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Progesterone in the clinical treatment of acute traumatic brain injury

, PhD & , MD FACEP
Pages 847-857 | Published online: 20 May 2010

Bibliography

  • Schouten JW. Neuroprotection in traumatic brain injury: a complex struggle against the biology of nature. Curr Opin Crit Care 2007;13(2):134-42
  • Roberts I, Schierhout G, Alderson P. Absence of evidence for the effectiveness of five interventions routinely used in the intensive care management of severe head injury: a systematic review. J Neurol Neurosurg Psychiatry 1998;65(5):729-33
  • Bullock R, Chesnut RM, Clifton G, Guidelines for the management of severe head injury. Brain Trauma Foundation. Eur J Emerg Med 1996;3(2):109-27
  • Fan L, Young PR, Barone FC, Experimental brain injury induces differential expression of tumor necrosis factor-alpha mRNA in the CNS. Brain Res Mol Brain Res 1996;36(2):287-91
  • Alderson P, Roberts I. Corticosteroids for acute traumatic brain injury. Cochrane Database Syst Rev 2005;(1):CD000196
  • Maas AI, Roozenbeek B, Manley GT. Clinical trials in traumatic brain injury: past experience and current developments. Neurotherapeutics 2010;7(1):115-26
  • Ippolito CJ. Battlefield TBI: blast and aftermath. Psychiatric Times 2007. Available from: www.psychiatrictimes.com/display/ article/10168/56916. [Accessed October 2009]
  • Gomes JA, Stevens RD, Lewin JJ III, Glucocorticoid therapy in neurologic critical care. Crit Care Med 2005;33(6):1214-24
  • Vink R, Van Den Heuvel C. Recent advances in the development of multifactorial therapies for the treatment of traumatic brain injury. Expert Opin Investig Drugs 2004;13(10):1263-74
  • Watson NF, Barber JK, Doherty MJ, Does glucocorticoid administration prevent late seizures after head injury? Epilepsia 2004;45(6):690-4
  • Roberts I, Yates D, Sandercock P, Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. Lancet 2004;364(9442):1321-8
  • Edwards P, Arango M, Balica L, Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months. Lancet 2005;365(9475):1957-9
  • Temkin NR, Anderson GD, Winn HR, Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trial. Lancet Neurol 2007;6(1):29-38
  • Xiong Y, Mahmood A, Chopp M. Emerging treatments for traumatic brain injury. Expert Opin Emerg Drugs 2009;14(1):67-84
  • Vink R, Nimmo AJ. Multifunctional drugs for head injury. Neurotherapeutics 2009;6(1):28-42
  • Hatton J, Rosbolt B, Empey P, Dosing and safety of cyclosporine in patients with severe brain injury. J Neurosurg 2008;109(4):699-707
  • Clinical Trials.gov. Available from: http://clinicaltrials.gov/ct2/show/NCT00260052?term=TRAUMATIC+ BRAIN+INJURY+erythropoietin&rank=2. [Accessed 22 February 2010]
  • Grasso G, Graziano F, Sfacteria A, Neuroprotective effect of erythropoietin and darbepoetin alfa after experimental intracerebral hemorrhage. Neurosurgery 2009;65(4):763-9; discussion 9-70
  • Mammis A, McIntosh TK, Maniker AH. Erythropoietin as a neuroprotective agent in traumatic brain injury review. Surg Neurol 2009;71(5):527-31; discussion 531
  • Poole NA, Agrawal N. Cholinomimetic agents and neurocognitive impairment following head injury: a systematic review. Brain Inj 2008;22(7-8):519-34
  • Clark WM, Wechsler LR, Sabounjian LA, Schwiderski UE. A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients. Neurology 2001;57(9):1595-602
  • Adelson PD, Bratton SL, Carney NA, Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 1. Introduction. Pediatr Crit Care Med 2003;4(Suppl 3):S2-4
  • Bayir H, Adelson PD, Wisniewski SR, Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children. Crit Care Med 2009;37(2):689-95
  • Harris OA, Muh CR, Surles MC, Discrete cerebral hypothermia in the management of traumatic brain injury: a randomized controlled trial. J Neurosurg 2009;110(6):1256-64
  • Hutchison JS, Ward RE, Lacroix J, Hypothermia therapy after traumatic brain injury in children. N Engl J Med 2008;358(23):2447-56
  • Shohami E, Gati I, Beit-Yannai E, Closed head injury in the rat induces whole body oxidative stress: overall reducing antioxidant profile. J Neurotrauma 1999;16(5):365-76
  • Glantz L, Avramovich A, Trembovler V, Ischemic preconditioning increases antioxidants in the brain and peripheral organs after cerebral ischemia. Exp Neurol 2005;192(1):117-24
  • Chen G, Shi J, Ding Y, Progesterone prevents traumatic brain injury-induced intestinal nuclear factor kappa B activation and proinflammatory cytokines expression in male rats. Mediators Inflamm 2007;93431
  • Chen G, Shi JX, Qi M, Effects of progesterone on intestinal inflammatory response, mucosa structure alterations, and apoptosis following traumatic brain injury in male rats. J Surg Res 2008;147(1):92-8
  • Hang CH, Shi JX, Li JS, Expressions of intestinal NF-kappaB, TNF-alpha, and IL-6 following traumatic brain injury in rats. J Surg Res 2005;123(2):188-93
  • Hang CH, Shi JX, Sun BW, Li JS. Apoptosis and functional changes of dipeptide transporter (PepT1) in the rat small intestine after traumatic brain injury. J Surg Res 2007;137(1):53-60
  • Zhou ML, Zhu L, Wang J, The inflammation in the gut after experimental subarachnoid hemorrhage. J Surg Res 2007;137(1):103-8
  • Vilalta A, Sahuquillo J, Rosell A, Moderate and severe traumatic brain injury induce early overexpression of systemic and brain gelatinases. Intensive Care Med 2008;34(8):1384-92
  • Utagawa A, Truettner JS, Dietrich WD, Bramlett HM. Systemic inflammation exacerbates behavioral and histopathological consequences of isolated traumatic brain injury in rats. Exp Neurol 2008;211(1):283-91
  • Margulies S, Hicks R. Combination therapies for traumatic brain injury: prospective considerations. J Neurotrauma 2009;26(6):925-39
  • Mautes AE, Thome D, Steudel WI, Changes in regional energy metabolism after closed head injury in the rat. J Mol Neurosci 2001;16(1):33-9
  • Kasturi BS, Stein DG. Progesterone decreases cortical and sub-cortical edema in young and aged ovariectomized rats with brain injury. Restor Neurol Neurosci 2009;27(4):265-75
  • Stein DG, Hurn PD. Effects of sex steroids on damaged neural systems. In: Pfaff DW, Arnold AP, Etgen AM, , editors, Hormones, brain and behavior. 2nd edition. Elsevier, Oxford; 2009. p. 2223-58
  • Sayeed I, Stein DG. Progesterone as a neuroprotective factor in traumatic and ischemic brain injury. In: Verhaagen J, Hol EM, Huitinga I, , editors, Neurotherapy. Elsevier, New York; 2009. p. i219-37
  • Schumacher M, Guennoun R, Stein DG, De Nicola AF. Progesterone: therapeutic opportunities for neuroprotection and myelin repair. Pharmacol Ther 2007;116:77-107
  • Fee DB, Swartz KR, Joy KM, Effects of progesterone on experimental spinal cord injury. Brain Res 2007;1137:146-52
  • Toung TJ, Chen TY, Littleton-Kearney MT, Effects of combined estrogen and progesterone on brain infarction in reproductively senescent female rats. J Cereb Blood Flow Metab 2004;24(10):1160-6
  • Cutler SM, Pettus EH, Hoffman SW, Stein DG. Tapered progesterone withdrawal enhances behavioral and molecular recovery after traumatic brain injury. Exp Neurol 2005;195(2):423-9
  • Gilmer LK, Roberts KN, Scheff SW. Efficacy of progesterone following a moderate unilateral cortical contusion injury. J Neurotrauma 2008;25(6):593-602
  • Baulieu EE, Robel P, Schumacher M. Neurosteroids: beginning of the story. Int Rev Neurobiol 2001;46:1-32
  • Baulieu EE, Robel P. Neurosteroids: a new brain function? J Steroid Biochem Mol Biol 1990;37(3):395-403
  • Schumacher M, Robel P, Baulieu EE. Development and regeneration of the nervous system: a role for neurosteroids. Dev Neurosci 1996;18(1-2):6-21
  • Stein DG, Hoffman SW. Estrogen and progesterone as neuroprotective agents in the treatment of acute brain injuries. Pediatr Rehabil 2003;6(1):13-22
  • Wright DW, Kellermann AL, Hertzberg VS, ProTECT: A randomized clinical trial of progesterone for acute traumatic brain injury. Ann Emerg Med 2007;49(4):391-402
  • Xiao G, Wei J, Yan W, Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial. Crit Care 2008;12(2):R61
  • Doppenberg EM, Choi SC, Bullock R. Clinical trials in traumatic brain injury: lessons for the future. J Neurosurg Anesthesiol 2004;16(1):87-94
  • Meffre D, Delespierre B, Gouezou M, The membrane-associated progesterone-binding protein 25-Dx is expressed in brain regions involved in water homeostasis and is up-regulated after traumatic brain injury. J Neurochem 2005;93(5):1314-26
  • Coughlan T, Gibson C, Murphy S. Modulatory effects of progesterone on inducible nitric oxide synthase expression in vivo and in vitro. J Neurochem 2005;93(4):932-42
  • Reddy DS, O'Malley BW, Rogawski MA. Anxiolytic activity of progesterone in progesterone receptor knockout mice. Neuropharmacology 2005;48(1):14-24
  • Sakamoto H, Shikimi H, Ukena K, Tsutsui K. Neonatal expression of progesterone receptor isoforms in the cerebellar Purkinje cell in rats. Neurosci Lett 2003;343(3):163-6
  • Inoue T, Akahira J, Suzuki T, Progesterone production and actions in the human central nervous system and neurogenic tumors. J Clin Endocrinol Metab 2002;87(11):5325-31
  • Guerra-Araiza C, Coyoy-Salgado A, Camacho-Arroyo I. Sex differences in the regulation of progesterone receptor isoforms expression in the rat brain. Brain Res Bull 2002;59(2):105-9
  • Quadros PS, Pfau JL, Wagner CK. Distribution of progesterone receptor immunoreactivity in the fetal and neonatal rat forebrain. J Comp Neurol 2007;504(1):42-56
  • Quadros PS, Lopez V, De Vries GJ, Progesterone receptors and the sexual differentiation of the medial preoptic nucleus. J Neurobiol 2002;51(1):24-32
  • Ozawa H. Steroid Hormones, their receptors and neuroendocrine system. J Nippon Med Sch 2005;72(6):316-25
  • Ghoumari AM, Baulieu EE, Schumacher M. Progesterone increases oligodendroglial cell proliferation in rat cerebellar slice cultures. Neuroscience 2005;135(1):47-58
  • Pierson RC, Lyons AM, Greenfield LJ. Gonadal steroids regulate GABAA receptor subunit mRNA expression in NT2-N neurons. Brain Res Mol Brain Res 2005;138(2):105-15
  • Lonstein JS, Blaustein JD. Immunocytochemical investigation of nuclear progestin receptor expression within dopaminergic neurones of the female rat brain. J Neuroendocrinol 2004;16(6):534-43
  • Blaustein JD. Progestin receptors: neuronal integrators of hormonal and environmental stimulation. Ann NY Acad Sci 2003;1007:238-50
  • Gruber CJ, Huber JC. Differential effects of progestins on the brain. Maturitas 2003;46(Suppl 1):S71-5
  • Labombarda F, Gonzalez SL, Deniselle MC, Effects of injury and progesterone treatment on progesterone receptor and progesterone binding protein 25-Dx expression in the rat spinal cord. J Neurochem 2003;87(4):902-13
  • Mani SK. Signaling mechanisms in progesterone-neurotransmitter interactions. Neuroscience 2006;138(3):773-81
  • Dufourny L, Skinner DC. Colocalization of progesterone receptors and thyroid hormone receptors alpha in the ovine diencephalon: no effect of estradiol. Neuroendocrinology 2003;77(1):51-8
  • Auger CJ, De Vries GJ. Progestin receptor immunoreactivity within steroid-responsive vasopressin-immunoreactive cells in the male and female rat brain. J Neuroendocrinol 2002;14(7):561-7
  • Attella MJ, Nattinville A, Stein DG. Hormonal state affects recovery from frontal cortex lesions in adult female rats. Behav Neural Biol 1987;48(3):352-67
  • Brinton RD, Thompson RF, Foy MR, Progesterone receptors: form and function in brain. Front Neuroendocrinol 2008;29(2):313-39
  • Gibson CL, Gray LJ, Bath PM, Murphy SP. Progesterone for the treatment of experimental brain injury; a systematic review. Brain 2008;131(Pt 2):318-28
  • Vandromme M, Melton SM, Kerby JD. Progesterone in traumatic brain injury: time to move on to phase III trials. Crit Care 2008;12:153
  • Stein DG. Progesterone exerts neuroprotective effects after brain injury. Brain Res Rev 2008;57(2):386-97
  • Zygun DA, Kortbeek JB, Fick GH, Non-neurologic organ dysfunction in severe traumatic brain injury. Crit Care Med 2005;33(3):654-60
  • Cai W, Zhu Y, Furuya K, Two different molecular mechanisms underlying progesterone neuroprotection against ischemic brain damage. Neuropharmacology 2008;55(2):127-38
  • Behera MA, Dai Q, Garde R, Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF\-10A benign breast epithelial cells. Am J Physiol Endocrinol Metab 2009. [Epub ahead of print]
  • Hu Z, Li Y, Fang M, Exogenous progesterone: a potential therapeutic candidate in CNS injury and neurodegeneration. Curr Med Chem 2009;16(11):1418-25
  • Sayeed I, Wali B, Stein DG. Progesterone inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. Restor Neurol Neurosci 2007;25(2):151-9
  • Mani SK, Portillo W, Reyna A. Steroid hormone action in the brain: cross-talk between signalling pathways. J Neuroendocrinol 2009;21(4):243-7
  • Sayeed I, Parvez S, Winkler-Stuck K, Patch clamp reveals powerful blockade of the mitochondrial permeability transition pore by the D2-receptor agonist pramipexole. FASEB J 2006;20(3):556-8
  • Ziegler E, Bodusch M, Song Y, Interaction of androsterone and progesterone with inhibitory ligand-gated ion channels: a patch clamp study. Naunyn Schmiedebergs Arch Pharmacol 2009;380(4):277-91
  • Djebaili M, Guo Q, Pettus EH, The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats. J Neurotrauma 2005;22(1):106-18
  • Yao XL, Liu J, Lee E, Progesterone differentially regulates pro- and anti-apoptotic gene expression in cerebral cortex following traumatic brain injury in rats. J Neurotrauma 2005;22(6):656-68
  • Wise PM. Estrogen therapy: does it help or hurt the adult and aging brain? Insights derived from animal models. Neuroscience 2006;138(3):831-5
  • You JM, Yun SJ, Nam KN, Mechanism of glucocorticoid-induced oxidative stress in rat hippocampal slice cultures. Can J Physiol Pharmacol 2009;87(6):440-7
  • Robertson CL, Puskar A, Hoffman GE, Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell loss after traumatic brain injury in female rats. Exp Neurol 2006;197(1):235-43
  • Roglio I, Bianchi R, Gotti S, Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury. Neuroscience 2008;155(3):673-85
  • Garay L, Gonzalez Deniselle MC, Gierman L, Steroid protection in the experimental autoimmune encephalomyelitis model of multiple sclerosis. Neuroimmunomodulation 2008;15(1):76-83
  • De Nicola AF, Labombarda F, Deniselle MC, Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration. Front Neuroendocrinol 2009;30(2):173-87
  • Henderson LP. Steroid modulation of GABAA receptor-mediated transmission in the hypothalamus: effects on reproductive function. Neuropharmacology 2007;52(7):1439-53
  • Pan DS, Liu WG, Yang XF, Cao F. Inhibitory effect of progesterone on inflammatory factors after experimental traumatic brain injury. Biomed Environ Sci 2007;20(5):432-8
  • Chen G, Shi J, Jin W, Progesterone administration modulates TLRs/NF-kappaB signaling pathway in rat brain after cortical contusion. Ann Clin Lab Sci 2008;38(1):65-74
  • Chen J, Chopp M, Li Y. Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat. J Neurol Sci 1999;171(1):24-30
  • Rhodes ME, Frye CA. Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins. Epilepsy Behav 2005;6(3):320-7
  • Moorthy K, Sharma D, Basir SF, Baquer NZ. Administration of estradiol and progesterone modulate the activities of antioxidant enzyme and aminotransferases in naturally menopausal rats. Exp Gerontol 2005;40(4):295-302
  • Chataigneau T, Zerr M, Chataigneau M, Chronic treatment with progesterone but not medroxyprogesterone acetate restores the endothelial control of vascular tone in the mesenteric artery of ovariectomized rats. Menopause 2004;11(3):255-63
  • Orshal JM, Khalil RA. Gender, sex hormones, and vascular tone. Am J Physiol Regul Integr Comp Physiol 2004;286(2):R233-49
  • Cutler SM, Cekic M, Miller DM, Progesterone improves acute recovery after traumatic brain injury in the aged rat. J Neurotrauma 2007;24(9):1475-86
  • Guo Q, Sayeed I, Baronne LM, Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats. Exp Neurol 2006;198(2):469-78
  • Vanlandingham JW, Cutler SM, Virmani S, The enantiomer of progesterone acts as a molecular neuroprotectant after traumatic brain injury. Neuropharmacology 2006;51:1078-85
  • Charalampopoulos I, Remboutsika E, Margioris AN, Gravanis A. Neurosteroids as modulators of neurogenesis and neuronal survival. Trends Endocrinol Metab 2008;19(8):300-7
  • Reddy DS, Apanites LA. Anesthetic effects of progesterone are undiminished in progesterone receptor knockout mice. Brain Res 2005;1033(1):96-101
  • Zheng P. Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance. Prog Neurobiol 2009;89(2):134-52
  • Akk G, Covey DF, Evers AS, Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacol Ther 2007;116(1):35-57
  • Covey DF. ent-Steroids: novel tools for studies of signaling pathways. Steroids 2009;74(7):577-85
  • Jones LA, Anthony JP, Henriquez FL, Toll-like receptor-4-mediated macrophage activation is differentially regulated by progesterone via the glucocorticoid and progesterone receptors. Immunology 2008;125(1):59-69
  • Hwang JY, Duncan RS, Madry C, Progesterone potentiates calcium release through IP3 receptors by an Akt-mediated mechanism in hippocampal neurons. Cell Calcium 2009;45(3):233-42
  • Viero C, Dayanithi G. Neurosteroids are excitatory in supraoptic neurons but inhibitory in the peripheral nervous system: it is all about oxytocin and progesterone receptors. Prog Brain Res 2008;170:177-92
  • Sakamoto H, Ukena K, Kawata M, Tsutsui K. Expression, localization and possible actions of 25-Dx, a membrane associated putative progesterone-binding protein, in the developing Purkinje cell of the cerebellum: a new insight into the biosynthesis, metabolism and multiple actions of progesterone as a neurosteroid. Cerebellum 2008;7(1):18-25
  • Guennoun R, Meffre D, Labombarda F, The membrane-associated progesterone-binding protein 25-Dx: expression, cellular localization and up-regulation after brain and spinal cord injuries. Brain Res Rev 2008;57(2):493-505
  • Cekic M, Sayeed I, Stein DG. Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease. Front Neuroendocrinol 2009;30(2):158-72

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