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Review

N-cadherin as a therapeutic target in cancer

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Pages 451-465 | Published online: 20 Mar 2007

Bibliography

  • GUMBINER BM: Regulation of cadherin-mediated adhesion in morphogenesis. Nat. Rev. Mol. Cell Biol. (2005) 6(8):622-634.
  • HATTA K, OKADA TSTAKEICHI M: A monoclonal antibody disrupting calcium-dependent cell–cell adhesion of brain tissues: possible role of its target antigen in animal pattern formation. Proc. Natl. Acad. Sci. USA (1985) 82(9):2789-2793.
  • GRUNWALD GB, BROMBERG RE, CROWLEY NJ et al.: Enzymatic dissection of embryonic cell adhesive mechanisms. II. Developmental regulation of an endogenous adhesive system in the chick neural retina. Dev. Biol. (1981) 86(2):327-338.
  • COOK JH, LILIEN J: The accessibility of certain proteins on embryonic chick neural retina cells to iodination and tryptic removal is altered by calcium. J. Cell Sci. (1982) 55:85-103.
  • VOLK T, GEIGER B: A 135-kDa membrane protein of intercellular adherens junctions. EMBO J. (1984) 3(10):2249-2260.
  • YOSHIDA-NORO C, SUZUKI N, TAKEICHI M: Molecular nature of the calcium-dependent cell–cell adhesion system in mouse teratocarcinoma and embryonic cells studied with a monoclonal antibody. Dev. Biol. (1984) 101(1):19-27.
  • HATTA K, NOSE A, NAGAFUCHI A et al.: Cloning and expression of cDNA encoding a neural calcium-dependent cell adhesion molecule: its identity in the cadherin gene family. J. Cell Biol. (1988) 106(3):873-881.
  • TAKEICHI M: Morphogenetic roles of classic cadherins. Curr. Opin. Cell Biol. (1995) 7(5):619-627.
  • SHAN WS, TANAKA H, PHILLIPS GR et al.: Functional cis-heterodimers of N- and R-cadherins. J. Cell Biol. (2000) 148(3):579-590.
  • KOCH AW, MANZUR KL, SHAN W: Structure-based models of cadherin-mediated cell adhesion: the evolution continues. Cell. Mol. Life Sci. (2004) 61(15):1884-1895.
  • BLASCHUK OW, SULLIVAN R, DAVID S et al.: Identification of a cadherin cell adhesion recognition sequence. Dev. Biol. (1990) 139(1):227-229.
  • SHAPIRO L, FANNON AM, KWONG PD et al.: Structural basis of cell–cell adhesion by cadherins. Nature (1995) 374(6520):327-337.
  • TAMURA K, SHAN WS, HENDRICKSON WA et al.: Structure–function analysis of cell adhesion by neural (N-) cadherin. Neuron (1998) 20(6):1153-1163.
  • RENAUD-YOUNG M, GALLIN WJ: In the first extracellular domain of E-cadherin, heterophilic interactions, but not the conserved His–Ala–Val motif, are required for adhesion. J. Biol. Chem. (2002) 277(42):39609-39616.
  • WILLIAMS E, WILLIAMS G, GOUR BJ et al.: A novel family of cyclic peptide antagonists suggests that N-cadherin specificity is determined by amino acids that flank the HAV motif. J. Biol. Chem. (2000) 275(6):4007-4012.
  • WILLIAMS EJ, WILLIAMS G, GOUR B et al.: INP, a novel N-cadherin antagonist targeted to the amino acids that flank the HAV motif. Mol. Cell Neurosci. (2000) 15(5):456-464.
  • SIVASANKAR S, BRIEHER W, LAVRIK N et al.: Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains. Proc. Natl. Acad. Sci. USA (1999) 96(21):11820-11824.
  • CHAPPUIS-FLAMENT S, WONG E, HICKS LD et al.: Multiple cadherin extracellular repeats mediate homophilic binding and adhesion. J. Cell Biol. (2001) 154(1):231-243.
  • TAKEICHI M: The cadherins: cell–cell adhesion molecules controlling animal morphogenesis. Development (1988) 102(4):639-655.
  • RADICE GL, RAYBURN H, MATSUNAMI H et al.: Developmental defects in mouse embryos lacking N-cadherin. Dev. Biol. (1997) 181(1):64-78.
  • TANAKA H, SHAN W, PHILLIPS GR et al.: Molecular modification of Ncadherin in response to synaptic activity. Neuron (2000) 25(1):93-107.
  • RANSCHT B: Cadherins: molecular codes for axon guidance and synapse formation. Int. J. Dev. Neurosci. (2000) 18(7):643-651.
  • MARIE PJ: Role of N-cadherin in bone formation. J. Cell. Physiol. (2002) 190(3):297-305.
  • GEORGE-WEINSTEIN M, GERHART J, BLITZ J et al.: N-cadherin promotes the commitment and differentiation of skeletal muscle precursor cells. Dev. Biol. (1997) 185(1):14-24.
  • LINASK KK, KNUDSEN KA, GUI YH: N-cadherin–catenin interaction: necessary component of cardiac cell compartmentalization during early vertebrate heart development. Dev. Biol. (1997) 185(2):148-164.
  • ONG LL, KIM N, MIMA T et al.: Trabecular myocytes of the embryonic heart require N-cadherin for migratory unit identity. Dev. Biol. (1998) 193(1):1-9.
  • GARCIA-CASTRO MI, VIELMETTER E, BRONNER-FRASER M: N-cadherin, a cell adhesion molecule involved in establishment of embryonic left-right asymmetry. Science (2000) 288(5468):1047-1051.
  • LUO Y, FERREIRA-CORNWELL M, BALDWIN H et al.: Rescuing the N-cadherin knockout by cardiac-specific expression of N- or E-cadherin. Development (2001) 128(4):459-469.
  • LUO Y, HIGH FA, EPSTEIN JA et al.: N-cadherin is required for neural crest remodeling of the cardiac outflow tract. Dev. Biol. (2006) 299(2):517-528.
  • DANEN EH: Integrins: regulators of tissue function and cancer progression. Curr. Pharm. Des. (2005) 11(7):881-891.
  • GOEL HL, LANGUINO LR: Integrin signaling in cancer. Cancer Treat. Res. (2004) 119:15-31.
  • HAZAN RB, QIAO R, KEREN R et al.: Cadherin switch in tumor progression. Ann. NY Acad. Sci. (2004) 1014:155-163.
  • LASCOMBE I, CLAIROTTE A, FAUCONNET S et al.: N-cadherin as a novel prognostic marker of progression in superficial urothelial tumors. Clin. Cancer Res. (2006) 12(9):2780-2787.
  • SARRIO D, MORENO-BUENO G, SANCHEZ-ESTEVEZ C et al.: Expression of cadherins and catenins correlates with distinct histologic types of ovarian carcinomas. Hum. Pathol. (2006) 37(8):1042-1049.
  • ROSIVATZ E, BECKER I, SPECHT K et al.: Differential expression of the epithelial–mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am. J. Pathol. (2002) 161(5):1881-1891.
  • YANAGIMOTO K, SATO Y, SHIMOYAMA Y et al.: Co-expression of Ncadherin and α-fetoprotein in stomach cancer. Pathol. Int. (2001) 51(8):612-618.
  • KHORRAM-MANESH A, AHLMAN H, JANSSON S et al.: N-cadherin expression in adrenal tumors: upregulation in malignant pheochromocytoma and downregulation in adrenocortical carcinoma. Endocr. Pathol. (2002) 13(2):99-110.
  • LI G, SATYAMOORTHY K, HERLYN M: N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells. Cancer Res. (2001) 61(9):3819-3825.
  • HERMISTON ML, GORDON JI: In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death. J. Cell Biol. (1995) 129(2):489-506.
  • PELUSO JJ: Putative mechanism through which N-cadherin-mediated cell contact maintains calcium homeostasis and thereby prevents ovarian cells from undergoing apoptosis. Biochem. Pharmacol. (1997) 54(8):847-853.
  • PELUSO JJ, PAPPALARDO A, TROLICE MP: N-cadherin-mediated cell contact inhibits granulosa cell apoptosis in a progesterone-independent manner. Endocrinology (1996) 137(4):1196-203.
  • PELUSO JJ: N-cadherin-mediated cell contact regulates ovarian surface epithelial cell survival. Biol. Signals Receptor (2000) 9(2):115-121.
  • MAKRIGIANNAKIS A, COUKOS G, CHRISTOFIDOU-SOLOMIDOU M et al.: N-cadherin-mediated human granulosa cell adhesion prevents apoptosis: a role in follicular atresia and luteolysis? Am. J. Pathol. (1999) 154(5):1391-1406.
  • TRAN NL, ADAMS DG, VAILLANCOURT RR et al.: Signal transduction from N-cadherin increases Bcl-2. Regulation of the phosphatidylinositol 3-kinase/Akt pathway by homophilic adhesion and actin cytoskeletal organization. J. Biol. Chem. (2002) 277(36):32905-32914.
  • LAMBERT M, CHOQUET D, MEGE RM: Dynamics of ligand-induced, Rac1dependent anchoring of cadherins to the actin cytoskeleton. J. Cell Biol. (2002) 157(3):469-479.
  • GAVARD J, LAMBERT M, GROSHEVA I et al.: Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J. Cell Sci. (2004) 117(Part 2):257-270.
  • CHARRASSE S, MERIANE M, COMUNALE F et al.: N-cadherin-dependent cell–cell contact regulates Rho GTPases and β-catenin localization in mouse C2C12 myoblasts. J. Cell Biol. (2002) 158(5):953-965.
  • KOVACS EM, GOODWIN M, ALI RG et al.: Cadherin-directed actin assembly: E-cadherin physically associates with the Arp2/3 complex to direct actin assembly in nascent adhesive contacts. Curr. Biol. (2002) 12(5):379-382.
  • VERMA S, SHEWAN AM, SCOTT JA et al.: Arp2/3 activity is necessary for efficient formation of E-cadherin adhesive contacts. J. Biol. Chem. (2004) 279(32):34062-34070.
  • HELWANI FM, KOVACS EM, PATERSON AD et al.: Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization. J. Cell Biol. (2004) 164(6):899-910.
  • EL SAYEGH TY, ARORA PD, LASCHINGER CA et al.: Cortactin associates with N-cadherin adhesions and mediates intercellular adhesion strengthening in fibroblasts. J. Cell Sci. (2004) 117(Part 21):5117-5131.
  • MONIER-GAVELLE F, DUBAND JL: Cross talk between adhesion molecules: control of N-cadherin activity by intracellular signals elicited by β1 and β3 integrins in migrating neural crest cells. J. Cell Biol. (1997) 137(7):1663-1681.
  • ARREGUI C, PATHRE P, LILIEN J et al.: The nonreceptor tyrosine kinase fer mediates cross-talk between N-cadherin and β1-integrins. J. Cell Biol. (2000) 149(6):1263-1274.
  • YANO H, MAZAKI Y, KUROKAWA K et al.: Roles played by a subset of integrin signaling molecules in cadherin-based cell–cell adhesion. J. Cell Biol. (2004) 166(2):283-295.
  • QI J, CHEN N, WANG J et al.: Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the β-catenin signaling pathway. Mol. Biol. Cell (2005) 16(9):4386-4397.
  • QI J, WANG J, ROMANYUK O et al.: Involvement of Src family kinases in Ncadherin phosphorylation and β-catenin dissociation during transendothelial migration of melanoma cells. Mol. Biol. Cell (2006) 17(3):1261-1272.
  • XU G, ARREGUI C, LILIEN J et al.: PTP1B modulates the association of β-catenin with N-cadherin through binding to an adjacent and partially overlapping target site. J. Biol. Chem. (2002) 277(51):49989-49997.
  • XU G, CRAIG AW, GREER P et al.: Continuous association of cadherin with β-catenin requires. The non-receptor tyrosine-kinase Fer. J. Cell Sci. (2004) 117(Part 15):3207-3219.
  • KIM L, WONG TW: The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors. Mol. Cell Biol. (1995) 15(8):4553-4561.
  • FUKATA M, KAIBUCHI K: Rho-family GTPases in cadherin-mediated cell–cell adhesion. Nat. Rev. Mol. Cell Biol. (2001) 2(12):887-897.
  • YANAGISAWA M, ANASTASIADIS PZ: p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness. J. Cell Biol. (2006) 174(7):1087-1096.
  • LI H, LEUNG TC, HOFFMAN S et al.: Coordinate regulation of cadherin and integrin function by the chondroitin sulfate proteoglycan neurocan. J. Cell Biol. (2000) 149(6):1275-1288.
  • RHEE J, MAHFOOZ NS, ARREGUI C et al.: Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion. Nat. Cell Biol. (2002) 4(10):798-805.
  • WILLIAMS EJ, WILLIAMS G, HOWELL FV et al.: Identification of an Ncadherin motif that can interact with the fibroblast growth factor receptor and is required for axonal growth. J. Biol. Chem. (2001) 276(47):43879-43886.
  • EREZ N, ZAMIR E, GOUR BJ et al.: Induction of apoptosis in cultured endothelial cells by a cadherin antagonist peptide: involvement of fibroblast growth factor receptor-mediated signalling. Exp. Cell Res. (2004) 294(2):366378.
  • HAZAN RB, PHILLIPS GR, QIAO RF et al.: Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J. Cell Biol. (2000) 148(4):779-790.
  • SUYAMA K, SHAPIRO I, GUTTMAN M et al.: A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. Cancer Cell (2002) 2(4):301-314.
  • PLOTNIKOV AN, SCHLESSINGER J, HUBBARD SR et al.: Structural basis for FGF receptor dimerization and activation. Cell (1999) 98(5):641-650.
  • KIM JB, ISLAM S, KIM YJ et al.: N-cadherin extracellular repeat 4 mediates epithelial to mesenchymal transition and increased motility. J. Cell Biol. (2000) 151(6):1193-206.
  • FEDOR-CHAIKEN M, MEIGS TE, KAPLAN DD et al.: Two regions of cadherin cytoplasmic domains are involved in suppressing motility of a mammary carcinoma cell line. J. Biol. Chem. (2003) 278(52):52371-52378.
  • REISS K, MARETZKY T, LUDWIG A et al.: ADAM10 cleavage of N-cadherin and regulation of cell–cell adhesion and β-catenin nuclear signalling. EMBO J. (2005) 24(4):742-752.
  • MARAMBAUD P, WEN PH, DUTT A et al.: A CBP binding transcriptional repressor produced by the PS1/ε-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell (2003) 114(5):635-645.
  • PARADIES NE, GRUNWALD GB: Purification and characterization of NCAD90, a soluble endogenous form of N-cadherin, which is generated by proteolysis during retinal development and retains adhesive and neurite-promoting function. J. Neurosci. Res. (1993) 36(1):33-45.
  • UTTON MA, EICKHOLT B, HOWELL FV et al.: Soluble N-cadherin stimulates fibroblast growth factor receptor dependent neurite outgrowth and Ncadherin and the fibroblast growth factor receptor co-cluster in cells. J. Neurochem. (2001) 76(5):1421-1430.
  • UEMURA K, KIHARA T, KUZUYA A et al.: Activity-dependent regulation of β-catenin via ε-cleavage of N-cadherin. Biochem. Biophys Res. Commun. (2006) 345(3):951-958.
  • BROWN DA, LONDON E: Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J. Biol. Chem. (2000) 275(23):17221-17224.
  • RAJENDRAN L, SIMONS K: Lipid rafts and membrane dynamics. J. Cell Sci. (2005) 118(Part 6):1099-1102.
  • NAKAI Y, KAMIGUCHI H: Migration of nerve growth cones requires detergent-resistant membranes in a spatially defined and substrate-dependent manner. J. Cell Biol. (2002) 159(6):1097-1108.
  • CAUSERET M, TAULET N, COMUNALE F et al.: N-cadherin association with lipid rafts regulates its dynamic assembly at cell–cell junctions in C2C12 myoblasts. Mol. Biol. Cell (2005) 16(5):2168-2180.
  • CAVALLARO U, LIEBNER S, DEJANA E: Endothelial cadherins and tumor angiogenesis. Exp. Cell Res. (2006) 312(5):659-667.
  • NAVARRO P, RUCO L, DEJANA E: Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization. J. Cell Biol. (1998) 140(6):1475-1484.
  • SALOMON D, AYALON O, PATEL-KING R et al.: Extrajunctional distribution of N-cadherin in cultured human endothelial cells. J. Cell Sci. (1992) 102(Part 1):7-17.
  • GILBERTSON-BEADLING SK, FISHER C: A potential role for N-cadherin in mediating endothelial cell-smooth muscle cell interactions in the rat vasculature. Lab. Invest. (1993) 69(2):203-209.
  • GERHARDT H, LIEBNER S, REDIES C et al.: N-cadherin expression in endothelial cells during early angiogenesis in the eye and brain of the chicken: relation to blood–retina and blood–brain barrier development. Eur. J. Neurosci. (1999) 11(4):1191-201.
  • GERHARDT H, WOLBURG H, REDIES C: N-cadherin mediates pericytic–endothelial interaction during brain angiogenesis in the chicken. Dev. Dyn. (2000) 218(3):472-479.
  • LUO Y, RADICE GL: N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis. J. Cell Biol. (2005) 169(1):29-34.
  • PAIK JH, SKOURA A, CHAE SS et al.: Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Genes Dev. (2004) 18(19):2392-2403.
  • TILLET E, VITTET D, FERAUD O et al.: N-cadherin deficiency impairs pericyte recruitment, and not endothelial differentiation or sprouting, in embryonic stem cell-derived angiogenesis. Exp. Cell Res. (2005) 310(2):392400.
  • DERYCKE L, MORBIDELLI L, ZICHE M et al.: Soluble N-cadherin fragment promotes angiogenesis. Clin. Exp. Metastasis (2006) 23(3-4):187-201.
  • JONES M, SABATINI PJ, LEE FS et al.: N-cadherin upregulation and function in response of smooth muscle cells to arterial injury. Arterioscler. Thromb. Vasc. Biol. (2002) 22(12):1972-1977.
  • PHAN QT, FRATTI RA, PRASADARAO NV et al.: N-cadherin mediates endocytosis of Candida albicans by endothelial cells. J. Biol. Chem. (2005) 280(11):10455-10461.
  • PANORCHAN P, THOMPSON MS, DAVIS KJ et al.: Single-molecule analysis of cadherin-mediated cell–cell adhesion. J. Cell Sci. (2006) 119(Part 1):66-74.
  • AUGUSTINE C, YOSHIMOTO Y, ZIPFEL P et al.: Inhibition of N-cadherin enhances anti-tumor activity and overcomes chemoresistance in regional melanoma therapy. 18th EORTC – NCI AACR Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic (7 – 10 November 2006).
  • CHANG YS, DI TOMASO E, MCDONALD DM et al.: Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood. Proc. Natl. Acad. Sci. USA (2000) 97(26):14608-14613.
  • HENDRIX MJ, SEFTOR EA, HESS AR et al.: Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma. Nat. Rev. Cancer (2003) 3(6):411-421.
  • ADHEREX: Adherex Investigator's Brochure.
  • STEWARD DJ, JONKER DJ, GOEL R et al.: Final clinical and pharmacokinetic (PK) results from a Phase 1 study of the novel N-cadherin (N-cad) antagonist, exherin (ADH-1): in patients with refractory solid tumors stratified according to N-cad expression. Proc. Am. Soc. Clin. Oncol. (2006) 24(124s):3016 (Abstract).
  • SESSA C, PEROTTI A, MAUR M et al.: An enriched Phase I, pharmacokinetic and pharmacodynamic study of the N-cadherin (NCAD) cyclic competitive binder exherin (ADH-1) in patients with solid tumors. Proc. Am. Soc. Clin. Oncol. (2006) 24(131s):3042 (Abstract).
  • ALGHISI GC, RUEGG C: Vascular integrins in tumor angiogenesis: mediators and therapeutic targets. Endothelium (2006) 13(2):113-135.
  • RUEGG C, HASMIM M, LEJEUNE FJ et al.: Antiangiogenic peptides and proteins: from experimental tools to clinical drugs. Biochim. Biophys. Acta (2006) 1765(2):155-177.
  • CAI W, CHEN X: Anti-angiogenic cancer therapy based on integrin αvβ3 antagonism. Anticancer Agents Med. Chem. (2006) 6(5):407-428.
  • LIAO F, LI Y, O'CONNOR W et al.: Monoclonal antibody to vascular endothelial-cadherin is a potent inhibitor of angiogenesis, tumor growth, and metastasis. Cancer Res. (2000) 60(24):6805-6810.
  • BERGERS G, SONG S, MEYER-MORSE N et al.: Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J. Clin. Invest. (2003) 111(9):1287-1295.
  • RUEGG C, MEUWLY JY, DRISCOLL R et al.: The quest for surrogate markers of angiogenesis: a paradigm for translational research in tumor angiogenesis and anti-angiogenesis trials. Curr. Mol. Med. (2003) 3(8):673-691.

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