630
Views
40
CrossRef citations to date
0
Altmetric
Original Research

The safety and tolerability evaluation of DepoFoam bupivacaine (bupivacaine extended-release liposome injection) administered by incision wound infiltration in rabbits and dogs

, PhD, , , , , , , & show all
Pages 1327-1341 | Published online: 26 Aug 2011

Bibliography

  • Onel E, Miller H, Patou G, White P. EXPAREL™, a liposomal bupivacaine local analgesic, extends pain relief and decreases opioid use. Presented at American Society of Anesthesiologists (ASA 2010 Annual meeting). October 19, 2010. Available from: http://www.pacira.com/pdf/EXPARELT-ASA-2010-Presentation.pdf
  • Moiniche S, Kehlet H, Dahl JB. A qualitative and quantitative systematic review of preemptive analgesia for postoperative pain relief: the role of timing of analgesia. Anesthesiology 2002;20:725-41
  • Jirasiritham S, Tantivitayatan K, Jirasiritham S. Perianal blockage with 0.5% bupivacaine for postoperative pain relief in hemorrhoidectomy. J Med Assoc Thai 2004;87:660-4
  • Chester JF, Stanford BJ, Gazet JC. Analgesic benefit of locally injected bupivacaine after hemorrhoidectomy. Dis Colon Rectum 1990;33:487-9
  • Yu H-Y, Li S-D, Sun P. Kinetic and dynamic studies of liposomal bupivacaine and bupivacaine solution after subcutaneous injection in rats. J Pharm Pharmacol 2002;54(9):1221-7
  • Lazaro JJ, Franquelo C, Navarro X, Prolongation of nerve and epidural anesthetic blockade by bupivacaine in a lipid emulsion. Anesth Analg 1999;89:121-77
  • Liu P, Feldman H, Giasi R, Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine, and tetracaine in awake dogs following rapid intravenous administration. Anesth Analg 1983;62(4):375-9
  • Scott B, Lee A, Fagan D, Acute toxicity of ropivacaine compared with that of bupivacaine. Anesth Analg 1989;69:563-9
  • Peddie JF. Inguinal hernia repair in the dog. Mod Vet Pract 1980;61(10):859-61
  • Peiper C, Junge K, Klinge U, Is there a risk of infertility after inguinal mesh repair? Experimental studies in the pig and the rabbit. Hernia 2006;10(1):7-12
  • Available from: http://www.pacira.com/depofoam-about.aspx
  • Kim S, Turker MS, Chi EY, Preparation of multivesicular liposomes. Biochim Biophys Acta 1983;728(3):339-48
  • Sankaram M. A lipid based depot (DepoFoam® technology) for sustained release drug delivery. Prog Lipid Res 2002;41:392-406
  • International Conference on Harmonization. Non clinical safety studies for the conduct of human clinical trial for Pharmaceuticals. ICH M3(M), 2000 Nov 9. Available from: http://www.ich.org/LOB/media/MEDIA506.pdf
  • Federal Register (61 FR 43934), Guidance for Industry. Single dose acute toxicity testing for pharmaceuticals. Center for Drug Evaluation and Research 1996 Aug 26. Available from: http://www.fda.gov/cder/guidance/pt1.pdf
  • Curley J, Castillo J, Hotz J, Prolonged regional nerve blockade. Injectable biodegradable bupivacaine/polyester microspheres. Anesth Analg 1996;84(6):1401-10
  • Deng JS, Li L, Tian Y, In vitro characterization of polyorthoester microparticles containing bupivacaine. Pharm Dev Technol 2003;8(1):31-8
  • Estebe J, Le Corre P, Du Plessis L, The pharmacokinetics and pharmacodynamics of bupivacaine loaded-microspheres lack systemic toxicity in a brachial plexus block model. Anesth Analg 2001;93(2):447-55
  • Soderberg L, Dyhre H, Roth B, Bjorkman S. In-vitro release of bupivacaine from injectable lipid formulations investigated by a single drop technique–relation to duration of action in-vivo. J Pharm Pharmacol 2002;54(6):747-55
  • Shah J-C. Maniar M. pH-dependent solubility and dissolution of bupivacaine and its relevance to the formulation of a controlled release system. J Control Release 1993;23:261-70
  • Kohane DS, Lipp M, Kinney RC, Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium. J Biomed Mater Res 2002;59(3):450-9
  • Larsen DB, Joergensen S, Olsen N, In vivo release of bupivacaine from subcutaneously administered oily solution. Comparison with in vitro release. J Control Release 2002;17(81):145-54
  • Storm G, Oussoren C, Peters PAM, Tolerability of liposomes in vivo. In: Gregoriadis G, editors. Liposome technology. Volume 3 Liposomes Technology. 2nd ed. Florida, Boca Raton CRC Press; 1993. p. 345-83
  • Adams DH, Joyce G, Richardson VJ, Liposome toxicity in the mouse central nervous system. J Neurol Sci 1977;31(2):173-9
  • Gutteridge JMC. Free radicals in disease processes: a compilation of cause and consequence. Free Radic Res Commun 1993;19:141-58
  • Lichtenberg D, Barenholz Y. Liposomes: preparation, characterization, and preservation. Methods Biochem Anal 1988;33:337-462
  • Yanez A, Wallace M, Ho R, Touch-evoked agitation produced by spinally administered phospholipids emulsion and liposomes in rats: structure--activity relation. Anesthesiology. 1995;82(5):1189-98
  • Hall SM, Gregson NA. The in vivo and ultrastructural effects of injection of lysophosphatidyl choline into myelinated peripheral nerve fibres of the adult mouse. J Cell Sci 1971;9:769-89
  • Xu Y, Xiao YJ, Zhu K, Unfolding the pathophysiological role of bioactive lysophospholipids. Curr Drug Targets Immune Endocr Metabol Disord 2003;3:23-32
  • Masters DB. Domb AJ. Liposphere local anesthetic timed-release for perineural site application.. Pharm Res 1998;15(7):1038-45
  • Boogaerts J, Lafont N, Donnay M, Motor blockade and absence of local nerve toxicity induced by liposomal bupivacaine injected into the brachial plexus of rabbits Acta Anaesthesiol Belg. 1995;46(1):19-24
  • Firth G, Oliver AS, McKera RO. Studies on the intracerebral injection of bleomycin free and entrapped within liposomes in the rat. J Neurol Neurosurg Psychiatry 1984;47(6):585-9
  • Malinovsky JM, Benhamou D, Alafandy M, Neurotoxicological assessment after intracisternal injection of liposomal bupivacaine in rabbits. Anesth Analg 1997;85(6):1331-6
  • Grant G, Lax J, Susser L, Wound infiltration with liposomal bupivacaine prolongs analgesia in rats. Acta Anaesthesiol Scand 1997;41(2):204-7
  • Boogaerts J, Lafont N, Luo H, Legros F. Plasma concentrations of bupivacaine after brachial plexus administration of liposome-associated and plain solutions to rabbits. Can J Anaesth 1993;40(12):1201-4
  • Skarda RT. Local and regional anesthetic and analgesic techniques: dogs. In: Thurmaon JC, Tranquilli WJ, Benson GJ. editors. 3rd edition. Lumb & Jones' Veterinary Anesthesia; Baltimore, Williams and Wilkins 1996;426-47
  • Welters ID, Menzebach A, Langefeld TW. Menzebach, et al. Inhibitory effects of S(-) and R(+) bupivacaine on neutrophil function. Acta Anaesthesiol Scand 2001;45:570-5

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.