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Original Article

Drug Evaluation Cardiovascular & Renal: Ibutilide fumarate: a new class III agent for termination of atrial fibrillation and atrial flutter

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Pages 1511-1522 | Published online: 03 Mar 2008

References

  • HALPERN SW, ELLRODT G, SINGH BN, MANDEL WJ: Effi-cacy of intravenous procainamide infusion in convert-ing atrial fibrillation to sinus rhythm Br. HeartJ. (1980) 44:589–595.
  • CIMINI MG, BRUNDEN MN, GIBSON JK: Effects of ibutilide fumarate, a novel antiarrhythmic agent, and its enan-tiomers on isolated rabbit myocardium. Eur. J. Pharma-col. (1992) 222:93–98.
  • LEE KS: Ibutilide, a new compound with potent class HI ••antiarrhythmic activity, activates a slow inward Na.current in guinea-pig ventricular cells. J. Pharmacol. Exp. Ther. (1992) 262:99408, Description of basic electrophysiology.
  • MCKAY MC, SYKES JS, LEE KS: Effects of U-70226E, a novel antiarrhythmic drug on the action potential parameters of isolated guinea-pig ventricular myocytes. J. Mot Cell. Cardiol. (1990) 22\(Suppl. 1):S15.
  • LEE KS, TSAI TD, LEE EW: Membrane activity of class M ••antiarrhythrnic compounds; a comparison betweenibutilide, d-sotalol, E-4031, sematilide and dofetilide. Eur. J. Pharrnacol. (1993) 234:43-53. Comparative drug effects on basic electrophysiology.
  • TWEEDIE D, HENDERSON C, KANE K: Glibendamide, but not class III drugs, prevents ischaemic shortening of the refractory period in guinea-pig hearts. Eur. J. Phar-macol. (1993) 240:251–257.
  • GIBSON JK, BUCIIANAN LV, KABELL GG: Ibutilide, a classIII antiarrhythroic agent, rapidly terminates sustained atrial flutter in a canine model The Pharmacologist (1992) 36:165.
  • STAMBLER BS, WOOD MA, ELLENBOGEN KA: Compara- tive efficacy of intravenous ibutilide versus procai- namide for enhancing termination of atrial flutter by atrial overdrive pacing. Am.J. Cardiol. (1996) 77:960-966. Differential effects of ibutilide on atrial action potential duration and conduction velocity.
  • Data on file. Pharmacia & Upjohn Company. Kalamazoo, MI49001, USA.
  • VANDERLUGT JT, GAYLO SK, WAKEFIELD LK etal.: Effectsof ibutilide fumarate, a new class M antiarrhythmic agent in man. Clin. Pharmacol. Ther. (1991) 49:188.
  • CIMINI MG, GIBSON JK: The electrophysiologic effects of U-70226E on isolated rabbit myocardium. J. Mol. Cell. Cardiol. (1990) 22\(Suppl. 1):S17.
  • BUCHANAN LV, LEMAY RJ, GIBSON JK: Comparison of the class HI agents d, 1 sotalol HCIand ibutilide fumarate for atrial use dependence and antiarrhythmic effects. Pace (1996) 19:687.
  • SANGUINETFI MC, JURKIEWICZ NK: Two components of cardiac delayed rectifier IC current. Differential sensi-tivity to block by class III antiarrhythmic agents. J. Gen. Physiol. (1990) 96:195–215.
  • YANG T, SNYDERS DJ, RODEN D: Ibutilide, a methane- ••sulfonanilicle antiarrhythmic, is a potent blocker of therapidly activating delayed rectifier IC current (1k, ) in AT-1 cells. Circulation (1995) 91:1799-1806. Supports Ikr blockade as a mechanism of action.
  • CHADWICKE CC, EZRIN AM, O'CONNOR B etal.: Identifi-cation of a specific radioligand for the cardiac rapidly activating delayed rectifier IC channel Circ. Res. (1993) 72:707–714.
  • LYNCH JJ, BASKIN EP, NUTT EM et at.: Comparison of binding to rapidly activating delayed rectifier K* chan- nel, effects on myocardial refractoriness for class M antiarrhythmic agents. J. Cardiovasc. Pharmacol. (1995) 25:336–340.
  • LEE KS, LEE EW: Human atrial plateau inward currents are large, stable and increased by sub-nanomolar ibu-tilide. Biophys. J. (1996) 70:A315.
  • LEE KS, PISER TM: Ibutilide, a potent class M antiarrhyth-mic compound, activates a slow Na sensitive inward current in guinea-pig atrial cells. Biophys. J. (1996) 70:A319.
  • LEE KS, GIBSON JK: Unique ionic mechanism of actionof ibutilide on freshly isolated heart cells. Circulation (1995) 92:2755–2756.
  • JUNGBLUTH GL, BELLA-COLETTA AA, VANDERLUGT JT: Evolution of the phamacokinetics and pharmacody-nannies of ibutilide fumarate and its enantiomers in healthy male volunteers. Pharmaceut. Res. (1991) 8:S–249.
  • Ibutilide package insert. Pharmacia & Upjohn Company. Kalamazoo, MI 49001, USA. January 1996.
  • BUCHANAN LV, THOMPSON DD, IISU CL, WALTERS RR, GIBSON JK: Electrophysiologic effects of sublingual Ibutilide fumarate. EASES J. (1994) 18:A609.
  • BUCHANAN LV, LEMAY RJ, WALTERS RR et al.: Antiar-rhythmic and electrophysiologic effects of intravenous Ibutilide and sotalol in the canine sterile pericarditis modeL J. Cardiovasc. Electrophysiol. (1996) 7:113–119.
  • NABIH MA, PRCEVSKI P, FROMM BS et al.: Effects of Ibutilide, a new class M agent, on sustained atrial fibrillation in a canine model of acute ischernia and myocardial dysfunction induced by microembolism. Pace (1993) 16:1975–1983.
  • BUCHANAN LV, TURCOTTE VM, KABELL GG, GIBSON JK:Antiarrhythmic and electrophysiologic effects of ibu-tilde in a chronic canine model of atrial flutter. J. Cardiovasc. Pharmacol. (1993) 33:10–14.
  • BUCHANAN LV, TURCOTTE VM, GIBSON JK, KABELL GG:Antiarrhythmic effects of ibutilide, a new class M agent, in a 24 hour canine myocardial infarction. Circulation (1990) 82\(Suppl. 110:11I–638. ••
  • BUCHANAN LV, KABELL G, TUCOTTE VM, BRUNDEN MN,GIBSON JK: Effects of ibutilide on spontaneous and induced ventricular arrhythmin,s in 24-hour canine myocardial infarction: a comparative study with sotalol and encainide. J. Cardiovasc. Pharmacol. (1992) 19:256–263.
  • WESLEY RC, FARKHANI F, MORGAN D, ZIMMERMAN D:Ibutilide: enhanced defibrillation via plateau sodium current activation. Am, J. Physiol. (1993) 264:H1269–H1274 .
  • LEBHASETWAR V, UNDERWOOD T, HEIL RW et al.: Epi-cardial administration of ibutilide from polyurethane matrices: effects on defibrillation threshold and elec-trophysiologic parameters. J. Cardiovasc. Pharmacol. (1994) 24:826–840.
  • ELLENBOGEN KA, STAMBLER BS, WOOD MA et al.: Effi-cacy of intravenous ibutilide for rapid termination of atrial fibrillation and atrial flutter: a dose-response study. J. Am. Coll. Cardiol. (1996) 28: 130–136. First large clinical study on efficacy for atrial fibrillation and flutter.
  • STAMBLER BS, WOOD MA, ELLENBOGEN KA et al. AND 00THE IBUTILIDE REPEAT DOSE STUDY INVESTIGATORS:Efficacy and safety of repeated doses of ibutilide for rapid conversion of atrial flutter or fibrillation. Circu-lation (1996) 94:1613-1621. Safety and efficacy in a large clinical trial.
  • WOOD M, STAMBLER B, GILLIGAN DM et al. AND THE IBUITLIDE INVESTIGATORS: Suppression of inducible ventricular tachycardia by intravenous ibutilide in pa-tients with coronary artery disease. Pace (1996) 19:618.
  • Data on file. Pharmacia & Upjohn Company. Kalamazoo, MI 49001, USA.
  • VOLGMAN AS, STAMBLER BS, KAPPAGODA C et al.: Com-parison of intravenous ibutilide versus procainamide for the rapid termination of atrial fibrillation or flutter. Pace (1996) 19(Pt. 11):608.
  • BUCHANAN LV, KABELL GG, GIBSON JK: Comparison ofclass III agents in a canine model of proarrhythmia. J. Am. Coll. Cardiol. (1993) 21:248A.
  • BUCHANAN LV, KABELL GG, BRUNDEN MN, GIBSON JK:Comparative assessment of ibutilide, D-sotalol, clofilium, E-4031 and UK-68,798 in a rabbit model of proarrhythmia. J. Cardiovasc. Pharmacol. (1993) 220:540–549.
  • MARKS TA, TERRY RD: Developmental toxicity of ibu-Oleic fumarate in rats. Teratology (1994) 49:406.

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