7
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Section Review: Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Development of NSAIDs with reduced gastrointestinal and renal toxicity

, &
Pages 613-619 | Published online: 03 Mar 2008

References

  • GARNER A: Adaptation in the pharmaceutical industry, with particular reference to gastrointestinal drugs and diseases. Scand. J. Gastroentera (1992) 27\(Suppl. 193):83–89
  • SOIL AH, WEINSTEIN WM, KURATA J, MCCARTHY D: Nonsteroidal anti-inflammatory drugs and peptic ulcer disease. Ann. Intern. Med. (1991) 114:307-319. A comprehensive review of the pathogenesis, epidemiology and treatment of NSAID-related gastrointestinal damage.
  • SEGASOTHY M, SAMAD SA, ZULFIGAR A, BENNETT Di7M: Chronic renal disease and papillary necrosis associated with the long-term use of nonsteroidal anti-inflamma-tory drugs as the sole or predominant analgesic. Am.J. Kidney Dis. (1994) 24:17–24.
  • VANE JR: Inhibition of prostaglandin synthesis as a •meclhanism of action for aspirin-like drugs. Nature NewBiol. (1971) 231: 232-235. First report of the effects of NSAIDs on prostaglandin synthesis, and the suggestion that this would account for both the desired and toxic effects of this class of drugs.
  • WALLACE JL, TIGLEY AW: New insights into prostagland-ins and mucosal defence. Aliment. Pharmacol. Ther. (1995) 9. In press.
  • GRAHAM DY: The relationship between nonsteroidal anti-inflammatory drug use and peptic ulcer disease. Gastroenterol. Clinics N. Amer. (1990) 19:171–182.
  • WALLACE JL: Gastric ulceration: Critical events at theneutrophil-endothelium interface. Can.J. Physiol. Phar-macol, (1993) 71:98–102.
  • WALLACE JL, KEENAN CM, GRANGER DN: Gastric ulcera- tion induced by nonsteroidal anti-inflammatory drugs Is a neutrophil-dependent process. Am. J. Physiol. (1990) 259:G462-G467. First demonstration that neutropenic rats were very resistant to the gastric damaging actions of NSAIDs.
  • LEE M, LEE AK, FELDMAN M: Aspirin-induced acutegastric mucosal injury is a neutrophil-dependent proc-ess in rats. Am. J. Physiol. (1992) 263: G920–G926.
  • WALLACE JL, ARFORS K-E, MCKNIGHT GW: A monockmal antibody against the CD18 leukocyte adhesion mole-cule prevents indomethacin-induced gastric damage in the rabbit. Gastroenterology (1991) 100:878-883. First demonstration that prevention of leukocyte adherence to the vascular endothelium resulted in prevention of NSAID-induced gastric damage.
  • WALLACE JL, MCKNIGHT W, MIYASAKA M, TAMATANI T,PAULSON J, ANDERSON DC, GRANGER DN, KUBES P: Role of endothelial adhesion molecules in NSAID-induced gastric mucosal injury. Am. J. Physiol. (1993) 265:G993–G998.
  • KITAHORA T, GUTH PH: Effect of aspirin plus hydro-chloric acid on the gastric mucosal microcirculation. Gastroenterology (1987) 93:810-817. First report identifying leukocyte adherence to the vascular endothe-lium in the gastric microcirculation as an early event following administration of aspirin.
  • ASAKO H, KUBES P, WALLACE JL, GAGINELLA T, WOLF RE,GRANGER DN: Indomethacin-induced leukocyte adhe-sion in mesenteric venules: role of lipoxygenase prod-ucts. Am. J. Physiol. (1992) 262:G903–G908.
  • ASAKO H, KUBES P, WALLACE JL, WOLF RE, GRANGER DN: Modulation of leukocyte adhesion to rat mesenteric venules by aspirin and salicylate. Gastroenterology (1992) 103:146-152. This paper demonstrated the ability of aspirin to cause leukocytes to adhere to the vascular endothelium of mesenteric venules. Salicylate, on the other hand, did not cause leukocyte adherence.
  • WALLACE JL, MCCAlTht,RTY D-M, CARTER L, MCKNIGHT W,ARGENTIERI D: Tissue-selective inhibition of pro-staglandin synthesis in rat by tepoxalin: anti-inflamma-tory without gastropathy. Gastroenterology (1993) 105:1630–1636.
  • ANDREWS FJ, MALCONTENTI-WILSON C, O'BRIEN PE: Ef- fect of nonsteroidal anti-inflammatory drugs on LFA-1 and IC.AM-1 expression in gastric mucosa. Am.J. Physiol. (1994) 266: G657-G664. This paper demonstrated very rapid up-regulation of adhesion molecule expression on the vascular endothelium of gastric blood vessels following NSAID administration.
  • WALLACE JL, GRANGER DN: The pathogenesis of NSAID- gastropathy - are neutrophils the culprits? Trends Phar-macol. Sci. (1992) 13:129–131.
  • ASHLEY SW, SONNENSCHEIN LA, CHEUNG LY: Focal gas-tric mucosal blood flow at the site of aspirin-induced ulceration. Am. J. Surg. (1985) 149:53–59.
  • GANA TJ, HUHLEWYCH R, KOO J: Focal gastric mucosal blood flow in aspirin-induced ulceration. Ann. SuT. (1987) 203:399-403. 12.
  • JACKSON BA, GOLDSTEIN RH, ROY R, COZZANI M, TAY-LOR L, POLGAR P: Effects of transforming growth fac-tor-II and interleukin-113 on expression of cyclooxygenase 1 and 2 and phospholipase Az mRNA In lung fibroblasts and endothelial cells in culture. Biochem. Biophys. Res. Commun. (1993) 197:1465–1474.
  • MARTIN M, NEUMANN D, HOFF T, RESCH K, DEMI]. i DL,GOPPELT-STRUEBE M: Interleulcin-1-induced cyclooxy-genase 2 expression is suppressed by cyclosporin A in rat mesangial cells. Kidney Int. (1994) 45:150–158.
  • HEMPEL SL, MONICK MM, HUNNINGHAKE GW: Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes. j Clin. Invest. (1994) 93:391–396.
  • LYONS-GIORDANO B, PRAITA MA, GALBRAITH W, DAVIS GL, ARNER EC: Interleukin-1 differentially modulates chondrocyte expression of cyclooxygenase-2 and phospholipase Az. Exp. Cell. Res. (1993) 206:58–62.
  • HABIB A, CRÉMINON C, FROBERT Y, GRASSI J, PRADELLES P, MACLOUF J: Demonstration of an inducible cyclooxy-genase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cy-clooxygenase-2.J. Biol. Chem. (1993) 268:23448–23454.
  • VANE JR, MITCHELL JA, APPLETON I, TOMLINSON A, BISHOP-BAILEY D, GROXTALL J, WILLOUGHBY DA: In-ducible isofortns of cyclooxygenase and nitric oxide synthase in inflammation. Proc. Natl. Acad. Sci. USA (1994) 91:2046-2050. This paper demonstrates the time-course of induction of COX-2 and inducible nitric oxide synthase at sites of inflammation.
  • 'CIE W, ROBERTSON DL, SIMMONS DL: Mitogen-inducible prostaglandin G/H synthase: A new target for non-steroidal anti-inflammatory drugs. Drug Dev. Res. (1992) 25:249–265.
  • MITCHELL JA, AKARASEREENONT P, THIEMERMANN C,FLOWER RJ, VANE JR: Selectivity of nonsteroklal anti-in-flammatory drugs as inhibitors of constitutive and indudble cyclooxygenase. Proc. Natl. Acad. Sci. USA (1993) 90:11693–11697.
  • MEADE EA, SMITH WL, DEWITT DL: Differential inhibi-tion of prostaglandin endoperoxide synthase (cy-clooxygenase) isozymes by aspirin and other non-steroidal anti-bzflaaunatory drugs. J. Biol. Chem. (1993) 268:6610–6614.
  • MASFERRER JL, ZWEIFEL BS, MANNING PT, HAUSER SD, LEAHY KM, SMITH WG, ISAICSON PC, SEIBERT K: Selective inhibition of inducible cyclooxygenase 2 in vivo is anti-inflammatory and nonulcerogenic. Proc Nall Acad Sci. USA (1994) 91:3228-3232. This paper was the first full report of the effects of a selective COX-2 inhibitor with respect to both anti-inflammatory effects and safety in the gastrointestinal tract.
  • CHAN CC, GORDON R, BR1DEAU C, RODGER IW, LI CS,PRASIT P, TAGARI P, ETURER D, VICKERS P, BOYCE S, RUPNIAK N, WEBB J, HILL R, FORD-HUTCHINSON AW: In vivo pharmacology of L-745,337: a novel non-steroidal anti-inflammatory agent (NSAID) with an ulcerogenic sparing effect In rat and monkey stomach. Can. J. Physiol. Pharmacol. (1994) 72:266.
  • ELLIOTT SN, MCKNIGHT W, CIRINO G, WALLACE JL: A nitric oxide-releasing NSAID accelerates gastric ulcer healing in rats. Gastroenterology (1995). In press. Demonstrates that a nitric oxide-releasing NSAID accelerates ulcer healing. Also demonstrates that a 'selective' COX-2 inhibitor mark-edly suppresses COX-1 activity in vivo when given at anti-inflamma-tory doses.
  • WU ECK, SANDUJA AR, TSAI A, FERHANOGLU B, LOOSE-MITCHELL DS: Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endo-thelial cells. Proc. Natl. Acad. Sci. (1991) 88:2384-2387. A very important paper demonstrating that COX-1 can be induced and its levels in endothelial cells greatly increased by exposure to interleukin-1. Furthermore, salicylic acid appears to be capable of inhibiting this induction of COX-I.
  • SLATER DM, BERGER LC, NEWTON R, MOORE GE, BEN- •NETT PR: Expression of cyclooxygenase types 1 and 2In human fetal membranes at term. Am. J. Obstet. Gyne-col. (1995) 172:77-82. Demonstrates an apparent physiological role for cyclooxygenase-2 in the onset and maintenance of labour.
  • STADLER P, ARMSTRONG D, MARGALITH D, SARAGA E,STOLTE M, LUALDI P, MAUTONE G, LOUIS A: Diclofenac delays healing of gastroduodenal mucosal lesions. Dou-ble-blind, placebo-controlled endoscopic study in healthy volunteers. Dig. Dis. Sci. (1991) 36:594–600.
  • MATSUDA K, SAKAMOTO C, MIZUNO H, NOGUCHI H, MATOZAKI T, WADA K, UCHIDA T, KONDA Y, KASUGA M: Gene expression of cyclooxygenase and EGF-like growth factors in different stages of the mouse gastric ulcer. Gastroenterology (1994) 106:A132.
  • KAWAHITO Y, SANO H, MUKAI S, ASAI K, KIMURA S, YAMAMURA Y, KATO H, HLA T, KONDO M: Detection of cyclooxygenase-1 and -2-proteins and mRNA in gastric ulcer. Pathophysiology (1994) 1:288.
  • WHITTLE BJR: Temporal relationship between cy-clooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethadn in the rat. Gastroenterology (1981) 80:94–98.
  • PATRONO C: Aspirin as an antiplatelet drug. New EngLJ Med. (1994) 330:1287–1294.
  • WALLACE JL, REUTER B, CICALA C, MCKNIGHT W, •GRISHAM MB, CIRINO G: Novel nonsteroidal anti-inflam-matory drug derivatives with markedly reduced ukero-genic properties in the rat. Gastroenterology (1994) 107:173-179. First demonstration of the lack of gastrointestinal damage by nitric oxide-releasing NSAIDs, despite significant anti-inflammatory ef-fects.
  • WALLACE JL, REUTER B, CICALA C, MCKNIGHT W, GRISHAM MB, CIRINO G: A diclofenac derivative without uicerogenic properties. Eur.J. Pharmacol. (1994) 257:249–255.
  • REUTER BK, CIRINO G, WALLACE JL: Markedly reduced intestinal toxicity of a diclofenac derivative. Life Sci. (1994) 55:PL1-PL8. This paper demonstrated the lack of intestinal damage by a nitric oxide-releasing NSAID in a model of pre-existing intestinal inflam-mation.
  • MITCHELL JA, CIRINO G, AKARASEREENONT P, WALLACEJL, FLOWER RJ, VANE JR: Flurbinitroxybutylester: a novel anti-inflammatory drug devoid of uleerogenic activity, Inhibits cyclooxygenase-1 and cyclo-oxgenase-2. Can. J. Physiol. Pharmacol. (1994) 72:270.
  • WALLACE JL, KEENAN CM, GALE D, SHOUPE TS: Exacer-bation of experimental colitis by nonsteroidal anti-in-flammatory drugs is not related to elevated leukotriene 84 synthesis. Gastroenterology (1992) 101:18–27
  • WALLACE JL, MCKNIGHT W, DEL SOLDATO P, CIMINO G:Anti-thrombotic effects of a nitric oxide-generating, gastric-sparing aspirin derivative. Manuscript submitted.
  • THE SALT COLLABORATIVE GROUP: Swedish Aspirin Low-Dose Trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events. Lancet (1991) 338:1345–1349.
  • MEADE TW, RODERICK PJ, BRENNAN PJ, WILKES HC, KELLEHER CC: Fxtracranial bleeding and other symp-toms due to low dose aspirin and low intensity oral anticoagulation. Thromb. Haemost. (1992) 68:1–6.
  • CRYER B, LUK G, FELDMAN M: Effects of very low dosesof aspirin (ASA) on gastric, duodenal & rectal pro-staglandins (PGs) and mucosal injury. Gastroenterology (1995) 108:A77 (Abstract).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.