. Chem. (2003) 278:47281-47290.
  • SANNA MG, WANG SK, GONZALEZ-CABRERA PJ et al.: Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat. Chem. Biol. (2006) 2:434-441.
  • SINGLETON PA, DUDEK SM, MA SF, GARCIA JG: Transactivation of sphingosine-1-phosphate receptors is essential for vascular barrier regulation: novel role for hyaluronan and CD44 receptor family. J. Biol. Chem. (2006) 281(45):34381-34393.
  • COLOMBAIONI L, GARCIA-GIL M: Sphingolipid metabolites in neural signalling and function. Brain Res. Brain Res. Rev. (2004) 46:328-355.
  • JAILLARD C, HARRISON S, STANKOFF B et al.: Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival. J. Neurosci. (2005) 25:1459-1469.
  • MENO-TETANG GM, LI H, MIS S et al.: Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2[2-(-4-octylphenyl) ethyl]propane-1,3-diol hydrochloride) in rats after oral and intravenous doses. Drug Metab. Dispos. (2006) 34:1480-1487.
  • FUJINO M, FUNESHIMA N, KITAZAWA Y et al.: Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment. J. Pharmacol. Exp. Ther. (2003) 305:70-77.
  • WEBB M, THAM CS, LIN FF et al.: Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice. J. Neuroimmunol. (2004) 153:108-121.
  • KATAOKA H, SUGAHARA K, SHIMANO K et al.: FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. Cell. Mol. Immunol. (2005) 2:439-448.
  • RAUSCH M, HIESTAND P, FOSTER CA, BAUMANN DR, CANNET C, RUDIN M: Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: clinical implications for ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging. J. Magn. Reson. Imaging (2004) 20:16-24.
  • KAPPOS L, ANTEL J, COMI G et al.: Oral fingolimod (FTY720) for relapsing multiple sclerosis. N. Engl. J. Med. (2006) 355:1124-1140.
  • MASSBERG S, VON ANDRIAN UH: Fingolimod and sphingosine-1-phosphate-modifiers of lymphocyte migration. N. Engl. J. Med. (2006) 355:1088-1091.
  • KOYRAKH L, LUJAN R, COLON J et al.: Molecular and cellular diversity of neuronal G-protein-gated potassium channels. J. Neurosci. (2005) 25:11468-11478.
  • SANNA MG, LIAO J, JO E et al.: Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J. Biol. Chem. (2004) 279:13839-13848.
  • FORREST M, SUN SY, HAJDU R et al.: Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J. Pharmacol. Exp. Ther. (2004) 309:758-768.
  • GUO J, MACDONELL KL, GILES WR: Effects of sphingosine 1-phosphate on pacemaker activity in rabbit sino-atrial node cells. Pflugers Arch. (1999) 438:642-648.
  • BUNEMANN M, BRANDTS B, ZU HERINGDORF DM, VAN KOPPEN CJ, JAKOBS KH, POTT L: Activation of muscarinic K+ current in guinea-pig atrial myocytes by sphingosine-1-phosphate. J. Physiol. (1995) 489:701-707.
  • JAN LY, JAN YN: Heartfelt crosstalk: desensitization of the GIRK current. Nat. Cell Biol. (2000) 2:E165-E167.
  • TOLLE M, LEVKAU B, KEUL P et al.: Immunomodulator FTY720 induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3. Circ. Res. (2005) 96:913-920.
  • KIMURA T, SATO K, MALCHINKHUU E et al.: High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors. Arterioscler. Thromb. Vasc. Biol. (2003) 23:1283-1288.
  • HWANG MW, MATSUMORI A, FURUKAWA Y et al.: FTY720, a new immunosuppressant, promotes long-term graft survival and inhibits the progression of graft coronary artery disease in a murine model of cardiac transplantation. Circulation (1999) 100:1322-1329.
  • PINSCHEWER DD, OCHSENBEIN AF, ODERMATT B, BRINKMANN V, HENGARTNER H, ZINKERNAGEL RM: FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory. J. Immunol. (2000) 164:5761-5770.
  • MASOPUST D, LEFRANCOIS L: CD8 T-cell memory: the other half of the story. Microbes Infect. (2003) 5:221-226.
  • BRINKMANN V, CHEN S, FENG L, PINSCHEWER D, NIKOLOVA Z, HOF R: FTY720 alters lymphocyte homing and protects allografts without inducing general immunosuppression. Transplant. Proc. (2001) 33:530-531.
  • BRINKMANN V, PINSCHEWER D, CHIBA K, FENG L: FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation. Trends Pharmacol. Sci. (2000) 21:49-52.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.