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Drugs under early investigation for the treatment of bipolar disorder

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Bibliography

  • National Institute for Health and Care Excellence (NICE). Bipolar disorder: the assessment and management of bipolar disorder in adults, children and young people in primary and secondary care. NICE clinical guideline 185. September 2014
  • Krishnan KR. Psychiatric and medical comorbidities of bipolar disorder. Psychosom Med 2005;67(1):1–8
  • Miura T, Noma H, Furukawa TA, et al. Comparative efficacy and tolerability of pharmacological treatments in the maintenance treatment of bipolar disorder: a systematic review and network meta-analysis. Lancet Psychiatry 2014;1(5):351–9
  • Bauer M, Glenn T, Alda M, et al. Drug treatment patterns in bipolar disorder: analysis of long-term self-reported data. Int J Bipolar Disord 2013;1:5
  • Weinstock LM, Gaudiano BA, Epstein-Lubow G, et al. Medication burden in bipolar disorder: a chart review of patients at psychiatric hospital admission. Psychiatry Res 2014;216:24–30
  • Judd JL, Akiskal HS, Schettler PJ, et al. The long-term natural history of the weekly symptomatic status of bipolar I disorder. Arch Gen Psychiatry 2002;59:530–7
  • Judd JL, Akiskal HS, Schettler PJ, et al. A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar II disorder. Arch Gen Psychiatry 2003;60:261–9
  • MacQueen GM, Young LT, Joffe RT. A review of psychosocial outcome in patients with bipolar disorder. Acta Psychiatr Scand 2001;103:163–70
  • Burdick KE, Braga RJ, Goldberg JF, et al. Cognitive dysfunction in bipolar disorder. CNS Drugs 2007;21(12):971–81
  • Angst J, Azorin J-M, Bowden CL, et al. Prevalence and characteristics of undiagnosed bipolar disorders in patients with a major depressive episode: the BRIDGE study. Arch Gen Psychiatry 2011;68(8):791–9
  • Hoertel N, Strat YL, Angst J, et al. Subthreshold bipolar disorder in a U.S. national representative sample: prevalence, correlates and perspectives for psychiatric nosography. J Affect Disord 2013;146(3):338–47
  • ClinicalTrials.gov. A service of the U.S. National Institutes of Health. Available from: www.clinicaltrials.gov [Last assessed 10 November 2014]
  • European Union Clinical Trials Register. Available from: www.clinicaltrialsregister.eu/ctr-search/search [Last assessed 10 November 2014]
  • International Clinical Trials Registry Platform. Available from: www. apps.who.int/trialsearch/Default.aspx [Last assessed 10 November 2014]
  • Center Watch. Available from: www.centerwatch.com/clinical-trials/listings [Last assessed 10 November 2014]
  • Verrotti A, Loiacono G, Rossi A, et al. Eslicarbazepine acetate: an update on efficacy and safety in epilepsy. Epilepsy Res 2014;108(1):1–10
  • Nunes T, Almeida L, Costa R, et al. Efficacy, safety and tolerability of eslicarbazepine acetate in the recurrence prevention of bipolar I disorder: BIA-2093-205 phase II extension study. J Neurol Sci 2013;333(1):42
  • Keck PEJr, Hsu HA, Papadakis K, et al. Memantine efficacy and safety in patients with acute mania associated with bipolar I disorder: a pilot evaluation. Clin Neuropharmacol 2009;32(4):199–204
  • Anand A, Gunn AD, Barkay G, et al. Early antidepressant effect of memantine during augmentation of lamotrigine inadequate response in bipolar depression: a double-blind, randomized, placebo-controlled trial. Bipolar Disord 2012;14(1):64–70
  • Koukopoulos A, Serra G, Koukopoulos AE, et al. The sustained mood-stabilizing effect of memantine in the management of treatment resistant bipolar disorders: findings from a 12-month naturalistic trial. J Affect Disord 2012;136(1-2):163–6
  • Lee SY, Chen SL, Chang YH, et al. Add-on memantine to valproate treatment increased HDL-C in bipolar II disorder. J Psychiatr Res 2013;47(10):1343–8
  • Sarris J, Mischoulon D, Schweitzer I. Omega-3 for bipolar disorder: meta-analyses of use in mania and bipolar depression. J Clin Psychiatry 2012;73(1):81–6
  • Carlezon WA, Pliakas AM, Parow AM, et al. Antidepressant-like effects of cytidine in the forced swim test in rats. Biol Psychiatry 2002;51(11):882–9
  • Yoon SJ, Lyoo IK, Haws C, et al. Decreased glutamate/glutamine levels may mediate cytidine’s efficacy in treating bipolar depression: a longitudinal proton magnetic resonance spectroscopy study. Neuropsychopharmacology 2009;34(7):1810–18
  • Murphy BL, Stoll AL, Harris PQ, et al. Omega-3 fatty acid treatment, with or without cytidine, fails to show therapeutic properties in bipolar disorder: a double-blind, randomized add-on clinical trial. J Clin Psychopharmacol 2012;32(5):699–703
  • Stoll AL, Severus WE, Freeman MP, et al. Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial. Arch Gen Psychiatry 1999;56(5):407–12
  • Schaffer LC, Schaffer CB, Miller AR, et al. An open trial of pregabalin as an acute and maintenance adjunctive treatment for outpatients with treatment resistant bipolar disorder. J Affect Disord 2013;147:407–10
  • Toyoda A, Iio W. Antidepressant-like effect of chronic taurine administration and its hippocampal signal transduction in rats. Adv Exp Med Biol 2013;775:29–43
  • Oja SS, Saransaari P. Taurine and epilepsy. Epilepsy Res 2013;104(3):187–94
  • Goldstein I, Levy T, Galili D, et al. Involvement of Na(+), K(+)-ATPase and endogenous digitalis-like compounds in depressive disorders. Biol Psychiatry 2006;60(5):491–9
  • Mukai T, Kishi T, Matsuda Y, et al. A meta-analysis of inositol for depression and anxiety disorders. Hum Psychopharmacol 2014;29(1):55–63
  • Chengappa KN, Levine J, Gershon S, et al. Inositol as an add-on treatment for bipolar depression. Bipolar Disord 2000;2(1):47–55
  • Eden Evins A, Demopulos C, Yovel I, et al. Inositol augmentation of lithium or valproate for bipolar depression. Bipolar Disord 2006;8(2):168–74
  • Salloway S, Sperling R, Keren R, et al. A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease. Neurology 2011;77(13):1253–62
  • Grunze H, Almeida L, Nunes T, et al. Efficacy and safety of eslicarbazepine acetate in acute manic episodes associated with bipolar I disorder: BIA-2093-203 phase II study results. J Neurol Sci 2013;333(1):42
  • Cohen BM, Murphy B. The effects of pentazocine, a kappa agonist, in patients with mania. Int J Neuropsychopharmacol 2008;11(2):243–7
  • Effects of pentazocine on manic symptoms. Available from: www. clinicaltrials.gov/ct2/show/results/NCT00125931 [Last Accessed 10 November 2014]
  • Effects of Pentazocine versus lorazepam or placebo on manic symptoms. Available from: www. clinicaltrials.gov/ct2/show/results/NCT00431184?term=pentazocine&rank=1 [Last accessed 10 November 2014]
  • Ghanizadeh A, Hedayati A. Augmentation of fluoxetine with lovastatin for treating major depressive disorder, a randomized double-blind placebo controlled-clinical trial. Depress Anxiety 2013;30(11):1084–8
  • Ghanizadeh A, Omrani Sigaroodi M, et al. Lovastatin as an adjuvant to lithium for treating manic phase of bipolar disorder: a 4-week, randomized, double-blind, placebo-controlled clinical trial. Depress Res Treat 2014;2014:730505
  • Gao Y, Payne RS, Schurr A, et al. Memantine reduces mania-like symptoms in animal models. Psychiatry Res 2011;188(3):366–71
  • Faridhosseini F, Sadeghi R, Farid L, et al. Celecoxib: a new augmentation strategy for depressive mood episodes. A systematic review and meta-analysis of randomized placebo-controlled trials. Hum Psychopharmacol 2014;29(3):216–23
  • Efficacy of celecoxib as an adjunct in the treatment of bipolar disorder: A double blind and placebo controlled trial. Available from: www. irct.ir/searchresult.php?keyword=fibrinogen&id=1556&field=&number=53&prt=69&total=5&m=1 [Last accessed 10 November 2014]
  • Citrome L. Cariprazine in bipolar disorder: clinical efficacy, tolerability, and place in therapy. Adv Ther 2013;30(2):102–13
  • Forest Laboratories, Inc. and Gedeon Richter Plc. Forest Laboratories, Inc. and Gedeon Richter Plc. Announce positive phase IIb topline results for cariprazine for the treatment of bipolar depression. Available from: www. news.frx.com/press-release/r-and-d-news/forest-laboratories-inc-and-gedeon-richter-plc-announce-positive-phase–0 [Last accessed 10 November 2014]
  • Zarate CAJr, Quiroz JA, Singh JB, et al. An open-label trial of the glutamate modulating agent riluzole in combination with lithium for the treatment of bipolar depression. Biol Psychiatry 2005;57:430–2
  • Brennan BP, Hudson JI, Jensen JE, et al. Rapid enhancement of glutamatergic neurotransmission in bipolar depression following treatment with riluzole. Neuropsychopharmacology 2010;35(3):834–46
  • Chakrabarti S. Thyroid functions and bipolar affective disorder. J Thyroid Res 2011;2011:306367
  • Stamm TJ, Lewitzka U, Sauer C, et al. Supraphysiologic doses of levothyroxine as adjunctive therapy in bipolar depression: a randomized, double-blind, placebo-controlled study. J Clin Psychiatry 2014;75(2):162–8
  • Brennan BP, Jensen JE, Hudson JI, et al. A placebo-controlled trial of acetyl-L-carnitine and α-lipoic acid in the treatment of bipolar depression. J Clin Psychopharmacol 2013;33(5):627–35
  • Fornaro M, McCarthy MJ, De Berardis D, et al. Adjunctive agomelatine therapy in the treatment of acute bipolar II depression: a preliminary open label study. Neuropsychiatr Dis Treat 2013;9:243–51
  • Berk M, Copolov DL, Dean O, et al. N-acetyl cysteine for depressive symptoms in bipolar disorder – a double-blind randomized placebo-controlled trial. Biol Psychiatry 2008;64(6):468–75
  • Berk M, Dean O, Cotton SM, et al. The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: an open label trial. J Affect Disord 2011;135:389–94
  • Repligen Corp. Repligen announces plans to initiate a phase 2b trial for RG2417 in bipolar disorder. Available from: www.medicalnewstoday.com/articles/111085.php [Last accessed at 10 November 2014]
  • Asenapine for bipolar depression. Available from: www. clinicaltrials.gov/ct2/show/NCT01807741?term=NCT01807741&rank=1 [Last accessed 10 November 2014]
  • Ostacher MJ, Iosifescu DV, Hay A, et al. Pilot investigation of isradipine in the treatment of bipolar depression motivated by genome-wide association. Bipolar Disord 2014;16(2):199–203
  • Rahola JG. Somatic drugs for psychiatric diseases: aspirin or simvastatin for depression? Curr Neuropharmacol 2012;10(2):139–58
  • While A, Keen L. The effects of statins on mood: a review of the literature. Eur J Cardiovasc Nurs 2012;11(1):85–96
  • Desbonnet L, Garrett L, Clarke G, et al. Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience 2010;170(4):1179–88
  • Logan AC, Katzman M. Major depressive disorder: probiotics may be an adjuvant therapy. Med Hypotheses 2005;64(3):533–8
  • Miskowiak KW, Vinberg M, Harmer CJ, et al. Effects of erythropoietin on depressive symptoms and neurocognitive deficits in depression and bipolar disorder. Trials 2010;11:97
  • Miskowiak KW, Ehrenreich H, Christensen EM, et al. Recombinant human erythropoietin to target cognitive dysfunction in bipolar disorder: a double-blind, randomized, placebo-controlled phase 2 trial. J Clin Psychiatry 2014;75(12):1347–55
  • Young AH, Gallagher P, Watson S, et al. Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder. Neuropsychopharmacology 2004;29(8):1538–45
  • Watson S, Gallagher P, Porter RJ, et al. A randomized trial to examine the effect of mifepristone on neuropsychological performance and mood in patients with bipolar depression. Biol Psychiatry 2012;72(11):943–9
  • Kluge M, Hegerl U, Sander C, et al. Methylphenidate in mania project (MEMAP): study protocol of an international randomised double-blind placebo-controlled study on the initial treatment of acute mania with methylphenidate. BMC Psychiatry 2013;13:71
  • Dell’Osso B, Ketter TA. Use of adjunctive stimulants in adult bipolar depression. Int J Neuropsychopharmacol 2013;16(1):55–68
  • Li D, Herrera S, Bubula N, et al. Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation. J Neurochem 2011;118:237–47
  • Arey R, McClung CA. An inhibitor of casein kinase 1 ϵ/δ partially normalizes the manic-like behaviors of the ClockΔ19 mouse. Behav Pharmacol 2012;23(4):392–6
  • Posser T, Kaster MP, Baraúna SC, et al. Antidepressant-like effect of the organoselenium compound ebselen in mice: evidence for the involvement of the monoaminergic system. Eur J Pharmacol 2009;602(1):85–91
  • Singh N, Halliday AC, Thomas JM, et al. A safe lithium mimetic for bipolar disorder. Nat Commun 2013;4:1332
  • Gould TD, Zarate CA, Manji HK. Glycogen synthase kinase-3: a target for novel bipolar disorder treatments. J Clin Psychiatry 2004;65(1):10–21
  • Gould TD, Einat H, Bhat R, et al. AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int J Neuropsychopharmacol 2004;7:387–90
  • O’Brien WT, Harper AD, Jové F, et al. Glycogen synthase kinase-3β haploinsufficiency mimics the behavioral and molecular effects of lithium. J Neurosci 2004;24:6791–8
  • Du J, Wei Y, Liu L, et al. A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. Proc Natl Acad Sci USA 2010;107(25):11573–8
  • Chen W, Gaisina I, Gunosewoyo H, et al. Structure-guided design of a highly selective glycogen synthase kinase-3β inhibitor: a superior neuroprotective pyrazolone showing antimania effects. ChemMedChem 2011;6(9):1587–92
  • Kalinichev M, Dawson LA. Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania. Int J Neuropsychopharmacol 2011;14(8):1051–67
  • Schroeder FA, Lewis MC, Fass DM, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests. PLoS One 2013;8(8):e71323
  • Steckert AV, Valvassori SS, Varela RB, et al. Effects of sodium butyrate on oxidative stress and behavioral changes induced by administration of D-AMPH. Neurochem Int 2013;62(4):425–32
  • Stertz L, Fries GR, Aguiar BW, et al. Histone deacetylase activity and brain-derived neurotrophic factor (BDNF) levels in a pharmacological model of mania. Rev Bras Psiquiatr 2014;36(1):39–46
  • Moretti M, Valvassori SS, Varela RB, et al. Behavioral and neurochemical effects of sodium butyrate in an animal model of mania. Behav Pharmacol 2011;22(8):766–72
  • Resende WR, Valvassori SS, Réus GZ, et al. Effects of sodium butyrate in animal models of mania and depression: implications as a new mood stabilizer. Behav Pharmacol 2013. [Epub ahead of print]
  • Valvassori SS, Varela RB, Arent CO, et al. Sodium butyrate functions as an antidepressant and improves cognition with enhanced neurotrophic expression in models of maternal deprivation and chronic mild stress. Curr Neurovasc Res 2014;11(4):359–66
  • Dencker D, Dias R, Pedersen ML, et al. Effect of the new antiepileptic drug retigabine in a rodent model of mania. Epilepsy Behav 2008;12:49–53
  • Kristensen LV, Sandager-Nielsen K, Hansen HH. K(v) 7 (KCNQ) channel openers normalize central 2-deoxyglucose uptake in a mouse model of mania and increase prefrontal cortical and hippocampal serine-9 phosphorylation levels of GSK3β. J Neurochem 2012;121(3):373–82
  • Etain B, Lajnef M, Bellivier F, et al. Clinical expression of bipolar disorder type I as a function of age and polarity at onset: convergent findings in samples from France and the United States. J Clin Psychiatry 2012;73(4):e561–6
  • Samalin L, Llorca PM, Giordana B, et al. Residual symptoms and functional performance in a large sample of euthymic bipolar patients in France (the OPTHYMUM study). J Affect Dis 2014;159:94–102
  • Vieta E, Günther O, Locklear J, et al. Effectiveness of psychotropic medications in the maintenance phase of bipolar disorder: a meta-analysis of randomized controlled trials. Int J Neuropsychopharmacol 2011;14(8):1029–49
  • Osterberg L, Blaschke T. Adherence to medication. N Engl J Med 2005;353:487–97
  • Alsaif M, Haenisch F, Guest PC, et al. Challenges in drug target discovery in bipolar disorder. Expert Opin Ther Targets 2013;17(5):565–77
  • Hoertel N, de Maricourt P, Gorwood P. Novel routes to bipolar disorder drug discovery. Expert Opin Drug Discov 2013;8(8):907–18
  • Lu RB, Chen SL, Lee SY, et al. Neuroprotective and neurogenesis agent for treating bipolar II disorder: add-on memantine to mood stabilizer works. Med Hypotheses 2012;79(2):280–3
  • Balanzá-Martínez V, Fries GR, Colpo GD, et al. Therapeutic use of omega-3 fatty acids in bipolar disorder. Expert Rev Neurother 2011;11(7):1029–47
  • Li X, Jope RS. Is glycogen synthase kinase-3 a central modulator in mood regulation? Neuropsychopharmacology 2010;35:2143–54
  • Norris ER, Karen Burke Correll JR, et al. A double-blind, randomized, placebo-controlled trial of adjunctive ramelteon for the treatment of insomnia and mood stability in patients with euthymic bipolar disorder. J Affect Disord 2013;144(1-2):141–7
  • Durgam S, Starace A, Li D, et al. The efficacy and tolerability of cariprazine in acute mania associated with bipolar I disorder: a phase II trial. Bipolar Disord 2014;17(1):63–75
  • Sanches M, Bauer IE, Galvez JF, et al. The management of cognitive impairment in bipolar disorder: current status and perspectives. Am J Ther 2014; Epub ahead of print
  • Nestler EJ, Hyman SE. Animal models of neuropsychiatric disorders. Nat Neurosci 2010;13(10):1161–9
  • Bouaziz M, Ambroise C, Guedj M. Accounting for population stratification in practice: a comparison of the main strategies dedicated to genome-wide association studies. PLoS One 2011;6(12):e28845
  • Soreca I, Fagiolini A, Frank E, et al. Relationship of general medical burden, duration of illness and age in patients with bipolar I disorder. J Psychiatr Res 2008;42(11):956–61
  • Hoertel N, Le Strat Y, Lavaud P, et al. Generalizability of clinical trial results for bipolar disorder to community samples. J Clin Psychiatry 2013;74(3):265–70

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