167
Views
3
CrossRef citations to date
0
Altmetric
Drug Evaluations

The potential role for lixivaptan in heart failure and in hyponatremia

, MD, , MD, , MD & , MD
Pages 831-848 | Published online: 09 May 2011

Bibliography

  • Carnethon M, Rosamond W, Furie K, American heart association statistics committee and stroke statistics subcommittee. Heart disease and stroke statistics-2010 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2010;121:e46-215
  • Ghali JK, Tam SW. The critical link of hypervolemia and hyponatremia in heart failure and the potential role of arginine vasopressin antagonists. J Card Fail 2010;16:419-31
  • Waikar SS, Mount DB, Curhan GC. Mortality after hospitalization with mild, moderate, and severe hyponatremia. Am J Med 2009;122:857-65
  • Wald R, Jaber BL, Price LL, Impact of hospital-associated hyponatremia on selected outcomes. Arch Intern Med 2010;170:294-302
  • Sajadieh A, Binici Z, Mouridsen MR, Mild hyponatremia carries a poor prognosis in community subjects. Am J Med 2009;122:679-86
  • Ghali JK, Vaitkevicius P. Fluid removal: are we any wiser? J Card Fail 2008;14:6-8
  • Ghali JK. Mechanisms, risks, and new treatment options for hyponatremia. Cardiology 2008;111:147-57
  • Wang W, Zucker IH. Cardiac sympathetic afferent reflex in dogs with congestive heart failure. Am J Physiol 1996;271:R751-6
  • Decaux G. Is asymptomatic hyponatremia really asymptomatic? Am J Med 2006;119(7A):S79-82
  • Renneboog B, Vendemergel X, Manto MN, Mild chronic hyponatremia is associated with falls, unsteadiness and attention deficits. Am J Med 2006;119:71e1-8
  • Share L. Role of vasopressin in cardiovascular regulation. Physiol Rev 1988;4:1248-84
  • Kamoi K, Ishibashi M, Yamaji T. Interaction of osmotic and nonosmotic stimuli in regulation of vasopressin secretion in hypoosmolar state of man. Endocr J 1997;44:311-17
  • Ellison DH, Berl T. Clinical practice. The syndrome of inappropriate antidiuresis. N Engl J Med 2007;356:2064-72
  • Goldsmith SR, Francis GS, Cowley AW. Arginine vasopressin and the renal response to water loading in congestive heart failure. Am J Cardiol 1986;58:295-9
  • Pruszczynski W, Vahanian A, Ardaillou R, Role of antidiuretic hormone in impaired water excretion of patients with congestive heart failure. J Clin Endocrinol Metab 1984;58:599-605
  • Bichet DG, Kortas C, Mettauer B, Modulation of plasma and platelet vasopressin by cardiac function in patients with heart failure. Kidney Int 1986;29:1188-96
  • Francis GS, Benedict C, Johnstone DE, Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure. A substudy of the Studies of Left Ventricular Dysfunction (SOLVD). Circulation 1990;82:1724-9
  • Schrier RW. Water and sodium retention in edematous disorder: role of vasopressin and aldosterone. Am J Med 2006;119:S47-53
  • Suzuki S, Takeshita A, Imaizumi T, Biphasic forearm vascular responses to intraarterial arginine vasopressin. J Clin Invest 1989;84:427-34
  • Coyle S, Penney MD, Masters PW, Early diagnosis of ectopic arginine vasopressin secretion. Clin Chem 1993;39:152-4
  • Thibonnier M, Conarty DM, Preston JA, Molecular pharmacology of human vasopressin receptors. Adv Exp Med Biol 1998;449:251-76
  • Ali F, Guglin M, Vaitkevicius P, Therapeutic potential of vasopressin receptor antagonists. Drugs 2007;67:847-58
  • Bankir L. Antidiuretic action of vasopressin: quantitative aspects and interaction between V1A and V2 receptor-mediated effects. Cardiovasc Res 2001;51:372-90
  • Goldsmith SR. Current treatments and novel pharmacologic treatments for hyponatremia in congestive heart failure. Am J Cardiol 2005;95:14B-23B
  • Hirano T, Yamamura Y, Nakamura S, Effects of the V2-receptor antagonist OPC-41061 and the loop diuretic furosemide alone and in combination in rats. J Pharmacol Exp Ther 2000;292:288-94
  • Miller PD, Linas SL, Schrier RW. Plasma demeclocycline levels and nephrotoxicity: correlation in hyponatremic cirrhotic patients. JAMA 1980;243:2513-15
  • Jackson EK. Diuretics. Hardman JG, Limbird LE. editors, Goodman and Gilman's the pharmacological basis of therapeutics. 9th edition. McGraw-Hill; New York: 1996. p. 757-88
  • Yamamura Y, Ogawa H, Yamashita H, Characterization of a novel aquaretic agent, OPC-31260, as an orally effective, nonpeptide vasopressin V2 receptor antagonist. Br J Pharmacol 1992;105:787-91
  • Serradeil-Le Gal C, Lacour C, Valette G, Characterization of SR 121463A, a highly potent and selective orally active vasopressin V2 receptor antagonist. J Clin Invest 1996;98:2729-38
  • Tahara A, Tomura Y, Wada KI, Pharmacological profile of YM087, a novel potent nonpeptide vasopressin V1A and V2 receptor antagonist, in vitro and in vivo. J Pharmacol Exp Ther 1997;282:301-8
  • Chan PS, Couplet J, Park HC, VPA-985, a nonpeptide orally active and selective vasopressin V2 receptor antagonist. Adv Exp Med Biol 1998;449:439-43
  • Albright JD, Reich MF, Delos Santos EG, 5-Fluoro-2-methyl-N-[4-(5H-pyrrolo [2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors. J Med Chem 1998;41:2442-4
  • Park CH, Lock YW, Tanikella TK, In vitro pharmacology of VPA-985, a non-peptide V2 selective vasopressin antagonist. J Am Soc Nephrol 1998;9:A0120
  • Chan PS, Lai F, Ru X, Pharmacological characterization of VPA-985, a potent nonpeptidic orally-active and selective vasopressin (AVP) V2 receptor antagonist. J Am Soc Nephrol 1998;9:A0081
  • Muralidharan G, Meng X, DeCleene SA, Pharmacokinetics and pharmacodynamics of a novel vasopressin receptor antagonist, VPA-985, in healthy subjects. Clin Pharmacol Ther 1999;65(2):189
  • Guyader D, Patat A, Ellis-Grosse EJ, Pharmacodynamic effects of a nonpeptide antidiuretic hormone V2 antagonist in cirrhotic patients with ascites. Hepatology 2002;36(5):1197-205
  • Ellis-Grosse EJ, Meng X, Orczyk GP. Single dose pharmacokinetic (PK) -pharmacodynamic (PD) profile of VPA-985, a novel, V2 receptor antagonist, in patients with congestive heart failure (CHF) [abstract]. AAPS PharmSci 1999;1:S1
  • Orlandi C, Ticho B. The effect on renal function of lixivaptan (VPA-985), a vasopressin V2 receptor antagonist, in combination with furosemide [abstract 618]. Eur J Heart Fail 2009;8:2
  • Swan SK, Lambrecht LJ, Orczyk GP, Interaction between VPA-985, an ADH (V2) antagonist, and furosemide. J Am Soc Nephrol 1999;10:124A
  • Epstein M, Orczyk G, Muralidharan G, VPA-985: A novel non-peptide competitive vasopressin receptor antagonist for the treatment of dilutional hyponatremia. J Am Soc Nephrol 1998;9: abstract A0544
  • Swan SK, Anjum S, Lambrecht LJ, Pharmacodynamic effects of VPA-985, an ADH (V2) antagonist, in normal volunteers. J Am Soc Nephrol 1999;10:124A
  • Abraham W, Ghali J, Braman V, Effects of single dose administration of lixivaptan, a selective V2 receptor antagonist, or furosemide in healthy volunteers [abstract 1064]. Eur J Heart Fail 2010;9:1
  • Patat A, Ellis Grosse EJ, Orczyk G, Pharmacodynamic (PD) effects of a novel, non-peptide, V2 receptor antagonist, VPA-985 (VPA), given with hydrochlorothiazide (H) [abstract PI-84]. Clin Pharmacol Ther 2000;67:2
  • Radin J, McCune S, Park S, Effect of chronic administration of the vasopressin V2 receptor antagonist lixivaptan (VPA-985) on renal and cardiovascular functions in a rat model of heart failure [abstract 620]. Eur J Heart Fail 2009;8:2
  • Abraham WT, Shamshirsaz AA, McFann K, Aquaretic effect of lixivaptan, an oral, non-peptide, selective V2 receptor vasopressin antagonist, in New York Heart Association functional class II and III chronic heart failure patients. J Am Coll Cardiol 2006;47:1615-21
  • Martin PY, Abraham WT, Lieming X, Selective V2-receptor vasopressin antagonism decreases urinary aquaporin-2 excretion in patients with chronic heart failure. J Am Soc Nephrol 1999;10(10):2165-70
  • CardioKine, Inc. Study to evaluate the effects of oral administration of lixivaptan in patients with congestive heart failure. Clinicaltrials.gov NCT01055912. Available from: http://clinicaltrials.gov/ct2/show/NCT01055912
  • CardioKine, Inc. The BALANCE study: treatment of hyponatremia based on lixivaptan in NYHA class III/IV cardiac patient evaluation. Clinicaltrials.gov. NCT00578695. Available from: http://clinicaltrials.gov/ct2/show/NCT00578695
  • Wong F, Blei AT, Blendis LM, A vasopressin receptor antagonist (VPA-985) improves serum sodium concentration in patients with hyponatremia: a multicenter, randomized, placebo-controlled trial. Curr Mol Med 2003;37(1):182-91
  • Wong F, Blei AT, Blendis M, The efffects of VPA-985, a vasopressin receptor antagonist on water metabolism in patients with hyponatremia: a multi-center randomized placebo controlled trial [abstract 1094]. Gastroenterology 2000;118: Suppl 2):4
  • Gerbes AL, Golberg V, Gines P, Therapy of hyponatremia in cirrhosis with a vasopressin receptor antagonist: a randomized double-blind multicenter trial. Gastroenterology 2003;124(4):933-9
  • Gross P, Decaux G, Gerbes A, Treatment of hyponatremia (HYPO) with VPA-985. J Am Soc Nephrol 1999;10:121A
  • Gerbes AL, Guelberg V, Decaux G, VPA-985, an orally active vasopressin receptor antagonist improves hyponatremia in patients with cirrhosis: a double-blind placebo controlled multicenter trial. Hepatology 1999;30(4 Pt 2):419A
  • Decaux G, Hannotier P, Pennickx R, Difference in solute excretion after treatment of hyponatremia related to SIADH or cirrhosis by the non-peptide, oral active selective vasopressin V2 receptor antagonist, VPA-985. J Am Soc Nephrol 1999;10:120A
  • Decaux G. Difference in solute excretion during correction of hyponatremic patients with cirrhosis or syndrome of inappropriate secretion of antidiuretic hormone by oral vasopressin V2 receptor antagonist VPA-985. J Lab Clin Med 2001;138(1):18-21
  • Bichet DG, Remillard G, Madore F, Correction of hyponatremia by a single oral dose of 75 mg of the non-peptide vasopressin V2 antagonist VPA-985 in hyponatremic patients receiving carbamazepine (CBZ) (Tegretol) or oxcarbazepine (OBZ) (Trileptal). J Am Soc Nephrol 1999;10:119A
  • CardioKine, Inc. Multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of oral lixivaptan capsules in subject with euvolemic hyponatremia. Clinicaltrials.gov. NCT00660959. Available from: http://clinicaltrials.gov/ct2/show/NCT00660959
  • CardioKine, Inc. A multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety and tolerability of oral lixivaptan capsules in subjects with euvolemic hyponatremia. Clinicaltrials.gov. NCT00876798. Available from: http://clinicaltrials.gov/ct2/show/NCT00876798
  • CardioKine, Inc. International, multicenter study of a twenty-eight week, open-label, titrated oral lixivaptan administration in patients with chronic hyponatremia: extension to studies CK-LX3401, 3405, and 3430. Clinicaltrials.gov. NCT01056848. Available from: http://clinicaltrials.gov/ct2/show/NCT01056848
  • CardioKine, Inc. A study to define the ECG effects of lixivaptan compared to placebo and moxifloxacin in healthy adult men and women: a thorough EKG study. Clinicaltrials.gov. NCT00675701. Available from: http://clinicaltrials.gov/ct2/show/NCT00675701
  • Naitoh M, Suzuki H, Murakami M, Effects of oral AVP receptor antagonists OPC-21268 and OPC-31260 on congestive heart failure in conscious in dogs. Am J Physiol 1994;267:H2245-54
  • Konstam MA, Gheorghiade M, Burnett JC, Effects of oral tolvaptan in patients hospitalized for worsening heart failure, the EVEREST outcome trial. JAMA 2007;297:1319-31
  • Gheorghiade M, Konstam MA, Burnett JC, Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure, the EVEREST clinical status trials. JAMA 2007;297:1332-43

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.