Clinical Trials Report: Cardiovascular & Renal: Clinical trials in progress with antihypertensive therapy

References

• SHEP COOPERATIVE RESEARCH GROUP: Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final re-sults of the Systolic Hypertension in the Elderly Pro-gram. JAMA (1991) 265:3255–3264.
   PubMed Web of Science ®Google Scholar
• DAHLCIF B, LINDHOLM LH, HANSSON L, SCHERSTEN B, EKBOM T, WESTER P-0: Morbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension). Lancet (1991) 338:1281–1285.
   PubMed Web of Science ®Google Scholar
• MRC WORKING PARTY: Medical Research Council trialof treatment of hypertension in older adults: principal results. Br. Med. J. (1992) 304:405–412.
   PubMed Web of Science ®Google Scholar
• ZANCHETTI A: A re-examination of stepped-care: a ret-rospective and a prospective. J. Cardiovasc. Pbarmacol. (1985) 7\(Suppl. 2):8126–8131.
   Google Scholar
• THE 1988 JOINT NATIONAL COMMIII EE: The 1988 report of the Joint National Committee on Detection, Evalu-ation and Treatment of High Blood Pressure. Arch. Intern. Med. (1988) 148:1023–1028.
   Google Scholar
• THE JOINT NATIONAL commri LEE: The fifth report ofthe Joint National Committee on Detection, Evaluation and Treatment of High Blood Pressure (JNC V). National Institutes of Health Publication (Oct. 30, 1992):1–53.
   Google Scholar
• SEVER P, BEEVRS G, BLTLPITT C, LEVER A, RAMSAY L, REIDJ, ET AL.: Management guidelines in essential hyperten-sion: report of the Second Working Party of the British Hypertension Society. Br. Med. J. (1993) 306:983–987.
   Google Scholar
• JACKSON R, BARHAM P, BILLS J, BIRCH T, MCLENNAN L,MACMAHON S, MAL1NG T: Management of raised blood pressure in New Zealand: a discussion document. Br. Med. J. (1993) 307:107–110.
   PubMed Web of Science ®Google Scholar
• SWEDISH-NORWEGIAN EXPERT GROUP: Treatment ofhypertension lathe elderly (2 70 years). Blood Pressure (1994) 3:219–222.
   PubMedGoogle Scholar
• ZANCHETTI A, CHALMERS J, ARAKAWA K, GYARFAS I,HAMET P, HANSSON L, JULIUS S, MACMAHON S, MANCIA G, MENARD J, OMAE T, REID J, SAFAR M: The 1993 guidelines for the management of mild hypertension: Memorandum from a WHO/ISH meeting. Blood Pressure (1993) 2:86–100.
   PubMedGoogle Scholar
• COLLINS R, PETO R, MACMAHON S, HEBERT P, FIEBACHNH, EBERLEIN KA, GODWIN J, QIZILBASH N, TAYOR JO, HENNEKENS CH: Blood pressure, stroke, and coronary heart disease. Part 2, short-term reductions in blood pressure: over-view of randomised drug trials in their epidemiological context. Lancet (1990) 335:827–838.
   Google Scholar
• LINDHOLM L, EJLERTSSON G, SCHERSTEN B: High risk ofcerebro-cardiovascular morbidity in well treated male hypertensives. A retrospective study of 40-59-year-old hypertensives in a Swedish primary care district. Acta Med. Scand. (1984) 216:251–259.
   Google Scholar
• SAMUELSSON 0: Hypertension in middle-aged men. Management, morbidity and prognostic factors during long-term hypertensive care. Acta Med. Scand. (1985) 218\(Suppl. 702):1–79.
   Google Scholar
• ISLES CG, WALKER LM, BEEVERS DG, BROWN I, CAMERONFE, CLARKE J, HAWTHORNE V, HOLE D, LEVER AF, ROBERTSON JWK, WAPSHAW JP: Mortality in patients of the Glasgow Blood Pressure Clinic. J. Hypertens. (1986) 4:141–156.
   PubMed Web of Science ®Google Scholar
• STEWART IMcDG: Relation of reduction in pressure to first myocardial infarction in patients receiving treat-ment for severe hypertension. Lancet (1979) 1861–865.
   Google Scholar
• CRUICKSHANK JM, THORP JM, ZACHARIAS FJ: Benefits and potential harm of lowering high blood pressure. Lancet (1987) 1:581–584.
   PubMed Web of Science ®Google Scholar
• ALDERMAN MY, 001 WL, MADHAVAN S, COHEN H: Treat-ment-induced blood pressure reduction and the risk of myocardial infarction. JAMA (1989) 262:920–924.
   PubMed Web of Science ®Google Scholar
• HANSSON L: How far should blood pressure be lowered? What is the role of theycurve? Am.J. Hypertension (1990) 3:726–729.
   Web of Science ®Google Scholar
• THE BBB STUDY GROUP: The BBB Study: A prospective, randomized study of intensified antihypertensive treat-ment. J. Hypertens. (1988) 6:693–697.
   PubMed Web of Science ®Google Scholar
• HANSSON L FOR THE BBB STUDY GROUP: The BBB Study: The effect of intensified antihypertensive treatment on the level of blood pressure, side-effects, morbidity and mortality in 'well-treated' hypertensive patients. Blood Pressure (1994) 3:248–254.
   PubMedGoogle Scholar
• THE HOT STUDY GROUP: The Hypertension OptimalTreatment (HOT) Study - A prospective study of the optimal therapeutic goal and the value of low-dose aspirin in antihypertensive treatment. Blood Pressure (1993) 2:113–119.
   PubMedGoogle Scholar
• HANSSON L, ZANCHETTI A FOR THE HOT STUDY GROUP:The Hypertension Optimal Treatment (HOT) Study - Patient characteristics: randomization, risk profiles, and early blood pressure results. Blood Pressure (1994) 3:322–327.
   PubMedGoogle Scholar
• DAHLOF B, HANSSON L, LINDHOLM LH, SCHERSTEN B,WESTER P-0, EKBOM T, HEDNER T, DE FAIRE U: STOP-Hypertension-2: A prospective intervention trial of 'newer' versus `older' treatment alternatives in old patients with hypertension. Blood Pressure (1993) 2:136–141.
   PubMedGoogle Scholar
• AMERY A, BIRKENHAGER W, BULPITT CJ, ET AL.: SYST-EUR. A muhicentre trial on the treatment of isolated systolic hypertension in the elderly: objectives, proto-col, and organisation. Aging (1991) 3:287–302.
   Google Scholar
• THE CAPPP GROUP: The Captopril Prevention Project: A prospective intervention trial of angiotensin convert-ing enzyme inhibition in the treatment of hyperten-sion. J. Hypertens. (1990) 8:985–990.
   PubMed Web of Science ®Google Scholar
• THE NORDIL STUDY GROUP: The Nordic Diltiazem Study. An intervention study in hypertension compar-ing calcium antagonist based treatment with conven-tional therapy. Blood Pressure (1993) 2:312–321.
   Google Scholar
• HANSSON L, HEDNER T, DAHH5F B: Prospective Ran- domized Open Blinded End-point (PROBE) Study: A novel design for intervention trials. Blood Pressure (1992) 1:113.
   PubMedGoogle Scholar
• CUSHMAN WC FOR THE ALLHAT RESEARCH GROUP: The Antihypertensive and Lipid Lowering treatment to pre-vent Heart Attack Trial (ALLHAT) - Design and initial characteristics. Hypertension (1995) 25:4 (Abstract).
   Google Scholar