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Expert Opinion on Investigational Drugs Volume 5, 1996 - Issue 7
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Original Article

Editorial Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: The role of tumour necrosis factor-α in sepsis revisited: From good, to bad, to worse

Tom van der Poll Department of Internal Medicine, Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
&
Sander J.H. van Deventer Department of Internal Medicine, Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Pages 805-807 | Published online: 03 Mar 2008

References to Primarv Literature

  • AGGARWAL BB, KOHR WJ, HASS PE et al.: Human tumor necrosis factor. Production, purification, and charac-terization. J. Biol. Chem. (1985) 260:2345–2354.
  • BEUTLER B, MAHONEY J, LETRANG N, PEKALA P, CERAMIA: Purification of cachectin, a lipoprotein lipase sup-pressing hormone secreted by endotoxin-induced RAW 264.7 cells. J. Exp. Med. (1985) 161:984–995.
  • BEUTLER B, MILSARK IW, CERAMI A: Cachectin/tumornecrosis factor: production, distribution, and metabolic fate in vivo. J. Immunol. (1985) 135:3972–3977.
  • BEUTLER B, MILSARK IW, CERAMI A: Passive immunisa-tion against cachectinitumor necrosis factor protects mice from lethal effect of endotoxin. Science (1985) 229:869–871.
  • VAN DER POLL T, LOWRY SF: Tumor necrosis factor in sepsis: mediator of multiple organ failure or essential part of host defense? Shock (1995) 3:1–12.
  • HESSE DG, TRACEY KJ, FONG Y et al.: Cytokine appear-ance in human endotoxemia and primate bacteremia. Surg. Gynecol. Obstet. (1988) 166:147–53.
  • MICHIE HR, MANOGUE KR, SPRIGGS DR et al.: Detection of circulating tumor necrosis factor after endotoxin adm inistration. New Engl. J. Med. (1988) 318:1481–1486.
  • ECHTENACHER B, FALK W, MANNEL DN, KRAMMER PH:Requirement of endogenous tumor necrosis fac-torkachectin for recovery from experimental peritoni-tis. J. Immunol. (1990) 145:3762–3766.
  • VAN DER POLL T, KEOGH CV, BUURMAN WA, LOWRY SF:Passive immunization against tumor necrosis factor a Impairs host defense in murine streptococcal pneumo-nia. Eur. Cytokine Network. (1996) 7:276.
  • LOWRY SF, CALVANO SE, VAN DER POLL T: Measurementof inflammatory mediators in clinical sepsis. In: Clinical Trials for the Treatment of Sepsis. Sibbald WJ, Vincent JL (Eds.), Springer-Verlag (1995):886–105.
  • VAN DER POLL T, BULLER BR, TEN GATE H et al.: Activa-tion of coagulation after administration of tumor ne-crosis factor to normal subjects. New Engl.J. Med. (1990) 322:1622–1627.
  • VAN DER POLL T, LEVI M, BLLER HR et al.: Fibrinolytic response to tumor necrosis factor in healthy subjects. J. Exp. Med. (1991) 174:729–732.
  • VAN DER POLL T, VAN DEVENTER SJH, HACK CE et al.: Effects on leukocytes following injection of tumor ne-crosis factor into healthy humans. Blood (1992) 79:693–698.
  • TRACEY KJ, BEUTLER B, LOWRY SF et al.: Shock and tissueInjury induced by recombinant human cachectin. Sci-ence (1986) 234:470–474.
  • TRACEY KJ, FONG Y, HESSE DG et al.: Anti-cachectin/TNEmonoclonal antibodies prevent septic shock during lethal bacteraemia. Nature (1987)330:662–664.
  • HINSHAW LB, TEKAMP-OLSON P, CHANG ACK et al.: Survival of primates in LD100 septic shock following therapy with antibody to tumor necrosis factor (TNFa). Circ. Shock. (1990) 30:279–292.
  • FERRANTE A, MARTIN AJ, BATES EJ et al.: Killing ofStaphylococcus aureus by tumor necrosis factor-a-acti-vated neutrophils: the role of opsonins, integrin recep-tors, respiratory burst, and degranulation_ J. Immunol. (1993) 151:4821–4829.
  • HAVELL EA: Evidence that tumor necrosis factor has anImportant role in antibacterial resistance. J. Immunol. (1989) 143:2894–2899.
  • AGOSTI JM, FISHER CJ, OPAL SM et al. AND THE STNFRSEPSIS STUDY GROUP: Treatment of patients with sepsis syndrome with soluble TNF receptor (sTNER). Proceed-ings of the 34th Annual ICAAC (1994).

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