Dehydroaltenusin is a specific inhibitor of mammalian DNA polymerase α

Bibliography

• DePamphilis ML. DNA replication in eukaryotic cells. Cold Spring Harbor Laboratory Press; USA: 1996
   Google Scholar
• Kornberg A, Baker TA. Eukaryotic DNA polymerase. “DNA replication” (Chapter 6). 2nd edition. Freeman WD & Co; New York: 1992. p. 197-225
   Google Scholar
• Hubscher U, Maga G, Spadari S. Eukaryotic DNA polymerases. Annu Rev Biochem 2002;71:133-63
   PubMed Web of Science ®Google Scholar
• Friedberg EC, Feaver WJ, Gerlach VL. The many faces of DNA polymerases: strategies for mutagenesis and for mutational avoidance. Proc Natl Acad Sci USA 2000;97:5681-3
   PubMed Web of Science ®Google Scholar
• Takata K, Shimizu T, Iwai S, Wood RD. Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. J Biol Chem 2006;281:23445-55
   PubMed Web of Science ®Google Scholar
• Bebenek K, Kunkel TA. DNA repair and replication. In: Yang W. editor. Advances in protein chemistry. Volume 69 Elsevier; San Diego: 2004. p. 137-65
   Google Scholar
• So AG, Downey KM. Eukaryotic DNA replication. Crit Rev Biochem Mol Biol 1992;27:129-55
   PubMed Web of Science ®Google Scholar
• Ikegami S, Taguchi T, Ohashi M, Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-alpha. Nature 1978;275:458-60
   PubMed Web of Science ®Google Scholar
• Mizushina Y, Kamisuki S, Mizuno T, Dehydroaltenusin, a mammalian DNA polymerase alpha inhibitor. J Biol Chem 2000;275:33957-61
   PubMed Web of Science ®Google Scholar
• Thomas R, Rogers D, Williams DJ. J Chem Soc D 1971;8:393
   Google Scholar
• Nakanishi S, Toki S, Saitoh Y, Isolation of myosin light chain kinase inhibitors from microorganisms: dehydroaltenusin, altenusin, atrovenetinone, and cyclooctasulfur. Biosci Biotechnol Biochem 1995;59:1333-5
   PubMed Web of Science ®Google Scholar
• Mizushina Y, Tanaka N, Yagi H, Fatty acids selectively inhibit eukaryotic DNA polymerase activities in vitro. Biochim Biophys Acta 1996;1308:256-62
   PubMed Web of Science ®Google Scholar
• Mizushina Y, Yoshida S, Matsukage A, Sakaguchi K. The inhibitory action of fatty acids on DNA polymerase beta. Biochim Biophys Acta 1997;1336:509-21
   PubMed Web of Science ®Google Scholar
• Takahashi S, Kamisuki S, Mizushina Y, Total synthesis of dehydroaltenusin. Tetraherdon Lett 2003;44:1875-7
   Web of Science ®Google Scholar
• Kamisuki S, Takahashi S, Mizushina Y, Precise structural elucidation of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha. Bioorg Med Chem 2004;12:5355-9
   PubMed Web of Science ®Google Scholar
• Kuramochi K, Fukudome K, Kuriyama I, Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase alpha inhibitors. Bioorg Med Chem 2009;17:7227-38
   PubMed Web of Science ®Google Scholar
• Kamisuki S, Murakami C, Ohta K, Actions of derivatives of dehydroaltenusin, a new mammalian DNA polymerase alpha-specific inhibitor. Biochem Pharmacol 2002;63:421-7
   PubMed Web of Science ®Google Scholar
• Mizushina Y, Motoshima H, Yamaguchi Y, 3-O-methylfunicone, a selective inhibitor of mammalian Y-family DNA polymerases from an Australian sea salt fungal strain. Mar Drugs 2009;7:624-39
   PubMed Web of Science ®Google Scholar
• Takada-Takayama R, Tada S, Hanaoka F, Ui M. Peptide mapping of the four subunits of the mouse DNA polymerase alpha-primase complex. Biochem Biophys Res Commun 1990;170:589-95
   PubMed Web of Science ®Google Scholar
• Suzuki M, Enomoto T, Masutani C, DNA primase-DNA polymerase alpha assembly from mouse FM3A cells: purification of constituting enzymes, reconstitution, and analysis of RNA priming as coupled to DNA synthesis. J Biol Chem 1989;264:10065-71
   PubMed Web of Science ®Google Scholar
• Miyazawa H, Izumi M, Tada S, Molecular cloning of the cDNAs for the four subunits of mouse DNA polymerase alpha-primase complex and their gene expression during cell proliferation and the cell cycle. J Biol Chem 1993;268:8111-22
   PubMed Web of Science ®Google Scholar
• Copeland WC, Wang TS. Catalytic subunit of human DNA polymerase alpha overproduced from baculovirus-infected insect cells. Structural and enzymological characterization. J Biol Chem 1991;266:22739-48
   PubMed Web of Science ®Google Scholar
• Copeland WC, Wang TS. Enzymatic characterization of the individual mammalian primase subunits reveals a biphasic mechanism for initiation of DNA replication. J Biol Chem 1993;268:26179-89
   PubMed Web of Science ®Google Scholar
• Murakami-Nakai C, Maeda N, Yonezawa Y, The effects of dehydroaltenusin, a novel mammalian DNA polymerase alpha inhibitor, on cell proliferation and cell cycle progression. Biochim Biophys Acta 2004;1674:193-9
   PubMed Web of Science ®Google Scholar
• Ohtsubo M, Theodoras AM, Schumacher J, Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol Cell Biol 1995;15:2612-24
   PubMed Web of Science ®Google Scholar
• Ohtsubo M, Roberts JM. Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science 1993;259:1908-12
   PubMed Web of Science ®Google Scholar
• Fang F, Newport JW. Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes. Cell 1991;66:731-42
   PubMed Web of Science ®Google Scholar
• Pagano M, Pepperkok R, Verde F, Cyclin A is required at two points in the human cell cycle. EMBO J 1992;11:961-71
   PubMed Web of Science ®Google Scholar
• Nurse P. Universal control mechanism regulating onset of M-phase. Nature 1990;344:503-8
   PubMed Web of Science ®Google Scholar
• Maeda N, Kokai Y, Ohtani S, Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha. Biochem Biophys Res Commun 2007;352:390-6
   PubMed Web of Science ®Google Scholar
• Oguro M, Suzuki-Hori C, Nagano H, The mode of inhibitory action by aphidicolin on eukaryotic DNA polymerase alpha. Eur J Biochem 1979;97:603-7
   PubMedGoogle Scholar
• Mizuno T, Yamagishi K, Miyazawa H, Hanaoka F. Molecular architecture of the mouse DNA polymerase alpha-primase complex. Mol Cell Biol 1999;19:7886-96
   PubMed Web of Science ®Google Scholar
• Mizuno T, Okamoto T, Yokoi M, Identification of the nuclear localization signal of mouse DNA primase: nuclear transport of p46 subunit is facilitated by interaction with p54 subunit. J Cell Sci 1996;109:2627-36
   PubMed Web of Science ®Google Scholar
• Mizushina Y, Ohkubo T, Date T, Mode analysis of a fatty acid molecule binding to the N-terminal 8-kDa domain of DNA polymerase beta. J Biol Chem 1999;274:25599-607
   PubMed Web of Science ®Google Scholar
• Mizushina Y, Ohkubo T, Sugawara F, Sakaguchi K. Structure of lithocholic acid binding to the N-terminal 8-kDa domain of DNA polymerase beta. Biochemistry 2000;39:12606-13
   PubMed Web of Science ®Google Scholar
• Mizushina Y, Sugawara F, Iida A, Sakaguchi K. Structural homology between DNA binding sites of DNA polymerase beta and DNA topoisomerase II. J Mol Biol 2000;304:385-95
   PubMed Web of Science ®Google Scholar
• Miyazawa H, Tandai M, Hanaoka F, Identification of a DNA segment containing the human DNA polymerase alpha gene. Biochem Biophys Res Commun 1986;139:637-43
   PubMed Web of Science ®Google Scholar
• Wang TS. Eukaryotic DNA polymerases. Annu Rev Biochem 1991;60:513-52
   PubMed Web of Science ®Google Scholar
• Wang J, Sattar AK, Wang CC, Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69. Cell 1997;89:1087-99
   PubMed Web of Science ®Google Scholar