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Novel metabotropic glutamate receptor 4 and glutamate receptor 8 therapeutics for the treatment of anxiety

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Bibliography

  • Pin JP, Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology 1995;34:1-26
  • Vaidya A, Jain S, Jain A, et al. Metabotropic glutamate receptors: a review on prospectives and therapeutic aspects. Mini Rev Med Chem 2013;13:1967-81
  • Bezerra de Menezes G, Fontenelle L, et al. Treatment-resistant anxiety disorders: social phobia, generalized anxiety disorder and panic disorder. Rev Bras Psiquiatr 2007;29:S55-60
  • Lanouette N, Stein M. Advances in the management of treatment-resistant anxiety disorders. Focus 2010;8:501-24
  • Polack M, Otto M, Roy-Bynne P, et al. Novel treatment approaches for refractory anxiety disorders. Depress Anxiety 2008;25:467-76
  • Grillon C, Cordova J, Levine LR, et al. Anxiolytic effects of a novel group ii metabotropic glutamate receptor agonist (ly354740) in the fear-potentiated startle paradigm in humans. Psychopharmacology (Berl) 2003;168:446-54
  • Schoepp D, Wright R, Levine L, et al. Ly354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress. Stress 2003;6:189-97
  • Paluchaa A, Pilc A. Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs. Pharmacol Ther 2007;115:116-47
  • Linden AM, Johnson BG, Peters SC, et al. Increased anxiety-related behavior in mice deficient for metabotropic glutamate 8 (mGlu8) receptor. Neuropharmacology 2002;43:251-9
  • Duvoisin R, Zhang C, Pfankuch T, et al. Increased measures of anxiety and weight gain in mice lacking the group iii metabotropic glutamate receptor mGlur8. Eur J Neurosci 2005;22:425-36
  • Gosnell H, Silberman Y, Grueter B, et al. Mglur8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner. Neuropsychoparmacology 2011;36:1599-607
  • Duvoisin R, Villasana L, Davis M, et al. Opposing roles of mGlur8 in measures of anxiety involving non-social and social challenges. Behav Brain Res 2011;221:50-4
  • Davis M, Iancu O, Acher F, et al. Role of mGlur4 in acquisition of fear learning and memory. Neuropharmacology 2013;55:365-72
  • Davis M, Haley T, Duvoisin R, et al. Measures of anxiety, sensorimotor function, and memory in male and female mGlur4-/- mice. Behav Brain Res 2012;229:21-8
  • Duvoisin R, Pfankuch T, Wilson J, et al. Acute pharmacological modulation of mGlur8 reduces measures of anxiety. Behav Brain Res 2010;212:168-73
  • Kalinichev M, Le Poul E, Bolea C, et al. Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 adx88178 in rodent models of neuropsychiatric disorders. J Pharmacol Exp Ther 2014;350:495-505
  • Mercier M, Lodge D. Group iii metabotropic glutamate receptors: pharmacology, physiology, and therapeutic potential. Neurochem Res 2014;39:1876-94
  • Becker JA, Clesse D, Spiegelhater C, et al. Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGlur4 activity. Neuropsychoparmacology 2014;39(9):2049-60
  • Lopez S, Turle-Lorenzo N, Acher F, et al. Targeting group iii metabotropic glutamate receptors produces complex behavioral effects in rodent models of parkinson’s disease. J Neurosci 2007;27:6701-11
  • Hopkins C, Lindsley C, Niswender C. Mglur4-positive allosteric modulation as potential treatment for parkinson’s disease. Future Med Chem 2009;1:501-13
  • Snead OCIII, Banerjee PK, Burnham M, et al. Modulation of absence seizures by the gaba(a) receptor: a critical role for metabotropic glutamate receptor 4 (mGlur4). J Neurosci 2000;20:6218-24
  • Fallarino F, Volpi C, Fazio F, et al. Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation. Nat Med 2012;16:897-903
  • Takaki H, Kikuta R, Shibata H, et al. Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (grm8) with schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2004;128B:6-14
  • Corti C, Aldegheri L, Somogyi P, et al. Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGlur4) in the rodent CNS. Neuroscience 2002;110:403-20
  • Tanabe Y, Nomuram A, Masu M, et al. Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGlur3 and mGlur4. J Neurosci 1993;13:1372-8
  • Bradley S, Levey A, Hersch S, et al. Immunocytochemical localization of group iii metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies. J Neurosci 1996;16:2044-56
  • Ohishi H, Akazawa C, Shigemoto R, et al. Distribution of the mrnas for metabotropic glutamate receptors, mGlur4 and mGlur7, in the rat brain. J Comp Neurol 1995;360:555-70
  • Saugstad JA, Kinzie JM, Shinora M. Cloning and expression of rat glutamate receptor 8 reveals a distinct pharmacological profile. Mol Pharmacol 1997;51:119-25
  • Duvoisin R, Zhang C, Ramonell K. A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb. J Neurosci 1995;15:3075-83
  • Malherbe P, Kratzeisen C, Lundstrom K, et al. Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Brain Res Mol Brain Res 1999;67:201-10
  • Shigemoto R, Kinoshita A, Wada A, et al. Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J Neurosci 1997;17:7503-22
  • Fendt M, Burki H, Imobersteg S. The effect of mGlu8 deficiency in animal models of psychiatric disease. Genes Brain Behav 2010;9:33-44
  • Raber J, Duvoisin R, Grueter B, et al. Age-dependent increases in measures of anxiety of mGlur8-/- mice in anxiety tests involving avoidable and inavoidable anxiety-provoking stimuli. Soc Neurosci Annual Meeting 2007; San Diego, CA; 2007
  • Duvoisin R, Villasana L, Pfankuch T, et al. Sex-dependent cognitive phenotype of mice lacking mGlur8. Behav Brain Res 2010;209:21-6
  • Liang KC, Melia KR, Campeau S, et al. Lesions of the central nucleus of the amygdala, but not the paraventricular nucleus of the hypothalamus, block the excitatory effects of corticotropin-releasing factor on the acoustic startle reflex. J Neurosci 1992;12:2313-20
  • Pekhletski R, Gerlai R, Overstreet LS, et al. Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGlur4 subtype of metabotropic glutamate receptor. J Neurosci 1996;16:6364-73
  • Grillon C, Davis M. Fear-potentiated startle conditioning in humans: explicit and contextual cue conditioning following paired versus unpaired training. Psychophysiology 1997;34:451-8
  • Mineka S, Oehlberg K. The relevance of recent developments in classical conditioning to understanding the etiology and maintenance of anxiety disorders. Acta Psychol(Amst) 2008;127:567-80
  • Phelps E, Delgrado M, Nearing K, et al. Extinction learning in humans: role of the amygdala and vmpfc. Neuron 2004;43:897-905
  • Johansen JP, Hamanaka H, Monfils MH, et al. Optical activation of lateral amygdala pyramidal cells instructs associative fear learning. Proc Natl Acad Sci USA 2010;107:12692-7
  • Morgan M, LeDoux J. Contribution of ventrolateral prefrontal cortex to the acquisition and extinction of conditioned fear in rats. Neurobiol Learn Mem 1999;72:244-51
  • Quirk GJ, Garci R, Gonzalez-Lima F. Prefrontal mechanisms in extinction of conditioned fear. Biol Psychiatry 2006;60:337-43
  • Iscru E, Goddyn H, Ahmed T, et al. Improved spatial learning is associated with increased hippocampal but not prefrontal long-term potentiation in mGlur4 knockout mice. Genes Brain Behav 2013;12:615-25
  • Davis M, Duvoisin R, Raber J. Related functions of mGlur4 and mGlur8. Pharmacol Biochem Behav 2013;111:11-16
  • Lin C, Lee C, Huang Y, et al. Activation of group ii metabotropic glutamate receptors induces depotentiation in amygdala slices and reduces fear-potentiated startle in rats. Learn Mem 2005;12:30-137
  • Rush A, Wu J, Rowan M, Anwyl R. Activation of group ii metabotropic glutamate receptors results in long-term potentiation following preconditioning stimulation in the dentate gyrus. Neuroscience 2001;105:335-41
  • Neugebauer V, Keele N, Shinnick-Gallagher P. Loss of long-lasting potentiation mediated by group iii mGlurs in amygdala neurons in kindling-induced epileptogenesis. J Neurophysiol 1997;78:3475-8
  • Neugebauer V, Zinebi F, Russell R, et al. Cocaine and kindling alter the sensitivity of group ii and iii metabotropic glutamate receptors in the central amygdala. Am J Physiol 2000;22:759-70
  • Schrader LA, Tasker JG. Presynaptic modulation by metabotropic glutamate receptors of excitatory and inhibitory synaptic inputs to hypothalamic magnocellular neurons. J Neurophysiol 1997;77:527-36
  • Grueter B, Winder D. Group ii and iii metabotropic glutamate receptors suppress excitatory synaptic transmission in the dorsolateral bed nucleus of the stria terminalis. Neuropsychopharmacology 2005;30:1302-11
  • Campogna M. Distinct properties of presynaptic group ii and iii metabotropic glutamate receptor-mediated inhibition of perforant pathway-CA1 EPSCs. Eur J Neurosci 2004;19:2847-58
  • Wieronska JM, Stachowicz K, Acher F, et al. Opposing efficacy of group iii mGlu receptor activators, lsp1-2111 and amn082, in animal models of positive symptoms of schizophrenia. Psychoparmacology 2012;220(3):481-94
  • Mercier M, Lodge D, Fang G, et al. Characterization of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus. Neuropharmacology 2013;67:294-303
  • Stachowicz K, Klak K, Klodzinska A, et al. Anxiolytic-like effects of phccc, an allosteric modulator of mGlu4 receptors, in rats. Eur J Pharmacol 2004;498:153-6
  • Wieronska JM, Szewszyk B, Palucha A, et al. Anxiolytic action of group ii and group iii metabotropic glutamate receptors agonist involves neuropeptide y in the amygdala. Pharmacol Rep 2005;57:734-43
  • Palucha A, Tatarczynska E, Branski P, et al. Group iii mGlu receptor agonists produce anxiolytic- and antidepressant-like effects after central administration in rats. Neuropharmacology 2004;46:151-9
  • Beurrier C, Lopez S, Revy D, et al. Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism. FASEB J 2009;23:3619-28
  • Wieronska JM, Stachowicz K, Palucha-Poniewiera A, et al. Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABA-ergic systems. Neuropharmacology 2010;59:627-34
  • LePoul E, Campo B, Bolea C, et al. Validating the role of mGlur4 receptors in the pathophysiology of anxiety using selective mGlur4 positive allosteric modulators. Soc Neurosci Annual Meeting 2010; San Diego, CA; 2010. Available from: http://www.addexpharma.com/fileadmin/user_upload/Conference_slideshows/mGluR4_anxiety_Poster_SfN_2010.pdf
  • Campo B. Role of mGlur4 receptors in anxiety disorders. Soc Neurosci Annual Meeting 2010; San Diego, CA; 2010. Available from: http://www.addexpharma.com/fileadmin/user_upload/Conference_slideshows/mGluR4_anxiety_Allost_Modul_Congress_San_Diego2010_V3_.pdf
  • Raber J, Villasana L, Pfankuch T, et al. Opposing roles of mGlur8 in measures of anxiety and social interaction. Soc Neurosci Annual Meeting 2010; San Diego, CA; 2010
  • Linden AM, Bergeron M, Baez M, et al. Systemic administration of the potent mGlu8 receptor agonist (s)-3,4-dcpg induces c-fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice. Neuropharmacology 2003;45:473-83
  • Tye KM, Prakash R, Kim SY, et al. Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature 2011;471:358-62
  • Pape H-C, Pare D. Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear. Phys Rev 2010;90:419-63
  • Milad M, Orr S, Pittman R, et al. Context modulation of memory for fear extinction in humans. Psychophysiology 2005;42:456-64
  • Huff N, Hernandez J, Fecteau M, et al. Revealing context-specific conditioned fear memories with full immersion virtual reality. Front Behav Neurosci 2011;5:75
  • Domino E, French J, Pohorecki R, et al. Further observation on the effects of subhyponotic doses of midazolam in normal volunteers. Psychoparmacol Bull 1989;25:460-5
  • Gupta A, Lind S, Eklund A, et al. The effects of midazolam and flumazenil on psychomotor function. J Clin Anesth 1997;9:21-5
  • Schlegel S, Steinert H, Bockisch A, et al. Decreased benzodiazepine receptor binding in panic disorder measured by iomazenil-spect. A preliminary report. Eur Arch Psychiatry Clin Neurosci 1994;244:49-51
  • Kaschka W, Feistel H, Ebert D. Reduced benzodiazepine receptor binding in panic disorder measured by iomazenil spect. J Psychiatr Res 1995;29:427-34
  • Roy-Byrne P, Wingerson D, Radant A, et al. Reduced benzodiazepine sensitivity in patients with panic disorder: comparison with patients with obsessive-compulsive disorder and normal subjects. Am J Psychiatry 1996;153:1444-9
  • Glue P, Nutt D. Benzodiazepine receptor sensitivity in panic disorder. Lancet 1991;337:563
  • Cowley D, Ha E, Roy-Byrne P. Determinants of pharmacologic treatment in panic disorder. J Clin Psychiatry 1997;58:555-61
  • Malizia A, Cunningham V, Bell C, et al. Decreased GABA (a)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study. Arch Gen Psychiatry 1998;55:715-20
  • Bremner J, Innis R, Southwick S, et al. Decreased benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder. Am J Psychiatry 2000;157:1120-6
  • Woods J, Katz J, Winger G. Benzodiazepines: use, abuse, and consequence. Pharmacol Rev 1992;44:151-347
  • Grynpore R, Mitenko P, Sitar D, et al. Drug-associated hospital admissions in older medical patients. J Am Geriatr Soc 1988;36:1092-8
  • Sangha S, Narayanan R, Bergado-Acosta J, et al. Deficiency of the 65 kda isoform of glutamic acid decarboxylase impairs extinction of cued but not contextual fear memory. J Neurosci 2009;29:15713-20
  • Horvath S, Zhang B, Carlson M, et al. Analysis of oncogenic signaling networks in glioblastoma indentifies aspm as a molecular target. Proc Natl Acad Sci USA 2006;103:17402-7
  • Langfelder P, Horvath S. Wgcna: an r package weighed correlation network analysis. BMC Bioinformatics 2008;9:559
  • Iancu O, Darakjian P, Walter N, et al. Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross mouse. BMC Genomics 2011;11:585
  • Anagnostaras S, Wood S, Shuman T, et al. Automated assessment of Pavlovian conditioned freezing and shock reactivity in mice using the video freeze system. Front Beahv Neurosci 2010;4:1-11

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